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  • human
  • We apply SS-CoSBI to identify multiple cell-type-specific combinatorial histone modification states associated with human enhancers. (biomedcentral.com)
  • The analysis presented here provides a systematic characterization of combinatorial histone codes of enhancers across three human cell types using a novel semi-supervised biclustering algorithm. (biomedcentral.com)
  • sequence
  • Unsurprisingly, the sequence of the histone is very well conserved as it probably cannot tolerate much change to structure. (everything2.com)
  • The term "Histone H3" alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state. (wikipedia.org)
  • For example, the amino acid sequence of histone H4 from a pea and cow differ at only 2 out of the 102 positions. (wikipedia.org)
  • Eukaryotic organisms can produce small amounts of specialized variant core histones that differ in amino acid sequence from the main ones. (wikipedia.org)
  • Except for cenH3 histone, H3 variants are highly sequence conserved differing only by a few amino acids. (wikipedia.org)
  • Current version of the Histone Database - HistoneDB 2.0 - with variants - includes sequence and structural annotations for all five histone types (H3, H4, H2A, H2B, H1) and major histone variants within each histone type. (wikipedia.org)
  • HDACs, are classified in four classes depending on sequence homology to the yeast original enzymes and domain organization: HDAC (except class III) contain zinc and are known as Zn-dependent histone deacetylases. (wikipedia.org)
  • binds
  • It is responsible for most of the cytoplasmic HAT activity in yeast, and it binds strongly to histone H4 by virtue of its association with an additional subunit, Hat2. (wikipedia.org)
  • The linker histone H1 binds the nucleosome at the entry and exit sites of the DNA, thus locking the DNA into place and allowing the formation of higher order structure. (wikipedia.org)
  • To facilitate this formation, histone H2B first binds to histone H2A to form a heterodimer. (wikipedia.org)
  • epigenetic
  • Histone modification provides an epigenetic mechanism that enables a range of essential healthy and disease-related processes to be regulated. (news-medical.net)
  • sequences
  • Histone GO Peptides include sequences that are acetylated and di- or tri-methylated. (anaspec.com)
  • It has many interactive tools to explore and compare sequences of different histone variants from various organisms. (wikipedia.org)
  • The core of the database is a manually curated set of histone sequences grouped into 30 different variant subsets with variant-specific annotations. (wikipedia.org)
  • classification of histone-like sequences and browsing of the taxonomic diversity for every histone variant. (wikipedia.org)
  • lysines
  • To give an idea of this complexity, histone H3 contains nineteen lysines known to be methylated - each can be un-, mono-, di- or tri-methylated. (wikipedia.org)
  • modification
  • A common approach in ChIP-Seq analysis is to obtain ChIP-Seq profiles for an experimental sample (disease sample) and a reference sample (healthy sample) and compare them to identify differences in the histone modification patterns. (news-medical.net)
  • variant
  • Histone variants from different organisms, their classification and variant specific features can be found in "HistoneDB 2.0 - Variants" database. (wikipedia.org)
  • changes in variant composition were seen among the H2A.1 histone. (wikipedia.org)
  • Other functions of H2A have been seen in the histone variant H2A.Z. This variant is associated with gene activation, silencing and suppression of antisense RNA. (wikipedia.org)
  • In vertebrates and invertebrates, Histone H2A variant is reported to be involved in host immune response by acting as antimicrobial peptides (AMPs). (wikipedia.org)
  • Histone variants from different organisms, their classification and variant specific features can be found in "HistoneDB - with Variants" database. (wikipedia.org)
  • structurally
  • According to this nomenclature, letter suffixes or prefixes are mainly used to denote structurally distinct monophyletic clades of a histone family (e.g. (wikipedia.org)
  • A number of structurally diverse histone deacetylase inhibitors have shown potent antitumor efficacy with little toxicity in vivo in animal models. (wikipedia.org)
  • genome
  • Histone H3.3 has been found to play an important role in maintaining genome integrity during mammalian development. (wikipedia.org)