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  • single nucleotide po
  • We sought to determine the minimum number of single nucleotide polymorphisms (SNPs) that could rapidly define the HLA-DR types relevant to T1D, namely, DR3/4, DR3/3, DR4/4, DR3/X, DR4/X, and DRX/X (where X is neither DR3 nor DR4), and could distinguish the highest-risk DR4 type (DR4-DQ8) as well as the non-T1D-associated DR4-DQB1*03:01 type. (diabetesjournals.org)
  • Pemphigus
  • DNA sequences and corresponding amino acid sequences from the HLA class II beta region of the human genome that are associated with insulin-dependent diabetes mellitus (IDDM) and Pemphigus vulgaris (PV) have been identified. (google.com.au)
  • diabetes
  • We analyzed 19,035 SNPs of 10,579 subjects (7,405 from a discovery set and 3,174 from a validation set) from the Type 1 Diabetes Genetics Consortium and developed a novel machine learning method to select as few as three SNPs that could define the HLA-DR and HLA-DQ types accurately. (diabetesjournals.org)
  • sequence
  • Specifically, marker DNA sequences which detect either directly or indirectly the identity of the codon encoding for the amino acid at position 57 of the DQ-beta protein sequence are disclosed as well as sequences from the DR-beta region. (google.com.au)
  • Individuals
  • Individuals homozygous for DR3 or DR4 also have an increased risk for developing T1D, but these and other DR types relevant to T1D were not distinguished by these SNPs ( 10 ). (diabetesjournals.org)
  • previous
  • We identified a significant interaction between HLA-DR15 and history of IM in predicting an FCD of CNS demyelination, which together with previous observations suggests that this is a true interaction. (ox.ac.uk)