Robert Douglas Sweet first described acute febrile neutrophilic dermatosis in 1964, leading to the eponym Sweet syndrome (SS). (medscape.com)
Sweet syndrome (acute febrile neutrophilic dermatosis) is a hypersensitivity reaction that occurs in response to systemic factors, such as hematologic disease, infection, inflammation, vaccination, or drug exposure. (medscape.com)
Sweet syndrome (SS) is defined as an acute febrile neutrophilic dermatosis, which can be subclassified as classical, drug induced, and malignancy associated. (medindiajournal.com)
The diagnosis of acute febrile neutrophilic dermatosis (Sweet syndrome) is usually based on histopathologic examination by a qualified dermatopathologist, but the laboratory findings are nonspecific. (medscape.com)
A chest radiograph should be obtained if pulmonary symptoms of acute febrile neutrophilic dermatosis (Sweet syndrome) are present because lung involvement may occur and is responsive to systemic corticosteroids. (medscape.com)
Skin biopsy should be performed to confirm the diagnosis of acute febrile neutrophilic dermatosis (Sweet syndrome). (medscape.com)
The classic histopathologic pattern of acute febrile neutrophilic dermatosis (Sweet syndrome) consists of a dense, diffuse neutrophilic infiltrate in the reticular dermis. (medscape.com)
Malignancy-associated2
Diagnostic criteria for sweet syndrome, including classical, drug-induced and malignancy-associated forms. (actasdermo.org)
Sweet syndrome is the presenting sign of malignancy in approximately two thirds of the cases of malignancy-associated Sweet syndrome. (medscape.com)
Myelodysplastic2
Leukemia cutis usually occurs in the setting of a previously diagnosed systemic leukemia or lymphoproliferative disorder/myelodysplastic syndrome. (medscape.com)
Cutaneous infiltration by neoplastic lymphocytes may be seen in acute myeloid leukemia , acute lymphocytic leukemia , chronic myeloid leukemia , chronic lymphoid leukemia , hairy cell leukemia, prolymphocytic leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndromes . (medscape.com)
Neutrophilic dermatoses2
Characteristics that distinguish the lesions of Sweet syndrome from other neutrophilic dermatoses are healing of the lesions without scarring and an absence of vasculitis on histopathological examination. (medscape.com)
Sweet syndrome is the most representative entity of febrile neutrophilic dermatoses. (actasdermo.org)
Drug-induced1
In addition to G-CSF, the use of ATRA in the context of acute promyelocytic leukemia has shown the propagation of aberrant neutrophils as seen in drug-induced Sweet syndrome. (medscape.com)
Sweet's2
Top 5 drugs related to Sweet's syndrome, based on case reports published on PubMed. (actasdermo.org)
Cohen PR, Kurzrock R. Sweet's syndrome revisited: a review of disease concepts. (medscape.com)
Chronic1
Blau syndrome Chronic infantile neurologic cutaneous and articular syndrome Familial cold urticaria (familial cold autoinflammatory syndrome) Familial Mediterranean fever Hyper-IgD syndrome Majeed syndrome Muckle-Wells syndrome TNF receptor associated periodic syndrome (familial Hibernian fever, TRAPS, tumor necrosis factor receptor associated periodic syndrome) Chronic blistering cutaneous conditions have a prolonged course and present with vesicles and bullae. (wikipedia.org)
RESUMEN1
En resumen, Actas Dermo-Sifiliográficas constituye una publicación imprescindible para quien necesite estar al día en todos los aspectos de la Dermatología española y mundial. (actasdermo.org)
Variant1
Histiocytoid Sweet syndrome is a variant that has been described and includes histiocytoid cells, which are immature myeloid cells commonly mistaken as histiocytes. (medscape.com)
Cutaneous2
[ 7 ] It is important to note that cutaneous lesions can also occur in the context of an established neoplastic process, as well as a paraneoplastic syndrome. (medscape.com)
Skin lesions are common in CLL and can be seen in the background of exaggerated insect bite reactions, cutaneous malignancies, Sweet syndrome, urticaria, infection, purpura, and erythroderma. (cdlib.org)
Diagnosis1
The diagnosis of Sweet syndrome is based on fulfillment of both clinical and histopathologic criteria. (medscape.com)
Neutropenic1
Neutrophilia is typically present, but the absence of neutrophilia in a patient who is neutropenic does not rule out Sweet syndrome. (medscape.com)
Lesions4
In some reports, the lesions of Sweet syndrome are the first clue of underlying malignancy. (medscape.com)
Finally, an iatrogenic form of Sweet syndrome is recognized based on reports of a variety of therapies bringing about lesions. (medscape.com)
[ 11 ] The functional properties of neutrophils, rather than the absolute number, is thought to be significant because patients with Sweet syndrome due to G-CSF develop lesions as the neutrophil count rapidly increases, despite a decreased absolute neutrophil count. (medscape.com)
Clinicopathologic correlation is important because the bowel bypass syndrome may present with skin lesions with an identical histologic picture. (medscape.com)
Patients3
G-CSF levels are increased in peripheral blood of patients with active Sweet syndrome, suggesting that high levels of G-CSF may correlate with the activity of disease. (medscape.com)
Antineutrophilic cytoplasmic antibodies (ANCAs) have been described but not consistently found in all patients with Sweet syndrome. (medscape.com)
[ 16 ] Some authors recommend a directed systemic evaluation in all patients with Sweet syndrome. (medscape.com)
Dermatosis2
s ndrome de Sweet, dermatosis neutrof lica febril aguda. (medigraphic.com)
El síndrome de Sweet es la entidad más representativa de las dermatosis neutrofílicas. (actasdermo.org)
Cells1
The biopsy from the right neck also showed a prominent granulomatous component with aggregates of histiocytoid cells forming perivascular epithelioid granulomas (Figure 4). (cdlib.org)
Treatment1
however, without treatment, the syndrome may persist for weeks or months and usually improves without scarring. (medscape.com)
Cases1
Bone marrow aspiration is indicated if CBC count is abnormal, and it should be considered in all cases of atypical bullous or ulcerative Sweet syndrome. (medscape.com)
Robert Douglas Sweet first described acute febrile neutrophilic dermatosis in 1964, leading to the eponym Sweet syndrome (SS). (medscape.com)
Sweet syndrome (acute febrile neutrophilic dermatosis) is a hypersensitivity reaction that occurs in response to systemic factors, such as hematologic disease, infection, inflammation, vaccination, or drug exposure. (medscape.com)
Clinical1
The diagnosis of Sweet syndrome is based on fulfillment of both clinical and histopathologic criteria. (medscape.com)
Mutations1
Here, we demonstrate that somatic mutations in the related KRAS gene can also be associated with a nonmalignant syndrome of autoimmunity and breakdown of leukocyte homeostasis. (nih.gov)
Association2
Histiocytoid Sweet syndrome: a novel association with relapsing polychondritis. (medscape.com)
The association of exogenous G-CSF with the development of Sweet syndrome also supports the impact of neutrophils and related endogenous cytokines in the underlying process. (medscape.com)
Reports2
In some reports, the lesions of Sweet syndrome are the first clue of underlying malignancy. (medscape.com)
Finally, an iatrogenic form of Sweet syndrome is recognized based on reports of a variety of therapies bringing about lesions. (medscape.com)
Treatment1
however, without treatment, the syndrome may persist for weeks or months and usually improves without scarring. (medscape.com)
Levels1
G-CSF levels are increased in peripheral blood of patients with active Sweet syndrome, suggesting that high levels of G-CSF may correlate with the activity of disease. (medscape.com)