Hla protein sequences. Medical search. Frequent questions

For example, cer- countries), and prevention and treatment of tain distributions of HLA class I alleles were opportunistic infections and cancers delay the observed in uninfected female commercial sex onset of AIDS and increase the life expectancy workers in Africa (13,14) and Thailand (11), who of HIV-infected persons. (cdc.gov)
The discovery of the gene sequences and predicted protein structures, role of CCR5 alleles has prompted studies of but their ligands have not been identified the possible role of many other host genes in (orphan receptors). (cdc.gov)
The peptide epitopes were restricted through several common HLA class I alleles for broader coverage across many ethnic groups. (news-medical.net)
Hundreds of HLA-A alleles have been described. (sigmaaldrich.com)
The length of HLA-I ligands typically ranges from 8 to 12 aa, but variability is observed across different HLA-I alleles. (aai.org)
In this study we collected recent in-depth HLA peptidomics data, including 12 newly generated HLA peptidomes (31,896 unique peptides) from human meningioma samples, to analyze the peptide length distribution and multiple specificity across 84 different HLA-I alleles. (aai.org)
We observed a clear clustering of HLA-I alleles with distinct peptide length distributions, which enabled us to study the structural basis of peptide length distributions and predict peptide length distributions from HLA-I sequences. (aai.org)
Partial sequences were also obtained for peptides from other HLA-DR alleles but none of these were attributable to known proteins. (ox.ac.uk)
These studies present evidence that an HLA-I genotype with two alleles with higher sequence divergence, known as the HLA-I evolutionary divergence (HED), may enable the presentation of more diverse immunopeptidomes and hence facilitate subsequent T cell recognition and the adaptive immune response. (biomedcentral.com)
The association between aPL antibodies and particular human leukocyte antigen (HLA) alleles and HLA-linked epitopes has been reported in studies of patients with lupus erythematous (eg, HLA-DR7, HLA-DR4). (medscape.com)
The HLA-DR3 phenotypes seem to predispose to the formation of aCL antibodies and antinuclear antibodies (ANAs), but this has not been confirmed in patients, and particular HLA alleles associated with recurrent miscarriage have not been reported. (medscape.com)
Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)

HLA-DR molecules were affinity purified and bound peptides acid eluted. (jci.org)
For the first time, to our knowledge, we have identified HLA-bound peptides presented in vivo during an inflammatory condition. (jci.org)
This approach can be extended to characterize HLA-bound peptides in various autoimmune settings. (jci.org)
peptides bound to HLA-DR17 from bronchoalveolar lavage cells of sarcoidosis patients were analyzed in order to identify target antigens of the autoimmune response (see the related article beginning on page 3576). (jci.org)
HLA-I molecules bind short peptides and present them for recognition by CD8 + T cells. (aai.org)
The claimed biochip consists of a three-dimensional mesoporous layer, where the mesoporous layer is chemically modified to recognize labeling DNAs, proteins, peptides, saccharides, and cells. (genomeweb.com)
It plays a central role in the immune system by presenting peptides derived from extracellular proteins. (antibodies-online.cn)
Peptides eluted from the Man-6-P/IGF-II receptor-binding fraction of immunoaffinity-purified MHC class II from the Swei cell line contained a sequence derived from the propiece of lysosomal acid lipase. (ox.ac.uk)
Show only peptides that were predicted to bind to only one HLA allele exclusively. (hla-ligand-atlas.org)
A number of microbially derived peptides that share sequence similarities to HLA-DQ2.5-restricted gliadin determinants known to be associated with CD have been identified and shown to activate disease-relevant, gliadin-reactive T-cells isolated from CD patients. (hesiglobal.org)
A urinary proteomic biomarker (COV50) developed by capillary-electrophoresis-mass spectrometry (CE-MS) technology, comprising 50 sequenced peptides and identifying the parental proteins, was evaluated in 228 patients (derivation cohort) with replication in 99 patients (validation cohort). (cdc.gov)
Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)

Several HLA genes or haplotypes immunodeficiency virus (HIV) as of mid-1996 (1). (cdc.gov)
Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
The role of genes ceptibility to HIV infection and the course of HIV of the human leukocyte antigen (HLA) system in disease. (cdc.gov)
It has been suggested that TEs are a source of variation as a result of the insertion of fragments of their sequence into functioning genes elsewhere in the genome. (ecancer.org)
One of the potential effects of TEs is the generation of new gene sequences [ 3 , 6 , 7 ] such as the envelope (env) genes of retroviral origin found in several mammals. (ecancer.org)
However, ~20,000 is the number of protein-coding genes. (tripod.com)
Highly polymorphic regions (such as HLA genes) are not represented either due to difficulty with designing primers because of the lack of constant regions flanking the variants. (tripod.com)
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. (nih.gov)
In matched tumor/normal mode, a full match is expected (i.e. all HLA types should match), whereas in pedigree mode, the inheritance of the HLA genes is checked to follow the expected Mendelian inheritance rules. (bihealth.org)
As the most polymorphic genes in the human genome, the HLA genes have a genetically predetermined background and play an essential role in host immune response. (biomedcentral.com)
Variants of the HLA genes can possibly shape the sequence repertoire of neopeptides presented and influence the T cell receptor (TCR) repertoire during their continuous interaction [ 11 ]. (biomedcentral.com)
Evaluation of phenotypic markers and expression of matrisome genes and proteins were evaluated by RNA-sequencing, mass spectrometry and immunohistochemistry. (lu.se)
The proteins produced from HLA genes help the immune system distinguish the body's own proteins from proteins made by foreign invaders (such as viruses and bacteria). (medlineplus.gov)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)
GCS also uses expertise to identify specific genes and studies, as well as extensive sequencing genomics to explore how the variants may genetic profiles that contribute to the work. (who.int)
Several regions throughout the human genome have been identified as potentially playing a role in inhibitor development, including the genetic variant in the clotting factor gene that causes a person's hemophilia, the human leukocyte antigen ( HLA ) region, and other genes known to be important in the body's immune response (e.g. (cdc.gov)
Investigators in the Division of Blood Disorders have used this information to develop a genetic inhibitor risk prediction tool (pages 537-538 in the linked document) that is based on information about the genetic variant causing a person's hemophilia, genetic variation in the HLA region of a person's genome, and genetic variation in a person's immune response genes. (cdc.gov)

Scientists analyzed known human CD8+ T cell epitopes from EBV antigens to design a polyepitope vaccine immunogen that incorporates 20 CD8+ T cell epitopes into an engineered protein immunogen. (news-medical.net)
Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
The initial NIOSH R01 grant award (2006-2012) identified candidate variants (snps) linked to Th2 cytokines, antioxidant enzymes, and HLA class I and II antigens. (cdc.gov)
A new nomenclature system for HLA antigens was recently devised by the WHO Nomenclature Committee for Factors of the HLA System. (bvsalud.org)
This system was needed to support the vast number of HLA antigens that are now characterized at the level of DNA sequence. (bvsalud.org)
See Nomenclature for Factors of the HLA System for further information on how HLA antigens are named. (bvsalud.org)

Recently, the first set of naturally presented human leukocyte antigen Class I (HLA-I) epitopes of MuV was identified by us. (mdpi.com)
We used a novel in vitro degradation assay involving cytosolic extracts as well as endogenous intracellular processing assays to examine 2 well-characterized HIV-1 Gag overlapping epitopes presented by the same HLA class I allele, one of which is consistently immunodominant and the other subdominant in infected persons. (jci.org)
Furthermore, specific point mutations in these portable flanking sequences modulated the production and antigenicity of epitopes. (jci.org)
The testing of the polyepitope vaccine immunogen using peripheral mononuclear cells isolated from EBV seropositive donors revealed that the immunogen can be effectively processed by antigen-presenting cells to generate epitopes that can be presented on HLA class I molecules and subsequently recognized by human CD8+ T cells to promote an immune response. (news-medical.net)
Population conservation studies of the selected protein and predicted epitopes were also performed using population conservancy analysis tool of immune epitope database resource. (ijpsonline.com)
Both technologies have been primarily focused on measurement of protein epitopes, but have been used to measure nucleic acids such as targeted mRNA 11 , 12 . (nature.com)
Current risk assessment approaches for novel foods include amino acid sequence comparison searches, with comparisons being made to approximately 70 known 9-amino acid celiac epitopes. (hesiglobal.org)

Provided that there is sufficient coverage of the HLA loci, comparing HLA types allows for simple, fast and robust matching of samples from whole genome, exome and RNA-seq data. (bihealth.org)
Six HLA loci were typed by next-generation sequencing. (bvsalud.org)

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry. (thermofisher.com)
Immunogenetic studies found a significant association between HLA-DR3 and the presence of antisynthetase antibodies (P = 0.049), anti-PM-Scl antibodies (P = 0.017), and interstitial lung disease (P = 0.03). (nih.gov)

We further identified multiple specificity in several HLA-I molecules and validated these observations with binding assays. (aai.org)
A comparison of HLA-B*3501/peptide complexes with structures of other HLA molecules exhibits allele-specific properties of HLA-B*3501, as well as peptide-induced structural changes. (rcsb.org)

We have investigated DA associated genotypes, using candidate gene studies, GWAS and Next Generation Sequencing (NGS) to identify gene variants associated with DA. (cdc.gov)

Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. (nih.gov)
The predominant Y1444F substitution seemingly impairs binding to the HLA-A*01 molecule, which may have an important impact on the ability to prime a functional CD8 response upon infection. (ox.ac.uk)
Taken together, these data illustrate the strong interdependence between the HLA class I molecule and the bound peptide. (rcsb.org)
This product is a MHC pentamer of peptide composed BCR-ABL 210 kD fusion protein-derived peptide of ATGFKQSSK sequence covering 259-269 and A*03:01, A*11:01 molecule. (peptides.de)

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. (wikipedia.org)
The S1 subunit (PDB I.D-6VSB) of the spike protein being reported to acts as receptor binding domain (RBD), binding to ACE-2 receptor with higher affinity. (ijpsonline.com)
Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses. (ox.ac.uk)
A second article in the same issue of The Journal of Experimental Medicine by Bulliard et al also explored the role of FcgR engagement on the effects of Ipilimumab as well as an agonistic antibody (DTA-1) targeting the T cell activating receptor GITR (TNFR glucocorticoid-induced TNFR-related protein), which is also expressed on both activated T cells and T REG s. (sanguinebio.com)

IMGT/HLA Database: Protein and and nucleotide HLA sequences. (ucm.es)
0.6% divergent (from PV2) in VP1 nucleotide sequences from the corresponding OPV strain ( 4 ). (cdc.gov)

However, limited data are available about sequence variability in CD8 + T cell epitope regions of mumps virus (MuV) proteins. (mdpi.com)
In the present study, sequences of 40 CD8 + T cell epitope candidates, including previously and newly identified, obtained from Jeryl-Lynn mumps vaccine strains were compared with genomes from 462 circulating MuV strains. (mdpi.com)
In this study, scientists have developed a lymph node-targeting multi-epitope subunit vaccine against EVB and tested its efficacy in Human Leukocyte Antigen (HLA)-expressing mice. (news-medical.net)
The aim of this study was to characterize the forces that contribute to viral evolution in an HLA-A*01-restricted epitope in HCV NS3. (ox.ac.uk)
In our cohort of subjects with chronic HCV infection (genotype 1b or 3a), it is a frequently recognized CD8 epitope in HLA-A*01-positive subjects. (ox.ac.uk)
In order to reflect the clinical scenario more wholistically, we propose the use of patient-derived human gut organoids as a model system to determine the celiac potential of a protein containing a single putative CD epitope. (hesiglobal.org)

The following product was used in this experiment: HLA-G Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-85340, RRID AB_2792482. (thermofisher.com)
A serum sample test showed a weak positive result for dengue virus by using IgM and IgG antibody tests, and a strong positive result for dengue virus nonstructural protein-1, or NS1, antigen, demonstrating acute dengue virus infection. (cdc.gov)

Bound proteins were purified by DNA affinity precipitation assays (DAPA) and eluted proteins analyzed by mass spectrometry (MS), demonstrating that rs14798008 bound H1 histones. (cdc.gov)

Translocon-associated protein subunit alpha is a protein that in humans is encoded by the SSR1 gene. (wikipedia.org)

HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint. (nih.gov)
Also discussed are HLA gene-specific primers and HLA allele-specific or SNP-specific hybridization probes. (genomeweb.com)

They identified highly-conserved antigenic peptide sequences from a range of latent and lytic EBV proteins and included them serially by separating each sequence using proteolytic cleavage sites. (news-medical.net)
The Protein Allergens, Toxins and Bioinformatics (PATB) Committee is seeking partners to help launch a new project to advance methods for the assessment of gluten-like peptide sequences that could trigger Celiac disease (CD) . (hesiglobal.org)

Study of association between HLA-DR4 and DR53 and autoantibody detection in rheumatoid arthritis. (medscape.com)

1993). "A tetrameric complex of membrane proteins in the endoplasmic reticulum" (PDF). (wikipedia.org)

These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. (nih.gov)
Sometimes additional numbers are added after a colon to identify allelic variants that encode identical proteins, and after another colon, other numbers are added to denote polymorphisms in introns or in 5' or 3' untranslated regions (eg, A*02:101:01:02, DRB1*03:01:01:02). (msdmanuals.com)

Explicitly modeling peptide length distribution and multiple specificity improved predictions of naturally presented HLA-I ligands, as demonstrated in an independent benchmarking based on the new human meningioma samples. (aai.org)
Specify peptide sequence, tissue, HLA allele and source protein constraints here to filter the HLA ligands. (hla-ligand-atlas.org)

The project will have relevance for those involved in the evaluation of genetically modified crops, novel foods, or proteins (e.g., for food ingredients) produced via precision fermentation or microbial production systems as well as those with an interest in NAMs for food safety and clinicians/researchers involved in the study of Celiac Disease pathology and immunology. (hesiglobal.org)

We have previously shown that Scandinavian sarcoidosis patients expressing the HLA-DR allele DRB1*0301 are characterized by large accumulations in the lungs of CD4+ T cells expressing the TCR AV2S3 gene segment. (jci.org)
To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301pos patients were obtained by bronchoalveolar lavage. (jci.org)
The haplotype HLA-A*01:01 ~ B1*08:01 ~ C*07:01 ~ DRB1*03:01 ~ DQB1*02:01 conferred an increased risk of low humoral response. (bvsalud.org)
especially the HLA-DRB1 gene. (medlineplus.gov)

The PATB is committed to advancing the scientific understanding of the relevant parameters defining allergenic proteins and protein toxins, and encouraging the development of reliable and accurate methodologies for characterizing the allergenic potential of novel proteins in order to leverage the potential of bioinformatics approaches in accomplishing these efforts. (hesiglobal.org)
Formerly the Protein Allergenicity Technical Committee (PATC), the committee has adopted a new designation, the Protein Allergens, Toxins and Bioinformatics (PATB) Committee, to embrace a broader scope, expertise, interests, and collaborators in the fields of bioinformatics and protein toxins, while strengthening its core focus in allergenicity. (hesiglobal.org)

To address this aim we have designed the lungNENomics study, an international cohort of over 250 cases of pulmonary carcinoids, with clinical data and central pathology review, as well as whole-genome sequencing, RNA sequencing, DNA methylation array, and digital spatial profiling data. (who.int)

For the PUCH cohort, we performed HLA genotyping by whole exome sequencing (WES) analysis on the peripheral blood samples from all patients. (biomedcentral.com)

HLA-G belongs to the HLA class I heavy chain paralogues. (thermofisher.com)
This study shows that peptide-specific HLA B27-restricted CTL following influenza virus infection use very similar TcR and, when considered with previous studies, suggests a pattern of TcR conservation for major histocompatibility complex class I-restricted responses. (ox.ac.uk)
HLA-DRB4 belongs to the HLA class II beta chain paralogues. (antibodies-online.cn)
Independent of the length of the bound peptide, HLA-B*3501 positions the peptide C terminus significantly closer to the alpha1-helix and nearer to the A pocket than observed for other HLA class I/peptide complexes. (rcsb.org)
The human leukocyte antigen class I (HLA-I) genotype has been linked with differential immune responses to infectious disease and cancer. (biomedcentral.com)
May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. (lu.se)
Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. (lu.se)
In cases where there is a distinct protein subtype that is only found in a specific organelle or organism the sub-concept was promoted to a new descriptor class. (bvsalud.org)

Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. (nih.gov)

These cells are specific for the peptide sequence GILGFVFTL, found in the matrix protein of influenza virus. (criver.com)

We determined the serological and cellular response to spike protein in 100 people aged 80-96 years at 2 weeks after the second vaccination with the Pfizer BNT162b2 mRNA vaccine. (elifesciences.org)
We undertook an analysis of serological and cellular immune responses to spike protein in 100 independently living people aged between 80 and 96 years who received BNT162b2 vaccine with a 3-week interval between the first and second doses. (elifesciences.org)
The immunogenicity of the vaccine was tested using HLA-expressing transgenic mice. (news-medical.net)
Associations between HLA and vaccine response were performed with univariate and multivariate analyses. (bvsalud.org)

Recent studies suggest that T-cell immune pressure is an important factor in the evolution of the nonstructural proteins in HCV. (ox.ac.uk)

Recombinant protein encompassing a sequence within the center region of human HLA-G. (thermofisher.com)
In the past a series of specific recombinant protein headings were created to distinguish several pharmaceutically-significant protein classes. (bvsalud.org)
However, the advent of recombinant protein technology for the production of most pharmaceutical proteins has made this distinction obsolete. (bvsalud.org)

Do most proteins show cross-species activity? (medchemexpress.com)
Other proteins may have a lower specific activity when used in the opposite species. (medchemexpress.com)

Hundreds of examples have been identified in which individual exons possess sequences that are similar or identical to TE fragments [ 3 , 4 ]. (ecancer.org)

This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. (nih.gov)

However, the clinical relevance of germline HLA-mediated immunity in gastrointestinal (GI) cancer remains elusive. (biomedcentral.com)

A molecular dynamic (MD) modeling approach was applied to evaluate the effect of external electric field on gliadin protein structure and surface properties. (mdpi.com)

Caris molecular profiling performs thorough molecular testing on DNA, RNA and proteins to identify the biomarkers driving a patient's tumor, and to compare the biomarkers with data from clinical studies around the world. (carislifesciences.com)

beta-chain variable-region usage was also conserved, with V beta 7 being used by five clones despite contributing less than 2% of peripheral blood lymphocyte V beta sequences of one individual studied. (ox.ac.uk)

Furthermore, patients with high HLA-B HED were characterized with a decreased prevalence of multiple driver gene mutations and an immune-inflamed phenotype. (biomedcentral.com)
The emergence of immune checkpoint blockade (ICB) therapy that targets programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) or anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has markedly revolutionized the therapeutic landscape of patients with metastatic cancers [ 1 , 2 ]. (biomedcentral.com)

Viral sequence data reveal that an escape variant is the dominant residue in both genotypes. (ox.ac.uk)

The terms of the agreement give Qiagen access to Protagen's proprietary SeroTag, an automated multiplex technology that can facilitate the discovery and validation of protein-based biomarker panels. (genomeweb.com)
Of note, a combinatorial biomarker of HLA-B HED and tumor mutational burden (TMB) may better stratify potential responders. (biomedcentral.com)
Our results unveil how HLA-B evolutionary divergence influences the ICB response in patients with GI cancers, supporting its potential utility as a combinatorial biomarker together with TMB for patient stratification in the future. (biomedcentral.com)

It is best to be aware of these definitions while sticking with the recommendations of the Human Genome Variation Society and to use ' sequence variant ' , ' alteration ' or ' allelic variant ' for any genomic change regardless of their frequency or phenotypic effects. (tripod.com)

We demonstrate that this method can be applied to multi-modal protein and RNA analyses. (nature.com)

The exact sequence is proprietary. (antibodies-online.cn)

Our data showed that neither HLA heterozygosity nor HED at the HLA-A/HLA-C locus correlated with the overall survival (OS) in the PUCH cohort. (biomedcentral.com)

We studied the associations of two parameters of germline HLA as heterozygosity and evolutionary divergence (HED, a quantifiable measure of HLA-I evolution) with the clinical outcomes of patients in both cohorts. (biomedcentral.com)

The antiphospholipid (aPL) autoantibodies bind moieties on negatively charged PLs or moieties formed by the interaction of negatively charged PLs with other lipids, PLs, or proteins. (medscape.com)

Recombinant Human MAGE-A3(HLA-A*01:01) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus, tetramer is assembled by biotinylated monomer and streptavidin.It contains Gly25-Thr305(HLA-A*01:01),Ile21-Met119(B2M) and EVDPIGHLY peptide. (kactusbio.com)
Recombinant Human KRAS WT(HLA-A*03:01) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVVGAGGVGK peptide. (kactusbio.com)

We identified 78 amino acid sequences from self proteins presented in the lungs of sarcoidosis patients, some of which were well-known autoantigens such as vimentin and ATP synthase. (jci.org)
The env gene maintained an ORF coding for a 538-amino acid polypeptide that has all the characteristic features of env proteins and mediates intercellular fusion in vitro [ 11 - 13 ]. (ecancer.org)

Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples. (nih.gov)

Electrophoretic mobility shift assays (EMSA) identified oligonucleotide-protein binding for risk and non-risk SNPs to nuclear extracts of A549, BEAS 2B, and IMR-90 lung cell lines. (cdc.gov)

Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. (medchemexpress.com)

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