Abdominal aortic aneurysms (AAA) occur in 5 to 9% of the population over the age of 65 years and transmural aneurysmrupture is the 10th most common cause of death in the industrialized world. (materialise.com)
Rates of IA formation and rupture were measured, and cerebral artery tissue was collected and utilized for histology and gene expression analysis. (biomedcentral.com)
The role of macrophages in IA formation and rupture has been well-characterized [ 17 ], yet the presence of other leukocyte populations has been noted in both IA and abdominal aortic aneurysms (AAA). (biomedcentral.com)
One of the diseases that we study is thoracic aortic aneurysm, a major cardiovascular health problem characterized by a dilated aorta that may eventually dissect or rupture. (wustl.edu)
May be relatively insignificant as in a bruise or may be life threatening e.g., a massive retroperitoneal hematoma resulting from rupture of a dissecting aortic aneurysm. (medicinembbs.org)
Abdominal9
In 2015, he won a Mimics Innovation Award for his research on the morphology of abdominal aortic aneurysms in mice infused with angiotensin II. (materialise.com)
In mice, the abdominal aortic aneurysm forms suprarenally (i.e. above the kidneys), while in humans most aneurysms form infrarenally (i.e. below the kidneys). (materialise.com)
The virtual 3D models greatly enhanced Dr. Trachet's capacity to study the morphology of the abdominal aortic aneurysms present in angiotensin II-treated mice. (materialise.com)
Objective The aim of this study was to investigate the reproducibility of anterior-posterior diameter (APd max ) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. (thieme-connect.com)
The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. (thieme-connect.com)
4 Martin-McNulty B, Vincelette J, Vergona R, Sullivan ME, Wang Y-X. Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system. (thieme-connect.com)
6 Ghulam QM, Kilaru S, Ou S-S, Sillesen H. Clinical validation of three-dimensional ultrasound for abdominal aortic aneurysm. (thieme-connect.com)
Lymphocytic infiltrates have been demonstrated in patient IA tissue specimens and have also been shown to play an important role in abdominal aortic aneurysms (AAA) and related diseases such as atherosclerosis. (biomedcentral.com)
After adjusting for the other major risk factors for CVD, one study found the odds of vascular diseases increased with every decade of life, demonstrating a strong increase in peripheral arterial disease (PAD), carotid artery stenosis, and abdominal aortic aneurysm (AAA) with advanced age [ 4 ] . (oaepublish.com)
Thoracic2
Thoracic aortic aneurysms are characterized by degraded elastic fibers in the aortic wall. (wustl.edu)
The student will contribute to experimental biotransport measurements and analysis of the aortic wall in mouse models of thoracic aortic aneurysms. (wustl.edu)
Angiotensin2
Although mice are the most commonly used animals in aneurysm research , there are some important differences between aneurysms that form in mice treated with angiotensin II, on the one hand, and aneurysms that form spontaneously in humans, on the other hand. (materialise.com)
Administration of anti-inflammatory M2 macrophages suppresses progression of angiotensin II-induced aortic aneurysm in mice. (nagoya-u.ac.jp)
Molecular biology1
While the project will be focused on mechanical manipulation and analyses, the student will also gain experience with basic molecular biology techniques such as histology, qPCR and western blotting. (wustl.edu)
Progression1
We hypothesize that degraded elastic fibers facilitate movement of cells and molecules into the aortic wall that contribute to aneurysm progression. (wustl.edu)
Tumors1
Although 10% of all pediatric tumors and 5% of all vascular anomalies occur in the brainstem, neurosurgeons have traditionally resisted dissecting lesions in this area. (ebooksmedicine.net)
Mice2
Aneurysms in mice often develop an intramural thrombus rather than an intraluminal thrombus as we see in human aneurysms. (materialise.com)
This explained the sudden dilatation: aneurysms in these mice are more reminiscent of aortic dissections. (materialise.com)
Aortic wall1
Moreover, as Dr. Trachet found out from his new and improved view of the aortic wall, wherever a luminal expansion appeared on histology, it was invariably accompanied by a tear in the tunica media. (materialise.com)
Stroke1
Included in this assortment are stroke, aneurysm, damage due to chronic hypoperfusion and damage due to chronic hypertension. (biomedcentral.com)
Experimental1
Dr. Bram Trachet, post-doctoral researcher at École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, explores novel high-resolution imaging techniques as well as image-guided histology to visualize experimental aneurysms in laboratory animals. (materialise.com)
Study2
While the mouse model has been used to study aneurysms in over 200 papers, these morphological differences have never been explained. (materialise.com)
It turned out that small suprarenal side branches, not visible using traditional imaging techniques, were responsible for the intramural hematoma, and therefore were also responsible for the suprarenal location of the aneurysms. (materialise.com)
Disease1
Intracranial aneurysms (IA) are increasingly recognized as a disease driven by chronic inflammation. (biomedcentral.com)
Model1
Development of a novel murine model of aortic aneurysms using peri-adventitial elastase. (thieme-connect.com)
Abdominal aortic aneurysms4
Objective The aim of this study was to investigate the reproducibility of anterior-posterior diameter (APd max ) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. (thieme-connect.com)
4 Martin-McNulty B, Vincelette J, Vergona R, Sullivan ME, Wang Y-X. Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system. (thieme-connect.com)
Despite the development of fenestrated and branched endovascular aortic repair (f/bEVAR), the surgical management of thoraco-abdominal aortic aneurysms (TAAAs) remains a major challenge. (bvsalud.org)
Ruptured abdominal aortic aneurysms (rAAA), with or without iliac involvement, are a life-threatening scenario with high mortality even after surgical therapy. (bvsalud.org)
Aortic12
Thoracic aortic aneurysms (TAAs) can involve the aortic root, ascending aorta, aortic arch, descending aorta, or a combination of these locations. (medscape.com)
The association of aortic root dilatation and ascending aneurysm is termed "annuloaortic ectasia. (medscape.com)
However, aortic dissections may occur with medial degeneration in the absence of preexisting aneurysm. (medscape.com)
Pseudoaneurysm denotes a ruptured aortic wall with healing of the extravasated blood and formation of the aneurysm wall by fibrous tissue. (medscape.com)
Aortic aneurysms are a leading cause of death in the United States. (medscape.com)
Improvements in screening and imaging techniques have shown that the incidence of thoracic aortic aneurysm (TAA) has increased steadily in the last decades. (medscape.com)
Idiopathic, noninflammatory aneurysms are associated with congenital conditions (bicuspid aortic valve) and acquired conditions (hypertension). (medscape.com)
Most commonly, the pathogenesis of the aneurysms is due to noninflammatory, medial degeneration of the elastic aortic wall. (medscape.com)
The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. (thieme-connect.com)
Development of a novel murine model of aortic aneurysms using peri-adventitial elastase. (thieme-connect.com)
6 Ghulam QM, Kilaru S, Ou S-S, Sillesen H. Clinical validation of three-dimensional ultrasound for abdominal aortic aneurysm. (thieme-connect.com)
Artery2
Anatomically and radiologically, an aneurysm is defined as a dilatation at least 50% above the normal diameter of an artery. (medscape.com)
in a dissecting aneurysm, the artery wall is split longitudinally by blood pumping through a tear in the inner arterial wall. (nih.gov)
Anatomy1
Histology -- The subset of the study of anatomy that deals with the minute structures, composition, and function of the tissues. (nih.gov)
Patients with idiopathic, noninflammatory aneurysms are typically adults and present with symptoms of aneurysm later than do those individuals with identified connective tissue disorders. (medscape.com)
Measurements1
In a study of 82 consecutive unoperated patients with TAA who underwent serial aneurysm measurements, Cheung et al found that TAA growth rates were greater in women than in men, and that this difference was specific to women with degenerative TAAs. (medscape.com)
Wall1
These can enlarge by detachment of residual connections to the wall and develop vascular aneurysms which is the most frequent angiographic feature of SAM. (medscape.com)
In the thoracic aorta, a diameter of 3 cm or greater is generally considered aneurysmal, although the average size of surgically corrected aneurysms is over 5 cm. (medscape.com)
Heart1
As we opened the rib cage and started to dissect the heart from the surrounding vessels - Jessica and I had to use a lot of suction to clear the area of blood for better visibility - she swooned. (blogspot.com)
Patients3
Patients with aortitis and aneurysms present at middle age or older, including advanced ages, especially in the case of giant cell aortitis. (medscape.com)
and the remaining 51% had idiopathic noninflammatory aneurysms, with approximately 60% of this last group of patients being hypertensive. (medscape.com)
Radiological investigations such as Computerised Tomography (CT) and angiography may reveal patterns consistent with SAM including single or multiple aneurysms, dissection, stenosis and occlusion, but these may not be feasible in the unstable patients and definitive diagnosis is usually only arrived at histology. (medscape.com)