Hla locus hla d antigens. Medical search. Frequent questions

Genetic association studies underscored the importance of human leucocyte antigen (HLA) genes within major histocompatibility complex (MHC) as susceptibility loci for DA. (cdc.gov)
In 2014, Genome-Wide Association Study (GWAS) was performed with 2,398 individuals with laryngeal squamous cell carcinoma cases and 2,804 cancer-free controls from Chinese populations, and identified a novel susceptibility loci in complex human leukocyte antigen (HLA), which plays crucial role in immune response. (who.int)
Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (musc.edu)

Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
The present results are consistent with the hypothesis that an immunological mechanism is involved in DA and that genetic variations within HLA genes play a role in DA risk. (cdc.gov)
AIH usually develops in individuals with a genetic background mainly consisting of some risk alleles of the major histocompatibility complex (HLA). (wjgnet.com)
Furthermore, his research spurred the discovery of H-2 haplotypes, HLA alleles and haplotypes, HLA loci genetic order, the role of histocompatibility antigens in skin graft rejection, and the outcome of kidney allografts. (brighthub.com)
A genetic predisposition has been identified and, in White populations, localized to a shared epitope in the HLA-DRB1 locus of class II histocompatibility antigens. (merckmanuals.com)
The examination of HLA in a patient, often referred to as "tissue typing" or "genetic matching. (hrsa.gov)
Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. (nih.gov)
Genetic factors are thought to play a role in susceptibility to Behcet's disease, with the human leukocyte antigen (HLA) B-51 gene region of the genome, accounting for about 20 percent of genetic risk for the disease. (nih.gov)
The current study represents an important advance because it dramatically broadens the spectrum of genetic loci associated with Behcet's disease," said Dan Kastner, M.D., Ph.D., scientific director of the Intramural Research Program at the National Human Genome Research Institute and senior author of the study. (nih.gov)
1. The use of sera and monoclonal antibodies has permitted the serological definition of three polymorphic genetic loci HLA-A, HLA-B, and HLA-C, which encode the 45kDa heavy chains of the classical class I transplantation antigens. (gla.ac.uk)
Molecular genetic analyses revealed that the vertebrate class I gene family was larger than expected, and there is evidence that at least some of these genes encode polypeptides whose structure and perhaps function is different from those of the classical class I loci. (gla.ac.uk)
Autoantibodies (rheumatoid factor, antinuclear antibodies and antibodies against cyclic citrullinated peptides (ACPAs)) and genetic markers (human leucocyte antibody (HLA) shared epitope and protein tyrosine phosphatase nonreceptor type 22 (PTPN22)) were analysed at the time of inclusion. (biomedcentral.com)
Replication of Associations of Genetic Loci Outside the HLA Region With Susceptibility to Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis. (ox.ac.uk)
OBJECTIVE: Genetic polymorphisms within the HLA region explain only a modest proportion of anti-cyclic citrullinated peptide (anti-CCP)-negative rheumatoid arthritis (RA) heritability. (ox.ac.uk)
This study was undertaken to replicate the associations of anti-CCP-negative RA with non-HLA genetic polymorphisms demonstrated in a previous study. (ox.ac.uk)
4 Genetic association studies of SLE have been successful in identifying multiple loci. (cdc.gov)
Our aim was to discover genetic loci within the MHC region that are associated with specific clinical and/or immunological manifestations within SLE cases and hence to find evidence of genetic variants that may drive specific forms of the disease. (cdc.gov)
The major histocompatibility complex (MHC) on chromosome 6, which contains the human lymphocyte antigens (HLA), was the first described genetic link to SLE. (medscape.com)
Genome-wide association studies have identified more than 100 genetic loci for SLE susceptibility across populations, with most of the genetic risk shared across borders and ethnicities. (medscape.com)

At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 . (medlineplus.gov)
Association of various HLA haplotypes with SARS-CoV-2 infection and the course of COVID-19 could improve assessment of viral severity in the population. (antibodies-online.com)
This family study allowed the establishment of the precise composition of the 200 HLA haplotypes, which cannot be obtained from unrelated individuals. (wayne.edu)
Five HLA-B,HLA-DR haplotypes showed significant delta values (observed vs. expected frequencies) after correcting for the number of comparisons. (wayne.edu)
Ten of the 17 HLADR, HLA-DQ haplotypes had significant postcorrection delta values. (wayne.edu)
CONCLUSIONS: In black South Africans there is evidence for a locus on DR2 haplotypes contributing to SLE. (ox.ac.uk)
Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. (cdc.gov)

Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04. (rcsb.org)
Jamie Rossjohn, Frits Koning, Hugh Reid and colleagues isolated four different TCRs from celiac disease individuals and captured their structure during the central event in the disease: recognition of gluten peptides presented by HLA-DQ2, the variant of the peptide-presenting molecule that is associated with 90-95% of celiac cases. (scienceinpublic.com.au)
Class I HLAs present peptides from inside the cell whereas class II HLAs present antigens from outside of the cell to T-lymphocytes. (antibodies-online.com)
A recent study shows that individuals with the allele HLA-B*46:01 have the fewest predicted binding peptides for SARS-CoV-2, suggesting they may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS. (antibodies-online.com)
A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. (antibodies-online.com)
Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. (musc.edu)
Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)

Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*04:02 allomorph interacted with arginine or citrulline-containing epitopes. (rcsb.org)
Citrullination altered protease susceptibility of vimentin, thereby generating self-epitopes that are presented to T cells in HLA-DRB1*04:01(+) individuals. (rcsb.org)
for example the MHC Class II antibody based on clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. (antibodies-online.com)
Epitopes are a component of the antigen that are recognized by the immune system and determine whether the cellular or the humoral arm of the immune system shall be activated against that particular antigen. (medscape.com)
Immunoglobulins (Igs), the term is sometimes used interchangeably with "antibodies," are glycoprotein molecules produced by B lymphocytes and plasma cells in response to an immunogen or after recognition of specific epitopes on the antigen. (medscape.com)

In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. (antibodies-online.com)
As the MHC is encoded by highly polymorphic human leukocyte antigen (HLA) loci in humans, this process of thymic selection occurs within the context of an individual's HLA type. (biorxiv.org)
The genes are found in the HLA-D region in humans and include H-2M, I-A, and I-E loci in mice. (nih.gov)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)

Consequently, matching has been proposed of deduced amino acid residues of the individual HLA molecules shared by cross- reactive antigen groups (CREGs). (pitt.edu)
Variants of this protein can lead to more or less efficient processing of microbial proteins before they are loaded onto HLA molecules for presentation to the immune system. (nih.gov)
Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. (musc.edu)
Several DLL3-targeted therapies are being developed for the treatment of SCLC and other neuroendocrine carcinomas, including antibody-drug conjugates (ADCs), T-cell engager (TCE) molecules, and chimeric antigen receptor (CAR) therapies. (bvsalud.org)
Antigens are the molecules that are recognized and stimulate the cells of immune system. (medscape.com)
Variable region constitutes the antibody binding region of the molecule to the different antigens as it consists of about 110 amino acids that vary widely among the different antibody molecules. (medscape.com)
Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)

Human leukocyte antigens are highly polymorphic loci located on chromosome six. (wits.ac.za)

CONCLUSIONS: HLA genotype associates with CC, thus implicating HLA-related immune mechanisms in its pathogenesis. (edu.au)
As specialized HLA genotyping tools have been developed which utilize NGS data, the aim of this study was to compare four HLA genotyping tools, namely - BWAkit, xHLA, Kourami and HISAT-Genotype, and to evaluate whether population-speciﬁc HLA variability would aﬀect their accuracy. (wits.ac.za)
It was also noted that, with the exception of HISAT-Genotype, each tool was most accurate at HLA-B, and least accurate at HLA-C. From evaluating HLA population-speciﬁc variability, it was found that the four super-populations tested African, Asian, European and South American, did not signiﬁcantly vary, in regards to HLA variability. (wits.ac.za)
It is not clear which factors are responsible for variation in clinical picture of APECED, but human leukocyte antigen (HLA) genotype may be important. (ersjournals.com)
The HLA genotype of the patient (DRB1*01/DRB1*11, DQB1*0301/DQB1*0501) has been previously reported as a predisposing factor to PPH. (ersjournals.com)
The human leukocyte antigen (HLA) genotype may be important, since it was observed that autoimmune conditions in the APECED cohort showed HLA associations that were similar to those found in non‐APECED patients with respective autoimmune disorders 4 . (ersjournals.com)
METHODS: HLA-DRB1 genotype frequencies assigned by polymerase chain reaction (PCR) amplification and sequence specific oligonucleotide probes were compared between 49 black SLE patients from Baragwanath Hospital and 87 ethnically matched controls. (ox.ac.uk)
Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)

Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. (rcsb.org)

In The History and Geography of Human Genes (Princeton, 1994), Cavalli-Sforza, Menozzi and Piazza grouped Greeks with other European and Mediterranean populations based on 120 loci (view MDS plot). (wikipedia.org)
The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
Classical human leucocyte antigen (HLA) variants at 2-digit and 4-digit resolution were obtained via imputation from single marker genotypes. (edu.au)
95% of individuals with celiac disease carry the HLA (human leukocyte antigen) -DQ2 locus. (scienceinpublic.com.au)
Allocation of cadaver kidneys by graded human leukocyte antigen (HLA) compatibility scoring arguably has had little effect on overall survival while prejudicing the transplant candidacy of African-American and other hard to match populations. (pitt.edu)
Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2. (antibodies-online.com)
Histocompatibility laboratories test compatibility of transplant candidate and organ donor tissues using the human leukocyte antigen (HLA) complex. (hrsa.gov)
The appearance of DSA were preformed (n=5, anti-human leukocyte antigen class II=3, anti-class I and II=2), de novo (n=4, 15.25±4.72 days after transplantation, anti-class II=1, and anti-class I and II=3) and never (n=6). (lww.com)
Two human monoclonal antibodies (HuMAbs) with widely different HLA specificities were raised from a uniparous HLA-seropositive female. (elsevierpure.com)
Human leucocyte antigen (HLA) genes play an important role in determining the outcome of organ transplantation and are linked to many human diseases. (biomedcentral.com)
Surface expression of human leukocyte antigen (HLA) class I antigens on melanoma lines was evaluated by locus-specific monoclonal antibodies (mAbs) with three different techniques: Fluorescence-activated cell sorting (FACS), immunohistochemistry with cytospin preparation (ICP), and complement- mediated cytotoxicity (CMC). (elsevierpure.com)
HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. (musc.edu)
We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. (cdc.gov)
13 Our study substantially expands this work by not only analysing imputed classical human leukocyte antigen (HLA) alleles, but also examining variant HLA amino-acid positions in conjunction with single-nucleotide polymorphism (SNP) genotypes across the extended MHC region (chromosome 6: 26-34 Mb). (cdc.gov)
An association between Human Leukocyte Histocompatibility Antigen B-27 (HLA-B27) and major arthritis syndromes such as Ankylosing Spondylitis and Reactive Arthritis is well documented (Khan et al. (cdc.gov)

HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint. (nih.gov)
The accuracy of the tools were compared to Sanger sequenced HLA data, where exons 2 and 3 were sequenced for HLA class I. As exons 2 and 3 were available as a reference from the Sanger sequencing, an accurate allele call was determined on its similarity to the reference data. (wits.ac.za)
However, we detect a significant correlation between increased HLA allele sharing and increased number of shared TCRβ clones, with each additional shared HLA allele contributing to an increase in ∼0.01% of the total TCRβ clones being shared, supporting a key role for HLA type in shaping the immune repertoire. (biorxiv.org)
Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)
Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. (cdc.gov)
The cross-linked sample DNA was hybridized with sequence-specific oligonucleotide probes to identify HLA-B27 allele sequences. (cdc.gov)

RESULTS: Forty-two markers gave rise to genome-wide significant association signals, all contained within the HLA region on chromosome 6 (best p=4.2×10(-10) for SNP rs4143332). (edu.au)
Two years ago, the research team identified gene associations at two other specific chromosome locations, or loci. (nih.gov)
Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)
The higher risk of SLE in women and men with Klinefelter syndrome may be associated with enhanced expression of toll-like receptor 7 (TLR7), a key pathogenic factor in SLE that is encoded on an X chromosome locus. (medscape.com)

HLA class II antigens associated with systemic lupus erythematosus in black South Africans. (ox.ac.uk)
OBJECTIVE: To assess the associations of HLA class II antigens with systemic lupus erythematosus (SLE) in black South Africans. (ox.ac.uk)

It is characterized by loss of tolerance to self-antigens, formation of immune complexes, and an activated type I interferon system. (medscape.com)

Antigen recognition depends on both T-cell specificity and the molecular complex presenting the antigen. (biorxiv.org)

Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
The body's immune system can react adaptively against the antigen via 2 pathways: cellular or humoral. (medscape.com)

Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. (nih.gov)
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles. (musc.edu)

MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
Their encoded proteins are involved in presenting antigen derived from pathogens to immune cells, which then trigger a cascade of immune responses [ 3 , 4 ]. (biomedcentral.com)

HLA-DQA1 and -DQB1 genotypes were also assigned in 45 of the SLE patients and 74 controls by PCR using sequence specific primers. (ox.ac.uk)

After adjusting for potential confounders, single nucleotide polymorphisms (SNPs) mapping to HLA-E, HLA-B, HLA-DOA, HLA-DQA2, and HLA-DPB1 genes showed associations with altered risk of developing DA. (cdc.gov)
RESULTS: After genotyping and imputation quality control procedures, data were available for 15 non-HLA single-nucleotide polymorphisms in 1,024 cases and 6,348 controls. (ox.ac.uk)

HLA-DRB1*03 was less strongly linked to DQB1*02 in this population than in white populations and was not associated with SLE. (ox.ac.uk)

Since many of these patients lack HLA-identical sibling donors and are older or have comorbidity, a fully ablative HSCT is not feasible and an alternative approach is required. (nih.gov)
Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)

The results were compared with those obtained by the matching of amino acid residues that identified CREG-compatible cases with as many as four (but not five and six) HLA mismatches. (pitt.edu)
antigen mismatches at this and mismatches other HLA loci are deleterious. (bvsalud.org)

Dr. Amos organized the first World Health Organization Nomenclature Committee, which has been responsible for the naming of HLA specificities and alleles since 1967. (brighthub.com)

Successful antigen recognition requires T cells to effectively recognize the body's MHC and coordinate a response. (biorxiv.org)
Their true function is to serve as restriction elements by presenting peptidic antigens for recognition by cytotoxic T lymphocytes in MHC restricted responses. (gla.ac.uk)
This low expression of the HLA-B antigens may play a role in the evasion of the host immune response and its up-regulation may be useful in allowing tumor antigen recognition. (elsevierpure.com)

0.01), suggesting that down-regulation and sensitivity to IFN-γ are shared by the two loci. (elsevierpure.com)
HLA-DQB1*0201 was not associated with development of the disease itself, but was associated with the presence of Ro antibodies (p = 0.01). (ox.ac.uk)

Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics. (biomedcentral.com)

The most general pre-nanomedical method to suppress immune system acute responsiveness is called antigen nonspecific immunosuppression. (nanomedicine.com)
The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
[ 10 ] The protein products of the HLA genes are critical components of cell-to-cell communication in the immune system. (medscape.com)

HLA class II antigens (DR, DQ loci) and peripheral arthritis in ankylosing spondylitis. (bmj.com)
Using HLA-II tetramers, we observed citrullinated vimentin- and aggrecan-specific CD4(+) T cells in the peripheral blood of HLA-DRB1*04:01(+) RA-affected and healthy individuals. (rcsb.org)
The AIRE protein is a transcriptional regulator expressed mainly in the thymus and plays a central role in the development and maintenance of immunological tolerance by promoting the ectopic expression of peripheral tissue-restricted antigens in medullary epithelial cells of the thymus 2 . (ersjournals.com)

The differences found in the patterns of selection between the class I and II loci are consistent with the hypothesis that different mechanisms shape the sequence evolution of MHC class I and class II genes. (biomedcentral.com)
12 - 15 These studies focused mainly on major histocompatibility complex (MHC) class II genes, and found evidence that class II alleles such as HLA-DRB1*03:01 are associated with auto-antibody production. (cdc.gov)

one of his notable collaborative achievements was the identifcation and definition of alleles of the various loci used in research of transplantation, disease association, and immune responses. (brighthub.com)

The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)

Exons 2 and 3 of the HLA-B locus were amplified with locus specific primers and the amplified DNA was arrayed onto seven replicate nylon membranes and immobilized by UV cross-linking. (cdc.gov)

The other haplotype, known as DQ8, is composed of the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 . (medlineplus.gov)
SNPs and HLA variants passing quality control filters were tested for association with CC with logistic regression adjusting for age, sex and country of origin. (edu.au)
These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. (nih.gov)
The variants of ERAP1 identified in this study increase the risk of Behcet's disease, but only in those individuals with one specific HLA type, HLA-B51, which has previously been associated with Behcet's disease. (nih.gov)
Recently, this signal of HLA region was confirmed to be specific to HPV(+) in oropharyngeal cancer suggesting the role of HLA variants in the immune pathogenesis. (who.int)

Screening against a large panel of serologically HLA-typed lymphocytes in the complement-dependent cytotoxicity test showed that one of these HuMAbs, VP6G3, was specific for HLA-Cw1, thereby constituting the first HuMAb against an HLA-C locus product. (elsevierpure.com)
Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)

and 4) an increased frequency of HLA class II antigens DR3 12 and DQ7 11 have been reported among PPH patients, further suggesting that immune deregulation plays a role in the pathogenesis of the disorder. (ersjournals.com)

Once the graft has escaped the initial acute phase rejection reactions, a cumulative unresponsiveness to the graft develops as the recipient is continually exposed to donor MHC, a stable state that sometimes depends on the development of antigen-specific T-suppressor cells [ 371 , 5349 - 5354 ]. (nanomedicine.com)
Using Cox proportional hazards regression modeling, we studied the relationship between levels of conventional HLA mismatch and other donor and recipient factors on primary cadaver kidney survival between 1981 and 1995 at the University of Pittsburgh (n=1,780) and in the United Network for Organ Sharing (UNOS) Scientific Registry during 1991-1995 (n=31,291). (pitt.edu)
Require notifications when there is a critical change to candidate, recipient, or donor HLA typing. (hrsa.gov)
Improve patient safety by requiring notification when there is a critical change in a donor, candidate or recipient's HLA. (hrsa.gov)
The form submitted by the histocompatibility laboratory containing HLA information of a deceased donor or living donor. (hrsa.gov)

The protein produced from the HLA-DQB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQA1 . (medlineplus.gov)
Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. (medlineplus.gov)

Tissue Antigens , 52 (4), 393-396. (elsevierpure.com)
Tissue antigens 2004 Apr 63 (4): 293-325. (cdc.gov)
Tissue antigens 2006 Jan 67 (1): 30-7. (cdc.gov)

Most people who have narcolepsy with cataplexy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes (including HLA-DQA1 ). (medlineplus.gov)
All three TCRs specific for DQ2.5-glia-a2 docked centrally above HLA-DQ2, which together with mutagenesis and affinity measurements provided a basis for the biased TCR usage. (scienceinpublic.com.au)
T cells that encounter their specific cognate MHC-presented antigen will bind and proliferate, leading to an immune response. (biorxiv.org)
Specific expression of HLA loci was examined under routine culture conditions and after 48-h incubation in interferon-γ (IFN-γ 500 U/ ml). (elsevierpure.com)
Nonetheless, carriage of specific alleles of HLA imparts about a 2-fold risk of SLE above that of the general population. (medscape.com)

In the UNOS (but not Pittsburgh) category of one-HLA mismatch (n=1334), a subgroup of CREG-matched recipients (35.3%) had better graft survival than the remaining 64.7%, who were CREG-mismatched. (pitt.edu)
The potential value of CREG matching observed in the one-HLA-mismatched recipients of the UNOS (but not the Pittsburgh) experience deserves further study. (pitt.edu)

Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies. (cdc.gov)

Many observations point to a major role for classical HLA loci in determining susceptibility to viral infections 1 . (antibodies-online.com)
We describe new information on the frequency and association of class II antigens (HLA-DR and HLA-DQ) of the major histocompatibility complex (MHC) in Mexicans. (wayne.edu)
Surprisingly, we find that shared antigen exposure to CMV leads to fewer shared TCRβ clones, even after controlling for HLA, indicative of a largely private response to major viral antigenic exposure. (biorxiv.org)
Foreign antigens are first processed and presented by an individual's major histocompatibility complex (MHC). (biorxiv.org)
This graph shows the total number of publications written about "HLA-DR3 Antigen" by people in this website by year, and whether "HLA-DR3 Antigen" was a major or minor topic of these publications. (musc.edu)

Subsequently, two separate GWASs has been conducted and consistently identified locus in HLA region in association with HNC. (who.int)

As a result, VDJ recombination, HLA restriction, and antigen exposure collectively contribute to a largely private TCRβ repertoire. (biorxiv.org)

The antibodies then specifically bind to only those particular antigens. (medscape.com)

These findings reshape our understanding of the association between citrullination, the HLA-DRB1 locus, and T cell autoreactivity in RA. (rcsb.org)
The study includes HLA-B typing and its association with the HLA-DR antigens determined in 50 families, which included 100 individuals. (wayne.edu)
Researchers have been aware of the HLA B-51 association for about 40 years. (nih.gov)
A genome-wide study in a northern European population replicated the association of SLE with susceptibility genes related to B-cell receptor pathway signaling, as well as confirmed the association of SLE with genes at the interferon regulatory factor 5 (IRF5)-TNPO3 locus. (medscape.com)
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). (lu.se)

Prednisone and prednisolone [ 386 ] act powerfully to suppress the inflammation accompanying a rejection crisis, and also appear to reduce the expression of class II histocompatibility antigens, thus reducing the immunogenicity of the transplant. (nanomedicine.com)
Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples. (nih.gov)
Loss of allelic expression was seen in one line (586-MEL): Products of genes coding for HLA-A29 and -B44, in strong linkage disequilibrium, were not detectable. (elsevierpure.com)
Hla-Antigen Expression in Colon-Carcinoma Cells. (ntu.ac.uk)

Neither of these loci is associated with other common, complex autoimmune diseases. (ox.ac.uk)

Despite these significant findings, it is important to note that imputed data for the HLA locus may pose challenges due to high level of linkage disequilibrium and polymorphism. (who.int)
are in linkage disequilibria with the HLA-drb1 locus in a japanese population. (lu.se)

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