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  • epitope
  • Residues 24-31 (GGKKKYKL) of the HIV-1 Gag protein p17, a region overlapping the nuclear localization site (1), have been mapped as an HLA B8-restricted epitope capable of eliciting a CTL response in HIV-1 seropositive individuals (2). (nih.gov)
  • Our present study focuses on four peptides which are related to the index peptide (GGKKKYKL) by single residue changes corresponding to naturally occurring variant epitope sequences, each of which has occured in more than one HLA B8 positive, HIV infected patient (Table 1, denoted as 3R, 5R, 7R, and 7Q). (nih.gov)
  • We also demonstrate that new protein synthesis is required for the generation of the HLA-B8 epitope for T cell recognition, suggesting that defective ribosomal products (DRiPs) are the major source of T cell epitopes. (nih.gov)
  • Arnett KL, Adams EJ, Gumperz JE, Darke C, Marsh SGE, Gelsthorpe K, Parham P: Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B* (anthonynolan.org)
  • Arnett KL, Moses JH, Williams F, Marsh SGE, Bodmer JG, Parham P, Middleton D: HLA-A *2607: sequence of a novel A*26 subtype predicted by DNA typing which shares the MA2.1 epitope with A*02, B*57 and B*58. (anthonynolan.org)
  • METHODS: Using epitope-specific T-cell clones tested for recognition of HLA-matched target cells infected with vaccinia viruses expressing HIV-1 nef genes derived from different HIV-1 clades, we examined the efficiency of presentation of an HLA-B*40 restricted HIV-1 nef epitope compared to that of an HLA-B*08 restricted epitope with which it overlaps by 6 amino acides. (ox.ac.uk)
  • RESULTS: This small shift in epitope position substantially changed the patter or epitope processing and led either to an increase or decrease in antigen generation dependent on the viral sequences present. (ox.ac.uk)
  • haplotype
  • Relations of varying strength (odds ratios 6.1-10.3) were seen with several HLA antigens often linked in the A1-Cw7-B8-DR3 haplotype. (nih.gov)
  • These findings strengthen the suggested link between the product of a gene in the A1-Cw7-B8-DR3 haplotype and HIV-1-related disease. (nih.gov)
  • The length of the haplotype is remarkable because of the rapid rate of evolution at the HLA locus should degrade such long haplotypes. (wikipedia.org)
  • presentation
  • This protein is involved in antigen presentation. (healthmatics.info)
  • We further investigated the effect that simultaneous presentation of APL and native antigen at low, physiological, peptide concentrations (1 nM) has on TCR signal transduction, and we found that the presence of APL can completely inhibit induction of the protein tyrosine phosphorylation events of the TCR signal transduction cascade. (pnas.org)
  • CONCLUSIONS: These data demonstrate the complexity of the antigen presentation pathway and the difficulties associated with selecting CTL epitopes as targets for an HIV-1 vaccine that will be effective in many populations and against several viral strains. (ox.ac.uk)
  • donors
  • Histocompatibility antigens were determined in 30 patients with temporal arteritis, 27 patients with polymyalgia rheumatica, and 216 normal blood donors. (bmj.com)
  • 1. Human leucocyte AB antigens were determined by means of a lymphocyte toxicity test in 84 patients with essential hypertension and in 1000 blood donors. (clinsci.org)
  • Jordan F, McWhinnie AJ, Turner S, Gavira N, Calvert AA, Cleaver SA, Holman RH, Goldman JM, Madrigal JA: Comparison of HLA-DRB1 typing by DNA-RFLP, PCR-SSO and PCR-SSP methods and their application in providing matched unrelated donors for bone marrow transplantation. (anthonynolan.org)
  • frequencies
  • The remaining 100 patients, who did not have endocrine disease, showed increased frequencies of HLA-B7 and B12. (bmj.com)
  • The positive association with HLA-B12 among this subgroup was confined to 62 patients with severly impaired vitamin B12 absorption, including 13 patients with vitamin B12 neuromyelopathy, who had the highest frequencies of HLA-B7 and B12. (bmj.com)
  • Bunce M, Barnardo MC, Procter J, Marsh SGE, Vilches C, Welsh KI: High resolution HLA-C typing by PCR-SSP: identification of allelic frequencies and linkage disequilibria in 604 unrelated random UK Caucasoids and a comparison with serology. (anthonynolan.org)
  • genetic
  • 5. In view of a previous report of HLA antigens in a Spanish diabetic population, this study does not support the suggestion of a genetic and possibly HLA-linked connection between essential hypertension and diabetes mellitus among the Spanish population. (clinsci.org)
  • The significant heterogeneity in HLA patterns in different clinical subgroups of these patients indicates genetic heterogeneity in pernicious anaemia and explains previous discrepancies in the associations between HLA antigens and pernicious anaemia. (bmj.com)
  • The other pair did not possess either of these antigens, suggesting that the reaction to gold therapy in patients with rheumatoid arthritis may be determined by other HLA or genetic factors coded for by chromosome 6, or both. (bmj.com)
  • protein
  • Influenza nuclear protein (residues 380-388, ELRSRYWAI) was used as a HLA B8 restricted control peptide. (nih.gov)
  • Originally thought to be a unique protein of the lamina lucida, further research reveals that the 97-kd protein may represent a portion of the extracellular domain of the 180-kd bullous pemphigoid antigen (BPAg2). (medscape.com)
  • The etiology underlying drug-induced linear IgA dermatosis remains elusive but is speculated to be caused by an immune response towards a drug-derived hapten-protein antigen. (medscape.com)
  • rheumatoid
  • Remarkably similar response to gold therapy in HLA identical sibs with rheumatoid arthritis. (bmj.com)
  • gluten
  • The milder, but similar brain dysfunctions observed with gluten allergy suggests that food allergy may play a role in schizophrenia, with gluten as a set of triggering antigens. (conductdisorders.com)
  • nuclear
  • The Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) is expressed in all EBV-associated tumors, making it an important target for immunotherapy. (nih.gov)
  • differences
  • The differences between the index and the four variant HLA B8-peptide complexes have been analysed in a series of x-ray crystallographic structure determinations at 2.3 Å resolution or better. (nih.gov)
  • toxicity
  • One of the pairs possessed the HLA antigens B8 and DR3, which have been associated with both drug toxicity and excellent clinical response. (bmj.com)
  • immune response
  • HLA-DQβ and HLA-DR3 polymorphisms have been linked to myasthenia gravis ( 5 ) and MHC class II has been shown to restrict immune response to AChR in humans as well ( 6 ). (jimmunol.org)
  • clinical
  • The subjects underwent full clinical assessment, plus pathology tests, an ophthalmological and cardiological review (including electrocardiography and echocardiography) and HLA histocompatibility testing. (mja.com.au)
  • complex
  • We have examined the high resolution crystal structures of four of these APLs in complex with HLA B8 to determine alterations in the shape, chemistry, and local flexibility of the TCR binding surface. (nih.gov)
  • ethnic
  • Patel HS, Rice AH, Avakian H, Goldman JM: A new HLA Cw6 split -Cw6.2- detected in three ethnic groups that is inherited in families. (anthonynolan.org)
  • similar
  • Normal subjects with B8 show greater immunity than those lacking B8 and give similar results to untreated coeliacs. (ed.ac.uk)
  • B8 and non-B8 coeliacs give similar results. (ed.ac.uk)
  • results
  • These results contrast with those seen with PPD as antigen. (ed.ac.uk)
  • These results are provocative given that the 97-kd linear IgA dermatosis antigen may represent a portion of the extracellular domain of BPAg2. (medscape.com)
  • Control
  • Gag p24 (residues 261-269, GEIYKRWII) was used as a control HLA-B8 restricted peptide. (nih.gov)