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  • lipoatrophy
  • This is a multi-centre, open-label, 96 week study to evaluate the safety, tolerability and extent and duration of improvement in HIV-1 infected subjects with antiretroviral induced facial lipoatrophy, randomised in a 1:1 ratio to receive immediate or deferred deep subcutaneous injections of poly-L-lactic acid (PLA). (clinicaltrials.gov)
  • 100 HIV-infected ART-experienced subjects with facial lipoatrophy will be randomised in a 1:1 ratio at study entry to receive either immediate or deferred treatment (delayed 24 weeks) treatment with PLA. (clinicaltrials.gov)
  • rosiglitazone
  • Interest in the biguanide metformin and the thiazolidinediones rosiglitazone and pioglitazone has stemmed in part from the documented efficacy of all three drugs for improving insulin sensitivity [ 16 , 17 ] and reducing the progression from impaired glucose tolerance to diabetes [ 18 - 20 ] in non-HIV populations. (springer.com)
  • human immun
  • Human immunodeficiency virus (HIV) is a lentivirus that has two major species, HIV-1 which causes the majority of the epidemic, and HIV-2, a close relative whose distribution is concentrated in western Africa. (wikipedia.org)