Rearrangements of the KMT2A gene are characteristic of infantile acute lymphoblastic leukemia (ALL) and are associated with increased lineage plasticity and resistance to therapy. (authorea.com)
Childhood acute myeloid2
Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. (cancerindex.org)
Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. (shengsci.com)
Chronic7
The primary goal of TKI therapy in patients with chronic phase-CML is to prevent disease progression to accelerated phase-CML or blast phase-CML. (bvsalud.org)
The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 (i.e. high eosinophil blood counts caused by mutations in the eosinophil cell line of one of these three genes), 'b) Chronic eosinophilic leukemia, and c) the Idiopathic hypereosinophiic syndrome. (wikipedia.org)
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
The clinical manifestations of CML are insidious, changing somewhat as the disease progresses through its 3 phases (chronic, accelerated, and blast). (medscape.com)
Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. (shengsci.com)
He had a history of hypertension and chronic kidney disease, and his regular. (annals.edu.sg)
Bone marrow2
Abnormalities in this process lead to a group of diseases known as myeloid malignancies, which include acute myeloid leukaemia-in which the bone marrow produces abnormal white blood cells-and myelodysplastic syndromes, which are caused by too few mature blood cells being produced. (elifesciences.org)
Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. (shengsci.com)
Leukemia3
A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)
Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). (shengsci.com)
The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice. (shengsci.com)
Lymphoid1
In the recent fifth edition of the World Health Organization classification, similar to the recent update to the International Consensus Classification, the category was renamed to "myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions" and both classifications added novel subtypes with new JAK2 rearrangements (e.g. (nature.com)
Neoplasms1
A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)
Eosinophilia3
A marked increase in non-blood tissue eosinophil count noticed upon histopathologic examination is diagnostic for tissue eosinophilia. (wikipedia.org)
Specific treatments are dictated by the causative condition, though in idiopathic eosinophilia, the disease may be controlled with corticosteroids. (wikipedia.org)
Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA. (lookformedical.com)
Tumor2
In addition to revealing a new tumor suppressor gene and its contribution to myeloid malignancies, the study by Heinrichs et al. (elifesciences.org)
They also participate in transplant rejection, Graft-versus-host disease, and the killing of tumor cells. (wikipedia.org)
Patients16
In 15 patients (9.9% of all 151 cases) the manifestation of MS preceded the systemic hematological disease. (biomedcentral.com)
Cases were included into the study either with histopathological confirmation of MS ( n = 109/151, 72.2% of all included patients) or with clinical highly suspicious lesions of MS with histopathological confirmed of associated hematological disease ( n = 42/151, 27.8% of all included patients). (biomedcentral.com)
Further, both primary BP disease and secondary BP disease as a consequence of rapid progression from CP, usually within 1-2 years, are reported in many patients [ 6 ]. (nature.com)
Myeloid malignancy patients lacking one copy of this gene showed levels of MYBL2 expression that were less than 50% of those in healthy individuals. (elifesciences.org)
Standard management of pediatric Non-Hodgkin's Lymphoma (NHL) patients have included an initial assessment of the disease at presentation to establish it's extent. (authorea.com)
Of the 10 response evaluable patients, one had partial response (Ewing sarcoma), seven had stable disease, and two had progressive disease. (authorea.com)
The actuarial event-free survival for these 56 patients at 3 years was 37% and was at least as good as that reported for relapsed Hodgkin's disease patients treated with CBV and ABMT. (shengsci.com)
CBV and PSCT for patients with relapsed Hodgkin's diseases who have marrow hypocellularity in traditional harvest sites or histopathologic evidence of BM metastases can result in long-term event-free survival. (shengsci.com)
Patients then receive autologous CD8+ melanoma-specific T cells IV over 30-60 minutes on day 0, aldesleukin subcutaneously (SC) twice daily (BID) on days 0-13 and ipilimumab IV over 90 minutes on days 1, 22, 43, and 64 in the absence of disease progression or unacceptable toxicity. (survivornet.com)
This is an observational registry database for adult patients diagnosed with degenerative spine disorders, which aims to add information to the understanding of the disease management of this spine diseases. (umn.edu)
Data from this registry may be used to generate descriptive statistics on demographics, and clinical characteristics, including co-morbidities, treatment patterns and adverse outcomes (resulting from treatment or disease), as well as patients' quality of life measurements. (umn.edu)
If patients have grade 3 disease, they will usually receive EPOCH-rituximab (EPOCH-R) chemotherapy (each letter representing a drug). (survivornet.com)
If patients have grade 1 or 2 disease, the will usually receive alpha interferon. (survivornet.com)
Researchers will also try to obtain a biopsy of patients lesions, to help in understanding the disease. (survivornet.com)
If there is residual low grade disease, patients may receive alpha interferon. (survivornet.com)
We believe that cysteinyl leukotriene type 1 receptor antagonists are safe and effective drugs for most patients with asthma but caution is needed for those with more severe disease who require systemic corticosteroids, especially if they show characteristics of the atypical allergic diathesis seen in the prodromal phase of Churg-Strauss syndrome. (lookformedical.com)
Symptoms3
The underlying hematological disease, localizations, and clinical symptoms as well as imaging features on CT and MRI were investigated. (biomedcentral.com)
used gene silencing techniques to reduce the expression of MYBL2 in mice and showed that this induced symptoms of myeloid malignancies in the animals. (elifesciences.org)
Initial symptoms attributable to neuropathy were acute painful dysaesthesiae and oedema in the dysaesthetic portion of the distal limbs. (lookformedical.com)
Extramedullary1
Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. (biomedcentral.com)
Proliferation1
The disease causes proliferation of destructive cells involving the lungs, skin, kidneys, and central nervous system. (survivornet.com)
Disorder1
By 6 months post-transplantation, the reconstituted mice had developed a clonal myeloproliferative/myelodysplastic disorder originating from the cells with aberrantly reduced Mybl2 expression. (elifesciences.org)
Eosinophils1
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. (lookformedical.com)
Systemic1
In 1969, Rosai and Dorfman first described a newly recognised benign systemic histioproliferative disease characterised clinically by bilateral striking cervical lymphadenopathy, fever, leukocytosis, and. (annals.edu.sg)
Gene1
This deletion is only ever seen in one of their two copies of the chromosome-suggesting that at least some of these genes are essential for survival-but the identity of the gene(s) that are associated with the increased risk of myeloid malignancies is unknown. (elifesciences.org)
Hematological disease2
MS occurs in most cases meta-chronous to the hematological disease and most commonly affects the cutis. (biomedcentral.com)
Nevertheless, the identification of novel additional molecular alterations is of great interest, opening to new prognostic and therapeutic strategies for such heterogeneous hematological disease. (cancerindex.org)
Clinical3
This case highlights the unique clinical challenges infantile ALL poses on monitoring therapeutic response with current methods of measuring minimal residual disease as well as the challenges in treating infantile B-ALL. (authorea.com)
Such efforts have not occurred in clinical trials of NHL and thus we are left to examine case series and try to discern its value for this disease. (authorea.com)
The grades of disease are histologically-based and do not necessarily correlate with clinical outcome. (survivornet.com)
Recurrence1
The course of the disease and the tendency for recurrence make the treatment of these relatively rare fibrous tumors challenging. (ommegaonline.org)
Previously1
MLN with FGFR1 rearrangement was previously known as 8p11 myeloproliferative syndrome [ 14 ]. (nature.com)
Kidney2
The use of glucarpidase in the management of acute kidney injury and delayed methotre. (authorea.com)
This is a case of a 43 year old woman with medical history of Berger`s disease, immunosuppressive therapy, a kidney transplant and sporadic mesenteric desmoid tumors appearing after solid organ transplantation. (ommegaonline.org)
Cells1
Current evidence shows that LYG is a disease of B cells. (survivornet.com)
Severe disease1
All gravidas with moderate or severe disease are treated. (jpgo.org)
Toxicity1
Non-concomitant administration of cabozantinib with cytotoxic therapy in this population has acceptable toxicity while allowing for potential disease control. (authorea.com)
Human1
We conclude that downregulation of MYBL2 activity below levels predicted by classical haploinsufficiency underlies the clonal expansion of hematopoietic progenitors in a large fraction of human myeloid malignancies. (elifesciences.org)
Conditions1
It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions. (lookformedical.com)