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  • epitope
  • The microarray measured potentially important differences in antibody epitope diversity, particularly regarding the depth of epitope variants recognized at each binding site. (osti.gov)
  • sequences
  • Here we describe the development of a global HIV-1 peptide microarray that contains 6564 peptides from across the HIV-1 proteome and covers the majority of HIV-1 sequences in the Los Alamos National Laboratory global HIV-1 sequence database. (osti.gov)
  • clinical
  • Our data suggest that the global HIV-1 peptide microarray may be a useful tool for both preclinical and clinical HIV-1 research. (osti.gov)
  • neutralize
  • CN) - People living with HIV but whose bodies neutralize the virus may have special immunological profiles that could be used to develop better vaccines to protect against the virus, according to new research. (courthousenews.com)
  • Such antibodies have the potential to neutralize many of the types of HIV in circulation worldwide. (iavi.org)
  • Maxygen-Monogram co-authored abstracts presented at the meeting in Banff included an oral presentation by Dr. X. Sean Du of Maxygen, "Directed Molecular Evolution Created Genetic and Antigenic Diversity and Improved Overall Immunogenicity of HIV-1 gp12- Immunogen," which detailed Maxygen's program to recombine and manipulate viral envelope DNA in order to produce vaccines which can neutralize a broad number of HIV variants. (bio-medicine.org)
  • It would be very interesting to know whether the antibodies … can not only neutralize the virus, but also kill the cells that produce it," she said. (amfar.org)
  • Scientists
  • In a new study published in Science Immunology , scientists have identified and described the immunological profile of some people with HIV who are better able to resist the effects of the virus. (medicalnewstoday.com)
  • In the studies, scientists deployed two antibodies, called 3BNC117 and 10-1074, which had been identified by examining rare individuals whose bodies successfully combat HIV without the help of drugs. (reuters.com)
  • Scientists are conducting a separate ongoing study of VRC01 as pre-exposure prophylaxis (PrEP) against the virus among HIV-negative individuals. (poz.com)
  • Scientists working for the UK's Health Protection Agency carrying out a test for the human immunodeficiency virus (HIV). (sciencephoto.com)
  • To increase the number of biomedical HIV prevention tools available, scientists have begun to test whether giving people periodic infusions of powerful anti-HIV antibodies can prevent HIV infection, a strategy called passive immunization. (nih.gov)
  • Led by NIAID scientists, the first clinical trial of VRC01LS has now demonstrated that the antibody is safe for people and persists in the human body more than four times longer than VRC01, according to a new report published in the journal PLOS Medicine . (nih.gov)
  • The approach used by the scientists yielded powerful antibodies modelled after those found in rare individuals infected with HIV. (ibtimes.com.au)
  • Conflict in Ukraine has increased the risk of HIV outbreaks throughout the country as displaced HIV-infected people move from war-affected regions to areas with higher risk of transmission, according to analysis by scientists. (medicalxpress.com)
  • This newly identified site on the viral spike is where a new antibody found by the scientists in an HIV-infected person binds to the virus. (nih.gov)
  • Over the last few years, scientists have identified something like 100 of these anti-HIV antibodies, giving them plenty of opportunities to mix and match for maximum effectiveness. (npr.org)
  • In one study, a group of scientists - which included Dr. Daniel Douek, chair of amfAR's Scientific Advisory Committee - used bispecific, or two-pronged, antibodies to access and eliminate hidden HIV reservoirs in CD4 T cells located in the lymph nodes. (amfar.org)
  • Scientists studied the patient's virus five times between 2006 and 2015 and found that a single bNAb was associated with decreased viral load and all three together completely shut down HIV. (amfar.org)
  • viral
  • Antibodies are generated in response to many different viral antigens. (aidsmap.com)
  • A neg ative HIV antibody test and a very high viral load indicate recent HIV infection, most likely within the past two. (thebody.com)
  • Routine blood tests are normal, an HIV test comes back negative, and the pediatrician sends the patient home with a diagnosis of acute viral infection. (health.am)
  • We think this approach might be an important way to prevent transmission in humans, particularly in regions of the world where HIV is endemic," says Malcolm Martin , chief of the viral pathogenesis and viral section of the National Institute of Allergies and Infectious Diseases and a senior author of the paper. (npr.org)
  • Immunology
  • The team's work, published Friday in journal Science Immunology, indicate that bNAb production may be associated with specific variations in individual immune functions, which may be triggered by unchecked HIV infection. (courthousenews.com)
  • A staff member at St. Vincent's Hospital Centre for Immunology in Sydney removes archived plasma samples used for HIV research from a minus 80 degree Celsius (-112 Fahrenheit) freezer July 20, 2007. (ibtimes.com.au)
  • prevention
  • It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update . (thebodypro.com)
  • Moreover, several early-phase NIAID clinical trials of VRC01LS for HIV prevention and treatment, as well as other antibodies with the LS change, are planned or underway. (nih.gov)
  • And other means of prevention, such as a daily pill containing anti-HIV drugs, have proved too cumbersome. (npr.org)
  • This is not just about doing cool science - and this is cool science," says Mitchell Warren, executive director of AVAC , a global HIV prevention advocacy group. (npr.org)
  • People are excited about this antibody research as a whole new prevention approach. (npr.org)
  • But in HIV prevention we will take what we can get. (npr.org)
  • gp120
  • Molecular model of the interaction of the HIV surface protein gp120 (green, lower right) as it interacts with a human white blood cell surface protein (CD4, blue, upper right) and the anti-HIV antibody (17B, yellow, red and orange, upper left). (sciencephoto.com)
  • infusions
  • Reuters Health) - People living with HIV might someday be able to combat the virus with twice-a-year infusions of anti-HIV antibodies instead of daily antiretroviral pills, two preliminary experiments suggest. (reuters.com)
  • For one of the experiments, nine HIV-positive patients stopped taking daily antiretroviral pills and then received three infusions of the two anti-HIV antibodies over the course of six weeks. (reuters.com)
  • Participants received either a single infusion with both antibodies or three infusions of both antibodies across six weeks. (reuters.com)
  • immune system
  • As the virus spreads through the body, the immune system will launch an attack by HIV antibodies to fight the virus. (medicalnewstoday.com)
  • Their theory is that in people with this particular immune system profile, the activity of antibody-producing immune cells, known as B cells, could be less restricted. (medicalnewstoday.com)
  • Some cancer medicines use a similar approach to attack tumors by harnessing the immune system, but this approach hasn't yet been proven safe and effective for people with HIV. (reuters.com)
  • Antibodies are protein molecules produced by the immune system in response to allergens, infectious organisms (including viruses, bacteria, fungi and parasites), and sometimes (in autoimmune disorders) the body's own components. (aidsmap.com)
  • The immune system recognises and responds to antigens by generating corresponding antibodies. (aidsmap.com)
  • If you are infected, your immune system will make antibodies against HIV. (thebody.com)
  • The study has outlined a streamlined path to priming immune system to resist HIV. (ibtimes.com.au)
  • With this immune system configuration, the activity of antibody-producing immune cells called B cells may be less restricted because they are supported by T follicular helper cells and may be hindered by regulatory T cells. (eatg.org)
  • A group of broadly neutralizing antibodies obtained from four unrelated slow-progressing HIV patients show striking sequence and structural similarities, suggesting that the path for the immune system to achieve this potent activity against the CD4 binding site might be narrow. (medicalxpress.com)
  • In addition, despite undergoing extensive hypermutation, these antibodies show striking sequence and structural similarities suggesting that the path for the immune system to achieve this potent activity against the CD4 binding site might be narrow. (medicalxpress.com)
  • rapid HIV test
  • The most commonly used rapid HIV test resulted in a false negative the first time around, which happens quite often during the earliest - and most contagious - stages of HIV infection, known as acute retroviral syndrome (ARS), explains Allison Agwu, M.D., a pediatric infectious disease specialist at Johns Hopkins Children's Center. (health.am)
  • Agwu cautions that "if a teen engages in risky behaviors and has symptoms of flu or mononucleosis, pediatricians should look further and not be lulled into a false sense of security by a negative rapid HIV test. (health.am)
  • taking antiretroviral
  • One drawback of this experiment was that participants didn't have HIV circulating in their blood because they had been taking antiretroviral pills. (reuters.com)
  • infections
  • Subcutaneous doses of a broadly neutralizing monoclonal antibody, known as VRC01LS, given at birth and 12 weeks were well-tolerated by HIV-exposed infants, according to the results of an open-label safety and pharmacokinetic study presented at the Conference on Retroviruses and Opportunistic Infections. (healio.com)
  • Because an estimated 14 teenagers become infected with HIV every day in the United States, because ARS is both under-reported and underdiagnosed and because early infections are highly contagious, ARS should be on every pediatrician's radar screen, Agwu says. (health.am)
  • To rule out HIV in teens deemed to be at high risk for sexually transmitted infections, Johns Hopkins HIV experts recommend the use of polymerase chain reaction (PCR) tests, which directly detect the virus' genetic markers, rather than antibodies to the virus. (health.am)
  • The hope is that an injection of these antibodies every six to 12 months could protect large numbers of people from HIV in parts of the world where most infections are occurring. (npr.org)
  • infection in infants
  • recommended for establishing the diagnosis of infection in infants born to HIV-1-infected mothers. (thebody.com)
  • Elizabeth J. McFarland, MD, medical director of Children's Hospital Colorado's HIV program and professor of pediatrics at the University of Colorado School of Medicine, said at a press conference that passive immunization has successfully been used to prevent hepatitis B, and neutralizing antibodies are also used to prevent respiratory syncytial virus infection in infants. (healio.com)
  • Anti-HIV
  • Higher levels of anti-HIV-1 neutralizing responses in the mother associated with both transmission and infant morbidity. (medindia.net)
  • Preexisting anti-HIV-1 neutralizing activity does not prevent breast milk transmission. (medindia.net)
  • And they only show that the anti-HIV antibodies have potential, not that they actually work. (reuters.com)
  • Antiretroviral drug chart A one-page reference guide to the anti-HIV drugs licensed for use in the European Union, with information on formulation, dosing, key side-effects and food restrictions. (aidsmap.com)
  • If the anti-HIV CTLs arent hanging out at the site of infection, and HIV gets a foothold, youre still screwed. (scienceblogs.com)
  • Anti-HIV properties of. (scienceblogs.com)
  • The idea is to inject anti-HIV antibodies that would kill the virus when people get exposed. (npr.org)
  • A single injection of two anti-HIV antibodies protected five of six macaque monkeys from infection for six to nine months as they got weekly inoculations of a potent human-simian hybrid of the virus called SHIV. (npr.org)
  • virus
  • Another human retrovirus, human T-cell leukemia virus ( HTLV ), was discovered three years prior to the discovery of HIV. (encyclopedia.com)
  • HIV positive mothers who possess a strong neutralizing antibody response may be more likely to pass the virus on to her infant through breast feeding. (medindia.net)
  • In addition, infants born to mothers with a strong antibody response are significantly more likely to have a serious illness or death, regardless of whether or not they acquire the virus. (medindia.net)
  • Importantly, we did find that mothers who transmitted the virus to their infant were significantly more likely to have a broad and potent neutralizing antibody response and possibly a stronger response against their own virus. (medindia.net)
  • A second experiment focused on seven people who had been diagnosed with HIV but were not currently taking antiretrovirals, so the virus was circulating in their blood. (reuters.com)
  • Antiretrovirals suppress HIV replication, but they aren't able to clear the virus-infected cells that remain hidden," Bar said by email. (reuters.com)
  • Antibodies that target the same portion of the virus tend to have similar fingerprints. (medicalnewstoday.com)
  • PCR tests, while more expensive than standard antibody tests, can detect the virus within two to three weeks after it enters the body. (health.am)
  • The concept is pretty similar to the cocktail of HIV drugs approach used by doctors to reduce the chances of the virus' escape through mutating. (ibtimes.com.au)
  • His team at the California Institute of Technology in Pasadena, Calif., has stitched genes that code for antibodies into a harmless virus, which they then inject into mice. (scienceblogs.com)
  • The virus infects mouse cells, turning them into factories that produce the antibodies. (scienceblogs.com)
  • Each time a virus invades a healthy individual, antibodies created by the body fight to fend off the intruders. (medicalxpress.com)
  • A first-of-its-kind study has found that the genetic diversity of human immunodeficiency virus type 1 (HIV-1) is higher in the vaginal tract than in the blood stream during early infection. (medicalxpress.com)
  • They discovered that the virus was undetectable in two-thirds of the mice three weeks after the antibodies were administered. (amfar.org)
  • Johnston noted in the Healthline article that the combination of antibodies may prevent a treatment-resistant virus from emerging. (amfar.org)
  • IAVI
  • We are very pleased to be working with the world-class science team at IAVI and the network of collaborators they have assembled as part of their Neutralizing Antibody Consortium," commented David Fanning, CEO of Theraclone Sciences. (iavi.org)
  • 2016
  • This study is important because despite the effectiveness of anti-retrovirals, 160,000 infants were infected with HIV from their mother in 2016. (medindia.net)
  • passive immunization
  • These characteristics could reduce the cost and increase the convenience of passive immunization against HIV because fewer doses of the antibody could achieve the same protective effect. (nih.gov)
  • Passive immunization involves the direct injection of antibodies extracted from survivors of a particular infection. (npr.org)
  • people
  • People with HIV have a range of immune and antibody profiles. (medicalnewstoday.com)
  • HIV treatment is not a cure, but it is keeping millions of people well. (aidsmap.com)
  • Your next steps A booklet with information for people who've just found out they have HIV. (aidsmap.com)
  • A range of interactive tools to support people living with HIV to get involved in decisions about their treatment and care. (aidsmap.com)
  • This represented only an apparent slight delay from the typical two weeks that HIV takes to rebound after people stop their ARVs. (poz.com)
  • POZ Poll: Has HIV ever made you feel isolated from other people? (poz.com)
  • Only a few people make broadly neutralizing antibodies. (thebodypro.com)
  • Certain people are capable of developing antibodies in their systems that are capable of coping with the disease without the need for medication. (ibtimes.com.au)
  • There is just no way to make people make this antibody, no matter how awesome it is. (scienceblogs.com)
  • That isnt exactly a viable option in most cases, or with most people at risk for HIV-1 infection. (scienceblogs.com)
  • Many people who seek anonymous HIV-antibody testing would avoid it under other circumstances. (nih.gov)
  • Decreases in high-risk behavior have been observed when people have sought anonymous or confidential HIV-antibody testing accompanied by counseling. (nih.gov)
  • HIV-antibody testing also benefits those who are tested, since people who find that they are seropositive can receive closer medical follow-up, and, in certain cases, medical treatment. (nih.gov)
  • Currently 1.8 million people are newly infected with HIV every year. (npr.org)
  • test
  • Got tested for hiv at 4 weeks with an hiv rna qualatative test (a. (medhelp.org)
  • I got a hiv test at. (medhelp.org)
  • Have an HIV test - it's the only way to know for sure. (aidsmap.com)
  • I had an appointment yesterday with another dr she explained everything even the hiv test she said its something they take very seriously and that it was Negative. (empowher.com)
  • Dr. Bob, sorry i missed a point, i mean to say that i got my HIV antibody test results yesterday after 7 months after exposure. (thebody.com)
  • Elevated liver function tests (enzymes) and having a fatty liver (or even a chubby gallbladder) will not affect HIV-antibody test results or delay HIV seroconversion.2. (thebody.com)
  • my means test is postive, can i not have hiv? (thebody.com)
  • The HIV antibody test (called. (thebody.com)
  • Negative HIV test but reactive? (thebody.com)
  • My OBGYN doctor called this afternoon and told me that my HIV test came back negative but reactive? (thebody.com)
  • This time, a repeat HIV test comes back positive. (health.am)
  • This is an HIV-1/2 antibody test. (sciencephoto.com)
  • They plan to test the antibodies directly in HIV-positive patients or individuals at risk of HIV, but must first conduct animal studies before progressing to tests with humans. (thebodypro.com)
  • I recently had a Serum HIV test for life insurance which came back negative. (thebody.com)
  • My husband just had an HIV antibody test which came back Indeterminate, showing P51 and P55. (thebody.com)
  • Since finding this out, I also had an anti-body HIV test and are waiting for the results. (thebody.com)
  • He has passed an HIV test when we started dating and I have also passed 2 HIV tests. (thebody.com)
  • broad
  • In addition, infants born to mothers with a broad and potent antibody response were more than three times as likely to have serious illness or death post-partum," explained corresponding author Manish Sagar, MD, associate professor of medicine at Boston University School of Medicine (BUSM). (medindia.net)
  • Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface. (nih.gov)
  • Nussenzweig
  • If the larger trial with modified antibodies produces the expected results, they would be given once every six to nine months," said Dr. Michel Nussenzweig, senior author of both studies and a researcher at the Howard Hughes Medical Institute at Rockefeller University in New York City. (reuters.com)
  • Later, Hugo Mouquet and colleagues in Nussenzweig s lab investigated how polyreactivity might be selected for in the antibody response against HIV. (medicalxpress.com)
  • make
  • What really surprised us was how similar these antibodies were even though they came from different donors, so the path to make them seems to be quite narrow. (medicalxpress.com)
  • It stimulates the recipient to make antibodies that protect against a disease. (npr.org)