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  • peptide
  • leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). (uniprot.org)
  • Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. (nih.gov)
  • We have determined the 2.45 A crystal structure of the human class II MHC protein HLA-DR1 in complex with the tight binding endogenous peptide A2 (103-117) in order to discover peptide-MHC interactions that are important in determining the binding motif and to investigate conformational constraints on the bound peptide. (rcsb.org)
  • molecules
  • three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. (uniprot.org)
  • HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. (uniprot.org)
  • the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. (uniprot.org)
  • HLA-DQ8 and DRB1FNx010401 molecules predispose to develop arthritis while DRB1FNx010402 provides protection. (nih.gov)
  • This antibody can be used for the identification of class II HLA molecules. (abcam.com)
  • genetic
  • HLA-DR Class II expression on myeloid and lymphoid cells in relation to HLA-DRB1 as a genetic risk factor for visceral leishmaniasis. (beds.ac.uk)
  • Haplotypes
  • Both DRB1*01 and DRB1*14 haplotypes carry DQA1*01-DQB1*05 alleles, suggesting a common DQ-related mechanism for the protection mediated by these haplotypes. (ox.ac.uk)
  • Species
  • The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (nih.gov)
  • Specificity
  • B27-restricted CTLs with specificity for arthritogenic bacteria or autoantigens provide a missing link in the pathogenesis of the HLA-B27-associated spondylarthropathies. (uvm.edu)
  • peptides
  • Here, we used discovery-based proteomics to detect HLA-DR-presented peptides in synovia or peripheral blood mononuclear cells and identified 2 autoantigens, N -acetylglucosamine-6-sulfatase (GNS) and filamin A (FLNA), as targets of T and B cell responses in 52% and 56% of RA patients, respectively. (jci.org)
  • Onset
  • The HLA-Cw*06 phenotype was associated with type I psoriasis (OR 6.9, 95% CI 4.4, 11.1, p = 2.2 x 10(-21)) and with patients with PsA having type I psoriasis (OR 5.0, 95% CI 3.2, 7.9, p = 4.39 x 10(-13)), but not with patients with PsA having type II psoriasis (age of onset >40 years). (nih.gov)
  • HLA-Cw*06 and HLA-DRB1*07 are associated with patients with PsA having type I psoriasis, suggesting that the primary association is with age of onset of psoriasis. (nih.gov)
  • associated variants
  • One of the associated variants was also found to be linked with increased expression of MERTK in monocytes and higher expression of MERTK was associated with either increased or decreased risk of developing MS, dependent upon HLA-DRB1*15:01 status. (nih.gov)
  • polymorphisms
  • Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. (nih.gov)
  • Psoriasis
  • In a case-control association study, HLA-Cw*06 phenotype frequencies were compared between patients with PsA (n = 480), psoriasis alone (n = 611) and healthy controls (n = 166). (nih.gov)
  • Comparison of HLA-Cw*06 phenotype in psoriatic arthritis (PsA) cases, psoriasis and controls. (nih.gov)
  • However, the association with HLA-Cw*06 was confined to the subgroup of patients with PsA with type I psoriasis (OR 5.0, 95% CI 3.2, 7.9, p = 4.39×10−13) and was not observed in patients with PsA with type II psoriasis (OR 1.1, 95% CI 0.6, 2.1, p = 0.76). (nih.gov)
  • Relationship between human leukocyte antigen DRB1 and psoriasis in Iraqi patients. (beds.ac.uk)
  • The association of HLA with PsA is more complex than that found in psoriasis. (hindawi.com)
  • strongly
  • When compared with controls, the HLA-Cw*06 phenotype was shown to be strongly associated with PsA (odds ratio (OR) 3.6, 95% CI 2.3, 5.8 and p = 5.5×10−9) (table 2 and fig 1). (nih.gov)
  • AB: Ankylosing spondylitis and seronegative spondylarthropathies such as Reiter's syndrome and reactive arthritis are strongly associated with HLA-B27. (uvm.edu)
  • beta
  • The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. (uniprot.org)
  • The beta chain is approximately 26-28 kDa. (nih.gov)
  • DA2 will detect dimers and the beta chain by western blot. (novusbio.com)
  • association
  • HLA-DRB1*04 had no association. (nih.gov)
  • Only the association between HLA-DQA1*01 and CFS was significant in logistic regression models containing HLA-DQA1*01 and HLA-DRQB1*06, and this was independent of HLA-DRB1 alleles. (bmj.com)
  • There was a decreased expression of HLA-DRB1*11 in CFS, although this association disappeared after correction for multiple comparisons. (bmj.com)
  • bacteria
  • An important question is whether 'arthritogenic' bacteria such as yersinia or salmonella can generate HLA-B27-restricted bacteria-specific CTLs. (uvm.edu)