LymphomaHistiocytosisCanine Histiocytic SarcomaTumorsDendritic cell sarcomaTumorDisordersDISEASESCellsCellSoft tissue sarcomasPatientsExpressionOriginTreatmentNeoplasmLymphomaNeoplasmsReticulum cell sarcomaSomaticHistiocytosisAcute monocytiMutationsCanineMalignantLymphomasCancerLiver2023HistologicalSpontaneousLesionsPathologyRatsFrequencyPrognosisPrimaryRareTreatmentCases
Lymphoma7
- Kaposi sarcoma herpesvirus (KSHV) is specifically associated with Kaposi sarcoma (KS) and 2 B cell lymphoproliferative diseases, namely primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). (jci.org)
- Primary central nervous system lymphoma (PCNSL) has been known by many other names, including reticulum cell sarcoma, diffuse histiocytic lymphoma, and microglioma. (medscape.com)
- [ 6 ] Additionally, a biopsy of lymphoma pre-treated with corticosteroids may reveal only gliosis or lymphocytic and histiocytic infiltrates without identifiable neoplastic cells. (medscape.com)
- Volition's Nu.Q® Vet Cancer Test detected 76% of systemic cancers ( including lymphoma, hemangiosarcoma, and histiocytic sarcoma) at 97% specificity versus control. (volition.com)
- CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. (thermofisher.com)
- However, when it comes to cancer they have a higher than average risk of developing a number of different cancers including soft tissue sarcomas, osteosarcoma (bone cancer), lymphoma, mast cell tumors, transitional cell carcinomas (bladder cancer) and hemangiosarcomas (cancer of the blood vessels). (vmsg.com)
- Unfortunately, Bernese Mountain Dogs do have a relatively high rate of cancer in comparison to other breeds, including mast cell tumours, lymphoma, and histiocytic sarcoma. (petinsuranceaustralia.com.au)
Histiocytosis3
- [ 5 , 6 ] Although several histiocytic disorders are briefly discussed in this article (see History ), the primary focus is on Langerhans cell histiocytosis. (medscape.com)
- Unfortunately, they have a short life expectancy and are more likely to develop cancers such as mast cell tumors and malignant histiocytosis (histiocytic sarcomas). (vmsg.com)
- The Memorial Sloan Kettering Make-an-IMPACT Initiative is a rare-cancer global outreach initiative that provides free genomic profiling for patients with Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), Rosai-Dorfman Disease (RDD), Juvenile Xanthogranuloma (JXG), and Histiocytic Sarcoma (HS). (histio.org)
Canine Histiocytic Sarcoma7
- Mesenchymal to epithelial transition driven by canine distemper virus infection of canine histiocytic sarcoma cells contributes to a reduced cell motility in vitro. (helmholtz-hzi.de)
- This study hypothesizes that a CDV infection of canine histiocytic sarcoma cells (DH82 cells) triggers the MET process leading to a decreased cellular motility. (helmholtz-hzi.de)
- Intratumoral Canine Distemper Virus Infection Inhibits Tumor Growth by Modulation of the Tumor Microenvironment in a Murine Xenograft Model of Canine Histiocytic Sarcoma. (helmholtz-hzi.de)
- Oxidative Stress in Canine Histiocytic Sarcoma Cells Induced by an Infection with Canine Distemper Virus Led to a Dysregulation of HIF-1α Downstream Pathway Resulting in a Reduced Expression of VEGF-B in vitro. (helmholtz-hzi.de)
- Persistent Infection of a Canine Histiocytic Sarcoma Cell Line with Attenuated Canine Distemper Virus Expressing Vasostatin or Granulocyte-Macrophage Colony-Stimulating Factor. (helmholtz-hzi.de)
- Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma. (go.jp)
- Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099 , in a xenograft mouse model of canine histiocytic sarcoma. (go.jp)
Tumors2
- reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)
- Interestingly, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic cell markers. (jci.org)
Dendritic cell sarcoma2
- Interdigitating dendritic cell sarcoma subtotally replacing lymph node shows that the neoplasm tends to spare lymphoid follicles. (basicmedicalkey.com)
- Interdigitating dendritic cell sarcoma involving lymph node shows that the neoplastic cells are spindled and epithelioid with abundant eosinophilic cytoplasm. (basicmedicalkey.com)
Tumor1
- Histiocytic sarcoma is a tumor derived from histiocytes. (wikipedia.org)
Disorders2
- Over the last several decades, the nomenclature used to describe histiocytic disorders has substantially changed to reflect the wide range of clinical manifestations and the variable clinical severities of some disorders that have the same pathologic findings. (medscape.com)
- Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
DISEASES1
- Dedicated to promoting scientific research to uncover the causes of histiocytic diseases and ensure early diagnosis, effective treatment and a cure. (histio.org)
Cells1
- Persistent Morbillivirus Infection Leads to Altered Cortactin Distribution in Histiocytic Sarcoma Cells with Decreased Cellular Migration Capacity. (helmholtz-hzi.de)
Cell1
- PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma. (uni-heidelberg.de)
Soft tissue sarcomas2
- Impact of dynamic 18F-FDG PET on the early prediction of therapy outcome in patients with high-risk soft-tissue sarcomas after neoadjuvant chemotherapy: a feasibility study. (uni-heidelberg.de)
- Prediction of chemotherapy outcome in patients with metastatic soft tissue sarcomas based on dynamic FDG PET (dPET) and a multiparameter analysis. (uni-heidelberg.de)
Patients1
- The other patients had an expansion of clones harboring del(8p) carrying additional driver mutations (EP300, MLL2, EIF2A), with one patient developing trans-differentiation into CD19-negative histiocytic sarcoma. (nih.gov)
Expression1
- Reduced angiogenic gene expression in morbillivirus-triggered oncolysis in a translational model for histiocytic sarcoma. (helmholtz-hzi.de)
Origin1
- Sarcomas especially of histiocytic origin often possess a poor prognosis and response to conventional therapies. (helmholtz-hzi.de)
Treatment1
- Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma. (uni-heidelberg.de)
Neoplasm6
- Introduction Histiocytic sarcoma is a rare neoplasm with few cases reported in the literature of which some were diagnosed in animals. (medscape.com)
- Histiocytic sarcoma (HS) is a rare neoplasm showing evidence of histiocytic differentiation. (medscape.com)
- Histiocytic sarcoma (Kupffer cell sarcoma) is a multicentric neoplasm of mice that frequently involves the liver. (nih.gov)
- Histiocytic sarcoma is a rare malignant neoplasm that may occur de novo or in the context of a previous hematologic malignancy or mediastinal germ cell tumor. (nih.gov)
- Histiocytic Sarcoma (HS) is a rare human hematopoietic neoplasm that accounts for less than 1% of hematolymphoid cancers and is usually fatal. (nih.gov)
- 9. t(2;5) associated with a histiocytic-monocytic neoplasm. (nih.gov)
Lymphoma5
- 8. True histiocytic lymphoma (monocytic sarcoma). (nih.gov)
- 13. True histiocytic lymphoma of small intestine. (nih.gov)
- 20. True histiocytic lymphoma: histopathologic, immunophenotypic and genotypic analysis. (nih.gov)
- Primary central nervous system lymphoma (PCNSL) has been known by many other names, including reticulum cell sarcoma, diffuse histiocytic lymphoma, and microglioma. (medscape.com)
- [ 6 ] Additionally, a biopsy of lymphoma pre-treated with corticosteroids may reveal only gliosis or lymphocytic and histiocytic infiltrates without identifiable neoplastic cells. (medscape.com)
Neoplasms3
- Histiocytic sarcomas may simultaneously occur in other organs such as the spleen, lung, and uterus and are regarded as systemic neoplasms. (nih.gov)
- Histiocytic sarcoma and tumors with dendritic cell differentiation (HDT) are uncommon neoplasms often with an aggressive clinical course that may occur in association with another hematologic malignancy or mediastinal germ cell tumor (secondary HDT, sHDT). (nih.gov)
- 2. High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms. (nih.gov)
Reticulum cell sarcoma1
Somatic1
- 11. Somatic mutations in histiocytic sarcoma identified by next generation sequencing. (nih.gov)
Histiocytosis3
- 19. Histiocytic sarcoma that mimics benign histiocytosis. (nih.gov)
- [ 5 , 6 ] Although several histiocytic disorders are briefly discussed in this article (see History ), the primary focus is on Langerhans cell histiocytosis. (medscape.com)
- The Memorial Sloan Kettering Make-an-IMPACT Initiative is a rare-cancer global outreach initiative that provides free genomic profiling for patients with Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), Rosai-Dorfman Disease (RDD), Juvenile Xanthogranuloma (JXG), and Histiocytic Sarcoma (HS). (histio.org)
Acute monocyti3
- 7. [Extramedullary infiltration of acute monocytic leukemia/monoblastic sarcoma: a clinicopathologic and immunophenotype analysis of 5 cases]. (nih.gov)
- 15. Histiocytic sarcoma combined with acute monocytic leukemia: a case report. (nih.gov)
- 17. Histiocytic differentiation in acute monocytic leukemia. (nih.gov)
Mutations1
- PTPN11 mutations in canine and human disseminated histiocytic sarcoma. (academictree.org)
Canine3
- Each time we learn that a Tripawd cat or dog has beaten the pet cancer odds for an especially aggressive cancer like canine histiocytic sarcoma , we love to celebrate by spreading the good news! (tripawds.com)
- Kennedy K, Thomas R, Durrant J, Jiang T, Motsinger-Reif A , Breen M . Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. (academictree.org)
- Histiocytic Sarcoma is a very aggressive canine cancer that is rare in the overall dog population, but incredibly common in Bernese Mountain dogs. (shipyarn.com)
Malignant1
- 6. Malignant lymphomas of true histiocytic origin. (nih.gov)
Lymphomas1
- It can also pick up 77% of lymphomas, 82% of hemangiosarcoma, and 54% of histiocytic sarcomas. (wearethecure.org)
Cancer2
- A splenectomy was performed and the splenic tumor was diagnosed as hemophagocytic histiocytic sarcoma, a cancer with very poor prognosis. (fidocure.com)
- Histiocytic sarcomas which are a serious type of cancer that starts in a particular type of immune cell. (purina.co.uk)
Liver2
- Low and high magnifications of a histiocytic sarcoma with a nodular growth pattern in the liver. (nih.gov)
- In both sexes of Crj:BDF1 mice, drinking water exposure to quinoline increased the incidences of liver histiocytic sarcoma, and in various organs, haemangioma and haemangiosarcoma. (cdc.gov)
20231
- We lost our beloved Bernese Mountain Dog, Pico, to Histiocytic Sarcoma on Sept 20th 2023. (shipyarn.com)
Histological1
- The histological findings revealed a histiocytic sarcoma. (medscape.com)
Spontaneous1
- Spontaneous histiocytic sarcomas occur at low frequency in mice. (nih.gov)
Lesions1
- 16. Clinicopathologic features of histiocytic lesions following ALL, with a review of the literature. (nih.gov)
Pathology1
- Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
Rats1
Frequency1
- 5. High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomas. (nih.gov)
Prognosis1
- Conclusion Although histiocytic sarcomas in the brain present an unusual location and have a poorer prognosis, we have identified the first primary leptomeningeal histiocytic sarcoma with a disease-free survival greater than 3 years following multidisciplinary treatment with surgery and chemotherapy and radiotherapy. (medscape.com)
Primary1
- Here, we performed whole exome sequencing and RNA-sequencing (RNA-Seq) on 21 archival cases of primary histiocytic sarcoma. (nih.gov)
Rare1
- Rare Multisystem Histiocytic Sarcoma on 18 F-FDG PET/CT. (snmjournals.org)
Treatment2
- We present the first case of a patient with histiocytic sarcoma that involved the meninges and had a good course after multidisciplinary treatment. (medscape.com)
- The standard treatment for these sarcomas is surgery. (medscape.com)
Cases1
- Histiocytic Sarcoma Arising From a Long Bone: Report of Two Cases. (rochester.edu)