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  • thymus
  • An important question is whether maternal effector cells are controlled exclusively by the peripheral presentation of nonpolymorphic HLA-G molecules at the uterine-placental interface or whether central presentation of HLA-G molecules occurs in the thymus. (rupress.org)
  • Previous studies have reported very low levels of HLA-G messenger RNA (mRNA) 1 in the fetal thymus (( 17 ), ( 18 )), but no evidence has been provided for the expression of the protein, nor for the identity of the cells exhibiting such expression. (rupress.org)
  • Demise
  • We study a model of in utero transmission of ZIKV and showed that ZIKV colonizes placental trophoblasts where it replicates and subsequently crosses the placental barrier to infect fetal endothelial cells, enters the fetal circulation ultimately leading to fetal brain damage and fetal demise. (wustl.edu)
  • Successful allopregnancy is a Th2 phenomenon: predominance of Th2 cytokine leads to fetal survival, whereas unbalance towards Th1 leads to fetal demise. (els.net)
  • perinatal
  • In addition to the perinatal complications of obesity during pregnancy, increasing epidemiological evidence suggests persistent and deleterious effects of maternal obesity (MO) on the offspring and through intrauterine programming [ 6 , 7 ]. (hindawi.com)
  • Maternal infections contribute to nearly 40% of all adverse perinatal outcomes . (plos.org)
  • intrauterine
  • Obesity and excessive GWG are related to several maternal and fetal complications, including diabetes (pregestational and gestational diabetes) and intrauterine programming of insulin resistance (IR). (hindawi.com)
  • Despite
  • Despite maternal immune recognition of the conceptus as evidenced by alloantibodies, unlike for conventional allografts, the immune response is spared, cytotoxic effectors being downregulated or suppressed, whereas several cytokinic responses, including inflammatory ones, are used or even provoked for their preimplantation or later on 'immunotrophic' effects. (els.net)