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  • Patterns
  • When comparing immunohistochemical patterns of antibodies against 5-methyl-cytosine, H3K4me3 and H3K9me2 modifications we observe similar pronuclear distribution and dynamics in mouse, bovine and rabbit zygotes. (biomedcentral.com)
  • Genomic methylation patterns are established in early embryos and are maintained during development through the interplay of demethylation mechanisms and the de novo and maintenance activities of DNA methyltransferases. (els.net)
  • DNA methylation is essential for mammalian development, and abnormal methylation patterns have been found in a great variety of human tumour cells. (els.net)
  • DNA methyltransferases reset the methylation patterns in early embryos and maintain their stability during development. (els.net)
  • Baubec T and Schubeler D (2014) Genomic patterns and context specific interpretation of DNA methylation. (els.net)
  • demethylation
  • Hence the observed decrease of DNA methylation during early embryonic development apparently largely reflects demethylation of (some) repetitive elements. (biomedcentral.com)
  • Conventionally, DNA methylation was considered to be a stable epigenetic mark, although this notion is being challenged by recent reports of active DNA demethylation [ 5 ]. (hindawi.com)
  • deacetylases
  • Our data indicate that expression of 41BBL and OX40L can indeed be epigenetically regulated, as inhibition of histone deacetylases and of DNA methyltransferases results in increased OX40L and 41BBL mRNA and protein expression. (biomedcentral.com)
  • centromeric
  • Hypomethylation of cytosine in centromeric and pericentromeric areas and higher-order repeats of satellite DNA in centromeric DNA can result in such chromosomal loss events. (wikipedia.org)
  • hypermethylation
  • Strikingly, we found that cytosine hypermethylation within the promoter region of the human transgene occurred in a subset of C9-BAC mice similar to what is observed in patient populations. (biomedcentral.com)
  • Expanded C9ORF72 alleles have reduced transcription rates, are depleted of active histone marks with concomitant enrichment of repressive epigenetic marks, including DNA hypermethylation in some cases. (biomedcentral.com)
  • CpGs
  • Epigenetic alterations, such as the methylation of CpGs islands, may reveal candidates for the development of specific markers for cancer detection, diagnosis and prognosis. (mdpi.com)
  • H3K4
  • However, H3K4 methylation has also been implicated in gene silencing. (plantcell.org)
  • Here, we show that Mut11p interacts with conserved components of H3K4 methyltransferase machineries, and an affinity-purified Mut11p complex(es) methylates histones H3, H2A, and H4. (plantcell.org)
  • inhibitors
  • We now aim to develop new inhibitors of DNA and histone methylation. (ibp.cz)
  • Classical satellite DNA is normally heavily methylated at cytosine residues but may become almost fully unmethylated due to ICF syndrome (Immunodeficiency, centromere instability, and facial anomalies syndrome) or after treatment by DNA methyl transferase inhibitors. (wikipedia.org)
  • gene expression
  • Following the initial observation of DNA methylation as one of the most critical aspects for the stable maintenance of gene expression pattern, today epigenetic regulation has earned a notable place in scientific research on cellular and physiological response mechanism towards multiple external stimuli, particularly in disease biology. (mdpi.com)
  • protein
  • Chemical "tags" called histones, collections of protein molecules, influence the DNA molecule. (blogspot.com)
  • The diverse functions of histone and DNA modifications are brought about by large protein complexes that regulate a number of biological processes, ranging from DNA replication, transcription and repair to cellular division, differentiation and apoptosis. (embopress.org)