• Reactive arthritis is an RF-seronegative , HLA-B27 -linked arthritis often precipitated by genitourinary or gastrointestinal infections . (wikipedia.org)
  • HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis. (biomedsearch.com)
  • Regression analysis showed a correlation of 0.7 in the HLA-B27-positive boys, pointing to a higher risk of more joint involvement with older age at disease onset. (biomedsearch.com)
  • CONCLUSION: HLA-B27 is of increasing importance with older age at disease onset in boys with JIA, predicting more active joints within the first 3 years of disease, and also involving small joints in the lower extremity to a greater degree than in HLA-B27-negative boys. (biomedsearch.com)
  • A gene marker called HLA-B27 is found in almost all Caucasians and half of of African Americans who have the disease. (ahealthyme.com)
  • lupus erythematosus (SLE), anti-double stranded DNA autoantibodies are features of active disease and are particularly associated with lupus nephritis, and the identity of the self or foreign antigens that "break tolerance", leading to anti-dsDNA and other autoantibody specificities, has been a topic of extensive study. (bioportfolio.com)
  • Among the alternatives to traditional typing by the complement‐dependent cytotoxicity assay, flow cytometric HLAB27 screening is most widely used in general diagnostic laboratories, as it is simple, rapid, and cost effective. (currentprotocols.com)
  • Binding to B27 appeared to be slightly stronger than to B7 and stronger than to B22 in an indirect binding assay, but no difference in B7 and B27 binding could be detected by Scatchard analysis. (semanticscholar.org)
  • In studies of antigenic peptide presentation, we have found a healthy volunteer whose lymphoblastoid cells were unable to present three different virus-derived epitopes to cytotoxic T lymphocytes (CTL) despite expressing the correct restricting HLA-B27 molecules on the cell surface. (rupress.org)
  • Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27. (semanticscholar.org)
  • The data support a stabilizing role of CD8 through its binding to the same class I (but not class II) molecule on the target cell bound by the T cell antigen receptor. (rupress.org)
  • We investigated the associations of HLA-B27 and the clinical manifestations of JIA using a method as close to a population-based study as possible. (biomedsearch.com)
  • Another reason for an HLA test is to see whether or not the patient can donate organs or bone marrow to another person. (reference.com)
  • If the patient has the particular HLA antigen, a complex will be formed on the cell surface. (wbccount.org)
  • This is a pretty important antigen, because it is associated with several diseases. (csl.name)
  • If a doctor could quickly see that the probability of HLA-B27 is low, and depending on the context, it may not be necessary to order a blood test at all. (csl.name)
  • You should be evaluated by a rheumatologist and have a complete physical examination including radiographs of your spine and a series of blood test including hla b27. (healthtap.com)
  • Recently, I wanted to see if I could impute the presence of the HLA-B27 antigen using my raw 23andMe DNA data. (csl.name)
  • So the probability is a whooping 88.8% for the complete absence of HLA-B27 in this case (but 11.2% for the presence of at least one copy). (csl.name)
  • Human leukocyte antigens help regulate the immune system, and their main role is to let the body tell the difference between normal cells and substances that it needs to attack, states MedlinePlus. (reference.com)
  • A common HLA genotype in either the father or child increases the likelihood that there are many potential fathers of that child. (wbccount.org)
  • Three to four parameters-forward scatter, side scatter, HLAB27 expression, and, in some cases CD3 or B7 expression-are acquired. (currentprotocols.com)
  • Yersinia enterocolitica serotype O:3 alters the expression of serologic HLA-B27 epitopes on human monocytes. (semanticscholar.org)
  • The first line is for HLA-B27 in general, ignoring any sub types. (csl.name)
  • Typically, people of primarily Caucasian heritage have a naturally higher level of HLA-B27, notes MedlinePlus. (reference.com)
  • By Fisher's exact test, involvement of small joints in the lower extremities was associated with HLA-B27 in boys (p=0.011), but not in girls (p=0.687). (biomedsearch.com)