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  • genotype
  • We published the first molecular HLA association study in childhood ALL and showed a convincing association for a homozygous genotype of the DQA1 locus by RFLP analysis 4 . (dorak.info)
  • This genotype more or less corresponds to homozygosity for HLA-DR53 and the current research specifically examined this genotype by PCR analysis against a newborn control group (as opposed to an adult control group in the previous RFLP study). (dorak.info)
  • Blood samples at diagnosis were analyzed to determine HLA genotype, islet autoantibodies and serum C-peptide. (pubmedcentralcanada.ca)
  • In this study we hypothesize that autoimmune processes resulting from HLA genotype and the relationship of these genes with islet autoantibody status and residual C-peptide production at the clinical onset of diabetes are associated with the risk of DR 15 years later. (pubmedcentralcanada.ca)
  • gene
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • In fact, the null allele of the HLA-DRB4 gene ( DRB4*0103102N ) is transcribed, but it is an aberrant protein due to the lack of splicing out of the first exon 11 . (dorak.info)
  • A recessive gene closely linked to HLA and with 50% penetrance. (springer.com)
  • DR53
  • Two British studies examined HLA-DR antigens in adult leukaemias and reported the involvement of HLA-DR53 or its members in adult ALL 11 and chronic lymphoid leukaemia (CLL) 12 . (dorak.info)
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • proteins
  • In fact, practically all the trials of immunotherapy of cancer (by and large of vaccination) conducted during the last 10 years were based on the use of TAAs encompassing normal proteins or peptides, to generate antitumor T cells mostly restricted by class I HLA ( 4 ). (aacrjournals.org)
  • Immune responses targeting these proteins could thus result in a limited or no generation of antigen-loss variants and, therefore, they may efficiently control in vivo tumor growth, thus meeting the requirements for an ideal TAA set forth above. (aacrjournals.org)
  • Our prediction is that at least some of the CSC antigens will match proteins already known to serve as TAAs and expressed by embryo-fetal tissues (e.g., survivin, telomerase, cancer/testis antigens) reflecting common functions between embryonic stem cells and CSCs, i.e., multipotent differentiation, plasticity, and self-renewal. (aacrjournals.org)
  • It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. (ubc.ca)
  • fetal
  • Recently, another group of TAAs was described that include antigens overexpressed by neoplastic and fetal cells, and was weakly expressed in a phase-specific way in a few normal cells ( 14 , 15 ). (aacrjournals.org)
  • genetic
  • The test checks for the presence of specific genetic material, called HLA-B*5701, which has been associated with the abacavir hypersensitivity reaction. (catie.ca)
  • When abacavir hypersensitivity testing was initially done, researchers in Australia who pioneered this screening used HIV-positive people whose ancestors were mainly from northwest Europe and found that HLA-B*5701 (genetic material) was relatively common. (catie.ca)
  • donors
  • These results indicate that E-specific clones are serotype specific and HLA-DR7 restricted in these two donors and suggest that a common epitope on E protein may be recognized. (umassmed.edu)
  • tissue
  • All the patients were subjected to tissue typing for HLA (A, B, C) and HLA DR-DQ with the aim of defining the relative immunogenetic order. (healthy.net)
  • expression
  • Immunohistochemical studies revealed significantly higher HLA-DR expression in keratinocytes from psoriatics than from controls. (smokershistory.com)
  • These results indicate that keratinocyte expression of HLA-DR enhances inflammatory skin responses to SAg's. (smokershistory.com)
  • The presence of GAS-reactive CD4+ or CD8+ T cells did not correlate with HLA-DR7 or HLA-Cw6 expression, respectively. (smokershistory.com)
  • disease
  • Why, then, in a disease which has attracted much attention for an HLA association since Lilly's original paper on mouse leukaemia in 1964 (Ref.2), and the first HLA association paper in childhood leukaemia 3 , no other strong HLA association has been reported? (dorak.info)
  • The D8/17 non-HLA B-cell antigen has not been studied in Australia, where Aboriginal people have among the world's highest prevalence of rheumatic heart disease (RHD). (mja.com.au)
  • Ninety-eight percent of probands possessed either DR3 (relative risk = 5.0), or DR4 (relative risk = 6.8) or both antigens (relative risk = 14.3), emphasizing the strong association of the disease with these two antigens. (springer.com)
  • Batchelor JR, Morris PJ (1977) Joint report on HLA and disease: juvenile onset diabetes. (springer.com)
  • Bodmer WF (1980) The HLA system and disease. (springer.com)
  • According to the data of P. M. Alyeva (1993) DR5 antigen is a risk factor of disease development, and DR4 and DRw6 antigens are resistance factors. (bestskincare101.com)
  • cellular
  • However, the corresponding antigens are not present on the cellular key players in TRALI: neutrophils and endothelium. (bloodjournal.org)
  • In CRS patients E2 was the dominant antigen to which both cellular and humoral immune responses were elicited. (ubc.ca)
  • inflammatory
  • DLQI items Factor 1 Share full text access The epidermal barrier dysfunction hypothesis suggests that AD patients develop AD as a result of skin barrier defects that allow for the entry of antigens, resulting in the production of inflammatory cytokines. (bestskincare101.com)
  • accurately
  • The B-cell antigen D8/17 accurately identifies Australians with a past history of RF, and the assay is feasible in remote settings with access to facilities capable of performing D8/17 staining within half a day of sample collection. (mja.com.au)
  • found
  • HLA-DR7 was also found increased in childhood ALL in another study 10 . (dorak.info)
  • The latest list of officially recognized HLA-DRB alleles can be found at the ANRC site . (dorak.info)
  • several
  • Several of these antigens (e.g. (healthmatics.info)
  • 6 - 8 A non-HLA B-cell antigen known as D8/17 has been investigated in several population groups. (mja.com.au)
  • The first HLA workshop involved scientists from several countries and proved to be a seminal event, an impetus for more extensive collaborations in the following years. (ihiws.org)
  • common
  • An exchange of reagents was necessary to compare antisera to standardize the definition of antigens and to establish a common nomenclature. (ihiws.org)
  • cell
  • However, because these TAAs are expressed even by the majority of cancer cells of a given tumor, while CSCs encompass a small subpopulation of the tumor mass, CSCc may represent a better target if specifically enriched in cancer/testis, IAP-derived and/or mutated (unique) antigens in parallel with stem cell markers (e.g. (aacrjournals.org)
  • To test the B-cell antigen D8/17 as a marker of past rheumatic fever (RF) in a predominantly Aboriginal Australian population, and to evaluate technical modifications to allow its use in remote settings. (mja.com.au)
  • The first HLA antigens were defined by individual groups using their own reagents, antisera and cell panels, identified locally. (ihiws.org)
  • occur
  • In HLA-DRB4, allelic differences occur and are not limited to exon 2 ( b 1 domain) but involve exon 3 ( b 2 domain) too. (dorak.info)
  • HP develops as a result of the immunologically mediated events and the physiologic consequences that occur in the lung after inhalation of the responsible antigen in a sensitized individual. (worldallergy.org)
  • system
  • The dramatic advance in knowledge has been due largely to the early appreciation of the scope of work necessary to elucidate the HLA system requiring broad collaboration beyond what is possible within individual laboratories. (ihiws.org)
  • results
  • It is believed that acute HP usually results from intense intermittent exposure to inhaled antigens and that subacute HP results from a less intense but more persistent exposure. (worldallergy.org)
  • systems
  • The workshop was convened for the purpose of comparing the different in vitro assay systems used at the time to define antigens which were described as Hu-1 (Dausset and Ivanyi), LA (Payne and Bodmer), and Four (van Rood). (ihiws.org)
  • mechanism
  • In addition to providing a mechanism for exchanging reagents, the International HLA Workshops have also been on the forefront of promoting new technology and disseminating both reagents and technical skills worldwide. (ihiws.org)
  • reports
  • In a meta-analysis of published reports, HLA-A2 and -B12 are separately associated with childhood ALL 7 . (dorak.info)