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  • AIDS
  • To determine the effectiveness and safety of dextran sulfate (DS) as a treatment for patients with AIDS, AIDS related complex (ARC), or asymptomatic HIV infection with or without persistent generalized lymphadenopathy (PGL), and to determine antiviral activity at different doses of DS. (clinicaltrials.gov)
  • The study will begin with 10 patients with AIDS, 10 with ARC, and 10 with asymptomatic HIV infection taking DS by mouth 3 times a day for 24 weeks. (clinicaltrials.gov)
  • antiviral
  • DS might be a suitable drug since it has shown antiviral activity against HIV in the laboratory, and in preliminary studies it has shown little toxicity. (clinicaltrials.gov)
  • test
  • 70 picograms/ml, defined by the Abbott HIV antigen test, on two occasions, each within 1 month prior to entry, separated by at least 72 hours, the last of which must be within 2 weeks of starting therapy. (clinicaltrials.gov)
  • peptides
  • We examined the effect of alcohol on natural killer (NK) cell activities and lymphocyte proliferative response (LPR) of lymphocytes from normal donors to peptides derived from the HIV. (springer.com)
  • ELISA
  • An HIV-1 p24 antigen test involving signal amplification-boosted ELISA of heat-denatured plasma was evaluated prospectively in 55 patients whose viral RNA in plasma had previously been suppressed for at least 6 months under antiretroviral combination therapy. (uzh.ch)
  • The objective of this proposal is to develop ultra-sensitive ELISA (Enzyme-Linked ImmunoSorbent Assay) methods for quantification of HIV p24 antigen. (grantome.com)
  • Preferred test is Human Immunodeficiency Virus (HIV) Combo Antigen/Antibody (HIV-1/O/2) by ELISA, Reflexive Panel ( 2012674 ). (aruplab.com)
  • Inhibition of HIV-1 replication was determined in culture by measuring the amount of p24 produced by ELISA. (harvard.edu)
  • specificity
  • We analyzed the phenotype, gene expression, T cell receptor (TCR) repertoire, and HIV specificity of CD8 T cells in cerebrospinal fluid (CSF) of a unique cohort captured during the earliest stages of AHI (n = 26), chronic (n = 23), and uninfected (n = 8). (nih.gov)
  • To evaluate false-positivity and specificity, 54 HIV false-positive and HIV-negative serum samples from 100 hospitalized patients and 600 healthy subjects were included. (curehunter.com)
  • epitopes
  • CSF CD8 T cells in AHI exhibited increased functional gene expression profiles associated with CD8 T cells effector function, proliferation, and TCR signaling, a unique restricted TCR Vbeta repertoire and contained HIV-specific CD8 T cells directed to unique HIV epitopes compared with the periphery. (nih.gov)
  • The grant was awarded to test a novel, patented mechanism to increase the potency and repertoire of antigenic epitopes in a classical HIV DNA vaccine. (infectioncontroltoday.com)
  • uptake
  • and fluconazole has potential interactions with both ART and tuberculosis (TB) medication ( Table I ). These issues have led to very limited uptake of fluconazole primary prophylaxis in HIV treatment programmes. (scielo.org.za)
  • detection
  • Finally, we show that the SiO 2 substrates serve as a suitable platform for disease diagnostics, and show improved limits of detection (LOD) for the human immunodeficiency virus type 1 (HIV-1) p24 antigen. (rsc.org)
  • The specific aims of the Phase I and Phase II, in part, include 1) analyzing and optimizing of all variables affecting the accuracy and functionality of the p24 tests;and 2) validation of the HIV-1 p24 detection assay. (grantome.com)
  • antiretroviral therapy
  • Fifteen patients previously immunized with MicroGeneSys rgp160 antigen in ACTG 137 and not on antiretroviral therapy will receive intradermal injections of Immuno-AG rgp160 IIIB (vero cell expressed) in one arm, followed 1 week later by intradermal injections of MicroGeneSys rgp160 IIIB (baculovirus expressed) in the opposite arm (stratum 1). (clinicaltrials.gov)
  • HIV-1 p24 antigen is a significant inverse correlate of CD4 T-cell change in patients with suppressed viremia under long-term antiretroviral therapy. (uzh.ch)
  • immune cells
  • However, HIV-1 can resist complement mediated lysis and become coated with complement fragments and this opsonization influences the viral interaction with immune cells. (diva-portal.org)
  • The fundamental questions of this thesis are the following: How is free and opsonized HIV-1 internalized, processed, and presented on MHC class I and II molecules by DCs and how do free and opsonized HIV-1 particles interact with immune cells in the cervical mucosa? (diva-portal.org)
  • Our results indicate that opsonization of HIV-1 plays a critical role in the interaction with immune cells. (diva-portal.org)
  • Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. (creative-diagnostics.com)
  • glycoprotein
  • To determine the frequency of delayed-type hypersensitivity (DTH) reactions in HIV-positive patients to two doses of two envelope glycoprotein antigens prepared differently. (clinicaltrials.gov)
  • hepatitis
  • If your wife is at risk for hepatitis B , then the surface antigen can mean a chronic carrier state that is inactive due to no virus in her blood. (thebody.com)
  • The hepatitis B surface antigen was confirmed. (thebody.com)
  • Dendritic Cells
  • After penetration of the mucosal epithelium HIV-1 interacts with potential target cells, i.e. dendritic cells (DCs) and CD4+ T cells. (diva-portal.org)
  • type
  • HIV-1 interacts with a range of receptors expressed by the DCs including C-type lectins, integrins and complement receptors (CRs). (diva-portal.org)
  • vaccine
  • So far as, there is no efficient vaccine to prevent this virus from humans, since the mutation rate of HIV is extremely high, and thus has become a great threat to human health. (creative-diagnostics.com)
  • Presentation of trimeric HIV-1 antigens on nanoparticles may thus provide promising vaccine candidates. (nih.gov)
  • Together, our study provides an arsenal of multivalent immunogens for HIV-1 vaccine development. (nih.gov)
  • WORCESTER, Mass. -- This $357,000 NIH Small Business Innovative Research (SBIR) award supports pre-clinical testing of a novel HIV DNA vaccine incorporating Antigen Express proprietary platform technology for boosting antigen-specific T-helper cell responses. (infectioncontroltoday.com)
  • Antigen Express scientists and collaborators already demonstrated at least a six-fold enhancement in the immune response to an HIV gp120 DNA vaccine. (infectioncontroltoday.com)
  • tuberculosis
  • The QFT-G assay was performed using QFT-G kits among 107 HIV-infected patients including 9 cases with active tuberculosis (TB). (hindawi.com)
  • Objective To investigate antigen-specific CD4 + T cell responses to influenza virus, Streptococcus pneumoniae and Mycobacterium tuberculosis antigens in bronchoalveolar lavage (BAL) and peripheral blood between HIV-infected individuals and HIV-uninfected Malawian adults. (bmj.com)
  • We determined the proportion of T cell subsets including naive, memory and regulatory T cells using flow cytometry, and used intracellular cytokine staining to identify CD4 + T cells recognising influenza virus-, S pneumoniae - and M tuberculosis -antigens. (bmj.com)
  • In particular, HIV-infected individuals are 30 times more likely than uninfected adults to suffer from bacterial pneumonia or active tuberculosis. (bmj.com)
  • evaluate
  • Further research is needed to evaluate this strategy in lower-prevalence populations and in persons using preexposure prophylaxis for HIV prevention," the authors write. (empr.com)
  • PREVENTION
  • The Centers for Disease Control and Prevention report that approximately 18 million people in the United States are tested for HIV each year. (nih.gov)
  • Questions related to HIV transmission , prevention, safer sex, HIV testing and risk should be sent to Dr. Bob at his "Safe Sex and HIV Prevention" expert forum. (thebody.com)
  • serum
  • This quantity of antigen may not be present in the serum of infected individuals, even when the virus is actively replicating. (grantome.com)
  • RETRO-TEK kits have been designed for the quantitative measurement of viral antigens from the retroviruses HIV-1, SIV and HTLV found in cell culture, serum, plasma or other biological fluids. (gentaur-worldwide.com)
  • gp120
  • Cocaine effects may be important in vivo since the neurons of drug abusing patients with HIV-1 associated dementia displayed gp120, p24 and Nef. (openvirologyjournal.com)
  • donors
  • B . Number of CD8+ T cells per mL of CSF in the different groups of donors including HIV-1 (n=8). (nih.gov)
  • blood
  • Based on an Aug. 8, 1995 FDA recommendation to all registered blood and plasma establishments, the Coulter HIV-1 p24 Antigen Assay, or other similar tests that may be approved later, will start being used within 90 days of this first approval. (nih.gov)
  • HIV damages a person's body by destroying specific blood cells, called CD4+ T cells, which are crucial to helping the body fight diseases. (nih.gov)
  • What Are The Three Different HIV Blood Tests? (stdcheck.com)
  • Methods We obtained BAL fluid and blood from HIV-infected individuals (n=21) and HIV-uninfected adults (n=24). (bmj.com)
  • responses
  • Conclusions BAL antigen-specific CD4 + T cell responses against important viral and bacterial respiratory pathogens are impaired in HIV-infected adults. (bmj.com)
  • dementia
  • Central nervous system (CNS) infiltration by CD8 T cells is associated with neuroinflammation in many neurodegenerative diseases, including HIV-associated dementia. (nih.gov)
  • frequency
  • The frequency of activated CSF CD8 T cells positively correlated to CSF HIV RNA and to markers of CNS inflammation. (nih.gov)
  • antigenic
  • Here we report the rational design, structural analysis and antigenic evaluation of HIV-1 trimer-presenting nanoparticles. (nih.gov)
  • CONCLUSIONS
  • Conclusions: These results suggest that one possible mechanism of action of this anti-LFA-1 antibody is to inhibit HIV-1 replication via the production of a soluble antiviral factor that is induced upon binding to cells. (harvard.edu)