StenosisDegenerativeEndocarditisCongenitalPatientsCalcification of valveLeafletsPathologyAlterationsPathophysiologyOccursValvularBiomarkersAcuteFindingsCardiovascular diseasesSymptomsProsthesisEvaluationIntrinsicOrificeAutoimmuneProcessesReplacementDevelopsCommonlySurgicalInfectionCasesHeartInfectiousConditionsComponentsDiarrheaResultsMadeDetails
Stenosis18
- Aortic stenosis can be caused by acquired conditions, be the result of a congenital malformation, or be a result of a combination of acquired and congenital processes. (medscape.com)
- Acquired stenosis of the aortic valve, which affects adults, is most often caused by calcification of the leaflets themselves and is considered an age-related or degenerative process. (medscape.com)
- Postrheumatic aortic stenosis is another common cause of acquired aortic stenosis, and is a result of remote infection from group A streptococci that triggers an autoimmune process resulting in scarring of the valve leaflets. (medscape.com)
- Radiation and ochronosis are rare causes of acquired aortic stenosis. (medscape.com)
- Congenital aortic stenosis is classified as valvular, subvalvular, and supravalvular. (medscape.com)
- Congenital aortic stenosis becomes symptomatic in childhood. (medscape.com)
- The pathologic findings, clinical symptoms, and treatment are similar to degenerative aortic stenosis in trileaflet valves. (medscape.com)
- A gradient of between 20 and 40 mm Hg is considered moderate, and more than 40 mm Hg severe aortic stenosis, according to American Heart Association guidelines. (medscape.com)
- See also Aortic Stenosis , Pediatric Valvar Aortic Stenosis , Pediatric Rheumatic Heart Disease , and Pathology of Rheumatic Heart Disease . (medscape.com)
- Calcific aortic stenosis has been also termed "degenerative aortic stenosis" and "fibrocalcific aortic stenosis. (medscape.com)
- [ 3 ] Degenerative aortic stenosis is currently the most common indication for valve surgery, as the population ages and newer techniques, such as minimally invasive surgery and transcutaneous methods, become available. (medscape.com)
- At present, the most common cause of valve replacement in the United States is aortic stenosis secondary to calcification. (medscape.com)
- The incidence of symptomatic stenosis, a more advanced form of sclerosis that causes symptoms, is approximately 5 in 10,000 and is generally a disease of the elderly. (medscape.com)
- [ 6 ] The role of hyperlipidemia and statin treatment in the prevention of aortic stenosis is unclear, although hypercholesterolemia is an often cited risk factor. (medscape.com)
- Patients with severe calcific degenerative aortic stenosis can be categorized into three clinical groups at the time of diagnosis: those without evidence of congestive heart failure, those with chronic congestive heart failure, and those with acute heart failure requiring hospitalization. (medscape.com)
- Among these cases, calcific aortic stenosis (CAS) stands out as the most prevalent form of valvular heart disease in the aging population. (bvsalud.org)
- We previously reported aberrant glycosylation of lumican, one of small leucine-rich proteoglycans (SLRPs), in aortic valves in patients with aortic valve stenosis (AS). (oatext.com)
- Aortic valve stenosis (AS), caused mainly by degenerative changes with calcification, is one of the most common cardiovascular diseases. (oatext.com)
Degenerative2
- Bicuspid and unicommissural unicuspid valves generally function normally for the first few decades, after which superimposed degenerative changes occur, at a faster rate that normal trileaflet aortic valves. (medscape.com)
- Hardening of the aortic valve, usually by degenerative calcification, with a jet velocity of less than 5 mm/second is considered aortic sclerosis and is asymptomatic. (medscape.com)
Endocarditis6
- Tricuspid valve insufficiency due to leaflet abnormalities may be secondary to endocarditis or rheumatic heart disease. (medscape.com)
- Very rarely the heart is involved in the process of the disease, leading to culture-negative infective endocarditis. (biomedcentral.com)
- The first patient was a 55 year-old Caucasian male with culture-negative Whipple-related adhesive pericarditis and endocarditis of the aortic valve. (biomedcentral.com)
- Aortic valve endocarditis developed during treatment with tocilizumab. (biomedcentral.com)
- The second patient was a 65-year-old male patient with no prior history of the classic Whipple's disease who presented with a culture-negative aortic valve endocarditis. (biomedcentral.com)
- The increased recognition rate led to the insight that Whipple's endocarditis can occur without other classical manifestations of Whipple's disease [ 4 ]. (biomedcentral.com)
Congenital2
- Ebstein anomaly is a congenital malformation of the tricuspid valve characterized by apical displacement of the annular insertion of the septal and posterior leaflets and atrialization of a portion of the ventricular myocardium. (medscape.com)
- Bicuspid and unicuspid aortic valve disease are congenital conditions. (medscape.com)
Patients7
- Aortic sclerosis, which is clinically defined as valve thickening without obstruction to outflow, is the most prevalent valve disease in developed countries, being present in about 25% of patients over age 65 years. (medscape.com)
- Although surgical treatment with adjuvant chemo-radiotherapy, targeted therapy and immunotherapy have been used in patients with this disease, the long-term survival is still disappointing[ 6 , 7 ]. (ijpsonline.com)
- To explore the possible pathological significance of calponin in ESCC, in this study, we first examined the expression of calponin isoforms in the tumor tissue of ESCC patients and further explored their association with the disease. (ijpsonline.com)
- Specifically, thickened and calcified (AS-C) areas and apparently non-thickened and non-calcified (AS-N) areas of aortic valves were sampled in 8 patients with AS. (oatext.com)
- Both patients underwent aortic valve replacement surgery. (biomedcentral.com)
- These data highlight the need for ruling out Whipple's disease in patients with a history of arthralgia prior to initiation of biological agents in treatment of rheumatoid arthritis. (biomedcentral.com)
- A symptomatic disease only develops in patients with partially defined immunologic defects, i.e. (biomedcentral.com)
Calcification of valve2
- The full-length PGRN can thus effectively reduce the calcification of valve interstitial cells, and the granulin precursor (GRN), among the degradation products of PGRN, can be beneficial. (biomedcentral.com)
- These processes transform valvular interstitial cells into osteoblastic ones, which results in calcification of valve tissue [6-7]. (oatext.com)
Leaflets5
- Rheumatic disease is the most common cause of pure tricuspid regurgitation due to deformation of the leaflets. (medscape.com)
- It was determined that the structures of valve leaflets after prolonged freezing time (4-5 years) do not return to their initial, pre-frozen state. (lupinepublishers.com)
- Macroscopic observations of the valve leaflets morphology showed that valves kept in deep freeze even for a long time do not differ from fresh valves (Photo 1). (lupinepublishers.com)
- However, observations of the leaflets' surface conducted in higher magnifications reveal a lot of details, including differences in the appearance of the valve leaflets' surface. (lupinepublishers.com)
- Apart from the visible differences resulting from the leaflets' structure, especially the layout of the collagen fibers (Photo 2(a)), defects connected with the process of harvesting the material for the valve bank are visible on the surface of some leaflets. (lupinepublishers.com)
Pathology1
- Tricuspid regurgitation secondary to rheumatic involvement is usually associated with mitral and aortic valve pathology. (medscape.com)
Alterations3
- Tricuspid regurgitation may result from structural alterations of any or all of the components of the tricuspid valve apparatus (see Anatomy ). (medscape.com)
- Histological examination of the floppy tricuspid valve shows alterations on the valve spongiosa. (medscape.com)
- As expected, mice receiving 6.7 MBq had significant weight loss and CKD evidence based on serum creatinine, cystatin C, and kidney histological alterations 28 weeks after treatment. (bvsalud.org)
Pathophysiology1
- The pathophysiology of tricuspid regurgitation focuses on the structural incompetence of the valve. (medscape.com)
Occurs1
- Calcific aortic valve disease occurs on previously normally-functioning valves, either bi- or trileaflet, and less commonly on unicuspid valves. (medscape.com)
Valvular1
- Introduction: Valvular heart disease represents a significant burden to the healthcare system, with approximately 5 million cases diagnosed annually in the US. (bvsalud.org)
Biomarkers1
- The approach enabled prospective kidney functional and injury biomarker evaluation and late kidney histological analysis to validate these biomarkers. (bvsalud.org)
Acute3
- The prognosis is especially poor in the setting of acute heart failure, for which aortic valve replacement provides the least benefit. (medscape.com)
- Radiolabeled peptides are filtered through glomeruli, followed by potential reabsorption of a fraction by proximal tubules, which may cause acute kidney injury (AKI) and chronic kidney disease (CKD). (bvsalud.org)
- CLASSIFICATION OF DISEASES AND INJURIES I. INFECTIOUS AND PARASITIC DISEASES (001-139) Includes: diseases generally recognized as communicable or transmissible as well as a few diseases of unknown but possibly infectious origin Excludes: acute respiratory infections (460-466) influenza (487. (cdc.gov)
Findings1
- A dose-dependent urinary Neutrophil gelatinase-associated lipocalin (NGAL, tubular injury biomarker) urinary excretion the day after [ 212 Pb]Pb-MC1L treatment highly correlated with the severity of late tubulointerstitial injury and histological findings. (bvsalud.org)
Cardiovascular diseases2
- Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). (biomedcentral.com)
- Many types of cardiovascular diseases (CVDs) are associated with complex immune responses that can significantly contribute to their progression and remission. (biomedcentral.com)
Symptoms1
- The changes gradually progress and lead to narrowing of the valve orifice, which brings about various symptoms such as chest pain and dyspnea [1]. (oatext.com)
Prosthesis2
- That is why, in addition to the pharmacological treatment [31-33], the choice of the right surgery technique and the right valve prosthesis [13, 34- 40] is essential. (lupinepublishers.com)
- Prosthesis, usually heart valve, composed of biological material and whose durability depends upon the stability of the material after pretreatment, rather than regeneration by host cell ingrowth. (lookformedical.com)
Evaluation2
- Evaluation of valve disease is typically performed by echocardiography. (medscape.com)
- by D. A. Nicholson, M. B. Sheridan and D. F. Martin Intra-operative liver ultrasound in the detection and evaluation of liver secondaries in colorectal carcinoma, by A. H. Davies, C. P. De Angelis, R. Cobb, D. Lindsell and N. J. M. Mortensen Ultrasound in polycystic disease, by D. LI. (docksci.com)
Intrinsic2
- The lesion may be classified as primary when it is caused by an intrinsic abnormality of the valve apparatus or as secondary when it is caused by right ventricular (RV) dilatation or other conditions (eg, left ventricular [LV] dysfunction). (medscape.com)
- The lesion may be classified as primary when it is caused by an intrinsic abnormality of the valve apparatus or as secondary when it is caused by right ventricular (RV) dilatation. (medscape.com)
Orifice1
- Inspiration induces widening of the RV, which enlarges the tricuspid valve annulus and thus increases the effective regurgitant orifice area. (medscape.com)
Autoimmune1
- PGRN has been introduced among the secreted growth factors as one related to wound healing, inflammation, and human embryonic development, as well as a wide variety of autoimmune diseases. (biomedcentral.com)
Processes1
- Changes in the structures after freezing time of over 5 years may, when the valves are implemented, favor faster damage processes, including calcification. (lupinepublishers.com)
Replacement1
- Depending on the etiology and severity of tricuspid regurgitation, treatment may involve medication or surgical repair or replacement of the valve. (medscape.com)
Develops2
- [ 1 ] The valve develops diffuse fibrous thickening without commissural fusion, fused chordae, or calcific deposits. (medscape.com)
- [ 1 ] The valve develops diffuse fibrous thickening without commisural fusion, fused chordae, or calcific deposits. (medscape.com)
Commonly1
- Phenomena occurring in the heart, including its valves, may be connected to their biomineralization, commonly known as "calcification" [1-4]. (lupinepublishers.com)
Surgical1
- Surgical insertion of synthetic material to repair injured or diseased heart valves. (lookformedical.com)
Infection1
- Factors that can contribute to infection of the valve include alcoholism, intravenous drug use, neoplasms, infected indwelling catheters, extensive burns, and immune deficiency. (medscape.com)
Cases1
- Histological confirmation was available in 39 cases. (docksci.com)
Heart6
- Macrophages and dendritic cells are also present in normal heart valves. (biomedcentral.com)
- particularly essential is the choice of methods of recognizing calcification in specific parts of the heart - especially the valves and coronary vessels [14-21]. (lupinepublishers.com)
- Particularly interesting are problems of valve mineralization, which causes a series of disorders not only of the heart but the whole circulatory system [26-30]. (lupinepublishers.com)
- One of the options is a frozen valve from a heart valve bank. (lupinepublishers.com)
- This publication discusses some aspects of freezing heart valves and changes in the structures of frozen valves [41]. (lupinepublishers.com)
- A device that substitutes for a heart valve. (lookformedical.com)
Infectious2
- Whipple's disease is a rare, often multisystemic chronic infectious disease caused by the rod-shaped bacterium Tropheryma whipplei . (biomedcentral.com)
- certain localized infections Note: Categories for "late effects" of infectious and parasitic diseases are to be found at 137. (cdc.gov)
Conditions1
- AIDS-like syndrome: AIDS-like disease (illness) (syndrome) ARC AIDS-related complex Pre-AIDS AIDS-related conditions Prodromal-AIDS 3. (cdc.gov)
Components1
- The main components of the aortic valve ECM are collagens, elastin, and proteoglycans (PGs) [8]. (oatext.com)
Diarrhea1
- The disease classically manifests with diarrhea, weight-loss and arthropathy. (biomedcentral.com)
Results1
- Obtained results were compared to studies of fresh, non-frozen valves. (lupinepublishers.com)
Made2
- The coordinated actions of the tricuspid valve are made possible by the atrial and ventricular masses, conduction system tissue, and support structure of the fibroelastic cardiac skeleton. (medscape.com)
- Preparations made from valves were examined using the Motic microscope of Chinese production, model 07-100477, with side light. (lupinepublishers.com)
Details1
- See Tricuspid Valve Anatomy for further details. (medscape.com)