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  • tumor
  • The Major Histocompatibility Complex (MHC) was discovered as a con- sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. (waterstones.com)
  • Publications] Mikinori Miyazaki: 'Potential limitations in using minor histocompatibility antigen-specific cytotoxic T cells for targeting solid tumor cells'Clinical Immunology. (nii.ac.jp)
  • Cellular and molecular characterization of antigens recognized by tumor-reactive T cells isolated from responding patients could potentially provide insight into the mechanisms of tumor regression. (aacrjournals.org)
  • CD8 + CTL clones that recognized a novel RCC-associated minor histocompatibility (H) antigen presented by HLA-A*0201 were isolated from two patients with metastatic RCC who experienced tumor regression or stable disease following nonmyeloablative allogeneic HCT. (aacrjournals.org)
  • Purpose:In HLA-matched allogeneic hematopoietic stem cell transplantation (alloSCT), donor T-cells recognizing minor histocompatibility antigens (MiHA) can mediate desired anti-tumor immunity as well as undesired side effects. (aacrjournals.org)
  • NY-ESO-1 is a member of the cancer-testis family of tumor antigens that elicits strong humoral and cellular immune responses in patients with NY-ESO-1-expressing cancers. (uzh.ch)
  • The characterization of HLA class II-restricted epitopes will be useful for the assessment of spontaneous and vaccine-induced immune responses of cancer patients against defined tumor antigens. (uzh.ch)
  • genome-wide
  • We identified this antigen using genome-wide zygosity-genotype correlation analysis of a mHag-specific CD8(+) cytotoxic T lymphocyte (CTL) clone derived from a multiple myeloma patient who achieved a long-lasting complete remission after donor lymphocyte infusion from an human leukocyte antigen (HLA)-matched sibling. (sigmaaldrich.com)
  • proteins
  • A histocompatibility antigen blood test looks at proteins called human leukocyte antigens (HLAs). (indiatoday.in)
  • This conclusion is based on the following observations: (i) Water-soluble octamers of viral coat proteins inhibit the complement-dependent cytotoxicity of antibodies directed against H-2K and H-2D antigens in mouse cells. (pnas.org)
  • ii) Isolated detergent-soluble HLA-A and HLA-B antigens reconstituted in lipid vesicles inhibit the binding of viral proteins to human cells (as do the water-soluble antigens to a lesser extent). (pnas.org)
  • iv) Complexes between viral spoke proteins and HLA-A and HLA-B antigens or H-2K and H-2D antigens can be isolated from the cell surface by utilizing affinity chromatography or immunoprecipitation. (pnas.org)
  • donor
  • We obtained a sequence of high-affinity ACC-1Y-specific TCR after the antigen-specific expansion of T cells derived from a healthy ACC-1Y -/- donor. (springer.com)
  • Tx occurs across histocompatibility antigen (HLA) barriers and requires life-long immunosuppression, to effectively suppress donor-specific injurious immune responses, while conserving immune recognition to foreign and infectious antigens. (frontiersin.org)
  • found
  • An unknown 'antigen' is found in this site in crystals of purified HLA-A2. (nih.gov)
  • For example, HLA-B27 antigen is found in many people (but not all) with ankylosing spondylitis and Reiter syndrome . (indiatoday.in)