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  • binds
  • It is responsible for most of the cytoplasmic HAT activity in yeast, and it binds strongly to histone H4 by virtue of its association with an additional subunit, Hat2. (wikipedia.org)
  • HATs
  • Type B HATs are located in the cytoplasm and are responsible for acetylating newly synthesized histones prior to their assembly into nucleosomes . (wikipedia.org)
  • protein
  • The 4 'core' histones (H2A, H2B, H3 and H4) are relatively similar in structure and are highly conserved through evolution, all featuring a 'helix turn helix turn helix' motif (DNA-binding protein motif that recognize specific DNA sequence). (wikipedia.org)
  • histone (hĬs´tōn) , any of a class of protein molecules found in the chromosomes of eukaryotic cells . (encyclopedia.com)
  • Histones do not occur in vertebrate sperm cells (see protamine ) or in bacteria, although a very similar protein has been found in the genome of the archaebacterium Thermoplasma. (encyclopedia.com)
  • A possible homolog of Dot1 was found in archaea which shows the ability to methylate archaeal histone-like protein in recent studies. (wikipedia.org)
  • The protein concentration (1 mg/ml, 89 µM) is calculated using the molar extinction coefficient for Histone H4 (5120) and its absorbance at 280 nm (3,4). (neb.com)
  • mRNA
  • The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). (yeastgenome.org)
  • In the January 1st issue of G&D, Drs. Thomas Mullen and William Marzluff (UNC Chapel Hill) lend new insight into the degradation of mammalian histone mRNA. (cshlpress.com)
  • Histone mRNA is rapidly degraded at the end of S phase, but the mechanism by which this occurs has remained elusive, as metazoan histone mRNAs have a unique, conserved 3' stem-loop structure rather than the canonical 3' poly(A) tail. (cshlpress.com)
  • Drs. Mullen & Marzluff demonstrate that uridine residues are added to the 3' end of histone mRNAs, after which the transcript is decapped and degraded at both ends by components of the general mRNA decay machinery. (cshlpress.com)
  • substrate
  • It has been proposed that histone proteins are evolutionarily related to the helical part of the extended AAA+ ATPase domain, the C-domain, and to the N-terminal substrate recognition domain of Clp/Hsp100 proteins. (wikipedia.org)
  • In order for the reaction to proceed, S-Adenosyl methionine (SAM) and the lysine residue of the substrate histone tail must first be bound and properly oriented in the catalytic pocket of the SET domain. (wikipedia.org)
  • arginine
  • Two major types of histone methyltranferases exist, lysine-specific (which can be SET ( S u(var)3-9, E nhancer of Zeste, T rithorax) domain containing or non-SET domain containing) and arginine-specific. (wikipedia.org)
  • nuclear
  • Only eukaryote s, with their millions and billions of base pair s have histones although there are homolog s in some non-nuclear species. (everything2.com)