• DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease DRB1*1201:DRB3*01/03: colorectal cancer HLA-DR12 is genetically linked to DR52 and HLA-DQ7 serotypes. (wikipedia.org)
  • HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
  • The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. (thermofisher.com)
  • The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
  • In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
  • The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
  • HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
  • HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
  • HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)
  • No significant difference of these allelic distributions was found according to the CFTR genotype. (nih.gov)
  • The analysis of genetic factors other than CFTR may help our understanding of genotype-phenotype relationships in CF. As human leukocyte antigen (HLA) class II polymorphism has been associated with a number of diseases including autoimmune and inflammatory diseases, asthma, and allergy, we investigated the possibility that HLA polymorphism contributes to CF-associated pulmonary inflammation. (nih.gov)
  • Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. (thermofisher.com)
  • The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens 1 . (bvsalud.org)
  • HLA class II polymorphism in cystic fibrosis. (nih.gov)
  • Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
  • Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and genetic factors. (cdc.gov)
  • Based on the product of single gene variant odds ratios, the risk of developing asthma was assigned to genotype profiles, and the frequency of each profile was estimated for the general population. (cdc.gov)
  • DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens. (wikipedia.org)
  • Applications Tested: This LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
  • HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
  • We screened the circulating B cell repertoires of COVID-19 survivors and vaccinees using multiplexed panels of uniquely barcoded antigens in a high-throughput single cell workflow to isolate over 9,000 SARS-CoV-2-specific monoclonal Abs (mAbs), providing an expansive view of the SARS-CoV-2-specific Ab repertoire. (bvsalud.org)
  • We show that for naive antibodies (those not yet adapted to antigens), the probability that they use the same light chain V gene is around 10%, whereas for memory (functional) antibodies, it is around 80%, even if only one cell per clonotype is used. (bvsalud.org)
  • The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
  • A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. (immport.org)
  • Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
  • During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
  • Before starting abacavir, she had tested negative for the HLA B*57:01 allele and had normal serum aminotransferase levels. (nih.gov)
  • The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
  • HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. (wikipedia.org)
  • HLA-DRB1*1501 plays a role in the disease. (eupedia.com)
  • HLA-DR11 is the short spelling for HLA-DRB1*11, just like HLA-C6 is short for HLA-Cw*06. (eupedia.com)
  • There is a suspected link with HLA-Cw4, DR7, DR11 and DQA1, among others. (eupedia.com)
  • weakly associated with HLA DR3, DR4, DR15 and DQA1. (eupedia.com)
  • Perhaps the most promising application is the potential use of the IL-28B genotype as a biomarker for treatment response in patients with chronic HCV infection. (medscape.com)
  • DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens. (wikipedia.org)
  • HLA DR1, DR4, DR5, DR8 and DR12 are associated with the disease at various levels. (eupedia.com)
  • The study aimed to identify genetic susceptible biomarkers associated with the TCE-induced hypersensitivity dermatitis in genes located in the human leukocyte antigen (HLA) region. (nih.gov)
  • 17. Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients. (nih.gov)
  • Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. (wjgnet.com)
  • Here is a very useful website that gives HLA allelle frequencies in worldwide populations (must be registered). (eupedia.com)
  • 13. Molecular Detection and Glycoprotein B (UL55) Genotyping of Cytomegalovirus among Sudanese Renal Transplant Recipients. (nih.gov)
  • 3. [Genotyping of viral glycoprotein B (gB) in hematopoietic stem cell transplant recipients with active cytomegalovirus infection: analysis of the impact of gB genotypes on the patients' outcome]. (nih.gov)
  • 15. An assessment of donor-to-recipient transmission patterns of human cytomegalovirus by analysis of viral genomic variants. (nih.gov)
  • 9. KIR and Human Leukocyte Antigen Genotype Associated Risk of Cytomegalovirus Disease in Renal Transplant Patients. (nih.gov)
  • The combination HLA-B7/B*2705 heterozygotes exhibited the highest risk for disease. (eupedia.com)
  • the main risk factors are HLA B8 and DR3 with DR1. (eupedia.com)
  • HLA-Cw*0602 is the main risk factor. (eupedia.com)
  • 2. Association of cytomegalovirus infection with human leukocyte antigen genotypes in recipients after allogeneic liver transplantation. (nih.gov)
  • Evidence that HLA-DR7-matched recipients are more susceptible to cytomegalovirus disease. (nih.gov)
  • 11. Impact of HLA-G 14-bp polymorphism on acute rejection and cytomegalovirus infection in kidney transplant recipients from northwestern China. (nih.gov)
  • 14. Single human cytomegalovirus gB genotype shed in multiple sites at the time of diagnosis in renal transplant recipients. (nih.gov)
  • This is largely explained by the shared association with major histocompatibility class II human leukocyte antigen (HLA) DQ2 and/or DQ8 between the two disease states. (nih.gov)
  • There is also an association with HLA DR2 and HLA DQ1. (eupedia.com)
  • Abacavir sulfate is a nucleoside analogue and reverse transcriptase inhibitor which is used in combination with other agents in the therapy of the human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). (nih.gov)
  • The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. (cdc.gov)
  • The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. (wjgnet.com)
  • HLA-DR3 plays a significant role in the disease. (eupedia.com)
  • HLA DR1 and DR7 may also play a role. (eupedia.com)
  • To describe the frequency of CD autoimmunity (CDA) and the distribution of HLA and haptoglobin genotypes in patients with T1D and their FDRs. (nih.gov)
  • 16. Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients. (nih.gov)
  • 18. Cytomegalovirus glycoprotein B genotype does not correlate with outcomes in liver transplant patients. (nih.gov)
  • Abnormal liver function tests occurring in a young HLA B*5701-negative woman shortly after switching to abacavir. (nih.gov)
  • 5. The influence of HLA A-B-DR matching on cytomegalovirus disease after renal transplantation. (nih.gov)
  • We obtained complete genotyping data of 113 cases and 142 controls. (nih.gov)
  • Ankylosing spondylitis (arthritis of the spine and sacroiliac joint) : caused by HLA-B27 in 95% of the cases. (eupedia.com)
  • There are tens of thousands of possible combinations of HLA, which is why some people never get sick, while other constantly have a cold, or are prone to some types of infections, depending on what HLA combination they have. (eupedia.com)
  • Some HLA types are known to attack the body's own cells, causing what is known as autoimmune diseases , in other words diseases caused by one's immune system attacking one's own body. (eupedia.com)