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  • Peptides
  • To investigate if the observed HLA-associated polymorphisms could in fact be the result of viral adaptation to CTL-mediated immune pressure on alternative-frame HIV peptides, in vitro T cell responses to ARF peptides spanning the region of the associations were assessed. (nih.gov)
  • This study tried to identify CTL epitope peptides as vaccine candidates sharing by HLA-A3 + , -A11 + , -A31 + , and -A33 + cancer patients. (aacrjournals.org)
  • Seven peptides possessing the ability to induce HLA-A31-restricted and tumor-reactive CTLs were examined for their ability to induce HLA-A3-, -A11-, and -A33-restricted and tumor-reactive CTLs from peripheral blood mononuclear cells (PBMCs) of 18 epithelial cancer patients. (aacrjournals.org)
  • The five reference peptides all have the ability to induce CTL activity restricted with one of the HLA-A3 supertypes, and, thus, were also examined as positive controls. (aacrjournals.org)
  • Among the five reference peptides tested, one peptide, TRP2-197, induced CTL activity in both HLA-A11 + - and -A33 + -restricted manners. (aacrjournals.org)
  • The relatively low frequency of the HLA-A31 allele in major ethnic groups (5-12.5%) may hamper the clinical application of these peptides in cancer patients with this allele. (aacrjournals.org)
  • Subsequently, we extended our previous study, and investigated here whether or not the seven CTL-epitope peptides with an HLA-A31-restriction would be able to induce tumor-reactive CTLs from peripheral blood mononuclear cells (PBMCs) of HLA-A3 + , -A11 + , and -A33 + cancer patients. (aacrjournals.org)
  • CD8 + CTLs and CD4 + Th cell lymphocytes recognize antigens presented as small peptides in the groove of MHC molecules. (biomedcentral.com)
  • We designed conditional peptides for HLA-A*02:01 and H-2K b that form stable peptide-MHC I complexes at low temperatures, but dissociate when exposed to a defined elevated temperature. (rupress.org)
  • specific
  • A specific HLA-A surface antigen subtype. (healthmatics.info)
  • Responses were observed in 21 out of 85 HIV-infected individuals and 0 out of 32 HIV-negative individuals tested (P = 0.001 using Fisher's exact test), indicating that responses are HIV specific (Fig. 1 A). Of note, there was no statistical difference in HLA class I allele representation between the HIV-infected and -uninfected individuals, indicating that the HIV-negative group was a suitable control population (Tables S2 and S3). (nih.gov)
  • Significant improvements may result from the selection of the appropriate tumor-specific target antigen (to overcome the peripheral immune tolerance) and/or the development of immunization strategies effective at inducing a protective immune response. (asm.org)
  • In this context, considering the disappointing results up to now, the quest for specific and selective tumor antigens for developing tumor-specific cancer vaccines, optimal delivery systems (i.e., dendritic cell [DC]-based vaccines), adjuvants, and strategies to overcome immune tolerance and regulatory T (Treg) cell responses is the main goal for several research groups and leading health care companies. (asm.org)
  • The protocols can be used for detecting and enumerating human antigen‐specific T cells. (currentprotocols.com)
  • Both CD8 + and CD4 + antigen‐specific T cells are rare events and require that sufficient numbers of cells be evaluated. (currentprotocols.com)
  • Phenotypic analysis of antigen‐specific T cells. (currentprotocols.com)
  • Cutting edge: Detection of antigen‐specific CD4+ T cells by HLA‐DR1 oligomers is dependent on the T cell activation state. (currentprotocols.com)
  • tissue
  • All patients were subjected to serologic testing for herpes virus (IgG and IgM) and to HLA (A, B, C) and HLA-DR-DQ tissue typing to see if there was any correlation between the emergence of CNS pathology and these various antigens, thus to show a possible autoimmune-type immunogenetic basis for demyelination processes. (healthy.net)
  • All the patients were subjected to tissue typing for HLA (A, B, C) and HLA DR-DQ with the aim of defining the relative immunogenetic order. (healthy.net)
  • cancer
  • We identified new peptide vaccine candidates for HLA-A3, -A11, -A31, and -A33 positive cancer patients. (aacrjournals.org)
  • Potential new target antigens have recently been described for breast cancer [ 2 ], but most of them are expressed on only a small percentage of breast cancers. (biomedcentral.com)
  • patients
  • The presence of A3 and/or DR-7 was observed in 22/30 (73.3%) of the patients. (healthy.net)
  • Only 3 HLA-A3 + patients were provided for the study because of its low frequency (1.6%) in the Japanese population. (aacrjournals.org)
  • review
  • This review focuses on HER2/neu, a tumour-associated antigen that is overexpressed in 10-40% of breast cancers and other carcinomata. (biomedcentral.com)
  • study
  • This study should also have an impact on HLA typing, since it shows that vaccinations can have an effect on the individual's HLA type (i.e., that it is not necessarily congenital). (healthy.net)