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  • peptide
  • It is then cleaved by cathepsin S (cathepsin L in cortical thymic epithelial cells), leaving only a small fragment called CLIP which blocks peptide binding until HLA-DM interacts with MHC II, releasing CLIP and allowing other peptides to bind. (wikipedia.org)
  • autoimmunity
  • To inform screening strategies, we evaluated risks of autoimmunity and diabetes associated with HLA DR3-DQ2/DR4-DQ8 in U.K. families. (diabetesjournals.org)
  • Current trials to prevent the initiation of islet autoimmunity use HLA-based risk assessment to identify individuals eligible for inclusion, but they use different strategies to assign risk that depend on the potential toxicity of the planned intervention ( 6 , 7 ). (diabetesjournals.org)
  • immune
  • For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. (wikipedia.org)
  • cytochrome
  • Naive CD4+ T cells (those that have not encountered any antigens before) recovered from these mice 36 hours post-anti-MHC administration showed decreased responsiveness to the antigen pigeon cytochrome C peptide, as determined by Zap-70 phosphorylation, proliferation, and Interleukin-2 production. (wikipedia.org)
  • confers
  • At birth, or soon after, their babies will be tested for HLA type (to look for the specific gene which confers a higher risk of developing T1D). (clinicaltrials.gov)
  • somatic
  • [ 8 ] Moreover, an analysis of antigen receptor H chain gene transcripts of B and plasma cells isolated from s-IBM muscle showed evidence of clonal expansion and variation, isotype switching, and somatic hypermutation, indicative of a local antigen-driven humoral response. (medscape.com)