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HLA AntigensHistocompatibility Antigens Class IIHLA-D AntigensAntibodiesHLA-DR AntigensIsoantibodiesImmunoglobulin Class SwitchingHLA-DQ AntigensHistocompatibility Antigens Class IHistocompatibility TestingImmunoglobulin MGenes, MHC Class IIHLA-DR3 AntigenImmunoglobulin GHLA-DR Serological SubtypesHLA-DQ beta-ChainsHLA-DRB1 ChainsHLA-DR4 AntigenImmunoglobulin AGraft RejectionImmunoglobulin Switch RegionAntibodies, BacterialB-LymphocytesAntibodies, MonoclonalAntigensAntibody SpecificityImmunoglobulin IsotypesAntibody FormationHLA-DP AntigensEpitopesHLA-DR2 AntigenEnzyme-Linked Immunosorbent AssayAllelesImmunoglobulinsAntigens, NeoplasmHLA-DQ alpha-ChainsAntigens, BacterialAntibodies, ViralMolecular Sequence DataAntigens, SurfaceAmino Acid SequenceAutoantibodiesT-LymphocytesHLA-A AntigensAntigens, ViralHLA-B AntigensHLA-DR7 AntigenHLA-DR1 AntigenAntigen PresentationHaplotypesHLA-DP beta-ChainsCD4-Positive T-LymphocytesEpitopes, T-LymphocyteFluorescent Antibody TechniqueMice, Inbred BALB CCoxiellaHLA-DRB5 ChainsQ FeverGenes, MHC Class ILymphocyte ActivationAntibodies, NeutralizingCell LineHLA-DRB4 ChainsCoxiella burnetiiAntigens, CDAnnexin A2Cross ReactionsDiabetes Mellitus, Type 1Genetic Predisposition to DiseaseAntibody AffinityHLA-DRB3 ChainsInterferon-gammaBase SequenceAntigen-Presenting CellsHLA-A2 AntigenHLA-C AntigensBinding Sites, AntibodyT-Lymphocytes, CytotoxicFlow CytometryMajor Histocompatibility ComplexCells, CulturedGene FrequencyPeptidesAntigens, ProtozoanH-2 AntigensAntibodies, Anti-IdiotypicBahrainAutoantigensAntigens, Differentiation, B-LymphocytePeptide FragmentsClone CellsKeratoconjunctivitis SiccaGraft SurvivalEpitope MappingAntibodies, AntinuclearReceptors, Antigen, T-CellRecombinant ProteinsHLA-DR5 AntigenGold Sodium ThiomalateKidney Transplantation
Monoclonal antibodyTransgenic mouseHaplotypesPeptidesDRB1GlycoproteinsCross-reactRheumatic diseasesMoleculesTitersPeptideImmunoglobulinCeliac diseaseGeneComplement02020701HaplotypeLymphocytesBone marrowHumanRecognizeSerologyTissueHeterodimericDifferences amongGeneticsMethodsExposureResponsesFrequenciesTendencyCounterpartsImmunePsoriasisCellsIsotypeAllelesSpecificMajorPositiveAssociationDiagnosisPatientsRiskFlowPopulationDiseaseCellResponseResults
Monoclonal antibody5
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • The TU169 monoclonal antibody specifically binds to the human Major Histocompatibility Complex (MHC) Class II HLA-DQ1 and DQ2 antigens and weakly to HLA-DQ3. (bdbiosciences.com)
  • Immunohistochemistry-Paraffin: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
  • The following product was used in this experiment: HLA-DR Monoclonal Antibody (LN3), Super Bright™ 436, eBioscience™ from Thermo Fisher Scientific, catalog # 62-9956-42, RRID AB_2744822. (thermofisher.com)
Transgenic mouse2
  • Methods Homocitrullinated peptides were identified and assessed in vitro for HLA-A2 binding and in vivo in human leukocyte antigen (HLA) transgenic mouse models for immunogenicity. (bmj.com)
  • Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. (musc.edu)
Haplotypes4
  • The most frequent A-B-DR-DQ haplotypes in Korea are found at ~3/4 the Korean frequencies in Japan, except A33-Cw7-B44-DR7-DQ2, which indicates that DR7 likely spread into Korea after the Japan's Yayoi migration when most of the Korean contribution occurred. (wikipedia.org)
  • The genetic susceptibility to celiac disease is conferred by well-identified haplotypes in the human leukocyte antigen (HLA) class II region (ie, DR3 or DR5/DR7 or HLA DR4). (medscape.com)
  • Gluten is the single major environmental factor that triggers celiac disease, which has a narrow and highly specific association with class II haplotypes of HLA DQ2 (haplotypes DR-17 or DR5/7) and, to a lesser extent, DQ8 (haplotype DR-4). (medscape.com)
  • HLA- DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative. (vdocuments.net)
Peptides5
  • HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
  • The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. (thermofisher.com)
  • Modified peptides showed enhanced binding to HLA-A2 compared with the native sequences and immunization of HLA-A2 transgenic mice generated high avidity modification specific CD8 responses that killed peptide expressing target cells. (bmj.com)
  • Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
  • The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
DRB15
  • HLA-DR7 (DR7) is a HLA-DR serotype that recognizes the DRB1*0701 to *0705 gene products. (wikipedia.org)
  • Western Blot: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Western Blot Analysis of Ramos cell lysate using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • Flow Cytometry: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Flow Cytometric Analysis of Human Raji cells using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles. (musc.edu)
  • The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
Glycoproteins3
Cross-react2
Rheumatic diseases1
  • BACKGROUND: HLA-B27 positivity is normal in patients undergoing rheumatic diseases. (bvsalud.org)
Molecules7
  • In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. (novusbio.com)
  • HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
  • Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. (musc.edu)
  • The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
  • In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
  • HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
  • HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
Titers1
  • Furthermore, determination of hepatitis B antibody titers could be useful in newly diagnosed CD subjects regardless of age at diagnosis. (mdpi.com)
Peptide1
  • Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. (thermofisher.com)
Immunoglobulin1
  • In clinical practice, it is recommended to obtain first serologic tests for celiac disease (namely the immunoglobulin A tissue transglutaminase antibody [anti-TTG-IgA] test) and then to proceed with the intestinal biopsy to diagnose the condition in positive cases. (medscape.com)
Celiac disease2
  • DR7-DQ2/DR5-DQ7 phenotype (transhaplotype encoded isoform DQα5β2) is the primary risk DQ isoform in celiac disease. (wikipedia.org)
  • [ 2 ] The term silent celiac disease refers to patients showing both serologic celiac-specific autoimmunity and consistent changes of the small intestinal pathology, but presenting no symptoms. (medscape.com)
Gene2
  • The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)
  • INTRODUCTION: Ankylosing spondylitis (AS), and carriage of HLA-B27 gene in otherwise healthy individuals, are reportedly associated with increased mortality. (bvsalud.org)
Complement1
02021
  • DR7:DQA1*0201:DQB1*0202 is associated with Graves' disease. (wikipedia.org)
07011
  • The serological reaction of DR7 is excellent for *0701. (wikipedia.org)
Haplotype2
Lymphocytes3
Bone marrow1
  • Following this model, the human immune system is divided into two major classes: Cellular Immunity, located in the mucous membranes of the gastrointestinal and respiratory tracts and their respective lymph nodes (outer defenses), and Humoral Immunity, with production of antigen-specific antibodies by plasma cells in the bone marrow (inner defenses). (medicalveritas.org)
Human5
  • Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
  • Applications Tested: This LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
  • Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. (thermofisher.com)
  • During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
  • HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. (musc.edu)
Recognize2
  • Background Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. (bmj.com)
  • Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)
Serology1
  • In group 2, the diagnosis of CD is based on positive serology and histology. (vdocuments.net)
Tissue2
Heterodimeric1
  • HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. (novusbio.com)
Differences among1
  • Finally, differences among 148 cases with HLA-B27 positivity and negativity suffering from ankylosing spondylitis (AS) were investigated. (bvsalud.org)
Genetics1
Methods1
  • METHODS: This study screened totally 1503 patients who underwent HLA-B27 examination, liver/kidney function tests, and complete blood routine examination in First Affiliated Hospital of Guangxi Medical University. (bvsalud.org)
Exposure1
  • The Col 4α3NC1 epitope is thought to be less accessible for anti-GBM binding in the lung, and partial denaturation of NC1 domains may be required for full exposure of this sequestered epitope to the antibody. (medscape.com)
Responses1
  • Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
Frequencies2
  • Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma. (musc.edu)
  • D′ can therefore take on values between 0 and 1, and it is a measure of linkage disequilibrium that is normalized for variations in allele frequencies at the two loci. (musculoskeletalkey.com)
Tendency1
  • The A19 (A29, A30, A31, A32, A33, A74) serotypes are very much enriched in sub-saharan and Western Africa, including Iberia, and disequilibrated components of DR7 show a tendency to be linked to A19 serotypes. (wikipedia.org)
Counterparts1
  • HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
Immune3
  • Definitions CD is an immune-mediated systemic disorder elicited by gluten and related prolamines in genetically susceptible individuals and characterised by the presence of a variable combination of gluten-dependent clinical manifestations, CD-specific antibodies, Received and accepted September 1, 2011. (vdocuments.net)
  • The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
  • CONCLUSION: To conclude, the proposed ML model can effectively predict HLA-B27 and help doctors in the diagnosis of various immune diseases. (bvsalud.org)
Psoriasis1
  • DR7 is positively associated with psoriasis vulgaris. (wikipedia.org)
Cells2
  • During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)
  • Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
Isotype1
  • An isotype control should be used at the same concentration as the antibody of interest. (bdbiosciences.com)
Alleles2
  • In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)
  • Another useful measure of LD is the correlation coefficient, r 2 , between alleles at A and B. Like D′, the value of r 2 can also vary between 0 and 1. (musculoskeletalkey.com)
Specific4
  • When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize any non-specific polymer interactions. (thermofisher.com)
  • Goodpasture's name has been used in a more specific clinical condition known as Goodpasture disease, which is the pulmonary renal syndrome specifically associated with anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
  • Because pulmonary renal syndrome is discussed extensively elsewhere (see Wegener Granulomatosis ), this article focuses on the specific form of this syndrome associated with anti-GBM antibodies. (medscape.com)
  • The discovery of the role of anti-GBM antibodies by Lerner et al in 1967 helped provide both a better understanding of the pathogenesis for this specific form of pulmonary renal syndrome and a more rational approach to treatment. (medscape.com)
Major1
  • This graph shows the total number of publications written about "HLA-DR3 Antigen" by people in this website by year, and whether "HLA-DR3 Antigen" was a major or minor topic of these publications. (musc.edu)
Positive3
  • This increase was significant for HLA-B27-positive AS (SMR 1.38, 95% CI 1.11 to 1.65). (bvsalud.org)
  • Shortened life expectancy was observed among both HLA-B27-positive AS women (SMR 1.77, 95% CI 1.09 to 2.70) and men (SMR 1.31, 95% CI 1.02 to 1.59). (bvsalud.org)
  • Increased mortality is particularly significant among women with HLA-B27-positive AS. (bvsalud.org)
Association1
  • OBJECTIVE: To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status. (bvsalud.org)
Diagnosis1
  • The diagnosis of many diseases requires an HLA-B27 examination. (bvsalud.org)
Patients3
  • The 2004 National Institutes of Health/ Agency for Healthcare Research and Quality report and a systematic literature search on antibody tests for CD in paediatric patients covering the years 2004 to 2009 was the basis for the evidence-based recommendations on CD-specific antibody testing. (vdocuments.net)
  • Elevation of platelet associated antibody levels in patients with chronic idiopathic thrombocytopenic purpura expressing the B8 and/or DR3 allotypes. (musc.edu)
  • Life expectancy was analysed in 377 axSpA patients having available pelvic radiographs and HLA-B27 status, comparing with matched Swiss population data. (bvsalud.org)
Risk3
  • DR7-DQ2/DR5-DQ7 (/DR11-DQ7 or /DR12-DQ7) is a clarifying identifier for the at risk transhaplotype. (wikipedia.org)
  • children with symptoms suggestive of CD (group 1) and asymptomatic children at increased risk for CD (group 2). (vdocuments.net)
  • HLA-B27 carriage in the European-ancestry general population does not influence survival, or the risk of death due to vascular disease. (bvsalud.org)
Flow2
Population1
  • Survival in relation to HLA-B27 status in the general population was studied in UK Biobank European-ancestry participants (n=407 480, n=30 419 deaths). (bvsalud.org)
Disease1
  • Anti-GBM disease is defined as the triad of glomerulonephritis (usually rapidly progressive or crescentic), pulmonary hemorrhage, and anti-GBM antibody formation. (medscape.com)
Cell2
  • Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. (novusbio.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Response2
  • Memory response becomes more potent and faster after subsequent exposures to an antigen . (amboss.com)
  • Produced by eosinophils in response to antibody -dependent processes (e.g. (amboss.com)
Results1
  • For optimal and reproducible results, BD Horizon Brilliant Stain Buffer should be used anytime two or more BD Horizon Brilliant dyes (including BD OptiBuild Brilliant reagents) are used in the same experiment. (bdbiosciences.com)