Histologic tumors. Medical search. Frequent questions

Thus, the term secondary glioblastoma for an IDH-mutant astrocytoma that presents with or has progressed with aggressive histology (ie, tumor necrosis or microvascular proliferation) is now termed astrocytoma, IDH-mutant, CNS WHO grade 4 . (cap.org)
This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). (clinicaltrials.gov)
To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the EFS of patients with standard-risk relapsed favorable histology Wilms tumor (SRrFHWT) as compared to historical controls. (clinicaltrials.gov)
To establish EFS and OS for high-risk (HRrFHWT) and very high risk (VHRrFHWT) relapsed favorable histology Wilms tumor treated with ifosfamide/carboplatin/etoposide alternating with cyclophosphamide/ topotecan. (clinicaltrials.gov)
Histologic Documentation: Confirmation of GCT histology (both seminoma and nonseminoma) on pathologic review at the center of enrollment. (cincinnatichildrens.org)
Stimulated Raman histology (SRH), a label-free method for generating histologic images of fresh specimens puts microscopic data at the surgeons' fingertips. (triconference.com)
Classification of childhood cancer based on tumor histology. (cdc.gov)
A classification system used by tumor or cancer registries to code the site and the histology of the cancer, usually from a pathology report. (cdc.gov)

On multivariate analysis, high CD68-positive TAMs infiltrating TS was significantly associated with larger tumor and positive nodal metastasis ( p = 0.006 and 0.016, respectively), whereas high CD163 TAMs density within TS was significantly associated with positive vascular invasion, nodal metastasis, and molecular subtypes ( p = 0.003, 0.001, and 0.009, respectively). (springeropen.com)
Insights into the oncological characteristics and tumor microenvironment (TME) of different histologic subtypes of LUAD at the single-cell level can help identify potential therapeutic vulnerabilities and combinational approaches to improve the survival of LUAD patients. (nih.gov)
Through comparative profiling of cell communities defined by scRNA-seq data, we characterized the TME of LUAD samples of distinct histologic subtypes, with relevant results further confirmed in multiple bulk transcriptomic, proteomic datasets and an independent immunohistochemical validation cohort. (nih.gov)
We find that the hypoxic and acidic situation is the worst in the TME of solid LUADs compared to other histologic subtypes. (nih.gov)
Besides, the tumor metabolic preferences vary across histologic subtypes and may correspondingly impinge on the metabolism and function of immune cells. (nih.gov)
KIT / PDGFRA mutational assessment is important for decision-making and treatment purposes, given that gastrointestinal (GI) stromal tumors (GISTs) have a variety of subtypes with different predictive and prognostic relevance. (arupconsult.com)
this is a heterogeneous group of tumors composed of several histologic subtypes. (sarcomahelp.org)
Well differentiated (WDLPS), also known as atypical lipomatous tumor (ALT), and dedifferentiated liposarcomas (DDLPS) are the most common subtypes. (sarcomahelp.org)
For example, the 2015 annual report showed breast cancer incidence by molecular subtypes using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. (cdc.gov)

Diagnosis of gastrointestinal stromal tumors: a consensus approach. (medscape.com)
Neither of these proteins has proven valuable in the diagnosis of pineal parenchymal cell tumors. (medscape.com)
Its metastatic potential depends on the phenotype of the tumor cells, and it frequently disseminates before diagnosis. (medscape.com)
The frozen section diagnosis was at least mucinous borderline tumor. (hindawi.com)
The frozen section diagnosis was at least mucinous borderline tumor, pending adequate tissue sampling for permanent sections to rule out mucinous adenocarcinoma. (hindawi.com)
6 - 8 In contrast, there are studies suggesting that DWI may be highly accurate in tumor diagnosis in the pediatric posterior fossa. (ajnr.org)
We hypothesized that overlap cases would be infrequent and would have obvious technical or histologic causes and that anatomic tumor features could supplement DWI to provide accurate diagnosis in these cases. (ajnr.org)
Differentiating GISTs from other intra-abdominal tumors (non-GISTs) is highly important for early diagnosis and treatment planning [ 3 ]. (springer.com)
In the 2016 WHO classification, the diagnosis of glioblastoma required the histologic features of tumor necrosis and/or microvascular proliferation. (cap.org)
Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
Clinical/demographic data and histologic slides of OMs and all lesions that could be considered in their differential diagnosis, reported from 1967-2008 were analyzed. (thejcdp.com)
Reporting more detailed histologic data can help clarify the biology of this tumor and aid in its histopathologic diagnosis. (thejcdp.com)
The diagnosis of GIST is based on histologic examination. (arupconsult.com)
Histologic examination by a pathologist is the gold standard for the diagnosis of GIST. (arupconsult.com)
Unless a tumor is small enough to be removed completely, incisional biopsy is indicated for histologic diagnosis. (aao.org)
This may be due to late diagnosis of these tumors in our patients as most cases diagnosed at advanced stage and the sections were taken from deep tumor tissue to increase the number of tumor cells in our samples. (researchgate.net)
Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
Cancer surveillance traditionally is conducted based on tumor anatomic location, histologic features, size, involvement of lymph nodes and distant metastasis (i.e., anatomic stage) at diagnosis. (cdc.gov)

1 Unfortunately, it is well-known that overlap between tumor grades and types is generally too great to specifically diagnose individual brain tumors with DWI alone, in adults 2 - 5 or children. (ajnr.org)
Our anecdotal experience, from several years of routine DWI in pediatric brain tumors, has been that ADC values have not been as helpful as in these reports. (ajnr.org)
Slightly more common in men than in women, malignant brain tumors (gliomas, meningiomas, and schwannomas) have an overall incidence of 4.5 per 100,000. (online-family-doctor.com)
Brain tumors are one of the most common causes of cancer death in children. (online-family-doctor.com)
The cause of brain tumors is unknown. (online-family-doctor.com)
Treatment for malignant brain tumors also includes chemotherapy with nitrosoureas, which cross the blood-brain barrier and allow other chemotherapeutic drugs to go through as well. (online-family-doctor.com)
Treatment of brain tumors can cause several complications. (online-family-doctor.com)
WHO) classification of CNS tumors, the following tumors brain tumors in the United States [1]. (bvsalud.org)

The American Joint Committee on Cancer tumor/node/metastasis (TNM) classification for gastrointestinal stromal tumors (GISTs) is provided below, along with anatomic stage/prognostic groups. (medscape.com)
Gastrointestinal Stromal Tumor. (medscape.com)
A modification of NIH consensus criteria to better distinguish the highly lethal subset of primary localized gastrointestinal stromal tumors: a subdivision of the original high-risk group on the basis of outcome. (medscape.com)
MRI Texture-Based Models for Predicting Mitotic Index and Risk Classification of Gastrointestinal Stromal Tumors. (medscape.com)
Gastrointestinal stromal tumors (GISTs) account for less than 1% of GI tumors, but they are the most common mesenchymal neoplasms of the GI tract. (medscape.com)
Shown here is a gastric gastrointestinal stromal tumor (GIST). (medscape.com)
Treatment planning of gastrointestinal stromal tumors (GISTs) includes distinguishing GISTs from other intra-abdominal tumors and GISTs' molecular analysis. (springer.com)
How are gastrointestinal stromal tumors diagnosed? (arupconsult.com)
Suspected gastrointestinal (GI) stromal tumors (GISTs) usually present initially with GI bleeding (the most common manifestation), abdominal pain, and obstructive symptoms. (arupconsult.com)
What is the role of mutational analysis in determining therapy for gastrointestinal stromal tumors? (arupconsult.com)

subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)

Rats fed ad libitum (free-fed) have lower survival and a higher incidence of pancreatic, mammary, and pituitary tumors than rats fed a moderate dietary restriction of identical diets (Boorman & Everitt, 2006). (ratguide.com)
Most pituitary tumors are adenomas. (msdmanuals.com)
Rarely, pituitary tumors are carcinomas. (msdmanuals.com)

Markers have been most helpful in the workup of patients with germ cell tumors. (medscape.com)
In addition to their histologic characteristics, germ cell tumors retain molecular characteristics of their primordial lineage. (medscape.com)
Other biological markers for germ cell tumors include lactate dehydrogenase isoenzymes and placental alkaline phosphatase, although these are less specific. (medscape.com)
AFP is a glycoprotein produced by fetal yolk sac elements and is produced by a wide range of cancers , including gastric , liver, and colon adenocarcinoma , as well as extracranial germ cell tumors. (medscape.com)
Non-germ cell tumors can derive from pineal parenchymal cells, as well as from surrounding tissue. (medscape.com)
This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. (cincinnatichildrens.org)
It is not yet known whether high-dose combination chemotherapy and stem cell transplant are more effective than standard-dose combination chemotherapy in treating patients with refractory or relapsed germ cell tumors. (cincinnatichildrens.org)
Parental occupation and childhood germ cell tumors: a case-control study in Denmark, 1968-2016. (cdc.gov)
Purpose: To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). (cdc.gov)

Invasive mucinous adenocarcinoma is uncommon and usually arises in the background of benign or borderline tumors. (hindawi.com)
The concentrations of these hormones are found to be higher in hormone dependent tumors, whereas in hormone independent tumors (as seen in latter stages of mammary adenocarcinoma) they tend to be lower. (ratguide.com)
Only adenocarcinoma in situ is identified in the histologic sections examined. (cancer.org)
As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)

In addition, benign tumors (fibroadenomas) exhibit growth primarily due to increased influence of circulating prolactin. (ratguide.com)
The malignant SGTs had higher SPF than the benign tumors but with no significant difference. (researchgate.net)

Although the type of tumor cannot be determined reliably from the radiographic characteristics alone, some patterns are associated with specific tumors. (medscape.com)
Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. (oncolink.org)
Biology, clinical characteristics, and management of adrenocortical tumors in children. (oncolink.org)
Only some of these characteristics are seen in atypical Spitz tumors and spitzoid melanomas. (atlasgeneticsoncology.org)
Cardiac myxoma: its origin and tumor characteristics. (thejcdp.com)
Patient characteristics, histologic variety of the tumor, morbidity, mortality and actuarial survival rates were studied. (sages.org)
E-mail: [email protected] ular and histological features of tumors and clinical characteristics of patients. (bvsalud.org)

The tumor marker CA-125, which increases with grade independent of the effect of stage in EOC, is predictive of lymph node metastasis with a high rate of false positivity in Turkish population. (hindawi.com)
miRNA deregulation has been identified in a variety of epithelial origin cancers, where changes in specific miRNAs expression possibly contribute to tumor growth, progression, metastasis, and chemoresistance. (sarcomahelp.org)

A 35 cm right ovarian mass submitted for intraoperative consultation was a multicystic mucinous tumor with an 8 cm area of hemorrhagic lesion between cystic locules. (hindawi.com)
A macroscopic hemorrhagic area in an ovarian mucinous tumor should be evaluated with care, and the possibility of angiosarcoma should be borne in mind. (hindawi.com)
Mucinous tumor is a common type of ovarian epithelial tumors. (hindawi.com)
The findings in this case may be useful for pathologists in the recognition of this uncommon type of ovarian tumors. (hindawi.com)
Borderline ovarian tumors represent 10-20% of epithelial ovarian neoplasm's [ 5 ] with an incidence of 1.8-4.8 out of 100.000 women per year [ 6 ] and typically have an excellent prognosis. (intechopen.com)
Carbohydrate antigen 125 (CA-125) is a high molecular-weight glycoprotein expressed by epithelial ovarian tumors as well as on the surface of cells of mesothelial origin [ 10 ]. (hindawi.com)
Benign ovarian tumors were associated with an increased risk of ovarian cancer (pooled relative risk [RR]=1.39, 95% confidence interval [CI]: 1.01-1.90), with high heterogeneity among studies. (frontiersin.org)
Benign ovarian tumors were associated with an increased risk of ovarian cancer. (frontiersin.org)
Benign ovarian tumors may be precursors and etiological risk factors for ovarian cancer. (frontiersin.org)
While numerous epidemiological studies have investigated the association between benign ovarian tumors and ovarian cancer risk, the results have been inconsistent ( 5 - 14 ). (frontiersin.org)
Two large cohort studies based on the Danish Cancer Register indicated that benign ovarian tumors may be associated with a long-term increased risk of both mucinous and borderline ovarian cancers ( 7 , 8 ). (frontiersin.org)
Since the relationship between benign ovarian tumors and ovarian cancer risk remains unclear, this systematic review and meta-analysis aimed to assess the association based on the most recent epidemiological evidence. (frontiersin.org)

Anderson SA, Singh N. Atypical teratoid / rhabdoid tumor. (pathologyoutlines.com)

Tumor in these nodes portends a high risk of recurrence. (ucsfhealth.org)
2-5 Long term survival of patients with WDLPS is common in that these tumors lack metastatic potential, whereas DDLPS are markedly aggressive and distant metastases and/or multi- focal recurrence followed by death constitutes a typical clinical course. (sarcomahelp.org)
To date, 5 years after surgery, the patient remains without evidence of tumor recurrence. (mdpi.com)
Surgery can result in immediate or delayed CNS infections, with symptoms that mimic tumor progression or recurrence. (online-family-doctor.com)

A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)
Nonepithelial malignant neoplasms sometimes arise in mucinous tumors, typically as mural nodules. (hindawi.com)
Odontogenic tumors, including odontogenic myxomas (OMs) are regarded as rare neoplasms in the human body. (thejcdp.com)
Finally, we will discuss distinctive novel/emerging renal neoplasms previously considered under the spectrum of ChRCC, low-grade oncocytic renal tumor and eosinophilic vacuolated tumor, with regard to their current significance and implications for future classification strategies. (lww.com)
Aim: The aim of this study is to investigate the DNA ploidy and S-Phase Fraction (SPF) of some Salivary Gland Tumors (SGTs) in Egyptian patients and to investigate the correlation between these two biological parameters and the presumptive behavior of these neoplasms. (researchgate.net)
Pineal region tumors constitute a rare group of neoplasms. (thieme-connect.com)

The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
The introduction of HPV vaccines has also drawn more attention to the fact that HPV is associated not only with cervical cancer and genital warts but also with other tumors, such as head neck and anogenital cancers ( 3 ). (cdc.gov)

Their neuropathological spectrum is divided into well-differentiated "pineocytoma" (World Health Organization [WHO] grade I), pineal parenchymal tumors of intermediate differentiation and papillary tumor of pineal region (WHO grades II and III), and poorly differentiated "pinealoblastoma" (WHO grade IV). (thieme-connect.com)

Irregular tumor borders can be suggestive of tumor invasiveness and associated histologic malignancy. (medscape.com)
The modified cells are able to expand more robustly than normal cells, and this dominance induced by downregulation of the tumor suppressor increases the risk of malignancy. (elifesciences.org)
Conclusion: DNA aneuploidy may be a key indicator for tumors activity and malignancy in SGTs, while the SPF has a minor role in the evaluation of SGTs activity. (researchgate.net)

CD68 and CD163 immunohistochemical expressions within TAMs infiltrating both tumor nest (TN) and tumor stroma (TS) were evaluated in 60 specimens with invasive breast carcinoma. (springeropen.com)
Eligibility in this study included patients who had pathologically confirmed invasive breast carcinoma of no special type, proper histologic specimens with sufficient tumor tissue, and complete clinicopathologic data. (springeropen.com)
Rats do well when having these tumors removed, especially since the tumor tends to remain localized and is less invasive. (ratguide.com)
It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth. (curehunter.com)
The mean tumour size for invasive lobular carcinoma was 4.5 cm, papillary carcinoma - 4.0 cm and mucinous carcinoma - 3.2 cm. (ispub.com)

Ciliary body melanoma is a subtype of uveal melanoma, the most common primary malignant tumor of the eye. (medscape.com)
Overall, our research proposes several potential entry points to improve the immunosuppressive TME of solid LUADs, thereby synergistically potentiating their immunotherapeutic efficacy, and may provide precise therapeutic strategies for LUAD patients of distinct histologic subtype constitution. (nih.gov)
Squamous cell carcinoma is the most prevalent histologic subtype of vulvar cancer, accounting for the majority of cases. (bvsalud.org)

The histologic findings show a lesion composed of spindle cells and lymphocytes. (uab.edu)

Continuing the trend from the 2016 revised 4th edition of the WHO Classification of Tumors of the Central Nervous System (CNS), the recent 2021 5th edition incorporates more molecular data into the classification and grading of many entities and introduces some new entities based on molecular alterations. (cap.org)

The aim of this study was to evaluate radiomics for distinguishing GISTs from other intra-abdominal tumors, and in GISTs, predict the c-KIT , PDGFRA , BRAF mutational status, and mitotic index (MI). (springer.com)

AFP is markedly elevated with endodermal sinus tumors and elevated to a lesser degree with embryonal cell carcinomas. (medscape.com)
The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities. (researchgate.net)
There was no significant correlation of ploidy status or SPF with the tumor grades of mucoepidermoid carcinomas. (researchgate.net)

Maximum size of the primary tumor (largest single dimension), in centimeters, on preoperative imaging studies. (mdanderson.org)
They are histological y are classified as WHO grade II gliomas: diffuse astrocytoma, diagnosed as the third most common primary tumor of the oligodendroglioma, pilomyxoid astrocytoma, pleomorphic xanthoastrocytoma, and ependymoma [3]. (bvsalud.org)

With rapidly evolving clinical applications in sequencing of the human genome as well as the genomes of tumors, the traditional anatomic descriptions of cancer types will be supplemented by molecular classification based on tumor genetic aberrations. (cdc.gov)

Their functions can dynamically change throughout tumor progression and in response to anticancer therapy TILs are implicated in killing tumor cells. (wikipedia.org)
TAMs are involved in multiple steps of tumor progression and invasion. (springeropen.com)
TAMs have a potential ability to differentiate into either M1- or M2-polarized macrophages, which have opposing effects on tumor progression. (springeropen.com)
Additionally, ubiquitination modifications may also be involved in the progression of histologic patterns. (nih.gov)

The ocular tissue where these tumors arise, the uvea, is a densely pigmented layer that lies for the most part between the sclera and the retina. (medscape.com)
Mammary fibroadenoma: A fibrous, benign, epithelial tumor in which cells are derived from glandular tissue. (ratguide.com)
Tumors can arise anywhere that mammary tissue type is present but is most often seen at the pit of the arm, abdomen, and groin of female rats. (ratguide.com)
A benign tumor made up of glandular tissue. (ucsfhealth.org)
To explore the pathologic significance of calponin 2 in esophageal squamous cell carcinoma, the expression level of calponin 2 proteins in the tumor tissue of 190 esophageal squamous cell carcinoma patients was examined with immunohistochemistry while the expression level of calponin 2 messenger ribonucleic acid was analyzed by using the data from The Cancer Genome Atlas database. (ijpsonline.com)
Both the calponin 2 messenger ribonucleic acid and protein level were increasingly expressed in the tumor tissues of esophageal squamous cell carcinoma patients compared with the adjacent non-tumor tissue and correlated negatively with the tumor grade. (ijpsonline.com)
Patients with higher calponin 2 in the tumor tissue were found to have longer overall survival time. (ijpsonline.com)
Further, in esophageal cancer tumor tissue, calponin 2 gene was found to co-express with genes associated with tight junction and the expression level of calponin 2 was observed to correlate significantly with the number of infiltrating immune cells. (ijpsonline.com)
To explore the possible pathological significance of calponin in ESCC, in this study, we first examined the expression of calponin isoforms in the tumor tissue of ESCC patients and further explored their association with the disease. (ijpsonline.com)
Methods: Flow cytometric analysis of DNA pliody and S-Phase Fraction (SPF) was done in 50 fresh tumor tissue sections of SGTs which diagnosed as 15 benign and 35 malignant tumors. (researchgate.net)
endocrinopathies result when the tumor produces hormones or destroys hormone-producing tissue. (msdmanuals.com)
Tumors may also compress or destroy pituitary or hypothalamic tissue, impairing hormone production or secretion. (msdmanuals.com)

Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
When considering only patients who had mastectomy or lumpectomy, the racial breakdown was 65 Chinese (60.7%), 30 Malay (28.0%) and 12 Indian (11.2%) The mean tumour size of infiltrating ductal carcinoma as measured in mastectomy and lumpectomy specimens (n = 107) was 3.75 cm (range 0.6 cm to 9.8 cm). (ispub.com)
The Histologic Diversity of Chromophobe Renal Cell Carcinoma. (lww.com)

The presence of lymphocytes in tumors is often associated with better clinical outcomes (after surgery or immunotherapy). (wikipedia.org)
There are several variants of cutaneous melanocytic tumors, characterized by differing clinical and pathologic features. (atlasgeneticsoncology.org)
Clinical and histologic information on OM in different populations may be useful in clinical settings and treatment planning. (thejcdp.com)
Conjunctival lymphoid tumors: clinical analysis of 117 cases and relationship to systemic lymphoma. (aao.org)
In three women clinical and histologic changes pointed towards oral submucous fibrosis. (who.int)

There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
An international system of tumour classification is important for consistency in patient treatments and to provide the basis of epidemiological and biological studies. (ersjournals.com)
At the time the World Health Organization's International Agency for Research on Cancer published their first monograph on childhood cancer in 1988, Dr. R. Marsden published an annex giving a classification scheme for childhood cancer that consisted of 12 groups based chiefly on histologic type. (cdc.gov)
The updated 4th edition of the WHO classification of CNS including various dose escalation [11], optimal timing of ra- tumors was published in 2016. (bvsalud.org)

Patients usually do not seek counseling until the tumors are large because small tumors cause little distress and may not be noticed by the patient. (cdc.gov)

The large majority of mucinous tumors are benign and borderline tumors. (hindawi.com)
Only 5 previous cases of angiosarcoma related to mucinous tumors have been reported [ 1 , 2 , 5 - 7 ]. (hindawi.com)
When stratifying by histological type, the pooled RRs were 1.53 (95% CI: 0.37-6.29) and 3.62 (95%CI: 0.81-16.20) for serous and mucinous tumors, respectively. (frontiersin.org)

Results: 93.3% of the benign SGTs tumors were diploid, while only 34% of malignant tumors were diploid and 66% were aneuploid. (researchgate.net)

Such methods allow for systematic TIL enumeration and characterization of the tumor microenvironment in diverse cancer types and across thousands of tumors, an approach largely led by Ash Alizadeh, Ajit Johnson among others. (wikipedia.org)
Tumor-associated macrophages (TAMs) are important in regulating cross-talk between tumor cells and tumor microenvironment. (springeropen.com)
Tumors are composed of malignant and non-malignant cells, which constitute the tumor microenvironment [ 3 ]. (springeropen.com)
Tumor-associated macrophages (TAMs) are crucial regulators of cancer cells and microenvironment. (springeropen.com)

At a large tertiary referral pediatric hospital, we examined initial pre-resection imaging and pathology reports for all children who had surgical biopsy or resection of a tumor located in the cerebellum and/or fourth ventricle from 2006 to 2009. (ajnr.org)

The process can also involve a preliminary chemotherapy regimen to deplete endogenous lymphocytes in order to provide the adoptively transferred TILs with enough access to surround the tumor sites. (wikipedia.org)
The ability of a tumor to resist chemotherapy treatment following an initial response. (ucsfhealth.org)
in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC) with no EGFR or ALK genomic tumor aberrations. (nih.gov)
Measure the maximum tumor size (single dimension) on imaging before and after neoadjuvant chemotherapy and calculate the percent decrease in size. (mdanderson.org)
Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (cincinnatichildrens.org)
Moreover, NACT makes it possible to monitor the tumor response in vivo during treatment when compared with adjuvant chemotherapy. (springer.com)

Although recent studies suggest a less favorable prognosis for patients with germinomas secreting bhCG, no established prognostic significance of tumor markers exists. (medscape.com)
Their abundance varies with tumor type and stage and in some cases relates to disease prognosis. (wikipedia.org)
An active immune environment within the tumor often indicates a better prognosis as can be determined by the Immunological constant of rejection. (wikipedia.org)
It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)

Erosion of the tumor into blood vessels in adjacent tissues, or areas of necrosis within the tumor, can lead to hyphema or vitreous hemorrhage. (medscape.com)
Grade 4 designation is achieved by any of the following features: tumor necrosis, microvascular proliferation, or homozygous loss of CDKN2A and/or CDKN2B . (cap.org)

Initial studies investigating mechanisms responsible for BC metastatic potential and treatment resistance have focused attention on tumor cells themselves. (springeropen.com)

Pineal parenchymal cell tumor markers are less well characterized than their germ cell counterparts and include melatonin and the S antigen. (medscape.com)
Primary neuronal tumor that intrinsically arise from the pineal gland are referred to as pineal parenchymal tumors (PPTs). (thieme-connect.com)

Histologic evaluation revealed that the tumor contained diffuse ethanol-induced microemboli. (nih.gov)
I. To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/ carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the event-free survival (EFS) of patients with newly diagnosed stage 4 diffuse anaplastic Wilms tumor (DAWT) as compared to historical controls. (clinicaltrials.gov)
Immunohistochemical examination revealed neuronal tumor immunophenotype with diffuse positivity for non-specific enolase, synaptophysin, and focal positivity for S-100. (thieme-connect.com)

Odontogenic tumors and allied lesions. (thejcdp.com)

In adults, incidence is highest between ages 40 and 60, and the most common tumor types are gliomas and meningiomas. (online-family-doctor.com)

Designation of grade 2 and 3 tumors continues to be made by increased anaplasia and proliferative activity in grade 3 tumors, though a precise cutoff for mitotic activity is not provided, making the distinction somewhat subjective. (cap.org)

Classically, activated M1 macrophages release pro-inflammatory cytokines and activate type1 T cell response that has a cytotoxic effect on tumor cells, whereas M2 macrophages produce proteolytic enzymes, suppress immune response, and contribute to hypoxia-induced angiogenesis, thus promoting tumor cell proliferation and migration [ 5 ]. (springeropen.com)
The purpose of this report is to describe the features of angiosarcoma arising in mucinous tumor that was misinterpreted as a benign vascular proliferation during the intraoperative consultation. (hindawi.com)
1% proliferation index in tumor cells. (thieme-connect.com)

DWI reportedly accurately differentiates pediatric posterior fossa tumors, but anecdotal experience suggests limitations. (ajnr.org)
One recent study showed no overlap between ADC values in the 3 main pediatric posterior fossa tumors: medulloblastoma ( n = 8), JPA ( n = 17), and ependymoma ( n = 5). (ajnr.org)

In cancer, the development of blood vessels can feed tumors and allow them to grow, and drugs that block angiogenesis are being tested as cancer treatment. (ucsfhealth.org)
Indicate whether tumor cells were present in blood vessels or lymphatic structures. (mdanderson.org)

Multiple individual cultures are established, grown separately and assayed for specific tumor recognition. (wikipedia.org)
Imatinib resistance, either primary or secondary, is associated with specific tumor genotypes, so genotyping of individual patient tumors helps guide decisions concerning whether to offer imatinib and at what dose, or whether an alternative tyrosine kinase inhibitor (TKI) (ie, sunitinib) is more appropriate. (arupconsult.com)

They usually occur above the covering of the cerebellum (supratentorial tumors). (online-family-doctor.com)

Ultrastructural studies demonstrate tumor cells with irregular nuclei, abundant perinuclear cytoplasmic filaments, and many pinocytotic vesicles. (medscape.com)

They can be classified as anterior uveal melanomas when the tumor arises in the iris and as posterior uveal melanomas when it arises in either the choroid or the ciliary body. (medscape.com)
Most tumors were observed in the posterior mandible. (thejcdp.com)

[ 32 ] This technique may produce a smear showing many small clusters of tumor cells with rosettelike arrangement, along with papillary fragments with a fibrovascular core and hobnail-like arrangement of the cells. (medscape.com)
Rare patterns of ChRCC have been described over the last few decades, showing a wide histologic spectrum including those with adenomatoid microcystic pigmented, multicystic, neuroendocrine, small cell, and papillary features. (lww.com)

Due to the rarity of angiosarcoma in the ovary, this tumor can be a diagnostic challenge to surgical pathologists, particularly during an intraoperative consultation. (hindawi.com)

In Adoptive T cell transfer therapy, TILs are expanded ex vivo from surgically resected tumors that have been cut into small fragments or from single cell suspensions isolated from the tumor fragments. (wikipedia.org)

These results supported the idea that calponin 2 is involved in esophageal cancer and may function as a tumor inhibitor probably through modulating cancer cells tight junction and tumor immunity. (ijpsonline.com)
Other tumor-related genome markers are rapidly maturing providing prognostic indicators for survival and response to therapy (e.g. gene expression profiling in prostate cancer ). (cdc.gov)
Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer. (cdc.gov)
Vulvar cancer is an uncommon gynecologic tumor and one of several human papillomavirus-associated malignancies. (bvsalud.org)

It is well known that caloric intake affects tumor incidence in rats. (ratguide.com)
In addition to increasing tumor incidence, high caloric intake decreases latency and enhances tumor growth (Keenan et al, 1995). (ratguide.com)
Internationally, however, the incidence of adrenocortical tumors appears to vary substantially. (oncolink.org)
Recently, in Finland, the United Kingdom, the Netherlands, the United States, and Sweden, incidence of OSCC has increased, and an increase in the proportion of HPV-positive tumors was noted. (cdc.gov)

1 While WDLPS can arise anywhere in the body, DD tumors mainly arise in the retroperitoneum (RPS). (sarcomahelp.org)
A large spectrum of neoplasm can arise in the vicinity of pineal gland including the tumor, metastasizing to the pineal region. (thieme-connect.com)

For schwannomas, microsurgical technique allows complete resection of the tumor and preservation of the facial nerve. (online-family-doctor.com)

It involves challenging tasks for pathologists, such as identifying rare events in very large images (e.g., micrometastases in lymph nodes), or classifying subtle differences between normal vs. tumor, or amongst similar-looking tumors that have very different treatment plans. (triconference.com)

Some patients experienced complete responses with no detectable tumor remaining years after treatment. (wikipedia.org)
Patients from our institute between 2004 and 2017 with a histopathologically proven primary GIST or intra-abdominal tumors resembling GIST with at least a contrast-enhanced venous-phase CT prior to treatment [ 3 , 18 ] were retrospectively included. (springer.com)
Furthermore, even when standardized treatment is used and tumors are at the same stage and have similar histologic features, it is difficult to predict the outcome. (cdc.gov)
Adult Central Nervous System Tumors Treatment (PDQ). (medscape.com)

They also may show positive reactivities for CD31, CD34, and alpha-smooth muscle actin in most of the tumor cells and CD68 in some tumor cells. (medscape.com)
Tumor-induced glaucoma may be produced by obstruction of outflow pathways by pigment cells (pigment dispersion syndrome), melanin-laden macrophages (melanomalytic glaucoma), or tumor cells. (medscape.com)
Tumor-infiltrating lymphocytes (TIL) are white blood cells that have left the bloodstream and migrated towards a tumor. (wikipedia.org)
They include T cells and B cells and are part of the larger category of 'tumor-infiltrating immune cells' which consist of both mononuclear and polymorphonuclear immune cells, (i.e. (wikipedia.org)
TILs can be found between the tumor cells, as TILs in the stroma surrounding the tumor cells do not count. (wikipedia.org)
TILs are often found floating around the tumor without actual penetration or action on the tumor cells. (wikipedia.org)
Remarkably, tumor cells from solid LUADs upregulate energy and substance metabolic activities, particularly the folate-mediated one-carbon metabolism and the key gene MTHFD2, which could serve as a potential therapeutic target. (nih.gov)
DWI might, in theory, effectively distinguish tumor types and histologic grades because higher grade tumors with more densely packed cells should have increasingly restricted diffusion (with a lower ADC). (ajnr.org)
In some areas, the tumor cells were small and uniform resembling pinealocytes, and arranged in sheets and at places forming pineocytomatous rosettes with abundant delicate tumor cell processes. (thieme-connect.com)
The tumor cells were negative for glial fibrillary acidic protein (GFAP), placental alkaline phosphatase (PLAP), Human Chorionic Gonadotropin (HCG), and pan-cytokeratin. (thieme-connect.com)
CD-117-Numerous mast cells exhibiting faint positivity are seen interspersed in the tumor. (thieme-connect.com)
2 ] The ominous nuclear appearance of tumor cells could be misleading and pose a diagnostic difficulty. (thieme-connect.com)
A malignant skin tumor composed of cells similar to those from the basal cell layer of the epidermis. (cdc.gov)
well as cytologic study for tumour cells. (who.int)

Tumor reduction of 50% or more was observed in about half of patients. (wikipedia.org)
Patients diagnosed at the Erasmus MC between 2004 and 2017, with GIST or non-GIST intra-abdominal tumors and a contrast-enhanced venous-phase CT, were retrospectively included. (springer.com)
Five patients were followed and none of their tumors recurred. (thejcdp.com)
SRH and AI can be combined to unlock and annotate histologic information that can be leveraged by surgeons to provide the best possible care to their patients. (triconference.com)

Previously untreated unresectable tumor or inoperable Stage III disease. (oncolink.org)
NACT enables tumor downstaging, thus rendering inoperable tumors operable or even allowing breast-conserving surgeries. (springer.com)

this overexpression is the most prominent diagnostic marker for GIST and enables differentiation of GIST from other subepithelial tumors of the GI tract, which are nearly universally negative for CD117. (arupconsult.com)
Subepithelial tumors of the conjunctiva. (aao.org)

The development and growth of mammary tumors are primarily dependent on estrogen and prolactin (hormones controlled by the pituitary gland and the hypothalamus) receptor concentrations. (ratguide.com)
Indicate whether the tumor is negative for expression of estrogen receptor (ER), progesterone receptor (PR) and HER/2 neu. (mdanderson.org)
Nodal positivity correlated with histological grade and tumour size, but not with estrogen receptor or c-erbB-2 status. (ispub.com)
Chi square was used to test the association between ethnic group, tumour size (categorized as ≤2 cm, >2 cm and ≤5 cm, and >5 cm), histological grade, estrogen receptor (ER) status, c-erbB-2 status and lymph node metastases. (ispub.com)

Anatomy14

Organisms10

Diseases98

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes47

Disciplines and Occupations1

Information Science4

Health Care9

Histology8

Subtypes9

Diagnosis18

Brain tumors8

Stromal10

Group of tumors1

Pituitary tumors3

Germ cell t9

Adenocarcinoma4

Benign tumors2

Characteristics7

Metastasis2

Ovarian12

Atypical1

Recurrence4

Neoplasms6

Cancers3

World Health Organ1

Malignancy3

Invasive5

Subtype3

Lesion1

20211

GISTs1

Carcinomas3

Primary tumor2

Anatomic1

Progression4

Tissue12

Carcinoma3

Clinical5

Classification4

Small tumors1

Mucinous tumors3

Malignant tumors1

Microenvironment4

Pathology1

Chemotherapy6

Prognosis4

Necrosis2

Metastatic potential1

Pineal parenchymal2

Diffuse3

Lesions1

Meningiomas1

Proliferative1

Proliferation3

Pediatric2

Blood vessels2

Specific tumor2

Cerebellum1

Cytoplasmic1

Posterior2

Papillary2

Ovary1

Surgically resected1

Cancer4

Incidence4

Arise2

Resection1

Lymph nodes1

Treatment4

Cells14

Patients4

Inoperable2

Subepithelial2

Estrogen4