Hla dr alpha chains. Medical search. Frequent questions

DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at positions 11 and 13, are associated risk of rheumatoid arthritis. (wikipedia.org)
Because certain HLA-DRB1*04 subtypes increase susceptibility to RA, investigation of the role of the TNF gene is complicated by linkage disequilibrium (LD) between TNF and DRB1 alleles. (nih.gov)
Identification of three novel HLA-DRA alleles by next-generation sequencing. (nih.gov)
Researchers have identified hundreds of different versions (alleles) of the HLA-DRB1 gene, each of which is given a particular number (such as HLA-DRB1 *04:01). (medlineplus.gov)
We provide a matrix of highly representative HLA-DQ alleles that help to drive novel research to prevent transplant rejection and to contribute to more insight into CD4+ T cell responses. (hlaprotein.com)
Download our list of HLA-DQ alleles to view all available sHLA proteins as well as products in development. (hlaprotein.com)
95% of CD patients carry (HLA), DQ2 and/or DQ8 alleles. (academic-accelerator.com)
This name assignment was decided because of the complex genetic characteristics of DPB1 alleles compared to alleles of other HLA loci. (wikidoc.org)
The majority of the HLA-DPB1 alleles cannot be simply grouped together by their nucleotide sequences. (wikidoc.org)
In the 2010 HLA nomenclature update, [1] all DPB1 alleles, except DPB1*0202 and *0402, discovered after DPB1*9901 were reassigned with new numbers. (wikidoc.org)
During the Ph.D. program in the Department of Transplantation Immunology and Immunogenetics, All India Institute of Medical Sciences, Dr. Raja developed DNA-based HLA typing method and studied the diversity of HLA in Asian Indians, and the association between HLA alleles and infectious diseases. (ucsf.edu)
HLA-DRB1 shared epitope (SE) alleles were detected in patients with RA. (bmj.com)
Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequencing data from neuroblastoma patients and identify a recurrent anaplastic lymphoma kinase mutation ( ALK R1275Q) that leads to two high affinity neoepitopes when expressed in complex with common HLA alleles. (frontiersin.org)
To evaluate the range of HLA alleles that could display the ALK neoepitopes, we used structure-based Rosetta comparative modeling calculations, which accurately predict several additional high affinity interactions and compare our results with commonly used prediction tools. (frontiersin.org)

2. Autologous B lymphoblastoid cell lines and long-term cultured T cells as stimulators in the mixed lymphocyte reaction: analysis of the role of HLA class II antigens as stimulatory molecules. (nih.gov)
9. T cells specific for different antigens express different HLA-D region products. (nih.gov)
13. HLA-DR is involved in the HIV-1 binding site on cells expressing MHC class II antigens. (nih.gov)
18. Cross-linking of HLA class II antigens modulates the release of tumor necrosis factor-alpha by the EBV-B lymphoblastoid cell line JY. (nih.gov)
Transmembrane proteins that form the alpha subunits of the HLA-DR antigens. (nih.gov)
Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. (bvsalud.org)
In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. (edu.au)
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. (rcsb.org)
Soluble HLA are extremely well suited as antigens in solid phase immunoassays for the detection and characterization of HLA-specific antibodies. (hlaprotein.com)
HLA DP functions as a cell surface receptor for foreign or self antigens. (wikidoc.org)
The immune system surveys antigens for foreign pathogens when presented by MHC receptors (like HLA-DP). (wikidoc.org)

HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. (wikipedia.org)
The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
The HLA class I histocompatibility antigen, A-1 alpha chain (HLA-A) is a α- or alpha protein sometimes glycoprotein present in blood. (gentaur.com)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
N-terminal amino acid sequence analyses of the alpha and beta polypeptides from four distinct subsets of sheep major histocompatibility complex class II molecules. (aai.org)
We have previously provided evidence suggesting that the sheep has multiple major histocompatibility complex class II alpha and beta genes related to those of all three HLA-D subregions. (aai.org)
Vaccine efficacy was assessed in tumor therapy studies using HLA-matched B16 melanoma expressing constitutive or interferon γ (IFNγ)-inducible major histocompatibility complex class II (MHC-II) as represented by most human tumors. (academic-accelerator.com)
The name 'HLA-DP' originally describes a transplantation antigen of MHC class II category of the major histocompatibility complex of humans, however this antigen is an artifact of the era of organ transplantation. (wikidoc.org)
The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)
A single amino acid substitution in the human histocompatibility leukocyte antigen DR3 beta chain selectively alters antigen presentation. (silverchair.com)
Dr. Raja has over 30 years of experience in studying the basic and clinical aspects of Histocompatibility and Immunogenetics. (ucsf.edu)
In 2002, Dr. Raja joined as Associate Director of the University of California at Los Angeles (UCLA) Immunogenetics Center, which provides clinical histocompatibility testing. (ucsf.edu)
As the CLIA-approved Laboratory Director, Clinical Consultant and Technical Supervisor, Dr. Raja provides leadership to all areas of clinical Histocompatibility and Immunogenetics testing including stem cell transplantation, various solid organ transplantations (kidney, pancreas, liver, heart, lung), testing for HLA-associated diseases, and testing for transfusion services. (ucsf.edu)
Dr. Raja involves in teaching and training in histocompatibility, immunogenetics and transplant immunology, and mentors post-doctoral research fellows, residents, and visiting scholars. (ucsf.edu)
Cancer immunotherapy harnesses a patient's CD4+ and CD8+ T cell responses toward peptide neoantigens, which are displayed on the surface of tumor cells by major histocompatibility complex molecules [MHC, termed human leukocyte antigen (HLA) in humans] ( 1 ). (frontiersin.org)

The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. (wikipedia.org)
Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. (wikipedia.org)
HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC. (nih.gov)
Intact class I molecules consist of an alpha heavy chain bound to a beta-2 microglobulin molecule. (msdmanuals.com)
The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)

Fluorescent in situ hybridization (FISH) for the translocation or reverse transcription-polymerase chain reaction (RT-PCR) for the PML-RAR alpha transcript should also be done. (medscape.com)
This translocation can be detected by karyotyping or fluorescence in situ hybridization (FISH) studies, and the transcript can be detected by polymerase chain reaction (PCR) techniques. (medscape.com)
Polymerase chain reaction (PCR) is a technique involving enzymatic amplification of nucleic acid sequences in repeated cycles of denaturation, oligonucleotide annealing and DNA polymerase extension. (openophthalmologyjournal.com)
The polymerase chain reaction (PCR) is a powerful molecular biologic tool that allows the rapid production of analytic quantities of DNA from small amounts of starting material. (openophthalmologyjournal.com)
Polymerase chain reaction (PCR) is a technique involving enzymatic amplification of nucleic acid sequences in repeated cycles of denaturation, oligonucleotide annealing and DNA polymerase extension [ 3 ].The PCR uses in vitro enzymatic synthesis to amplify specific DNA sequence within few hours. (openophthalmologyjournal.com)
TNF microsatellite genotyping was performed using fluorescent based polymerase chain reaction (PCR) techniques and HLA-DR typing using PCR based sequence specific oligonucleotide probing. (ox.ac.uk)
Determine the presence of the promyelocyte-retinoic acid receptor alpha (PML-RARa) transcript using polymerase chain reaction (PCR) in patients with CR after 3 sequential consolidation regimens comprising cytarabine (ARA-C) plus IDA, followed by mitoxantrone plus etoposide, and then IDA, ARA-C, and thioguanine. (knowcancer.com)

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. (wikipedia.org)
The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The protein produced from the HLA-DRB1 gene, called the beta chain, attaches (binds) to another protein called the alpha chain, which is produced from the HLA-DRA gene. (medlineplus.gov)
Together, they form a functional protein complex called the HLA-DR antigen-binding heterodimer. (medlineplus.gov)
Soluble HLA Class II glycosylated protein complexes are 61 kDa in size consisting of a 27 kDa beta chain and a 26 kDa alpha chain with a small size peptide (15 to 24mer) in the groove. (hlaprotein.com)
6028 Background: Eftilagimod alpha (efti) is a soluble LAG-3 protein that binds to a subset of MHC class II molecules to mediate antigen presenting cell (APC) activation and CD8 T-cell activation. (academic-accelerator.com)
Results from a phase II study of eftilagimod alpha (soluble LAG-3 protein) and pembrolizumab in patients with PD-L1 unselected metastatic second-line squamous head and neck carcinoma. (academic-accelerator.com)
HLA-DP is a protein/peptide-antigen receptor and graft-versus-host disease antigen that is composed of 2 subunits, DPα and DPβ. (wikidoc.org)
DPα and DPβ are encoded by two loci, HLA-DPA1 and HLA-DPB1 , that are found in the MHC Class II (or HLA-D) region in the Human Leukocyte Antigen complex on human chromosome 6 (see protein boxes on right for links). (wikidoc.org)
Analysis of the X-ray structures of the two peptides bound to HLA-B*15:01 reveals drastically different conformations with measurable changes in the stability of the protein complexes, while the self-epitope is excluded from binding due to steric hindrance in the MHC groove. (frontiersin.org)

3. Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 bind to distinct sites on HLA-DR and HLA-DQ molecules. (nih.gov)
7. Two distinct class II molecules encoded by the genes within HLA-DR subregion of HLA-Dw2 and Dw12 can act as stimulating and restriction molecules. (nih.gov)
14. Activation of human T cells by toxic shock syndrome toxin-1: the toxin-binding structures expressed on human lymphoid cells acting as accessory cells are HLA class II molecules. (nih.gov)
Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)
Because of the high polymorphism associated with DQ molecules, we have formulated a combinatorial matrix consisting of a selection of alpha (DQA1) and beta (DQB1) chains. (hlaprotein.com)
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. (academic-accelerator.com)
CD29 complexes with one of nine integrin alpha subunits to form the very late antigen (VLA) subfamily of adhesion molecules. (thermofisher.com)
Activation of T lymphocytes by immunogenic peptides bound to HLA molecules is a central event in the generation of an immune response. (silverchair.com)
To determine the sites on HLA molecules involved in this process, we isolated mutant EBV-transformed B cell clones that express altered HLA-DR3 molecules. (silverchair.com)

Antígenos humanos de clase II o asociados a la respuesta inmunitaria que se encuentran principal pero no exclusivamente en los linfocitos B y son producidos por genes del locus HLA-D. Son familias muy polimorfas de glicoproteínas, cada una de las cuales consta de dos cadenas, alfa y beta. (bvsalud.org)
These findings reshape our understanding of the association between citrullination, the HLA-DRB1 locus, and T cell autoreactivity in RA. (rcsb.org)
The α-chain and β- of DP is encoded by the HLA-DPA1 locus and HLA-DPB1 loci, respectively. (wikidoc.org)
Mice homozygous for the severe combined immunodeficiency ( scid ) gene mutation or for targeted mutations at the recombination-activating gene 1 ( Rag1 ) or Rag2 loci, that also have a targeted mutation at the interleukin-2 receptor γ-chain ( Il2rg ) locus, support high levels of engraftment and function of human haematopoietic stem cells (HSCs) and human immune systems. (nature.com)
Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of 'humanized' mouse strains that are based on severely immunodeficient mice with mutations in the interleukin-2 receptor common γ-chain locus. (nature.com)

Four class II alpha subunits designated 28-1 alpha, 37-68 alpha, 42-20 alpha, and 38-27 alpha and five class II beta subunits designated 28-1 beta, 37-68 beta 1, 37-68 beta 2, 42-20 beta, and 38-27 beta were compared by N-terminal sequence analyses. (aai.org)
the 28-1 alpha, 37-68 alpha, and 42-20 alpha subunits all had identical N-terminal amino acids sequences, which exhibited about 75% homology with HLA-DR alpha and mouse E alpha polypeptides. (aai.org)

The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
Structurally, sHLA Class II proteins are heterodimeric glycoproteins consisting of an alpha chain, a beta chain and an endogenously loaded peptide they present forming a trimeric complex. (hlaprotein.com)
In the endogenous presentation pathway (MHC class I), abundantly expressed intracellular proteins are processed by the immunoproteasome and proteasome to yield short peptide fragments that are transported into the endoplasmic reticulum and assembled together with the MHC-I heavy chain and β2-microglobulin light chain (β 2 m) by the peptide-loading complex ( 2 ). (frontiersin.org)

DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. (nih.gov)
The heavy chain consists of 2 peptide-binding domains, an immunoglobulin (Ig)-like domain, and a transmembrane region with a cytoplasmic tail. (msdmanuals.com)
each chain has a peptide-binding domain, an Ig-like domain, and a transmembrane region with a cytoplasmic tail. (msdmanuals.com)
Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04. (rcsb.org)

Less is known about HLA-DP relative to HLA-DQ and HLA-DR but the sequencing of DP types and determination of more frequent haplotypes has progressed greatly within the last few years. (wikidoc.org)
In addition, a link to certain HLA haplotypes has been reported. (laeknabladid.is)

Prevalence of the HLA-DRB1*10:01 allele was greatly increased in people with anti-IgLON5 disease. (wikipedia.org)
Before the April 2010 HLA nomenclature update, new HLA-DPB1 allele names were assigned within the existing nomenclature system. (wikidoc.org)
For example, the allele discovered after HLA-DPB1*9901 was assigned as DPB1*0102, the subsequent allele was named DPB1*0202, then *0302 and so on. (wikidoc.org)

HLA-DRB1, a major genetic determinant of susceptibility to rheumatoid arthritis (RA), is located within 1,000 kb of the gene encoding tumor necrosis factor (TNF). (nih.gov)
We identified 274 HLA-DRB1*04-positive cases of RA and 271 HLA-DRB1*04-positive population controls. (nih.gov)
Significant differences in LTA-TNF haplotype frequencies were observed between different subtypes of HLA-DRB1*04. (nih.gov)
The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA-DRB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
Certain variations in the HLA-DRB1 gene have been linked to an increased risk of developing an autoimmune disorder called autoimmune Addison disease. (medlineplus.gov)
A particular HLA-DRB1 gene variant called HLA-DRB1*04:04 is the most well-known risk factor for autoimmune Addison disease. (medlineplus.gov)
It is not clear how HLA-DRB1*04:04 and other HLA-DRB1 variations are involved in the inappropriate immune response that causes autoimmune Addison disease. (medlineplus.gov)
Variations in the HLA-DRB1 gene have been associated with an increased risk of developing multiple sclerosis. (medlineplus.gov)
We show how citrullinated aggrecan and vimentin epitopes bind to HLA-DRB1*04:01/04. (rcsb.org)
Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*04:02 allomorph interacted with arginine or citrulline-containing epitopes. (rcsb.org)
Citrullination altered protease susceptibility of vimentin, thereby generating self-epitopes that are presented to T cells in HLA-DRB1*04:01(+) individuals. (rcsb.org)
Using HLA-II tetramers, we observed citrullinated vimentin- and aggrecan-specific CD4(+) T cells in the peripheral blood of HLA-DRB1*04:01(+) RA-affected and healthy individuals. (rcsb.org)
From NCBI Gene: HLA-DRB1 belongs to the HLA class II beta chain paralogs. (nih.gov)

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. (edu.au)

The typical phenotype of acute promyelocytic leukemia (APL) is myeloperoxidase positive and CD33 positive, human leukocyte antigen (HLA)-DR negative. (medscape.com)
Epidemiologic investigations with an integrated genetic component have linked the development of CBD with the Human Leukocyte Antigen (HLA)-DPB1 gene [ 1-6 ]. (cdc.gov)
The conserved sequence surrounding the site for N-linked glycosylation within human/mouse beta polypeptides (residues 19 to 21) was not present in sheep beta sequences and in contrast with the beta-chains of mouse and man, sheep beta polypeptides contained between 1 and 3 positionally variable cysteine residues (residues 13 to 15 inclusive). (aai.org)
This cluster is located at the proximal (centromeric) end of the HLA superlocus in human chromosome 6p21.31. (wikidoc.org)
During 6 years of postdoctoral training in the Parham laboratory, Stanford University, Dr. Raja defined the KIR genomic diversity in several non-human species. (ucsf.edu)
Dr. Raja's current research is focused on understanding the KIR-HLA genomic differences in human populations and their relevance in therapeutic transplantations and disease association. (ucsf.edu)
The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. (frontiersin.org)

The retinoic acid alpha receptor gene (RARA) is encoded by the long arm of chromosome 17. (medscape.com)
Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)

The present results suggest that a number of these genes encode HLA-DQ-like heterodimers and that a sheep DR-like alpha gene product is shared with the products of a large and heterogeneous sheep beta gene family. (aai.org)

HLA-DP is an αβ- heterodimer cell-surface receptor . (wikidoc.org)

It is distal from HLA-DR and HLA-DQ encoding loci and therefore is much more equilibrated with respect to other HLA loci. (wikidoc.org)

Avoid cycles of freezing and thawing as they might denaturate the polypeptide chains. (gentaur.com)

Tregs were first described in 1995 as a subset of CD4 + T cells expressing high levels of the interleukin (IL)-2 receptor alpha-chain (CD25) whose depletion led to development of autoimmune diseases [ 1 ]. (biomedcentral.com)
Subsequent determination of the X-ray structure of an HLA-A*01:01 bound neoepitope validates atomic features seen in our Rosetta models with respect to key residues relevant for MHC stability and T cell receptor recognition. (frontiersin.org)

Tri-SNP polymorphism in the intron of HLA-DRA1 affects type 1 diabetes susceptibility in the Finnish population. (nih.gov)

Classical and nonclassical HLA class I antigen and NK cell-activating ligand changes in malignant cells: current challenges and future direction. (nature.com)

HLA-DRA is one of the HLA class II alpha chain paralogues. (nih.gov)

The strongest determinant is HLA-DR, followed by HLA-B and -A. These 3 loci are therefore the most important for matching donor and recipient. (msdmanuals.com)

We analyzed peripheral blood mononuclear cells (PBMCs) of patients with PTSD (N = 21) (mean age = 45.9) and age-matched healthy controls (N = 23) (mean age = 45.7) to determine the proportion of Tregs and their phenotype according to the expression of CD127 and HLA-DR markers which describe the differentiation stages of Tregs. (biomedcentral.com)
Finally, MHC tetramer staining of peripheral blood mononuclear cells from HLA-matched donors shows that the two neoepitopes are recognized by CD8+ T cells. (frontiersin.org)

HN - 2012 MH - alpha-2-HS-Glycoprotein UI - D060749 MN - D12.776.124.790.106.304.500 MN - D12.776.157.125.283.500 MN - D12.776.215.625.500 MN - D12.776.377.715.85.304.500 MN - D12.776.395.86 MS - A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. (nih.gov)

ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins. (thermofisher.com)

Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis development in the Korean population. (nih.gov)
This case study will focus on the role of HLA-DPB1 in CBD and the practical application of genetic information for the benefit of all members of the beryllium industry workforce. (cdc.gov)

Combination of HLA-DR on Mycobacterium tuberculosis -Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection. (nih.gov)
The cells stain intensely for Sudan black and myeloperoxidase, but not for periodic acid-Schiff (PAS) and HLA-DR. (medscape.com)
12. Monoclonal antibodies to HLA-DP, DQ, and DR determinants: functional effects on the activation and proliferation of normal and EBV-transformed B cells. (nih.gov)
HLA-specific B cells. (hlaprotein.com)
Sustained activation of the NF-κB pathway in the tumor milieu represents one mechanism that appears to favor tumor survival and drive abortive activation of immune cells. (nature.com)

Patients proceed to allogeneic bone marrow transplantation (BMT) on group B if they are PML-RARa-positive, achieve CR, are under age 55, and have an HLA-A, -B, and -DR identical, chronic myelomonocytic leukemia nonreactive, family donor after recovery from third consolidation. (knowcancer.com)
After 11 years of UCLA experience, Dr. Raja became the program director of the University of California San Francisco (UCSF) Immunogenetics and Transplantation Laboratory (ITL), which facilitates over 800 solid organ and bone marrow transplantations per year. (ucsf.edu)

Anatomy20

Organisms8

Diseases8

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes58

Disciplines and Occupations2

Information Science3

Alleles14

Antigens12

Histocompatibility15

Molecule5

Polymerase chain re7

Protein10

Molecules10

Locus5

Subunits2

Proteins3

Peptide4

Haplotypes2

Allele3

DRB114

Subunit1

Human7

Chromosome2

Genes encode1

Heterodimer1

Distal1

Polypeptide chains1

Receptor2

Susceptibility1

Nonclassical1

Paralogues1

Determinant1

Peripheral blood2

Glycoprotein1

Heterodimers1

Genetic2

Cells5

Transplantation2