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  • RPD3
  • Thus, in a mechanism analogous to that proposed for repression in budding yeast by Sir family corepressors [ 8 , 21 ], initial recruitment of Gro may lead to histone deacetylation by Rpd3, the recruitment of additional Gro through interactions with the deacetylated histones, and propagation of Gro along chromatin facilitated by Gro self-association. (biomedcentral.com)
  • The report provides comprehensive information on the Histone Deacetylase 2 (Transcriptional Regulator Homolog RPD3 or YY1-Associated Factor 1 or EC 3.5.1.98), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (reportsnreports.com)
  • Additionally, the report provides an overview of key players involved in Histone Deacetylase 2 (Transcriptional Regulator Homolog RPD3 or YY1-Associated Factor 1 or EC 3.5.1.98) targeted therapeutics development and features dormant and discontinued projects. (reportsnreports.com)
  • Inhibition
  • We have shown that PIASxα inhibits the transcription activity of the AR by binding to the DNA-binding domain of AR and that DJ-1 antagonizes this inhibition by sequestering PIASXα from the AR in CV-1, Cos1, and TM4 Sertoli cells, indicating that DJ-1 is a positive regulator of the AR ( 3 ). (aacrjournals.org)
  • HeLa
  • Immunoblotting: a minimum working dilution of 1:20,000 is determined using a nuclear extract of HeLa human epithelioid carcinoma cell line. (sigmaaldrich.com)
  • human
  • Indirect immunoperoxidase staining: a minimum working dilution of 1:500 is determined using protease-digested, formalin-fixed, paraffin-embedded human lymph node sections. (sigmaaldrich.com)
  • The human DJ-1 gene, which is comprised of seven exons, is mapped to 1p36.2-36.3, where many chromosome aberrations in cancer have been reported ( 2 ). (aacrjournals.org)
  • regulators
  • These results suggest that AR is positively regulated by DJ-1, which antagonizes the function of negative regulators, including DJBP. (aacrjournals.org)
  • expression
  • RT-PCR analysis confirmed that HCMV induced the expression of ICAM-1, integrin β 8 , integrin α 1 , IL-1β, TNF-α, and CCL2. (jimmunol.org)
  • Regions
  • CSR recombines S-region DNA located upstream of exons of constant H chain (C H ) regions, thereby encoding new Ig C H regions that endow Abs with new biological effector functions ( 1 ). (jimmunol.org)