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  • genotype
  • We published the first molecular HLA association study in childhood ALL and showed a convincing association for a homozygous genotype of the DQA1 locus by RFLP analysis 4 . (dorak.info)
  • This genotype more or less corresponds to homozygosity for HLA-DR53 and the current research specifically examined this genotype by PCR analysis against a newborn control group (as opposed to an adult control group in the previous RFLP study). (dorak.info)
  • Blood samples at diagnosis were analyzed to determine HLA genotype, islet autoantibodies and serum C-peptide. (pubmedcentralcanada.ca)
  • HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (springer.com)
  • genotypes
  • HLA-DR and MT1, MT2, MT3 genotypes have been investigated in 123 Type 1 (insulin-dependent) diabetic subjects and their families. (springer.com)
  • In this work, we tried to understand whether combined genotypes of CCR5-▵32, CCR2-64I, SDF1-3′A and HLA alleles can predict the LT-NP status. (bloodjournal.org)
  • In this report, we studied chemokine receptors (CCR2, CCR5), chemokine (SDF1), and HLA class I and II genotypes in LT-NP and attempted to find out whether any particular pattern of host genetics could be implicated in the LT-NP phenotype. (bloodjournal.org)
  • 11 Genetic mapping involved a comparison of HLA genotypes for 44 patients with Stevens-Johnson syndrome or toxic epidermal necrolysis with those of 101 controls who had taken carbamazepine for at least 3 months without development of any skin reaction, and 93 healthy individuals. (mja.com.au)
  • prevalence
  • The D8/17 non-HLA B-cell antigen has not been studied in Australia, where Aboriginal people have among the world's highest prevalence of rheumatic heart disease (RHD). (mja.com.au)
  • Intensity (concentration) and duration of exposure to the antigen, frequency of exposure, particle size, and antigen solubility may influence disease latency, prevalence, severity and course [6, (worldallergy.org)
  • DR53
  • The first childhood leukaemia studies examined HLA class-II antigen frequencies found an increased allele frequency of DR7 in Switzerland where DR7 is the most common DR53 group antigen 8;9 . (dorak.info)
  • Two British studies examined HLA-DR antigens in adult leukaemias and reported the involvement of HLA-DR53 or its members in adult ALL 11 and chronic lymphoid leukaemia (CLL) 12 . (dorak.info)
  • The increased HLA-DR53 allele frequency in adult ALL (66.7% vs 52.3%) could have been significant if homozygosity had been considered 11 . (dorak.info)
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • found
  • The very first paper which studied HLA-A, and -B frequencies in childhood leukaemia found a significant increase in HLA-A2B12 (Ref.3). (dorak.info)
  • HLA-DR7 was also found increased in childhood ALL in another study 10 . (dorak.info)
  • The latest list of officially recognized HLA-DRB alleles can be found at the ANRC site . (dorak.info)
  • It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. (ubc.ca)
  • HLA *B44 was also found to be over-represented among patients who presented to our clinic with adult-onset recurrent sinopulmonary infections (RESPI) and normal serum immunoglobulin levels, a cohort that included first and second degree relatives of patients with CVID. (beds.ac.uk)
  • The association of HLA with PsA is more complex than that found in psoriasis. (hindawi.com)
  • Although Stevens-Johnson syndrome with carbamazepine also occurs among Caucasians, HLA-B*1502 has not been found in this group. (mja.com.au)
  • proteins
  • Immune responses targeting these proteins could thus result in a limited or no generation of antigen-loss variants and, therefore, they may efficiently control in vivo tumor growth, thus meeting the requirements for an ideal TAA set forth above. (aacrjournals.org)
  • Our prediction is that at least some of the CSC antigens will match proteins already known to serve as TAAs and expressed by embryo-fetal tissues (e.g., survivin, telomerase, cancer/testis antigens) reflecting common functions between embryonic stem cells and CSCs, i.e., multipotent differentiation, plasticity, and self-renewal. (aacrjournals.org)
  • significantly
  • As for HLA-DQ, the frequency of HLA-DQB1*0501 was significantly lower in the patient group. (healthdocbox.com)
  • HLA-DM-mediated editing contributes significantly to immunodominance and is exploited in discovering immunodominant epitopes from novel or previously uncharacterized antigens, particularly antigens associated with pathogens, tumors or autoimmune diseases. (freepatentsonline.com)
  • 4-7 In contrast, the presence of HLA-B35, HLA-DR1, HLA-DR3, HLA-DQ1 antigens was significantly associated with a bad prognosis and a rapid progression to acquired immunodeficiency syndrome (AIDS). (bloodjournal.org)
  • Immunohistochemical studies revealed significantly higher HLA-DR expression in keratinocytes from psoriatics than from controls. (smokershistory.com)
  • donors
  • Stimulation of peripheral blood mononuclear cells from two dengue virus type 4 (D4V)-immune donors with live D4V or noninfectious D4V antigen generated 17 HLA class II-restricted CD4+ CTL capable of specific lysis of dengue virus antigen-treated autologous lymphoblastoid cell lines. (umassmed.edu)
  • they are also critical in the field of transplant surgery where the donors and the recipients must be HLA-compatible [ 3 ]. (hindawi.com)
  • protein
  • This protein is involved in antigen presentation. (healthmatics.info)
  • We have studied the HLA-class I and class II antigen distribution in a sample of 75 Spanish Gypsies and 74 Spanish non-Gypsies by serology, restriction fragment length polymorphism, and protein chain reaction and hybridization with allele-specific oligonucleotide probes. (semanticscholar.org)
  • However, a mutant TSST-1 protein that fails to bind HLA-DR did not elicit an inflammatory skin reaction. (smokershistory.com)
  • frequencies
  • There was a marked increase in DR3, DR4 heterozygosity, but no increase in homozygosity for these antigens compared with the expected frequencies. (springer.com)
  • homozygosity
  • We believe that the reasons are the general negligence of HLA supertypes, homozygosity and the gender effect. (dorak.info)
  • carbamazepine
  • In December 2007, the United States Food and Drug Administration announced that, because of the associated risk of Stevens-Johnson syndrome and toxic epidermal necrolysis, people of Asian descent should be genetically tested for the HLA-B*1502 allele before starting therapy with carbamazepine. (mja.com.au)
  • HLA-B*1502 was present in all the case patients, in 3% of control patients taking carbamazepine and in 9% of the healthy controls (see Box 2 ). (mja.com.au)
  • serologic
  • In order to standardize the HLA designation of prior low-resolution typings with the more advanced DNA based typings, all HLA-A, −B and -DR were analyzed using a low resolution serologic equivalent. (biomedcentral.com)
  • specific
  • Antigen recognition by six D4V-specific clones and three D2V- and D4V-cross-reactive clones was restricted by HLA-DR7. (umassmed.edu)
  • Other HLA associations are not sufficiently specific for translation but are still of interest in relation to underlying mechanisms for the reactions. (biomedcentral.com)
  • A specific HLA-A surface antigen subtype. (healthmatics.info)
  • However, specific HLA types associated with ESRD have not been well documented. (biomedcentral.com)
  • In addition, exposure to airborne endotoxins, which is common in workplaces associated with HP, potentiates antigen-specific airway inflammation and allergen responses . (worldallergy.org)
  • inflammatory
  • DLQI items Factor 1 Share full text access The epidermal barrier dysfunction hypothesis suggests that AD patients develop AD as a result of skin barrier defects that allow for the entry of antigens, resulting in the production of inflammatory cytokines. (bestskincare101.com)
  • These results indicate that keratinocyte expression of HLA-DR enhances inflammatory skin responses to SAg's. (smokershistory.com)
  • assay
  • The B-cell antigen D8/17 accurately identifies Australians with a past history of RF, and the assay is feasible in remote settings with access to facilities capable of performing D8/17 staining within half a day of sample collection. (mja.com.au)
  • The workshop was convened for the purpose of comparing the different in vitro assay systems used at the time to define antigens which were described as Hu-1 (Dausset and Ivanyi), LA (Payne and Bodmer), and Four (van Rood). (ihiws.org)
  • disease
  • Why, then, in a disease which has attracted much attention for an HLA association since Lilly's original paper on mouse leukaemia in 1964 (Ref.2), and the first HLA association paper in childhood leukaemia 3 , no other strong HLA association has been reported? (dorak.info)
  • Ninety-eight percent of probands possessed either DR3 (relative risk = 5.0), or DR4 (relative risk = 6.8) or both antigens (relative risk = 14.3), emphasizing the strong association of the disease with these two antigens. (springer.com)
  • Batchelor JR, Morris PJ (1977) Joint report on HLA and disease: juvenile onset diabetes. (springer.com)
  • Bodmer WF (1980) The HLA system and disease. (springer.com)
  • Combination of HLA class I (HLA-A1, HLA-A2, HLA-B14, HLA-B17, HLA-B27) and class II antigens (HLA-DR5 and HLA-DR6) have been correlated with low rates of disease progression. (bloodjournal.org)
  • According to the data of P. M. Alyeva (1993) DR5 antigen is a risk factor of disease development, and DR4 and DRw6 antigens are resistance factors. (bestskincare101.com)
  • group
  • The information of 141 ESRD patients was obtained from the medical record of the Keelung branch of Chang Gung Memorial Hospital and was compared to the HLA type of a control group comprized of 190 healthy unrelated Taiwanese from one of our previous studies. (biomedcentral.com)