• This led to the identification of a mutated form of human CDC27, which gave rise to an HLA-DR4-restricted melanoma antigen. (sciencemag.org)
  • Transduced hHSC expressing an HLA-A*0201-restricted melanoma-specific T-cell receptor were introduced into humanized mice, resulting in the generation of a sizeable melanoma-specific naïve CD8 + T-cell population. (pnas.org)
  • 17 ) transduced autologous T cells ex vivo with a vector expressing a natural T-cell receptor (TCR) specific for the melanoma-associated antigen recognized by T-cells 1 [MART-1(26-35)] epitope and reintroduced them into patients, resulting in tumor regression in two of the 15 subjects ( 17 ). (pnas.org)
  • Another group transduced mouse progenitors with an HLA-DR4-restricted TCR specific for melanoma ( 24 ). (pnas.org)
  • The aim of this study was to investigate possible T-B cell collaboration by determining whether autoantibodies to IA-2 epitopes are associated with T cell responses to IA-2 peptides presented by DR4. (ox.ac.uk)
  • T cells secreting the cytokines IFN-γ and IL-10 in response to seven peptides known to elicit T cell responses in type 1 diabetes were quantified by cytokine ELISPOT in HLA-typed patients characterized for Abs to IA-2 epitopes. (ox.ac.uk)
  • Presence of HLA-A10, HLA-DR4, and HLA-DRW6 antigens ( Proteins on the epithelial cell surface). (ecureme.com)
  • We then established peptide-specific T-cell clones for five of these six peptides and demonstrated that the T-cell clone specific for the PSMA 459 epitope (NYTLRVDCTPLMYSL) can recognize processed antigens from recombinant PSMA proteins. (aacrjournals.org)
  • These patterns correlate precisely with the HLA-D phenotype of the HCL donor as determined by reactivity in mixed lymphocyte culture. (pnas.org)
  • This study identifies a region of focus for B and T cell responses to IA-2 in HLA-DR4 diabetic patients that may explain HLA associations of IA-2 autoantibodies, and this region may provide a target for future immune intervention to prevent disease. (ox.ac.uk)
  • Of 138 informative DR3-DQ2/DR4-DQ8 siblings, 63% shared both haplotypes with their diabetic proband, 29% shared one, and 8% shared neither. (diabetesjournals.org)
  • A study of 48 families with siblings matched for the high-risk DR3-DQ2/DR4-DQ8 genotype participating from birth in the prospective Diabetes Autoimmunity Study in the Young (DAISY) reported a dramatically increased risk of islet autoimmunity and diabetes in 29 siblings who shared both extended high-risk haplotypes identical by descent (IBD) with the diabetic proband. (diabetesjournals.org)
  • This means HLA antigen testing is not diagnostic or accurate for prediction of the condition. (mydochub.com)
  • In the Finnish Diabetes Prediction and Prevention (DIPP study), high-risk HLA combinations identified children with no family history of type 1 diabetes who had a 36.4% (95% CI 20.0-52.8) risk of developing two or more antibodies and a 2.4% risk of diabetes within 5 years ( 9 ). (diabetesjournals.org)
  • The innate immune system, responsible for the initial non-specific response to foreign antigens, seems to be involved early in RA. (scielo.org.za)
  • Specific HLA antigens influence the development of many common disorders. (mydochub.com)
  • When a child has the specific HLA antigen type associated with the disease, he/she is thought to have an increased chance to develop the disorder. (mydochub.com)
  • To inform screening strategies, we evaluated risks of autoimmunity and diabetes associated with HLA DR3-DQ2/DR4-DQ8 in U.K. families. (diabetesjournals.org)
  • A person with this antigen may be more likely to have the disease. (rochester.edu)
  • 4 Certain antigen subtypes have been associated with more aggressive disease while other subtypes confer a protective effect. (scielo.org.za)
  • however, it is important to understand that a child without this antigen may also develop JRA. (mydochub.com)
  • Current trials to prevent the initiation of islet autoimmunity use HLA-based risk assessment to identify individuals eligible for inclusion, but they use different strategies to assign risk that depend on the potential toxicity of the planned intervention ( 6 , 7 ). (diabetesjournals.org)
  • Extended HLA haplotypes were determined in 2,134 siblings from the Bart's-Oxford Study followed to a median age of 22 years. (diabetesjournals.org)
  • Abs to juxtamembrane and central region constructs were both DR4 associated. (ox.ac.uk)