• 2 A smaller protein, derived from human fibroblasts, and identifiable from its amino acid sequence as a fragment of the SSP, has been found to bind to a hirudin-agarose affinity chromatography matrix. (bmj.com)
  • T he application of medicinal leeches was widely prac- been recommended for symptomatic treatment of osteoar- ticed in ancient times (1, 2), but their use declined rapidly in Europe and America with the advent of modernsurgery and pharmacology (3). (pdftreatment.com)
  • Leeches are still widely prescribed there - about 10 million every year - in many cases as a low-cost substitute for blood thinners like warfarin. (timesuniononline.com)
  • When the surgical procedure begins, leech therapy acts by letting leeches absorb the drainage of blood that appears as a result of the work of surgeons. (bestherbalhealth.com)
  • Leeches have been used for bloodletting, wound healing, and stimulating blood flow at postsurgical sites. (drugs.com)
  • Arterial insufficiency, previous exposure to leeches (risk of allergic reaction), immunosuppression (risk of infection), patient refusal to accept possible subsequent blood transfusions, and unstable medical conditions have been described as contraindications for extensive leech therapy. (drugs.com)
  • Pharyngobdella: These so-called worm-leeches consist of freshwater or amphibious leeches that have lost the ability to penetrate a host's tissue and suck blood. (wikipedia.org)
  • The more than 300,000 Americans, and 30,000 Canadians, who have their blood cleaned of toxins and metabolic waste, can thank leeches for the invention of this life-saving treatment. (blogspot.com)
  • Leeches are also used in Russia to treat glaucoma, prostatitis, high blood pressure and many more ailments. (timesuniononline.com)
  • Leeches are creeping back into Western medicine, and in the U.S., 6,000 leeches are used to remove excess blood from severed body parts that have been reattached. (timesuniononline.com)
  • Napoleon's military surgeon advocated using 30 to 50 leeches at a time, enough to draw up to 1½ quarts of blood. (timesuniononline.com)
  • The great advantage was that leeches could extract blood with very little pain and could be used on almost any part of the body. (timesuniononline.com)
  • Some doctors now use leeches to prevent the clotting of blood on some wounds following surgery or trauma. (wikipedia.org)
  • fulfilled the initial enrollment criteria were invited for fur-ther assessment by detailed physical examination, blood Other traditional uses of leeching, such as treating lo- analysis, and radiographs of the knee (first study visit, day calized inflammation and pain, are still part of many eth- Ϫ3). (pdftreatment.com)
  • Thanks to this process, the leeches are able to maintain the best liquidity of human blood and boost blood circulation in the area where they are used. (bestherbalhealth.com)
  • A scientific study conducted 5 years ago and revealed in the popular Alternative Medicine Review has shown that external leeching enhanced walking ability, eased pain and swelling and eliminated the discoloration in phlebitis patients (a health problem in which blood clotting occurs in the deep vein located on the legs). (bestherbalhealth.com)
  • Finally, leeches should be able to boost blood circulation after surgery. (bestherbalhealth.com)
  • 3 Given that hyperproliferation of synovial fibroblasts is believed to contribute to the formation of the destructive pannus that is characteristic of some arthritic joints, 5 the SSP and DING protein may act to promote this process, and hirudin may have the potential to retard it. (bmj.com)
  • The first DING protein isolates displayed proteolytic activity, and its inhibition was believed to be the basis of the action of hirudin, but subsequent DING preparations have had little or no proteolytic activity. (bmj.com)
  • A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught. (patentgenius.com)
  • 3. A method of making the immunogen according to claim 1, consisting essentially of polymerizing said monomers of hirudin under conditions such that a majority of polymers formed have at least 3 monomer units, said conditions including a molarexcess of cross-linking agent relative to said monomers, and an absence of carrier protein. (patentgenius.com)
  • The invention relates to a method of producing an antibody specific for a hirudinor a hirudin-like protein. (patentgenius.com)
  • Other substances produced by leeches include a vasodilator, hyaluronidase, and an anesthetic. (timesuniononline.com)
  • Besides hirudin, various anti- preceding 3 months, radiography was performed at day inflammatory substances and hyaluronidase have been Ϫ3. (pdftreatment.com)
  • Is hirudin a potential therapeutic agent for arthritis? (bmj.com)
  • 1 Although there was no evidence for any therapeutic outcomes, other than pain relief, the extended timescale suggests that one or more leech components may exert more than an anaesthetic or analgesic effect. (bmj.com)
  • It's been 12 years since the FDA (Food and Drug Administration) has approved the use of leeches for healing and prevention. (bestherbalhealth.com)
  • Hirudin might thus have value in treating arthritis. (bmj.com)
  • However in the 1960s, leech therapy found its way back and many doctors started using it during surgical procedures and in cases of arthritis, migraines and vascular diseases. (bestherbalhealth.com)
  • A scientific research revealed in the famous European Patent has shown that a synthetically-made hirudin injection has the ability to block the emergence of different tumor cells like those found in leukemia, lymphoma, sarcoma, pulmonary carcinoma, colorectal cancer and bladder cancer. (bestherbalhealth.com)
  • the Greek physician Galen (130 to 201 AD) commonly used leeches for bloodletting. (drugs.com)
  • Baseline measurements were done at visit 2 leech therapy, we designed this trial to assess the symptom- (day 0), when the participant was randomly assigned to atic short-term efficacy of leech therapy in osteoarthritis of either leech or topical diclofenac therapy and the allocated the knee. (pdftreatment.com)
  • True leeches of the infraclass Euhirudinea have both anterior and posterior suckers. (wikipedia.org)
  • 24 A meta-analysis of clinical studies (n=4) reported moderate to strong evidence for pain reduction, functional impairment, and joint stiffness following leech therapy. (drugs.com)
  • The specific value of leech therapy is related to the properties of its bite. (timesuniononline.com)
  • In ancient medical practice,phlebitis and thrombotic states were 2 main indications for leech therapy (4). (pdftreatment.com)
  • Leech therapy has been used as an efficient treatment for many diseases and disorders for hundreds of years now. (bestherbalhealth.com)
  • According to historical records, leech therapy was especially popular 3500 years ago. (bestherbalhealth.com)
  • We have made a short list of cases where leech therapy is applied today. (bestherbalhealth.com)
  • According to a huge number of physicians medicinal leech therapy is able to keep the tissues healthy during and after surgery. (bestherbalhealth.com)
  • The use of medicinal leeches (H. medicinalis) is preferred because of their ability to bite deeply and cause prolonged bleeding even after they are detached. (drugs.com)
  • The majority of people are worried about possible wounds that come in the form of letter Y caused by leech bite. (bestherbalhealth.com)
  • Haas performed the first human dialysis treatment in 1924 using this newly available purified hirudin. (blogspot.com)
  • In that country, a medicinal leech costs less than $1, and a typical treatment requires three to seven of these ravenous bloodsuckers. (timesuniononline.com)
  • By the early part of the 20th century, however, the use of leeches in medical treatment went into steep decline. (timesuniononline.com)
  • Ed.: The Chemistry and Physiology of Human Plasma, Pergamon Press, New York, pp. 151-182, 1979) and hence hirudin is able to induce the dissociation of thethrombin-platelet receptor complex (Tam S. W., Fenton J. W. and Detwiler T. C. (patentgenius.com)