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  • Antibody
  • Advances in desensitization therapy and immunosuppressants made kidney transplantation possible in a recipient who had incompatible blood type with donor or preformed antibody against donor human leukocyte antigen (HLA). (ovid.com)
  • 1) positive result in crossmatch test and/or (2) donor specific antibody with mean fluorescent intensity (MFI) over 5000 measured by Luminex single antigen assay. (ovid.com)
  • A recipient who had combined immunologic risk of blood type incompatibility and preformed antibody against donor HLA antigen presented comparable outcome to a patient who had one of these risk factors. (ovid.com)
  • Epitope analysis of HLA-DQ antigens: what does the antibody see? (sigmaaldrich.com)
  • Human leukocyte antigen (HLA)-DQ has emerged as the alloantibody most frequently associated with the generation of de novo donor-specific antibody (DSA), antibody-mediated-rejection, and unfavorable transplantation outcome. (sigmaaldrich.com)
  • Here, we have described Pr20, a TCR mimic (TCRm) human IgG1 antibody that recognizes the cell-surface ALY peptide/HLA-A2 complex. (jci.org)
  • An afucosylated Fc form (Pr20M) directed antibody-dependent cellular cytotoxicity against PRAME+HLA-A2+ leukemia cells and was therapeutically effective against mouse xenograft models of human leukemia. (jci.org)
  • The serotype is determined by the antibody recognition of α11 subset of HLA-A α-chains. (wikipedia.org)
  • DQ8 is determined by the antibody recognition of β8 and is complicated by the fact that DQ8 recognizes some HLA-DQB1*03 encoded isoforms well, partially or not well at all (See serology) DQ β3.2 and β3.5 are best recognized as DQ8. (wikipedia.org)
  • The NKR implemented a standardized HLA coding scheme and forced the identification of more antigen and antibody data such as DP, Bw, Cw, DQ and DQA. (wikipedia.org)
  • tissue
  • Because the HLA is a chemical tag that distinguishes "self" from "nonself," the antigen is important in the rejection of transplanted tissue and in the development of certain diseases (e.g., insulin-dependent diabetes). (encyclopedia.com)
  • Defects in the structure of the HLAs is the cause of some diseases where the body's immune system perceives a host antigen as foreign and begins to attack the body's own tissue. (encyclopedia.com)
  • The HLA system is used to assess tissue compatibility. (thefreedictionary.com)
  • Furthermore, we provide evidence that HLA-G expressed in this tissue may associate with a subset of insulin-containing granules and may be shuttled to the cell surface in response to secretory stimuli. (diabetesjournals.org)
  • Interestingly, these tissues represent immunologically protected sites (the fetal trophoblast), sites of immune privilege (the anterior chamber of the eye and the testis), or lymphocyte selection (the thymus), suggesting a role for HLA-G in tissue-specific immunoregulation. (diabetesjournals.org)
  • Today, a variety of techniques are applied for HLA tissue typing, providing an important tool to increase the success rate of human transplants. (bio-medicine.org)
  • Tissue Antigens. (wikipedia.org)
  • donor
  • The results will show the degree to which HLA antigens match between you and the donor. (rochester.edu)
  • We analyzed the graft survival according to presence of rejection episode, the result was inferior in patients who had rejection episode, but there was not statistical significance (p=0.102) We compared graft survival of presented patients with standard ABOi KT patients (n=88) and sensitized to donor HLA antigen patients (n=51) performed same period in our institute and there was no statistical significance (p=0.788). (ovid.com)
  • patients
  • 2. The prevalence of HLA B8 was 16.4% in hypertensive patients and 8.9% in controls ( P = 0.07). (clinsci.org)
  • 3. The prevalence of HLA B12 was 34.5% in hypertensive patients and 26.9% in the control group (N.S.). In WHO stage III hypertension HLA B12 was found in six out of 10 patients. (clinsci.org)
  • 6. A positive family history of hypertension tended to be more common in those patients with essential hypertension associated with HLA B8. (clinsci.org)
  • The serum of 100 patients with myasthenia gravis and 441 of their first-degree relatives was studied for the presence of autoantibodies against several antigens. (bmj.com)
  • Patients may get an HLA-B27 antigen test to find the cause of joint swelling and pain. (reference.com)
  • Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia). (wikipedia.org)
  • This refinement and expansion of HLA data increased the virtual cross match accuracy from less than 50% to greater than 95% allowing more patients to get transplanted in a shorter period of time. (wikipedia.org)
  • nomenclature
  • As the study of HLA genetics has evolved and expanded, the nomenclature has been continually altered, posing challenges for those attempting to follow the science. (uptodate.com)
  • The genetics, nomenclature, and typing of HLA, as well as the relationships between HLA and rheumatic disease, are discussed here. (uptodate.com)
  • http://hla.alleles.org/nomenclature/ (Accessed on November 29, 2017). (uptodate.com)
  • The current nomenclature system does not reflect the true nature of HLA-DQ polymorphism. (sigmaaldrich.com)
  • disease
  • Results of HLA typing vary according to a number of factors, including your age, the type of transplant, and your underlying disease. (rochester.edu)
  • However, A3 and A11 can process and load antigens even when proteosome activity is diminished suggesting an alternative mechanism for loading which may benefit in recovery from some disease but impair recovery of others. (wikipedia.org)
  • Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
  • HLA-B51 is found more frequently in disease that has an eye involvement. (wikipedia.org)
  • Myasthenia Gravis
  • Typing for HL-A antigens had shown a positive correlation between HL-A 8 and myasthenia gravis which was significantly higher in women than in men. (bmj.com)
  • HLA-DR3 is associated with early-age onset myasthenia gravis, Hashimoto's thyroiditis (along with DR5), primary sclerosing cholangitis, and opportunistic infections in AIDS, but lowered risk for cancers. (wikipedia.org)
  • DQ2.5
  • DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. (wikipedia.org)
  • HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. (wikipedia.org)
  • assay
  • In fact, this technique was used in the first commercially available PCR test (AmpliType HLA-DQ-alpha Forensic assay system). (bio-medicine.org)
  • class
  • We have studied the HLA-class I and class II antigen distribution in a sample of 75 Spanish Gypsies and 74 Spanish non-Gypsies by serology, restriction fragment length polymorphism, and protein chain reaction and hybridization with allele-specific oligonucleotide probes. (semanticscholar.org)
  • Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T Lymphocytes . (online-medical-dictionary.org)
  • Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele Marsh SG, Albert ED, Bodmer WF, et al. (wikipedia.org)
  • transplantation
  • The generation of HLA-DQ de novo DSA was interrogated in 40 transplant recipients who were immunologically naive before their failed transplantation. (sigmaaldrich.com)
  • This will pave the way to identifying acceptable mismatches and will allow risk stratification for generating de novo HLA-DSA after transplantation. (sigmaaldrich.com)
  • Typing
  • Today, several different types of HLA DNA typing methods exist and are commonly used by clinical laboratories. (bio-medicine.org)
  • Modifications such as this allow the HLA typing to be completed in two steps with high accuracy. (bio-medicine.org)
  • Of course, each HLA DNA typing technique has its advantages and disadvantages, and clinical laboratory personnel must choose the most appropriate test for their needs based on cost, average turnaround time, required resolution, and number of average samples per day. (bio-medicine.org)