Hla b7 class i antigen hla b7 antigen. Medical search. Frequent questions

The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region. (expasy.org)
2 HIX0018378 6p21.32 HLA-DRB1 HLA class II histocompatibility antigen, DRB1-15 beta chain precursor (MHC class I antigen DRB1*15) (DW2.2/DR2.2). (h-invitational.jp)
3 HIX0027959 6p21.32 HLA-DQA1 HLA class II histocompatibility antigen, DQ(5) alpha chain precursor (DC-1 alpha chain). (h-invitational.jp)
4 HIX0078231 6p21.32 HLA-DQB1 HLA class II histocompatibility antigen, DQ(W1.1) beta chain precursor (DQB1*0501). (h-invitational.jp)
6 HIX0078239 6p21.32 HLA-B HLA class I histocompatibility antigen, B-7 alpha chain precursor (MHC class I antigen B*7). (h-invitational.jp)
7 HIX0005684 6p21.32 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain precursor (MHC class I antigen A*3). (h-invitational.jp)
8 HIX0005683 6p21.32 HLA-G HLA class I histocompatibility antigen, alpha chain G precursor (HLA G antigen). (h-invitational.jp)
13 HIX0078437 6_cox_hap2 HLA class I histocompatibility antigen, B-8 alpha chain precursor (MHC class I antigen B*8). (h-invitational.jp)
16 HIX0033011 6_qbl_hap6 HLA-A HLA class I histocompatibility antigen, A-26 alpha chain precursor (MHC class I antigen A*26). (h-invitational.jp)
22 HIX0057992 6_mann_hap4 HLA-DMB HLA class II histocompatibility antigen, DM beta chain precursor (MHC class II antigen DMB). (h-invitational.jp)
24 HIX0005752 6_mann_hap4 HLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor (MHC class II antigen DRA). (h-invitational.jp)
25 HIX0078594 6_mann_hap4 HLA-C HLA class I histocompatibility antigen, Cw-16 alpha chain precursor (MHC class I antigen Cw*16). (h-invitational.jp)
28 HIX0078423 6_ssto_hap7 HLA-A HLA class I histocompatibility antigen, A-32 alpha chain precursor (MHC class I antigen A*32). (h-invitational.jp)
We have mapped the T cell recognition of MCPyV by use of a novel technology platform for T-cell enrichment and combinatorial encoding of histocompatibility antigen (HLA) class I multimers. (biomedcentral.com)

A common serologically defined haplotype in Europeans is HLA A3-Cw7-B7-DR15-DQ6.2 which is composed of alleles A*0301:Cw*0701:B*0702:DRB1*1501:DQA1*0102:DQB1*0602. (wikipedia.org)
In Croatian children, two HLA-B27 alleles were found associated with disease, B*2702, B*2705. (wikipedia.org)
A more recent study looked at a number of linked gene-alleles and found I82-2:D6S265-1:HLA-A3:D6S128-2:HLA-F1:D6S105-8 was constantly associated while B7 appeared beyond the haplotype linked to disease. (wikipedia.org)
Hundreds of HLA-B alleles have been described. (copy78.com)
Most HLA-B gene alleles are rare, while others do not affect protein function or change the structure of the protein. (medlineplus.gov)
Hundreds of versions (alleles) of the HLA-B gene are known, each of which is given a particular number (such as HLA-B27 ). (medlineplus.gov)
for example, more than 60 very similar alleles are subtypes of HLA-B27 . (medlineplus.gov)
Additional HLA-B alleles play a smaller role in disease risk: the HLA-B47 and HLA-B51 alleles can contribute to increased risk, whereas the HLA-B7 and HLA-B57 alleles might provide some small amount of protection against developing the condition. (medlineplus.gov)
Here we describe CD8+ T cell responses against each of these three "first wave" proteins, identifying target epitopes and HLA restricting alleles. (martinfitzpatrick.com)
While EBNA-LP and BHRF1 each contained one strong CD8 epitope, epitopes within EBNA2 induced immunodominant responses through several less common HLA class I alleles (e.g. (martinfitzpatrick.com)
B 3801 and B 5501), as well as subdominant responses through common class I alleles (e.g. (martinfitzpatrick.com)

for example the MHC Class II antibody based on clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. (antibodies-online.com)
Human leukocytes were stimulated in vitro with peptides corresponding in sequence to the highly variable helix of the alpha 1 domain of various HLA-B and -C molecules. (silverchair.com)
The HLA-DR11.2 molecule, which only differs at three residues from HLA-DR11.1, did not present the HLA-B7 peptide to CTL-AV. Peptides from the alpha 1 domain helix of other HLA-A and HLA-B molecules, but not HLA-C molecules, competed with the HLA-B7 peptide for binding to HLA-DR11.1. (silverchair.com)
Furthermore, introduction of purified HLA-B7 molecules into HLA-DR11.1+, HLA-B7- cells by cytoplasmic loading via osmotic lysis of pinosomes, but not by simple incubation, rendered them susceptible to CTL-AV killing. (silverchair.com)
Amino acid sequences of the HLA molecules which greatly contributed to our understanding of antibody and antigen reactivity has been introduced since 1963 [4C12]. (mundial-brasil2014.net)
Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. (copy78.com)
Upon infection many viruses, including Herpesviruses, target T cell function via specific interactions with TCR and HLA-I molecules. (frontiersin.org)
Det innebär att de flesta av There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a Den huvudsakligen genetiska riskfaktoren för AS är HLA B27 som finns hos B. vid långvarig inflammatorisk ryggsmärta i senare skede Penttinen, MA. (web.app)
To facilitate the discrimination, all nucleated cells present a selection of the peptides contained in their proteins on the cell surface in complex with Major Histocompatibility Complex class I (MHC class I) molecules. (biomedcentral.com)
Once inside the ER, the peptides may bind to MHC class I molecules, which are subsequently transported to the cell surface, where the complexes may be recognized by passing CTLs. (biomedcentral.com)
In a study of lung adenocarcinoma [ 4 ] , EMT markers were associated with enhanced tumor infiltration of CD4 + Foxp3 + Tregs and upregulation of inhibitory immune checkpoint molecules such as programmed cell death (PD)-ligand (L) 1, PD-L2, TIM-3, B7-H3, and CTLA-4. (encyclopedia.pub)
Classical human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules, the non-classical by e.g. (abeomics.com)
Specificity : The mouse monoclonal antibody TP25.99SF recognizes an extracellular epitope on HLA-ABC and HLA-E molecules, but not HLA-G. It can be used for discrimination between HLA-G and other HLA-class I antigens. (abeomics.com)

In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. (antibodies-online.com)
Click on the protein counts, or double click on taxonomic names to display all proteins containing IG domain in the selected taxonomic class. (embl.de)
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. (medlineplus.gov)
MHC class I proteins display these peptides to the immune system. (medlineplus.gov)
The HLA-B gene has many possible variations, that result in the production of proteins that differ by changes in at least one protein building block (amino acid). (medlineplus.gov)
We investigated the T cell recognition of both the oncogenic proteins, Large and Small T antigen and the capsid protein VP1 that is profoundly expressed also in the non-symptomatic MCPyV infected healthy individuals. (biomedcentral.com)
This test looks for HLA-B27, which are proteins called antigens. (web.app)
Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances. (web.app)
An HLA-B27 test is a blood test that identifies HLA-B27 proteins. (web.app)

Advances in testing assays and amino acid sequencing of HLA along with computer software contributed further to the understanding of antibody-antigen reactivity. (mundial-brasil2014.net)
The phenomenon of cross-reactivity in HLA testing, often explained as cross-reactive groups (CREGs) of antigens with antibody, can be clearly explained now by public epitopes. (mundial-brasil2014.net)
Determining specificity of the anti-HLA antibody has advanced in recent years using recombinant CHMFL-ABL-039 HLA single antigens (SA) coated on color-coded Luminex beads [3]. (mundial-brasil2014.net)
however, it is more accurate to describe the reactivity of the antibody as binding to specific epitopes on the surface of HLA antigensepitopes are conformational amino acid arrangements and are the targets of antibodies. (mundial-brasil2014.net)
Specificity : The mouse monoclonal antibody 3D11 recognizes an extracellular epitope of HLA-F, a 42 kDa type I transbembrane protein expressed on B cells, NK cells, monocytes, and T cells, but mainly in the endoplasmic reticulum and Golgi apparatus, only a small amount on the cell surface, where, however, it can be expressed after cell activation. (abeomics.com)
Collagen antibody-induced arthritis (CAIA) was induced in HLA-B27 transgenic and WT mice. (bmj.com)
and to block HLA-I restricted responses anti-HLA-I antibody W6/32 ascites (ATCC) was added at a final dilution of 1 : 40 for 30 min before adding peptides in ELISPOT assays. (peptidesprice.com)
Moreover, existing immunity should be assessed before any vaccination, via an accurate, dependable, and reliable antibody test (or T cell immunity test) or be based on documentation of prior infection (a previous positive PCR or antigen test). (petersmanjak.com)

Class I HLAs present peptides from inside the cell whereas class II HLAs present antigens from outside of the cell to T-lymphocytes. (antibodies-online.com)
A recent study shows that individuals with the allele HLA-B*46:01 have the fewest predicted binding peptides for SARS-CoV-2, suggesting they may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS. (antibodies-online.com)
A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. (antibodies-online.com)
These algorithms identified three candidate peptides that we studied for their capacity to induce CTL responses in vitro using lymphocytes from HLA-B7+ normal blood donors. (elsevierpure.com)
The results show that one of these peptides, CEA9 632 (IPQQHTQVL) was efficient in the induction of primary CTL responses when dendritic cells were used as antigen-presenting cells. (elsevierpure.com)
Decipher misregulations of the TGFß/BMP pathway induced by HLA-B27 in immune and intestine cells, in Drosophila and Human, to identify peptides and receptors involved in HLA-B27 non-canonical effects. (anr.fr)
Recombinant, truncated Class I soluble Human Leukocyte Antigen (sHLA), naturally folded and glycosylated, loaded with endogenous peptides. (hlaprotein.com)
Researchers speculate that HLA-B27 may abnormally display peptides that trigger an immune reaction, resulting in the inflammatory process that causes arthritis. (medlineplus.gov)
In the large-scale benchmark calculation consisting of 216 known HIV epitopes covering all 12 recognized HLA supertypes, the NetCTL-1.2 method was shown to have a sensitivity among the 5% top-scoring peptides above 0.72. (biomedcentral.com)
The most restrictive step involved in antigen presentation is binding of the peptide to MHC class I. It is estimated that only 1 out of 200 peptides will bind a given MHC class I allele with sufficient strength to elicit a CTL response [ 9 ]. (biomedcentral.com)
The same few peptides were consistently targeted in an additional 17 persons expressing HLA-A3 and/or -B7 during acute infection. (ox.ac.uk)

The identification of this HLA-B7-restricted CTL epitope will be useful for the design of ethnically unbiased, widely applicable immunotherapies for common solid epithelial tumors expressing CEA. (elsevierpure.com)
Figure G. Epitope 5037 shared by the HLA C-locus antigens Cw4, Cw6, Cw17, Cw18 and defined by 73A+77N. (mundial-brasil2014.net)
Figure H HLA class II DQB epitope 2007 shared by DQ4,5,6 antigens and define by 52P+55R on the beta chain of the DQ antigens. (mundial-brasil2014.net)
Figure J. Epitope 2018 shared by the alpha chains of the DQ4, 5, 6 antigens and defined by Glutamine (Q) at position 53. (mundial-brasil2014.net)
Figure K. Epitope 2002 shared exclusively by the beta chains of the DQ4 antigen and defined by Leucine (L) in position 56. (mundial-brasil2014.net)
Figure L. Epitope 2010 shared by the beta chains of DQ antigens DQ4, 5, 6, 8, 9 and defined by 45G+46V. (mundial-brasil2014.net)
Figure M. Epitope 2022 exclusive to DQB1?05:01 chain on the DQ5 antigen and defined by 125S+126Q. (mundial-brasil2014.net)
Figure N. Epitope 2006 shared by DQB1?03:01 (DQ7), DQB1?03:02 (DQ8), DQB1?03:03 (DQ9) and defined by Proline (P) at position 55 on the beta chains of the DQ antigens. (mundial-brasil2014.net)
These studies demonstrate a consistent pattern in the development of epitope-specific responses restricted by a single HLA allele during acute HIV-1 infection, as well as persistence of the initial pattern of immunodominance during subsequent STI. (ox.ac.uk)

One approach for the development of CTL-based cancer immunotherapy for solid tumors requires the use of the appropriate immunogenic peptide epitopes that are derived from defined tumor-associated antigens. (elsevierpure.com)
Moreover, our strategy of identifying MHC class I-restricted CTL epitopes without the need of peptide/HLA-binding assays provides a convenient and cost-saving alternative approach to previous methods. (elsevierpure.com)
Cytotoxic T cell recognition of an endogenous class I HLA peptide presented by a class II HLA molecule. (silverchair.com)
A CD4+ CD8- cytotoxic T cell line, CTL-AV, that is specific for the HLA-B7 peptide presented by HLA-DR11.1 was obtained. (silverchair.com)
A cell line (WT50) that coexpresses HLA-B7 and HLA-DR11.1 was killed by CTL-AV in the absence of any added HLA-B7 peptide. (silverchair.com)
3 are responsible for the peptide binding specificity of each class I molecule. (copy78.com)

In humans, the HLA-B gene and two related genes, HLA-A and HLA-C , are the main genes in MHC class I. (medlineplus.gov)

Sarcoidosis and human leukocyte antigen class I and II genes: it takes two to tango? (wikipedia.org)
Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2. (antibodies-online.com)
The human leukocyte Ag HLA-B27 (B27) is strongly associated with the spondyloarthritides. (ox.ac.uk)
HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
HLA B27 (human leukocyte antigen) is a protein found on the surface of white blood cells of certain individuals. (web.app)
Human lymphocyte antigen B27, human leukocyte A antigen, histocompatibility leukocyte A antigen What is this test? (web.app)
The protein is called human leukocyte antigen B27 (HLA-B27). (web.app)
HLA-B27 stands for human leukocyte antigen B27. (web.app)
The human leukocyte antigen B27 (HLA-B27) allele is present in 90% of White patients with ankylosing spondylitis, but it is also present in up to 10% of the general population depending on ethnicity. (msdmanuals.com)
Class II Human Leukocyte Antigen (HLA) play an important role in host protection from foreign. (hla-dr.com)
Background: Monocytic human leukocyte antigen DR (mHLA-DR) expression levels have been reported to be a marker of immunosuppression and predictors of sepsis and death. (hla-dr.com)

Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
These CTLs were efficient in killing tumor cells that express HLA-B7 and produce CEA. (elsevierpure.com)
KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis. (ox.ac.uk)
B27(2) tetramers bound KIR3DL2-transfected cells more strongly than HLA-A3. (ox.ac.uk)
KIR3DL2Fc bound to HLA-B27-transfected cells more strongly than to cells transfected with other HLA-class I. KIR3DL2Fc pulled down multimeric, dimeric, and monomeric FHC from HLA-B27-expressing cell lines. (ox.ac.uk)
The processing and presentation of HLA-B7 in these cells appears to be through the endogenous, and not the exogenous, pathway of antigen presentation. (silverchair.com)
Here we investigated the impact of the TIME and chimeric antigen receptor (CAR) design on anti-glioma activity of B7-H3-specific CAR T-cells. (bvsalud.org)
PURPOSE: We and others have demonstrated that MYC-amplified medulloblastoma (MB) cells are susceptible to class I histone deacetylase inhibitor (HDACi) treatment. (bvsalud.org)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Importantly, such EBNA2-specific CD8+ T cells recognised B cells within the first day post-infection, prior to CD8+ T cells against well-characterised latent target antigens such as EBNA3B or LMP2, and effectively inhibited outgrowth of EBV-transformed B cell lines. (martinfitzpatrick.com)
Importantly, we show for three different epitopes that MCC specific T cells are capable of killing target cells expressing Large T antigen, including HLA-matched MCC cell lines, indicating that these T cells could provide functional activity upon in vivo transfer, and thus be employed in adoptive T cell therapy for MCC. (biomedcentral.com)
The presence of antigens on the surface of cells allows the immune system to distinguish its own cells from foreign cells. (web.app)
HLA-B27 is a blood test to look for a protein that is found on the surface of white blood cells. (web.app)
ATDC5 cells and primary human periosteum-derived cells (hPDCs) were transduced with lentiviral vectors expressing HLA-B27 or HLA-B7. (bmj.com)
These cells and limb bud cells (from HLA-B27 transgenic and wild-type (WT) mice) were cultured in micromasses. (bmj.com)
HLA-identical sibling stem cells are used for the treatment of patients suffering from various hematologic malignant and nonmalignant diseases. (ashpublications.org)
However, a class of important immune-modulators is conspicuously absent: agents that utilize the power of innate immune cells to eradicate tumors. (frontiersin.org)
An important class of innate immune cells that play a critical role in mediating the antitumor immune response is the natural killer (NK) cell. (frontiersin.org)
HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. (abeomics.com)
bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)

These results provide an example of class II major histocompatibility complex (MHC) presentation of a constitutively synthesized self protein that uses the endogenous pathway of antigen presentation. (silverchair.com)
The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
Other research suggests that the joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of the protein on the cell surface. (medlineplus.gov)
5 HIX0032963 6p21.32 MHC class II, alpha chain, N-terminal domain containing protein. (h-invitational.jp)
11 HIX0005767 6_cox_hap2 HLA-DPB1 HLA-DPB1 precursor (MHC class II antigen) (Major histocompatibility complex, class II, DP beta 1) (HLA-DPB1 protein). (h-invitational.jp)
18 HIX0058200 6_qbl_hap6 HLA-J Pseudogene candidate (Immunoglobulin C1-set domain containing protein. (h-invitational.jp)
HLA-F, an MHC class I molecule, is a type I transmembrane protein (heavy chain), which forms heterodimers with beta-2 microglobulin (light chain) and binds to KIR3DS1, KIR3DS4, KIR3DL2, ILT2, ILT4, and TAP. (abeomics.com)
This HLA-B27 is a blood test to check for a specific protein on your white blood cell that could trigger an auto-immune disease such as Ankylosing Spondylitis (AS). (web.app)
PD-L1 (also known as CD274 or B7-homolog 1 [B7-H1]) is a transmembrane protein involved in the immune system suppression. (studylib.net)

This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). (copy78.com)

Browse our portfolio of HLA antibodies down below! (antibodies-online.com)
Sensitization is almost ubiquitous as anti-HLA antibodies are found in almost all sera of transplant recipients. (mundial-brasil2014.net)
It is commonly understood that antibodies bind to HLA antigens. (mundial-brasil2014.net)
With current knowledge of epitopes, it is more accurate to describe that antibodies bind to their target epitopes on the surface of HLA molecular chains. (mundial-brasil2014.net)
Sensitization is almost ubiquitous as it is evident in the detection of anti-HLA antibodies in the sera of recipientsin one study, almost all patients waiting for regraft of a kidney transplant have anti-HLA antibodies [2]. (mundial-brasil2014.net)
The reactivity of anti-HLA antibodies with HLA antigens and the phenomenon of cross-reactivity has been the subject of investigation for decades. (mundial-brasil2014.net)

A third cluster of HLAs (class III HLAs), situated between class I and class II HLAs, encodes components of the complement system and is not involved in the adaptive immune response. (antibodies-online.com)

In class I [ 2 ] the α chain is composed of three extracellular domains, a transmembrane region and a cytoplasmic tail. (expasy.org)
In class II [ 3 ], both the α and the β chains are composed of two extracellular domains, a transmembrane region and a cytoplasmic tail. (expasy.org)

Many observations point to a major role for classical HLA loci in determining susceptibility to viral infections 1 . (antibodies-online.com)
Association of various HLA haplotypes with SARS-CoV-2 infection and the course of COVID-19 could improve assessment of viral severity in the population. (antibodies-online.com)
In that context, EBNA2, EBNA-LP and BHRF1 are the first viral antigens expressed during the initial stage of B cell growth transformation, yet have been poorly characterised as CD8+ T cell targets. (martinfitzpatrick.com)

Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. (expasy.org)
Immunohistochemical staining of paraffin-embedded human tonsils using anti-HLA-B RabMAb (cat. (copy78.com)
HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
Figure B. PE conjugated Mouse anti Human CD11c ( MCA2087PE ) and Amethyst Orange conjugated Mouse anti Human HLA DP DQ DR ( MCA477AMO ). (bio-rad-antibodies.com)
Figure 1 : Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human HLA-ABCE (TP25.99SF) PE. (abeomics.com)
matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)

15 HIX0023200 6_qbl_hap6 HCG4P6 Pseudogene candidate (MHC class I antigen (Fragment). (h-invitational.jp)
21 HIX0058040 6_mann_hap4 Pseudogene candidate (Leucocyte antigen A (Fragment). (h-invitational.jp)

The serotype identifies the more common HLA-B*07 gene products. (wikipedia.org)
The HFE gene responsible for haemochromatosis is distal on chromosome 6 from HLA-A and more so from HLA-B, the distance suffices (3 million nucleotides) to allow equilibration of the loci. (wikipedia.org)
Variants in the HLA-B gene, particularly a version called HLA-B27 , significantly increase the risk of developing ankylosing spondylitis. (medlineplus.gov)
It is uncertain how the HLA-B27 gene variant causes the increased risk. (medlineplus.gov)
Although many people with ankylosing spondylitis have the HLA-B27 variation, most people with this version of the HLA-B gene never develop the disorder. (medlineplus.gov)
Several versions of the HLA-B gene, particularly HLA-B51 , are associated with an increased risk of developing Behçet disease, a chronic inflammatory condition that affects many parts of the body. (medlineplus.gov)
location HGNC gene symbol Definition HIF Gene family/group name 1 HIX0078236 6p21.32 HLA-DRA Major histocompatibility complex, class II, DR alpha precursor. (h-invitational.jp)
Multiple transcript variants encoding different isoforms have been found for HLA-F gene. (abeomics.com)
The Effect of the HLA-B27 Gene on COVID-19 Evidence has long suggested that the HLA-B27 gene offers protection against HIV, hepatitis C, and possibly influenza. (web.app)

23 HIX0032841 6_mann_hap4 HLA-H MHC class I antigen HLA-H ortholog (Fragment). (h-invitational.jp)

In october 2021, a team of researcher from Centre hospitalier universitaire Sainte-Justine in Montreal, Canada, announced the discovery of HLA-B7 genetic marker as a potential cause for severe form of covid-19. (wikipedia.org)
While they noted that more work will be necessary to confirm this discovery, they found that individuals carrying the HLA-B7 genetic marker, which represents 35% of the population worldwide, are more likely to have a less effective immune response to covid-19. (wikipedia.org)
For example, an HLA B7, DR2 individual who is also genetically predisposed to produce high levels of IgE is likely to have a more severe allergic disorder than an individual without this genetic combination. (brainkart.com)
HLA-B27 is the main genetic factor contributing to spondyloarthritis. (anr.fr)
It is possible that HLA-B27 may increase the risk of ankylosing spondylitis through more than one mechanism, or by different mechanisms in different individuals based on their genetic and environmental background. (medlineplus.gov)
Objective The strong genetic association between HLA-B27 and ankylosing spondylitis has been known for over 40 years. (bmj.com)
Increased prevalence of HLA-B27 in White people or HLA-B7 in Black people supports a genetic predisposition. (msdmanuals.com)

Numerous T cell responses were detected against MCPyV in both healthy donors and MCC patients, with a striking observation that T cell responses against Large and Small T antigens were found exclusively in MCC patients, suggesting that these oncoproteins are only presented to the immune system in the tumor-bearing host and represent highly specific targets for cancer immunotherapy of MCC. (biomedcentral.com)

These subtypes are designated as HLA-B*2701 to HLA-B*2763 . (medlineplus.gov)
2020-12-03 · There are multiple subtypes of HLA-B27, and the specific types associated with ankylosing spondylitis include HLA-B*2701, HLA-B*2702, HLA-B*2704, HLA-B*2705, and HLA-B*2707. (web.app)

We infer that "first wave" antigens of the growth-transforming infection, especially EBNA2, constitute potential CD8+ T cell immunogens for inclusion in prophylactic EBV vaccine design. (martinfitzpatrick.com)

Family studies further suggested that the ability to produce high levels of IgE is a recessive trait, controlled by unknown genes independent of the HLA system. (brainkart.com)
Genes in this complex are categorized into three basic groups: class I, class II, and class III. (medlineplus.gov)

HLA-B7 (B7) is an HLA-B serotype. (wikipedia.org)
For terminology help see: HLA-serotype tutorial) B7, previously HL-A7, was one of the first 'HL-A' antigens recognized, largely because of the frequency of B*0702 in Northern and Western Europe and the United States. (wikipedia.org)
Not everyone who carries the HLA-B27 serotype will have ankylosing spondylitis, but over 95% of people with AS carry HLA-B27. (web.app)

One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium. (wikipedia.org)
In persistent sarcoidosis this haplotype appears elevated, further study eliminated risk contributed by A3-Cw7 and DQ6.2 indicating B7-DR15 haplotype contains risk of disease (OR = 2.5). (wikipedia.org)
Nonetheless, a linkage has been found between A3-B7 haplotype and haemochromatosis. (wikipedia.org)
2 These observations point towards a potential influence of different HLA composition - the haplotype - in the present SARS-CoV-2 pandemic. (antibodies-online.com)

產品介紹】HLA-B belongs to the HLA class I heavy chain paralogues. (copy78.com)
These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. (abeomics.com)

This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)

HIV-1-specific CD8+ T-cell responses broadened significantly during subsequent exposure to the virus, ultimately targeting 27 distinct CTL epitopes, including 15 different CTL epitopes restricted by a single HLA class I allele (HLA-A3). (ox.ac.uk)
To identify antigenic M. tuberculosis CTL epitopes, a bioinformatics method (NetCTL) was employed to predict epitopes restricted to at least one of the 12 HLA-I supertypes.18 Based on the predictions, 206 potential CTL epitopes were synthesized. (peptidesprice.com)

exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)

Our previous work allowed us to identify that HLA-B27 misregulates the TGFß/BMP pathways in the Drosophila fruitfly. (anr.fr)

T cell epitopes from Large T antigen of MCPyV display a large sequence variation with other polyomaviruses, but are highly conserved among different strains of MCPyV. (biomedcentral.com)

HLA-A3, which is not associated with spondyloarthritis (SpA), is also a ligand for KIR3DL2. (ox.ac.uk)
In this study, we show that B27(2) and B27 FHC bind more strongly to KIR3DL2 than other HLA-class I, including HLA-A3. (ox.ac.uk)
Binding to B27(2) and B27 FHC stimulated greater KIR3DL2 phosphorylation than HLA-A3. (ox.ac.uk)

however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)

Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
We investigated the T cell recognition of 398 in silico predicted HLA-ligands from Large T, Small T and VP1 and identified T-cell responses restricted to HLA-A1, A2, A3, A11 and B7. (biomedcentral.com)
In this study, HIV-1-specific CD8+ T-cell responses in 18 acutely infected individuals expressing HLA-A3 and/or -B7 were characterized. (ox.ac.uk)

9 HIX0035763 6p21.32 HLA-F Major histocompatibility complex, class I, F isoform 3 precursor. (h-invitational.jp)
12 HIX0033491 6_cox_hap2 HLA-DRA Major histocompatibility complex, class II, DR alpha precursor. (h-invitational.jp)
20 HIX0058180 6_qbl_hap6 HLA-DOA Major histocompatibility complex, class II, DO alpha precursor. (h-invitational.jp)
27 HIX0058177 6_mcf_hap5 Major histocompatibility complex, class II, DQ alpha 2. (h-invitational.jp)

Expression of osteogenesis markers and Alizarin red staining was comparable in the HLA-B27 + and the HLA-B7 + hPDCs in monolayers. (bmj.com)

1. Introduction Sensitization to HLA antigens in organ transplant patients causes graft rejection, according to the humoral theory of transplantation [1]. (mundial-brasil2014.net)
HLA-B27: a blood test done as part of paternity investigations, to indicate tissue compatibility with tissue transplantation, and to assist in the diagnosis of Reiter's syndrome and other conditions. (web.app)

Since 2006, we defined and reported 194 HLA class I unique epitopes, including 56 cryptic epitopes on dissociated HLA class I heavy chains, 83 HLA class II epitopes, 60 epitopes on HLA-DRB1, 15 epitopes on HLA-DQB1, 3 epitopes on HLA-DQA1, 5 epitopes on HLA-DPB1, and 7 MICA epitopes. (mundial-brasil2014.net)

HOWEVER, having a positive HLA-B7 can put you at increased risk of developing what we call spondyloarthritis-associated diseases. (web.app)

It is estimated that among those with the HLA-B27 allele, only one to five percent develop ankylosing spondylitis. (medlineplus.gov)
The presence of HLA B27 (8% of the population) is associated with a higher risk of developing certain autoimmune diseases such as ankylosing spondylitis HLA-B27, humani (ljudski) leukocitni antigen, , (engl. (web.app)

Results There was no difference in chondrogenesis markers or in colorimetric tests between HLA-B27 + and HLA-B7 + micromasses. (bmj.com)

We show that five out of six B7-H3 CARs with varying transmembrane, co-stimulatory, and activation domains, exhibit robust functionality in vitro. (bvsalud.org)
We studied the in vitro and in vivo impact of HLA-B27 in models of chondrogenesis and osteogenesis. (bmj.com)

B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. (wikipedia.org)

Anatomy30

Organisms17

Diseases11

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes38

Disciplines and Occupations2

Humanities2

Information Science3

Named Groups1

Health Care2

Histocompatibility antigen14

Alleles11

Molecules13

Proteins10

Antibody8

Peptides11

Epitope9

Peptide6

Humans1

Leukocyte12

Cells23

Protein9

Molecule1

Antibodies6

HLAs1

Extracellular2

Viral3

Human6

Pseudogene2

Gene9

Fragment1

Genetic7

Immune1

27012

Infection1

Genes2

Serotype3

Haplotype4

Paralogues2

Renal1

Epitopes restricted2

Exogenous1

Pathways1

Sequence1

KIR3DL23

Macrophages1

Cell3

Complex4

Expression1

Transplantation2

DQB11

Spondyloarthritis1

Ankylosing2

Markers1

Vitro2

Major1