AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
HistamineCell DegranulationMast CellsHistamine ReleaseReceptors, Histamine H1Receptors, Histamine H2Receptors, HistamineHistamine AntagonistsHistamine AgonistsHistamine H1 AntagonistsReceptors, Histamine H3Histamine H2 Antagonistsp-Methoxy-N-methylphenethylamineHistamine N-MethyltransferaseReceptors, IgEImmunoglobulin EPyrilamineBasophil Degranulation TestCytoplasmic GranulesBasophilsAnaphylaxisDimapritMethylhistaminesPassive Cutaneous AnaphylaxisHistidine Decarboxylasebeta-N-AcetylhexosaminidasesCromolyn SodiumHistamine H3 AntagonistsCimetidineHistamine AgentsChlorpheniramineNeutrophilsEosinophilsMetiamideAnti-Allergic AgentsDiphenhydramineEosinophil PeroxidaseLeukemia, Basophilic, AcuteN-Formylmethionine Leucyl-PhenylalanineKetotifenHypersensitivityLysosomal-Associated Membrane Protein 1Cells, CulturedGuinea PigsAntigens, CD63Eosinophil Granule ProteinsTryptasesPeritoneal CavityNeutrophil ActivationExocytosisLactoferrinThioureaDose-Response Relationship, DrugCalcimycinImpromidineSkinMastocytosisAllergensSerine EndopeptidasesLeukotriene C4Mice, Inbred C57BLChymasesPruritusBurimamideCytochalasin BSerotoninSignal TransductionCalciumProto-Oncogene Proteins c-kitAntigensHistamine H1 Antagonists, Non-SedatingStem Cell FactorComplement C3aCapillary PermeabilityLungOvalbuminBronchial Provocation TestsUrticariaThioxanthenesHypersensitivity, ImmediateSubstance PTriprolidineDinitrophenolsMice, KnockoutRanitidineAsthmaCytokinesSuperoxidesGlucuronidaseAntibodies, Anti-IdiotypicCell CountTime FactorsTerfenadineLeukotrienesBronchiEosinophil-Derived NeurotoxinBronchoconstrictionPeroxidaseSRS-ACarboxypeptidases A
MediatorsInflammatorySerotoninIncluding mast cellsInhibited mast cell degranulationLeukotrienesInflammationBind to mast cells and basophilsCytokinesTryptaseGranulesEosinophilsHypersensitivityReceptorsBasophils and mast cellsBasophilRelease histamineTriggerAllergic reactionsPeripheralAntihistamineRole of mast cellsAnaphylaxisAntigenAntigensAntihistaminesDisordersAllergensCutaneous mastocytosisActivationReceptorSubstancesDegranulateRespiratorySerumTissueAllergies
Mediators17
  • It is most frequently associated with exposure to allergens and the release of mediators from mast cells and basophils. (onteenstoday.com)
  • This results in mast cell degranulation and release of histamine and other inflammatory mediators. (onteenstoday.com)
  • The World Allergy Organization defines "anaphylaxis" as an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast cell and basophil-derived mediators into the circulation. (worldallergy.org)
  • It is known that IgE-mediated mast cell degranulation, which results in the release of chemical mediators, such as histamine, is a strategy that evolved to eliminate respiratory or gastrointestinal pathogens. (usda.gov)
  • This stimulates the degranulation of mast cells and the sudden release of inflammatory mediators (histamine, serotonin, cytokines, etc) locally. (dvm360.com)
  • Cellular activation by IgE/Fc epsilon RI crosslinking causes degranulation, releasing histamine, leukotrienes, prostaglandins, and other mediators of immediate‑type and late‑phase allergic reactions. (rndsystems.com)
  • [2-6] In these patients, the pollen causes degranulation of mast cells, which contain inflammatory mediators (histamine and other allergy-causing chemicals). (medscape.com)
  • Pollen can also trigger asthma attacks, with inflammatory mediators from degranulated mast cells causing airway inflammation, bronchial hyperresponsiveness, and airflow obstruction-the last being a consequence of factors such as acute bronchoconstriction, airway edema, and mucous plug formation. (medscape.com)
  • This inflammation of the nasal mucosal lining is a result of inhaled aeroallergens, which the patient has been previously sensitized to, binding to immunoglobulin E (IgE) on the surface of mast cells, leading to mast cell degranulation and release of preformed mediators, such as histamine and leuko-trienes. (uspharmacist.com)
  • 12 However, the antagonism of histamine or serotonin, two important mast cell mediators, only partially reduce postoperative nociception, indicating that other mast cell components must be involved. (asahq.org)
  • This leads to the degranulation of mast cells and the release of histamine and other mediators of anaphylaxis. (ivoryresearch.com)
  • Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. (wikidoc.org)
  • Upon activation, mast cells release these mediators , resulting in localised itching, swelling, redness and sometimes blistering of the skin. (dermnetnz.org)
  • Antigen binds to IgE (bound to tissue mast cells and blood basophils), trigger the release of mediators (histamine, chemotactic factors, etc.), and synthesize other mediators (prostaglandins, leukotrienes, platelet-activating factor, interleukins). (ceufast.com)
  • Anaphylaxis is defined as an acute life-threatening systemic event triggered by the sudden release of mediators from basophils and mast cells after exposure to a triggering agent. (medscape.com)
  • The safety of higher-dose antihistamines (beyond the level of US Food and Drug Administration approval) has not been studied in pregnancy, and because mast cells mediators, including histamine, participate in uterine adaptation, there is reason for caution. (medscape.com)
  • Physicians treating mast cell diseases in pregnancy should remember that mast cells and their mediators are clinically relevant not only in disease, but also in the uterus of the healthy patient. (medscape.com)
Inflammatory9
  • These cells play a crucial role in the immune system by releasing inflammatory substances, such as histamine, in response to allergens or pathogens. (proprofs.com)
  • Histamine is a compound that plays a key role in the inflammatory response and allergic reactions. (proprofs.com)
  • Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects. (mdpi.com)
  • BZK induced a significant increase in the severity of the clinical score, infiltration of inflammatory cells, local expression of inflammatory cytokines in subcutaneous tissue, and total serum immunoglobulin (Ig) E. PVP-I increased the clinical score, number of mast cells, and production of inflammatory cytokines, and total serum IgE. (medsci.org)
  • In type 1 asthma, the Ig-E bind to mast cells, resulting in the release of histamines and leukotrienes leading to inflammation of eosinophils, which is a hallmark of allergic inflammatory response and a degranulation process. (bdbiosciences.com)
  • inflammatory [4] potentially induces mast cell degranulation [5]. (healinghistamine.com)
  • mast cell trigger, used to test anti-inflammatory drugs [6]. (healinghistamine.com)
  • Add these to the fact that vaccines in general cause inflammation - yes, oddly enough, injecting a virus into our body causes the immune system (mast cells, histamine, other inflammatory agents) to go completely berserk protecting us from it. (healinghistamine.com)
  • Don't miss the Low Histamine Beauty Survival Guide for non-toxic beauty tips, the skinny on histamine releasing (mast cell degranulating) beauty ingredients, antihistamine and anti-inflammatory beauty alternatives and the top brands natural brands I've found. (healinghistamine.com)
Serotonin3
  • MCs can secrete nociceptor sensitizing and activating agents, such as serotonin, prostaglandins, histamine, and proteolytic enzymes that can also activate the pain-mediating transient receptor potential vanilloid channels. (frontiersin.org)
  • In addition to histamine and serotonin, mast cell degranulation releases tryptase, which has been demonstrated to be an important pronociceptive protease related to some painful diseases such as irritable bowel syndrome. (asahq.org)
  • Mast cells are cells that reside in the connective tissue and contain a large number of granules, rich in histamine, heparin, chymase, serotonin, and also cytokines. (bvsalud.org)
Including mast cells2
  • Pluripotent stem cells are found in the bone marrow and can give rise to different blood cell lineages including mast cells. (proprofs.com)
  • The exact mechanism associated with this growth and expansion remains unclear, although it is known that several types of cells, including mast cells, do play a role in such phenomena 4 . (bvsalud.org)
Inhibited mast cell degranulation2
  • A 40.8μg/mL concentration of the ethyl acetate fraction of the ethanolic extracts of adlay bran (ABE-EtOAc) effectively inhibited mast cell degranulation. (greenmedinfo.com)
  • Since its discovery in 2000, initial in vitro studies have found that the engagement of Siglec-8 with a monoclonal antibody or with selective polyvalent sialoglycan ligands induced the cell death of eosinophils and inhibited mast cell degranulation. (mdpi.com)
Leukotrienes1
Inflammation4
  • Ehrlich's discovery of mast cells was a significant contribution to the understanding of the immune system and its role in allergic reactions and inflammation. (proprofs.com)
  • When mast cells are activated, they release cytokines such as histamine, interleukins, and tumor necrosis factor, which can trigger various immune responses and contribute to allergic reactions and inflammation. (proprofs.com)
  • it's my intention to approach it simply from the mast cell/histamine/allergy/inflammation angle, so that so that at least we're going into this with eyes open and armed with some information to help us better understand what to watch out for post-vaccination. (healinghistamine.com)
  • Continuous activation and degranulation of mast cells activate cellular-mediated inflammation, structural cells of the corneal and conjunctival epithelium, vascular endothelial cells and fibroblasts. (reviewofophthalmology.com)
Bind to mast cells and basophils1
Cytokines4
Tryptase3
  • The close association between mast cells and nerves in peripheral tissues, and the fact that large amounts of tryptase are released upon mast cell degranulation, makes tryptase an ideal candidate to activate PAR-2 on peripheral neurons. (asahq.org)
  • Elevated serum HISTAMINE and TRYPTASE levels and cutaneous MAST CELL degranulation are often associated with post-exertional allergic reactions which sometimes are triggered only in combination with prior consumption of a specific food such as wheat. (bvsalud.org)
  • In the pregnant uterus, mast cell numbers increase in the myometrium and shift from both tryptase and chymase mast cells to the tryptase-only phenotype. (medscape.com)
Granules4
Eosinophils1
Hypersensitivity3
Receptors7
  • This and other effects of histamine are mediated through their interaction with specific receptors, which is in vasodilatation of the post-capillaries venules, besides to bronchi-constriction and increase in the production and flow of bronchial mucus. (vin.com)
  • Furthermore, mast cells and H1 receptors have not been the primary sites of antipruritic action of this extract. (researchgate.net)
  • MCs express receptors for both estrogen and progesterone that induce degranulation upon binding. (frontiersin.org)
  • Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines - other agents may have antihistaminergic action but are not true antihistamines. (wikidoc.org)
  • Once released, histamine can react with local or widespread tissues through histamine receptors . (wikidoc.org)
  • The newer second-generation H 1 -antihistamines are far more selective for peripheral histamine H 1 -receptors and have a far improved tolerability profile compared to the first-generation agents. (wikidoc.org)
  • these activate local histamine receptors and initiate the classic hyperemia and pruritus responses of AC. (reviewofophthalmology.com)
Basophils and mast cells1
  • Fc epsilon RI alpha is a transmembrane protein that associates with beta and gamma subunits to form the high affinity IgE receptor on basophils and mast cells. (rndsystems.com)
Basophil2
  • Nonimmunologic anaphylaxis" is caused by agents or events that induce sudden, massive mast cell or basophil degranulation in the absence of immunoglobulins. (worldallergy.org)
  • Urticaria also may be accompanied by angioedema, which results from mast cell and basophil activation. (merckmanuals.com)
Release histamine2
Trigger4
Allergic reactions2
  • An H 1 antagonist is a histamine antagonist of the H 1 receptor that serves to reduce or eliminate effects mediated by histamine , an endogenous chemical mediator released during allergic reactions . (wikidoc.org)
  • In allergic reactions, an allergen (a type of antigen ) interacts with and cross-links surface IgE antibodies on mast cells and basophils . (wikidoc.org)
Peripheral1
Antihistamine2
  • [7,8] The use of oral antihistamines, corticosteroid and antihistamine nasal sprays, inhalant corticosteroids, and antihistamine and mast-cell stabilizer eye drops may help mitigate these symptoms. (medscape.com)
  • Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. (drugbank.com)
Role of mast cells2
  • We discuss the current knowledge about sex differences in migraine and its comorbidities, and focus on the potential role of mast cells (MCs) in both. (frontiersin.org)
  • The authors discuss the role of mast cells in pregnancy in both healthy and disease states in a review article published in May. (medscape.com)
Anaphylaxis2
Antigen1
  • Different populations of immune cells are engaged in an allergic reaction, including antigen presenting cells (e.g., dendritic cells), mast cells and Ig-E producing B cells and T cells. (bdbiosciences.com)
Antigens1
  • Airway hyperresponsiveness, an exaggerated bronchospastic response to nonspecific agents such as methacholine and histamine or specific antigens, is the physiologic cornerstone of this disorder. (jci.org)
Antihistamines3
  • It has been discovered that these H 1 -antihistamines are actually inverse agonists at the histamine H 1 -receptor, rather than antagonists per se . (wikidoc.org)
  • H 1 -antihistamines are clinically used in the treatment of histamine-mediated allergic conditions. (wikidoc.org)
  • One type of urticaria in pregnancy-pruritic urticaria papules and plaques of pregnancy-has not yet clearly been linked to mast cells, but antihistamines are effective in this condition. (medscape.com)
Disorders4
  • Mastocytosis is a diverse group of disorders characterised by the expansion and accumulation of mast cells in one or more organ systems. (dermnetnz.org)
  • I suggest googling Dr. Theoharides for his advice on spacing out vaccines for children with mast cell disorders. (healinghistamine.com)
  • Mast Cell-Mediated and Associated Disorders in Pregnancy: A Risky Game With an Uncertain Outcome? (medscape.com)
  • Mast cell disorders in pregnancy do not garner the same degree of attention but merit a closer look in no small way, because mast cells appear to play a critical role in pregnancy. (medscape.com)
Allergens1
Cutaneous mastocytosis1
Activation1
  • By binding to and preventing activation of the H1 receptor, bilastine reduces the development of allergic symptoms due to the release of histamine from mast cells. (drugbank.com)
Receptor1
Substances1
  • Conclusions and Clinical Relevance -Results of our study indicate that an unknown mast cell-degranulating substances contained in HW extract may degranulate mast cells directly, consequently releasing histamine that may participate in the onset of shock in HW extract-induced shock in dogs. (avma.org)
Degranulate1
  • 10 Mast cells have been previously shown to degranulate and its number are largely reduced following tissue incision. (asahq.org)
Respiratory1
  • Mast cells are found in various parts of the body, including the skin, gut, and respiratory tract. (proprofs.com)
Serum1
  • Some of the immunological properties of allergenic proteins include their ability to stimulate Th-2 type T-cell proliferation, bind serum IgE, elicit a positive prick skin test, and cause histamine and mediator release from mast cells and basophils of sensitive individuals. (usda.gov)
Tissue3
  • In early pregnancy, mast cells modulate "tissue remodeling, angiogenesis and spiral artery modifications. (medscape.com)
  • In the periapical granuloma cases, mast cells were found in eight cases (50%), located in the granulation tissue. (bvsalud.org)
  • Mast cells were detected in both cysts and periapical granuloma, located in the capsule and granulation tissue, respectively. (bvsalud.org)
Allergies1