• vivo
  • Inhibiting BMP signal, a known HFSC anti-proliferative factor, elevated HFSC methylation in vivo during quiescence prior to proliferation onset. (nih.gov)
  • stem cell
  • Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis. (nih.gov)
  • changes
  • ii) passive dilution over multiple divisions and (iii) changes in levels of histone-modifying enzymes26. (nih.gov)
  • These instant metabolic changes bypass the signaling pathways which are required for activating the TFs, but instead, they just alter the catalytic activities of the JMJDs, which are already assigned to specific histones through their interactions with the DNA-binding TFs. (bmbreports.org)