EpilepsyLithium-pilocarpineProtects the HippocampusRatsSubstantia nigraAdministration of pilocarpineSeizureThalamusHippocampalIntraperitonealEpilepticusTemporalSeizuresAmygdalaCornu ammonisEpileptogenesisCortexDentateModelInhibitoryVivoThetaDifferencesCentral nervouExpressionLevelsModelsStudyActivityHumanChannel
Epilepsy15
- In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. (scielo.br)
- Since the hippocampus is one of main structures in the development of this experimental model of epilepsy, the dopamine levels in this region were also determined after drug administration. (scielo.br)
- In general terms, epileptic discharge, seizure-like behaviors in the chronic phase of Pilocarpine experimental model, sudden unexpected death in epilepsy and consequently epileptic seizures have been associated with an imbalance between excitation and inhibition in specific brain circuitries ( Bozzi and Borrelli, 2013 BOZZI, Y. and BORRELLI, E., 2013. (scielo.br)
- A rat model of epilepsy was constructed with an injection of pilocarpine. (frontiersin.org)
- in temporal lobe epilepsy (tle) with evidence of hippocampal sclerosis (tle-mts) volumetric gray (gm) and white (wm) matter abnormalities are not restricted to the hippocampus but also are found in extrahippocampal structures. (brain-knowledge-engine.org)
- Reorganization of CA3 area of the mouse hippocampus after pilocarpine induced temporal lobe epilepsy with special reference to the CA3-septum pathway. (brain-knowledge-engine.org)
- we used the mouse pilocarpine model of temporal lobe epilepsy (tle), and injected iontophoretically the anterograde tracer phaseolus vulgaris leucoagglutinin (pha-l) into gliotic ca3, medial septum and the nucleus of diagonal band of broca, median raphe, and lateral supramammillary nuclei, or the retrograde tracer cholera toxin b subunit (ctb) into gliotic ca3 area of hippocampus . (brain-knowledge-engine.org)
- our results suggest that complex mdr expression changes not only in the hippocampus but in the gph may play a role in aed pharmacoresistance in intractable epilepsy patients with mesial temporal lobe epilepsy (mtle) by altering the permeability of aeds across the blood-brain barrier (bbb). (brain-knowledge-engine.org)
- patch-clamp recordings of ca1 interneurons and pyramidal cells were performed in hippocampal slices from kainate- or pilocarpine-treated rat models of temporal lobe epilepsy . (brain-knowledge-engine.org)
- hippocampal dentate granule cells in temporal lobe epilepsy (tle) patients with mesial sclerosis (mtle) are reported to be hyperexcitable compared to those in patients with a mass lesion outside the hippocampus (matle) (williamson, clin neurosci 1994;2: 47-52). (brain-knowledge-engine.org)
- Spontaneous seizures involving the hippocampus and parahippocampal structures are the hallmark of temporal lobe epilepsy. (romj.org)
- The present study investigated the effects of naringenin in pilocarpine-induced epilepsy in mice. (phcog.com)
- Naringenin, one of the most frequently occurring flavanone in citrus fruits, was evaluated for its shielding effect against the pilocarpine induced behavioural, oxidative and histopathological alterations in rodent model of epilepsy. (phcog.com)
- Epilepsy was induced by giving pilocarpine (300mg/kg) and sodium valproate (300mg/kg) was given as standard anti-epileptic drug Pilocarpine was administered (300 mg /kg body weight) intraperitoneally to the mice on 15th day while naringenin was administered orally (20 and 40 mg/kg body weight) for 15 days prior to administration of pilocarpine. (phcog.com)
- A study done on rats suffering from epilepsy caused by high pilocarpine levels treated with electro-acupuncture resulted in a significant reduction of the epilepsy attacks of the rats. (globalholisticnetwork.com)
Lithium-pilocarpine3
- We have utilized lithium-pilocarpine model of SE in adult Wistar rats to assess the potential effect of licofelone on seizure susceptibility. (j-epilepsy.org)
- 2015 : Application du carisbamate comme agent neuroprotecteur et modificateur de l'épileptogénèse dans le modèle Lithium-Pilocarpine : évaluation de l'expression protéique et des altérations neurochimiques cérébrales. (marques-carneiro.fr)
- reporting from the laboratory of Dr. Gregory Holmes, display that rats housed within an enriched environment after lithium-pilocarpine position epilepticus (SE) performed considerably better in the Morris drinking water maze, a check of visual-spatial memory space, than do rats housed in regular cages. (antiviralbiologic.com)
Protects the Hippocampus2
- A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice. (bvsalud.org)
- We have drawn the conclusion that Baicalin protects the hippocampus from apoptosis. (f6publishing.com)
Rats9
- In the first experiment, 62% (15/24) of 6-OHDA pre-treated rats and 45% (11/24) of those receiving ascorbic acid as control solution progressed to motor limbic seizures evolving to SE, after the administration of pilocarpine. (scielo.br)
- Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. (scielo.br)
- Silencing of miRNA-146a significantly alleviated the neuronal damage and cell apoptosis in the CA1 and CA3 regions of the hippocampus in TLE rats and decreased MDA, IL-1β, IL-6, and IL-18 levels and increased SOD levels in the hippocampus of TLE rats. (engreen.com.cn)
- In addition, silencing of miRNA-146a significantly decreased the expression levels of caspase-9, GFAP, Notch-1, and Hes-1 in the hippocampus of TLE rats. (engreen.com.cn)
- Silencing of miRNA-146a alleviated the neuronal damage in the hippocampus of TLE rats by down-regulating Notch-1. (engreen.com.cn)
- Thus, this project aims to assess the contribution of RyRs to ictal activity during SE induced by pilocarpine in rats, combining electrophysiological records in vivo and pharmacological manipulation of RyRs. (fapesp.br)
- With this project, it is hoped to elucidate the participation of RyRs in epileptiform activity in the hippocampus of rats, as a subsidy for future therapeutic interventions. (fapesp.br)
- In this study the temporal dynamics of directional interactions between the frontal cortex, hippocampus, thalamus and midbrain during limbic seizures are analyzed in rats. (romj.org)
- The level of declined Tug1 was decreased in the hippocampus of SE rats. (biomedcentral.com)
Substantia nigra1
- Neuropathological analysis, performed 5-7 days after SE, has shown a high degree of cell loss predominantly in the piriform cortex, amygdala, hippocampus, thalamus and substantia nigra. (unifesp.br)
Administration of pilocarpine1
- The intraperitoneal administration of pilocarpine enhanced lipid peroxidation, caused reduction in antioxidant enzymes, viz. (phcog.com)
Seizure5
- We will also inject KA, NMDA or AMPA into the hippocampus and record EEG activity to elucidate differences in seizure onset, frequency and duration in the presence of increased glutamate uptake (Specific Aim 1). (grantome.com)
- To determine if the effects of increased glutamate transporter expression are generalized or limited to convulsants acting directly through a glutamate receptor pathway, we will use pilocarpine, that acts through muscarinic receptors, to generate seizure activity in vivo and in an in vitro hippocampal slice preparation to compare wild-type to EAAT2 transgenic responses (Specific Aim 2). (grantome.com)
- After the seizure onset, coupling restored to normal levels in the midbrain - hippocampus pair, but remained reduced in all other studied channel pairs for at least 10 s after the onset. (romj.org)
- In the pilocarpine rat model for epileptogenesis CB agonists reduce early post-status epilepticus seizure manifestations and subsequent mortality [7]. (romj.org)
- Here, we report that spatial memory was altered soon after pilocarpine-induced status epilepticus, i.e., already during the seizure-free, latent period. (univ-amu.fr)
Thalamus1
- The present study was aimed to analyze directional functional coupling between the neocortex, hippocampus, thalamus and midbrain during ictal period of SLV326-induced limbic seizures. (romj.org)
Hippocampal3
- Interstrain differences of ionotropic glutamate receptor subunits in the hippocampus and induction of hippocampal sclerosis with pilocarpine in mice. (u-szeged.hu)
- Findings: We all demonstrated that dependable recognition associated with differentially depicted transcripts inside undissected user interface place with the parasite-host organization is feasible and also helpful when it comes to differential-expression patterns.Pilocarpine-induced epileptic point out (Position epilepticus) creates a good aberrant growing LGK-974 supplier regarding hippocampal mossy fibers, which usually affect the intrahippocampal build. (hsp70inhibitor.com)
- We conclude that the reorganization of hippocampal circuitry that immediately follows the initial insult can affect theta oscillation mechanisms, in turn, resulting in deficits in hippocampus-dependent memory tasks. (univ-amu.fr)
Intraperitoneal2
- A rat model of TLE was established by intraperitoneal injection of lithium chloride-pilocarpine. (engreen.com.cn)
- The SE rat model was established via intraperitoneal injection of lithium chloride-pilocarpine. (biomedcentral.com)
Epilepticus9
- Susceptibility to pilocarpine-induced status epilepticus (SE), as well as spontaneous and recurrent seizures (SRSs) frequency during the chronic period of the model were determined. (scielo.br)
- Under both control conditions and after pilocarpine-induced status epilepticus (SE), ERK/MAPK activation was repressed in STEP-immunoreactive hilar neurons. (jneurosci.org)
- Trichosanthes tricuspidata modulates oxidative toxicity in brain hippocampus against pilocarpine induced status epilepticus in mice. (imedpub.com)
- This study established the rat model of status epilepticus by intraperitoneally injecting LiCl-pilocarpine. (f6publishing.com)
- Yang B, Wen HY, Liang RS, Lu TM, Zhu ZY, Wang CH. Hippocampus protection from apoptosis by Baicalin in a LiCl-pilocarpine-induced rat status epilepticus model through autophagy activation. (f6publishing.com)
- Since its original description over 10 years ago, the pilocarpine model of status epilepticus (SE) has gained considerable attention. (unifesp.br)
- Animals injected with three specific dose combinations (pilocarpine dose/picrotoxin dose), 150/0.5, 75/1.5 and 50/2.0 mg/kg, evoked status epilepticus (SE) within 23, 31 and 27 min, respectively. (unifesp.br)
- To test this central hypothesis, we will use three models of status epilepticus (KA, pilocarpine and kindling). (grantome.com)
- En casos muy graves de epilepsia, se puede producir una enfermedad conocida como status epilepticus o estado epiléptico. (cannabismedicinal.cl)
Temporal2
- En 2008, un estudio publicado en la revista Nature indicó que los pacientes que sufren epilepsia del lóbulo temporal parecían tener sistemas endocannabinoides disfuncionales . (cannabismedicinal.cl)
- Como su propio nombre indica, la epilepsia del lóbulo temporal afecta al lóbulo temporal del cerebro, y por lo general produce crisis sin convulsiones que implican algún grado de perturbación sensorial (visual, auditiva, olfativa o gustativa incluso), aunque también puede producir convulsiones tónico-clónicas en los casos graves. (cannabismedicinal.cl)
Seizures1
- Endocanabinoid CB1 receptors [11, 12] play the critical role in the endocannabinoid-dependent protection against seizures, and local deletion of these receptors in the hippocampus strongly exacerbates seizures [13]. (romj.org)
Amygdala1
- Ictal events and EEG spikes were initially observed either in the amygdala or in the hippocampus, with a later spread to cerebral cortex. (unifesp.br)
Cornu ammonis2
- Then, neuronal damage and cell apoptosis in the cornu ammonis (CA) 1 and 3 regions of the hippocampus were assessed. (engreen.com.cn)
- Finally, the brains were removed to study the cell number in the cornu ammonis (CA1) hippocampus by light microscope, Bcl-2 by immunoblotting, and Bax manifestation by reverse transcription polymerase chain reaction (RT-PCR). (technuc.com)
Epileptogenesis1
- Using the rat pilocarpine model of TLE, we performed a longitudinal study to assess spatial and nonspatial cognitive performance during epileptogenesis. (univ-amu.fr)
Cortex1
- 5-HT 2A/2C receptor appears to be widely expressed in cortex and hippocampus which regulates central nervous system excitability. (j-epilepsy.org)
Dentate2
- Morphology of dentate granule cells in the human epileptogenic hippocampus. (brain-knowledge-engine.org)
- In recent years, a large body of research has focused on the beneficial impact of enriched environment on behavioral measures such as memory during senescence and after stroke or trauma, as well as on more fundamental phenomena such as long-term potentiation in the hippocampus and neurogenesis in the dentate gyrus. (antiviralbiologic.com)
Model1
- A rat model of TLE was successfully established, which exhibited significantly increased miRNA-146a expression in the hippocampus. (engreen.com.cn)
Inhibitory1
- It likewise lowers the excitatory neurotransmitter levels in the hippocampus and enhances inhibitory chemicals levels. (globalholisticnetwork.com)
Vivo1
- During pilocarpine-induced SE, in vivo disruption of STEP activity allowed activation of the MAPK pathway, leading to immediate-early gene expression and significant rescue from cell death. (jneurosci.org)
Theta1
- Lopez-Madrona VJ, Pérez-Montoyo E, Álvarez-Salvado E, Moratal D, Herreras O, Pereda E, Mirasso CR, Canals S ( 2020 ) Different theta frameworks coexist in the hippocampus and are coordinated during memory-guided exploration and novelty detection. (multichannelsystems.com)
Differences1
- In rat hippocampus and cerebellum there were neither differences in dystrophin positive cell types, nor in the regional dystrophin distribution between AK and control animals. (frontiersin.org)
Central nervou1
- In addition to its role in muscle tissue, it functions as an anchoring protein within the central nervous system such as in hippocampus and cerebellum. (frontiersin.org)
Expression2
- Then, we evaluated the expression levels of caspase-9, GFAP, Notch-1, and Hes-1 in the hippocampus. (engreen.com.cn)
- The expression of the lncRNA Tug1 in rat hippocampus and cultured microglia was confirmed by RT-PCR. (biomedcentral.com)
Levels1
- SOD and MDA levels in the hippocampus were detected by chromatometry, and IL-1β, IL-6, and IL-18 levels were detected by ELISA. (engreen.com.cn)
Models1
- The glutamate receptor agonist kainic acid [21] and the cholinergic agonist pilocarpine [22] are commonly used in SE models. (jle.com)
Study1
- the present study reveals a proconvulsant role for picrotoxin when co-administered with subconvulsant doses of pilocarpine. (unifesp.br)
Activity1
- Single injections of 150 mg/kg of pilocarpine or 3 mg/kg of picrotoxin did not evoke any form of sustained epileptic activity. (unifesp.br)
Human2
- Regional and cellular dystrophin distribution was evaluated in both human and rat hippocampi and in rat cerebellar tissue by immunofluorescent colocalization with neuronal (NeuN and calbindin) and glial (GFAP) markers. (frontiersin.org)
- Dystrophin is ubiquitously expressed by astrocytes in the human and rat hippocampus and in the rat cerebellum. (frontiersin.org)
Channel1
- Thus, we have decided to evaluate potential contributions of picrotoxin, a GABA, channel blocker, on pilocarpine-induced SE. (unifesp.br)