Hippocampal synaptic plasticity plasticity dendritic field excitatory postsynaptic potentials. Medical search. Frequent questions

To prevent neurons from becoming static, there are two regulatory forms of plasticity that provide negative feedback: metaplasticity and scaling. (wikipedia.org)
The weakening of a synapse is independent of the activity of the presynaptic or postsynaptic neurons as a result of the firing of a distinct modulatory interneuron. (wikipedia.org)
Amaral DG, Ishizuka N, Claiborne B (1990) Neurons, numbers and the hippocampal network. (yale.edu)
Andrasfalvy BK, Magee JC (2001) Distance-dependent increase in AMPA receptor number in the dendrites of adult hippocampal CA1 pyramidal neurons. (yale.edu)
Bekkers JM, Stevens CF (1996) Cable properties of cultured hippocampal neurons determined from sucrose-evoked miniature EPSCs. (yale.edu)
His work in the fields of Dendritic spine, such as Dendritic filopodia, overlaps with other areas such as Actin remodeling of neurons. (research.com)
In general Dendritic spine, his work in Dendritic filopodia is often linked to Actin remodeling of neurons, Actin remodeling and Plasma membrane Ca2+ ATPase linking many areas of study. (research.com)
His study in the fields of Axon, Cortical neurons and Phosphorylation under the domain of Cell biology overlaps with other disciplines such as Ubiquitin and Structured illumination microscopy. (research.com)
Here, we present our analysis of p35 conditional KO mice (p35cKO) in hippocampal pyramidal neurons or forebrain GABAergic neurons using electrophysiological and behavioral methods. (biomedcentral.com)
These results indicated that Cdk5/p35 in excitatory neurons is important for the hippocampal synaptic plasticity and associative memory retention. (biomedcentral.com)
CreER-p35cKO mice show reduced dendritic spine density in CA1 pyramidal neurons and impaired LTD induction in the hippocampus with impairment in spatial learning and memory and reduced anxiety-like behavior [ 11 ]. (biomedcentral.com)
Since these mice had p35 deletion in all cells, it was impossible to separate and analyze its functions in excitatory and inhibitory neurons. (biomedcentral.com)
In the present study, we created mice in which the p35 gene was deleted in hippocampal excitatory neurons (CaMKII-Cre p35cKO) or GABAergic inhibitory neurons (Dlx-Cre p35cKO). (biomedcentral.com)
Using behavioral and electrophysiological analyses, we investigate whether the p35/Cdk5 activity is involved in associative memory learning in excitatory or inhibitory neurons. (biomedcentral.com)
The expression and translocation of cyclinD1-CDK4 in post-mitotic neurons indicate that they may have supplementary functions in differentiated neurons that might be associated with neuronal plasticity. (biomedcentral.com)
The present results suggest that the expression of cell cycle-related markers may have supplementary functions in differentiated neurons that might be associated with neuronal plasticity. (biomedcentral.com)
Consequently, the intrinsic properties and pairwise interactions of their constituent neurons can be characterized, including analyses of their communication via gap junctions, action potential-gated synapses or graded synapses. (degruyter.com)
The Canadian psychologist Donald Hebb (1949 ) is credited with inventing the concept, which was based on appealing - but speculative - ideas of how excitatory neurons ought to be synaptically interconnected, ought to have their interconnections modified, and ought to function together. (degruyter.com)
Using these antibodies, in conjunction with GluR2-specific and synaptophysin antibodies, we have directly localized and quantified surface-expressed native AMPA and NMDA receptors on cultured living hippocampal neurons during development. (jneurosci.org)
Immunocytochemical analysis of hippocampal neurons between 3 and 20 d in vitro shows no change in the proportion of synapses expressing NMDA receptors (∼60%) but a dramatic increase (∼50%) in the proportion of them that also express AMPA receptors. (jneurosci.org)
Both BDNF and TrkB are present in presynaptic axon terminals and postsynaptic dendritic compartments of neurons, and they are capable of bidirectional release and activity [for review, see Tyler et al. (hyperthermicwellness.com)
The connectivity of axons emanating from one set of cells to post-synaptic side of synapse on the dendrites of the receiving cells must be intact for effective communication between neurons. (aopwiki.org)
Börgers C, Kopell N (2005) Effects of noisy drive on rhythms in networks of excitatory and inhibitory neurons. (yale.edu)
We introduce a novel approach to study neurons as sophisticated I/O information processing units by utilizing recent advances in the field of machine learning. (biorxiv.org)
With the recent development of sophisticated genetical, optical and electrical techniques it has become clear that many key neuron types (e.g., cortical and hippocampal pyramidal neurons, cerebellar Purkinje cells) are highly complicated I/O information processing devices. (biorxiv.org)
As a result of local nonlinear dendritic processing, a train of output spikes are generated in the neuron axon, carrying information that is communicated, via synapses, to thousands of other (postsynaptic) neurons. (biorxiv.org)
However, the basic function of the perceptron, a linear summation of its inputs and thresholding for output generation, highly oversimplifies the synaptic integration processes taking place in real neurons. (biorxiv.org)
neither does it changes dendrites morphology of primary cultured hippocampal neurons. (biomedcentral.com)
Following a fusion event, neurons must replenish their vesicle stocks to ensure that they are ready for the arrival of the next action potential. (elifesciences.org)
Additionally, we reproduced in silico the obtained experimental results with a novel spiking neurons network model of mouse V1, by implementing in the model both the synaptic alterations characterizing the FHM1 genetic mouse model adopted. (biomedcentral.com)
FHM1 has a differential effect on short-term depression (STD) at TC synapses: compared to wild type (WT) mice, STD is greater at synapses contacting layer IV (L4) excitatory neurons while it is unaltered at synapses contacting L4 inhibitory neurons. (biomedcentral.com)
As a result, during repetitive thalamic firing, the gain-of-function of TC excitatory inputs on inhibitory neurons becomes larger than that on excitatory neurons and the I/E balance is relatively skewed towards inhibition in FHM1 L4 excitatory neurons [ 16 ]. (biomedcentral.com)
Using subcellular channelrhodopsin-2-assisted circuit mapping in mouse visual cortex, we compared feedforward (FF) or feedback (FB) cortico-cortical (CC) synaptic input to cells projecting back to the input source (looped neurons) with cells projecting to a different cortical or subcortical area. (elifesciences.org)
Our results reveal that CC connections are selectively wired to form monosynaptic excitatory loops and support a differential role of supragranular and infragranular neurons in hierarchical recurrent computations. (elifesciences.org)
One possibility is that CC inputs specifically modulate neurons projecting back to the source of those inputs (looped neurons) indirectly via intermediary inhibitory or excitatory cells in the local circuit. (elifesciences.org)
Another possibility, not mutually exclusive to the previous one, is that CC projections selectively synapse onto looped neurons directly to form interareal monosynaptic loops, which would be excitatory since most long-range cortical afferents are glutamatergic. (elifesciences.org)
Thus, long-range CC projections could selectively participate in excitatory monosynaptic loops by preferentially contacting looped IT neurons, while avoiding neighboring non-looped IT, PT, and CT neurons. (elifesciences.org)
K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. (modeldb.science)
1998). Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. (modeldb.science)
Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. (modeldb.science)

As the opposing process to long-term potentiation (LTP), LTD is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. (wikipedia.org)
Thus, this form of LTD impacts synapses nearby those receiving action potentials. (wikipedia.org)
LTD affects hippocampal synapses between the Schaffer collaterals and the CA1 pyramidal cells. (wikipedia.org)
However, relatively little is known about the synaptic mechanisms responsible for activating these interneurons in addition to the specialized dendrodendritic synapses located on distal dendrites. (jneurosci.org)
Using two-photon guided minimal stimulation in acute rat brain slices, we found that distal and proximal excitatory synapses onto granule cells are functionally distinct. (jneurosci.org)
Most excitatory synapses we examined onto granule cells activated both NMDARs and AMPA receptors, whereas a subpopulation appeared to be NMDAR silent. (jneurosci.org)
A , Schematic diagram of excitatory synapses onto granule cells. (jneurosci.org)
Baker JL, Perez-Rosello T, Migliore M, Barrionuevo G, Ascoli GA (2011) A computer model of unitary responses from associational/commissural and perforant path synapses in hippocampal CA3 pyramidal cells. (yale.edu)
The axon is responsible for integrating synaptic signals, generating action potentials (APs), propagating those APs to downstream synapses and converting them into patterns of neurotransmitter vesicle release. (frontiersin.org)
These changes will dramatically alter the functional properties of hippocampal synapses. (jneurosci.org)
Dentate gyrus (DG) granule cells carrying homozygous mutation of L100P exhibit decreased synaptic excitation and intact synaptic inhibition, meanwhile Schaffer collateral-CA1 synapses of L100P mice display impaired synaptic plasticity. (biomedcentral.com)
The FHM1 mouse model is consequently characterized by increased neurotransmission at both intra-cortical [ 15 ] and thalamocortical (TC) excitatory synapses [ 16 ]. (biomedcentral.com)
TSP binds to α2δ‐1 to drive the formation of excitatory synapses during development, suggesting that overactivation of this pathway may lead to exuberant excitatory synaptogenesis and network hyperexcitability seen in DCMs. (eneuro.org)
signalling at excitatory forebrain synapses Glutamatergic synapses are situated on dendritic propionate (AMPA) receptor subunit levels (NR1, NR2A, spines containing postsynaptic densities (PSDs), which NR2B, GluR1 and GluR2) were analysed in the forebrain by allow glutamate receptors to anchor through interactions both western blot of homogenates and immunohistochemis- with scaffolding proteins. (health-articles.net)
A number of different kinds of interneurons make inhibitory GABAergic synapses at different levels in the dendritic trees. (modeldb.science)
2001). Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. (modeldb.science)

Long-term potentiation (LTP) and long-term depression (LTD) are considered as the most important forms of synaptic plasticity involved in learning and memory. (gu.se)
Both LTD and LTP are forms of synaptic plasticity. (wikipedia.org)
non-linear excitation and inhibition properties and multiple forms of synaptic plasticity that cooperate to generate the computational schemes that process incoming signals and generate the cerebellar output. (frontiersin.org)

The experiments were performed in hippocampal slices, 400 m thick, from 12 to 20 days old Sprague-Dawley rats. (gu.se)
2. Dozmorov M, Li R, Abbas A-K, Hellberg F, Farre C, Huang F-S, Jilderos B and Wigström H, Contribution of AMPA and NMDA receptors to early and late phases of LTP in hippocampal slices. (gu.se)
Colquhoun D, Jonas P, Sakmann B (1992) Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. (yale.edu)
Furthermore, NMDAR-dependent long-term depression (LTD) induction by low-frequency stimuli in hippocampal slices from CamkII-p35cKO mice was impaired compared to that in control mice. (biomedcentral.com)
In contrast, Dlx-p35cKO mice showed no abnormalities in behavioral tasks and electrophysiological analysis in their hippocampal slices. (biomedcentral.com)
Ca 2+ image analysis reveals suppression of glutamate-evoked elevation of cytoplasmic [Ca 2+ ] in L100P hippocampal slices. (biomedcentral.com)
L100P mutant slices exhibit decreased excitatory synaptic transmission (sEPSCs and mEPSCs) in dentate gyrus (DG) and impaired long-term potentiation in the CA1 region of the hippocampus. (biomedcentral.com)

Scaling has been found to occur when the strength of all of a neuron's excitatory inputs are scaled up or down. (wikipedia.org)
The convergence of two types of excitatory inputs onto GABAergic granule cells provides a novel mechanism for regulating the degree of interglomerular processing of sensory input in the olfactory bulb through piriform cortex/olfactory bulb synaptic interactions. (jneurosci.org)
Although the dendritic arborization of granule cells is relatively small (50-200 μm) ( Shepherd and Greer, 1998 ), a single granule cell may receive synaptic inputs from mitral cells several millimeters away ( Shepherd and Greer, 1998 ), providing a theoretical basis for massive synaptic divergence. (jneurosci.org)
These findings raise the possibility that the pattern of interneuronal activation, and thus lateral inhibition onto principal cells, is not regulated predominately by dendrodendritic synaptic inputs but instead may reflect the temporal coincidence of several types of synaptic inputs to granule cells. (jneurosci.org)
These results suggest that the proximal excitatory inputs to granule cells may play an important role in gating recurrent and lateral dendrodendritic inhibition (DDI) in the olfactory bulb. (jneurosci.org)
Local neuronal microcircuits play a key role in brain computation by processing synaptic inputs and integrating incoming information to elaborate the neuronal discharges relayed to other brain areas. (frontiersin.org)

In other words, this form of LTD is activity-dependent, because the events causing the synaptic weakening occur at the same synapse that is being activated. (wikipedia.org)
Richard J. Weinberg focuses on Neuroscience, Cell biology, Postsynaptic density, Dendritic spine and Synapse. (research.com)
Neuroscience, Synapse, Dendritic spine, Cell biology and Synaptic plasticity are his primary areas of study. (research.com)
The arrival of an electrical signal called an action potential at the first neuron triggers the release of chemicals called neurotransmitters into the synapse. (elifesciences.org)
Here, we used mice with a genetic deletion of α2δ‐1 to determine how α2δ‐1 contributes to cell death, elevated excitatory synapse number, and in vitro network function after FL and to examine the molecular specificity of GBP's effects. (eneuro.org)
We also find that GBP can reduce FL-induced increases in excitatory synapse number in α2δ-1 knock-out (KO) mice, indicating GBP has α2δ-1-independent anti-synaptogenic effects. (eneuro.org)
The molecular mechanisms that underpin synapse formation and plasticity. (edu.au)

Debanne D, Gähwiler BH, Thompson SM (1998) Long-term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice cultures. (yale.edu)

and tried to elucidate the possible mechanisms underlying NMDA-induced plasticity. (gu.se)
3. Li R, Abbas A-K, Huang F-S and Wigström H, Possible involved mechanisms of NMDA-induced synaptic plasticity. (gu.se)
However, it is likely that other plasticity mechanisms play a role as well. (wikipedia.org)
We then examine how these mechanisms could modulate synaptic function by focusing on three key features of synaptic information transmission: synaptic strength, synaptic variability, and short-term plasticity. (frontiersin.org)
In this study, we further analyzed the cognitive and affective behaviors of L100P homozygotes and their WT littermates, and explored the underlying synaptic mechanisms as well. (biomedcentral.com)
The review focuses on discussing the neuroplastic mechanisms of those brain stimulation techniques in stroke rehabilitation, also including some new options for neuromodulation which have great potential in stroke rehabilitation, such as optogenetic stimulation and environmental stimulation. (bnmjournal.com)
However, the potential mechanisms underlying the relationships among depression, APOE genotype, and mild cognitive impairment remain largely unknown. (biomedcentral.com)

Our results indicated that the activation of cyclinD1-CDK4 is required for short-term synaptic plasticity and mGluR-dependent LTD, and suggested that this cyclin-dependent kinase may have different roles during the postnatal development in mice hippocampus area CA1. (biomedcentral.com)
For example, the replenishment of synaptic vesicles (SV) in the readily releasable pool (RRP), which can be exhausted during high frequency stimulation (HFS), plays a critical role in determining the rate and degree of short-term synaptic depression ( Wang and Kaczmarek, 1998 ). (elifesciences.org)

As a part of the same scientific family, Richard J. Weinberg mostly works in the field of Excitatory postsynaptic potential, focusing on Neurotransmission and, on occasion, Glutamatergic. (research.com)
In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-function associated with a monogenic form of migraine (familial-hemiplegic-migraine-type-1: FHM1). (biomedcentral.com)

These modulatory events dramatically affect how synaptic information is integrated to generate patters of action potentials (APs) as well as how those APs are transformed into transmitter release at axon terminals ( Figure 1A ). (frontiersin.org)

Notably, NR2A subunits play an essential role in all types of synaptic plasticity examined in this study whereas NR2B also contribute under certain circumstances. (gu.se)

Do VH, Martinez CO, Martinez JL, Derrick BE (2002) Long-term potentiation in direct perforant path projections to the hippocampal CA3 region in vivo. (yale.edu)
His Synaptic plasticity research is multidisciplinary, incorporating elements of Long-term potentiation, Perineuronal net, Hippocampus and Forebrain. (research.com)
Channel gating kinetics and synaptic efficacy: a hypothesis for expression of long-term potentiation. (escholarship.org)

Alexa 594-filled stimulating electrode positioned ∼20 μm from imaged dendritic region) reliably triggered Ca accumulations in two of the three imaged spines (sp1 and sp2) but not in the dendritic shaft segment. (jneurosci.org)
Bloodgood BL, Sabatini BL (2007) Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. (yale.edu)
opment of dendritic spines begins with the formation of branes, we found increases of NR2A and GluR2 but not filopodia. (health-articles.net)
The latter represent were co-immunoprecipitated from postsynaptic densities the most mature and stable spines. (health-articles.net)

His Dendritic spine study integrates concerns from other disciplines, such as Cerebral cortex, Striatum and Biological neural network. (research.com)
In the hippocampus, the involvement of BDNF in neural plasticity and neurogenesis is important to learning and memory, but less is known about how BDNF participates in energy homeostasis. (hyperthermicwellness.com)
We review current research about BDNF in specific brain locations related to energy balance, environmental, and behavioral influences on BDNF expression and the possibility that BDNF may influence energy homeostasis via its role in neurogenesis and neural plasticity. (hyperthermicwellness.com)
Here, we review what is known about cerebellar network organization, neural dynamics and synaptic plasticity and point out what is still missing and would require experimental assessments. (frontiersin.org)
The establishment of neural circuits depends on the ability of axonal growth cones to sense their surrounding environment en route to their target. (biologists.com)
Future directions include the clarification of the pathways of synaptic plasticity in the whole brain network following neuromodulation after stroke, and investigation of the different roles of distinctive cell populations in neural plasticity enhancement. (bnmjournal.com)
The recent observation of neural power-law scaling relations has made a significant impact in the field of deep learning. (uni-frankfurt.de)
Markram's research has focused on synaptic plasticity and the microcircuitry of the neocortex, in which he has discovered fundamental principles governing synaptic plasticity and the structural and functional organization of neural microcircuitry. (epfl.ch)

L-glutamate acts on the N-methyl-D- aspartate receptors (NMDARs), α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs), kainate receptors (KARs), and metabotropic glutamate receptors (mGluRs) during LTD. It can result from strong synaptic stimulation (as occurs in the cerebellar Purkinje cells) or from persistent weak synaptic stimulation (as in the hippocampus). (wikipedia.org)
Hippocampal/cortical LTD can be dependent on NMDA receptors, metabotropic glutamate receptors (mGluR), or endocannabinoids. (wikipedia.org)
AMPA and NMDA receptors mediate most excitatory synaptic transmission in the CNS. (jneurosci.org)
Ionotropic glutamate receptors (iGluRs) are the principal excitatory neurotransmitter receptors in the CNS. (jneurosci.org)
One possible mechanism to explain this observation is that a pool of pre-assembled AMPA receptors can be moved from an intracellular compartment to the postsynaptic membrane. (jneurosci.org)
Positive allosteric modulators of α-amino-3-hydroxyl-5-methyl-4-isoxazole- propionate (AMPA)-type glutamate receptors ("ampakines" and functionally related compounds) constitute a relatively new class of psychoactive drugs that enhance fast, excitatory transmission in the brain. (escholarship.org)
Here we used two-electrode voltage clamp electrophysiology to compare the actions of CBD with those of the major central endocannabinoid, 2-arachidonoyl glycerol (2-AG) on human recombinant GABAA receptors (synaptic α1-6βg2 and extrasynaptic α4β2δ) expressed on Xenopus oocytes. (researchgate.net)
Several reports have shown modulation of Cys-loop receptors by phytocannabinoids and endocannabinoids independent of cannabinoid receptors with potential physiological or therapeutic consequences. (researchgate.net)

In the olfactory bulb (OB), locally generated inhibitory synaptic interactions play a central role in shaping mitral and tufted cell responses to sensory stimuli ( Hamilton and Kauer, 1985 , 1989 ). (jneurosci.org)

His study in Cell biology is interdisciplinary in nature, drawing from both NMDA receptor, AMPA receptor, Biochemistry and Hippocampal formation. (research.com)
His work carried out in the field of Neuroscience brings together such families of science as Glutamate receptor, AMPA receptor and Synaptic plasticity. (research.com)

Homosynaptic LTD is also associative in that it correlates the activation of the postsynaptic neuron with the firing of the presynaptic neuron. (wikipedia.org)

The timing of Met expression is linked to axon terminal outgrowth and synaptogenesis in the developing rodent and primate forebrain, and both in vitro and in vivo studies implicate this RTK in dendritic branching, spine maturation, and excitatory connectivity in the neocortex. (biomedcentral.com)
A paper recently published by eLife on forebrain cortical synaptic plasticity reports that retinoic acid (RA) alters synaptopodin-dependent metaplasticity in mouse dentate granule cells (Lenz et al. (preprints.org)

Few cerebellar studies have examined changes in synaptic organization and function, although it has been recognized that synaptopathies play a central role in developmental brain disorders, including autism 19 . (nature.com)
Overall, we provide pioneer observations from a faithful A-T mouse model, which suggest general changes in synaptic and dense-core vesicle stress adaptation. (preprints.org)

Clinical studies have shown that cortical and hippocampal hyperactivity are a feature shared by patients in the early stages of disease, progressing to hypoactivity during later stages of neurodegeneration. (nature.com)

Berzhanskaya J, Urban NN, Barrionuevo G (1998) Electrophysiological and pharmacological characterization of the direct perforant path input to hippocampal area CA3. (yale.edu)

While examining BDNF and neuronal plasticity in vivo, Lapchak et al. (hyperthermicwellness.com)

Erreger K, Dravid SM, Banke TG, Wyllie DJ, Traynelis SF (2005) Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. (yale.edu)

In this study, we initiated to investigate the potential functions of cyclinD1-CDK4 in neuronal plasticity during the postnatal development in mice hippocampus area CA1. (biomedcentral.com)

In contrast to the axonal origin of voltage-sensitive dye signals, hVOS signals represent predominantly post-synaptic responses. (stanford.edu)

All of them are present in the hippocampus, where they participate in the regulation of synaptic functionality and gene transcription [ 12 - 14 ]. (biomedcentral.com)

As altered responsivity to visual stimuli and abnormal processing of visual sensory information are common hallmarks of migraine, herein we investigated the effects of FHM1-driven synaptic alterations in the visual cortex of awake mice. (biomedcentral.com)

The traditional way to induce LTP and LTD is by electric stimulation leading to activation of NMDA-R. Later research also revealed a form of NMDA-dependent plasticity induced by direct application of NMDA. (gu.se)
Our results demonstrate that NMDA applied on brain tissue induces multiple synaptic plasticity. (gu.se)
4. Li R, Huang F-S, Abbas A-K and Wigström H, Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. (gu.se)
NMDA-receptor dependent LTD is induced by moderate rises in postsynaptic calcium levels. (wikipedia.org)
This complexity primarily arises from local NMDA-based nonlinear dendritic conductances. (biorxiv.org)

These techniques allow now to record the activity of several cells simultaneously, monitoring their interactions and evaluating excitation-inhibition integration and synaptic plasticity. (frontiersin.org)

These findings point to deficits in synaptic plasticity and pruning as potential causes for motor problems and abnormal circuit development in autism. (nature.com)
To examine which cerebellar synaptic alterations might contribute to motor deficits in autism, we studied cerebellar synaptic function and plasticity as well as motor coordination and learning in a mouse model for the human 15q11-13 duplication. (nature.com)
Whereas our understanding of its pathophysiology is limited, postmortem studies suggest that schizophrenia is associated with deficits of GABA-mediated synaptic transmission. (hindawi.com)
Interestingly, a number of findings from postmortem brain studies suggest that schizophrenia is associated with deficits of GABA-mediated synaptic transmission [ 6 ]. (hindawi.com)
Our findings suggest that the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice. (biomedcentral.com)

LTD is thought to result mainly from a decrease in postsynaptic receptor density, although a decrease in presynaptic neurotransmitter release may also play a role. (wikipedia.org)

At this location, synaptic currents are converted from a graded voltage signal into a train of APs. (frontiersin.org)

Taken together, these findings revealed the E/I synaptic abnormalities in the amygdala from two generations of the VPA-induced offspring with GABAergic deteriorations in the F2 generation, suggesting a potential therapeutic role of the GABAergic system to generational pathophysiology of ASD. (biomedcentral.com)

Extracellular recording was used to study field excitatory postsynaptic potential (EPSPs) in the CA1 apical dendritic layer. (gu.se)
Depressed excitatory postsynaptic potentials (EPSPs) result from this particular stimulation pattern. (wikipedia.org)

Chen N, Ren J, Raymond LA, Murphy TH (2001) Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation. (yale.edu)
to protein complexes, downstream signalling, receptor traf-ficking and synaptic targeting Glutamate receptor availability de- *Corresponding author. (health-articles.net)

We recorded extracellular field potentials from the primary visual cortex (V1) of head-fixed awake FHM1 knock-in ( n = 12) and wild type ( n = 12) mice in response to square-wave gratings with different visual contrasts. (biomedcentral.com)

Changes in the placement of cells within the network due to delays in neuronal migration, the absence of a full formation of dendritic arbors and spine upon which synaptic contacts are made, and the lagging of transmission of electrical impulses due to insufficient myelination will individually and cumulatively impair synaptic function. (aopwiki.org)

Richard J. Weinberg mainly investigates Cell biology, Postsynaptic density, Neuroscience, Postsynaptic potential and Excitatory postsynaptic potential. (research.com)
Richard J. Weinberg mostly deals with Neuroscience, Cell biology, Inhibitory postsynaptic potential, Nerve net and Synaptic plasticity. (research.com)

Since synaptogenesis follows the early neurodevelopmental processes such as neuronal and glial cells proliferation, migration, alterations in dendritic arborisation etc., therefore, it encompasses, possible changes in these early stages of brain development that could also be triggered under hypothyroidism, leading to defective synaptogenesis and resulting in abnormal function of neuronal network function. (aopwiki.org)
Here we report alterations in motor behaviour and cerebellar synaptic plasticity in a mouse model (patDp/+) for the human 15q11-13 duplication, one of the most frequently observed genetic aberrations in autism. (nature.com)

Beaumont V, Zucker RS (2000) Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels. (yale.edu)

Amaral DG, Witter MP (1989) The three-dimensional organization of the hippocampal formation: a review of anatomical data. (yale.edu)
Potential for tissue repair in multiple sclerosis Jack Antel Neuroimmunology Unit, Montreal Neurologic Institute, McGill University Demyelination with inflammation is the hallmark of acute lesions underlying relapses in MS. Clinical recovery reflects resolution of inflammation, axonal re-organization, and remyelination. (docksci.com)
Here we demonstrate that this can be achieved by a well-established model of cortical self-organization based on a well-orchestrated interplay between several plasticity processes. (preprints.org)

Increases in rate constants produced two other aspects of LTP: (i) an alteration of the waveform of the synaptic response and (ii) an interaction with changes in desensitization kinetics. (escholarship.org)

α2δ-1 signaling drives apoptotic cell death, anatomic reorganization, excitatory synaptogenesis, astrocytosis, and network hyperexcitability in a model of insult-induced cortical malformation known as freeze lesion (FL). (eneuro.org)

Recent advancements of neuromodulation techniques emerge as promising tools for enhancing stroke recovery, such as transcranial electric stimulation and transcranial magnetic stimulation, which can induce short- and long-term changes of synaptic excitability to restore the impaired functions in stroke patients. (bnmjournal.com)

Moreover, developmental elimination of surplus climbing fibres-a model for activity-dependent synaptic pruning-is impaired. (nature.com)

Here, we resolved Ca 2+ -dependent and Ca 2+ -independent synaptic vesicle (SV) replenishment pathways, and found that syt 7 plays a selective and critical role in the Ca 2+ -dependent pathway. (elifesciences.org)

His Postsynaptic density research is multidisciplinary, incorporating perspectives in PDZ domain and Microtubule. (research.com)
His work on SHANK2 and Disks Large Homolog 4 Protein as part of his general Postsynaptic density study is frequently connected to Actin cytoskeleton, thereby bridging the divide between different branches of science. (research.com)

Excitatory/inhibitory (E/I) imbalance within the brain is one of the pathophysiological theories of ASD [ 22 ]. (biomedcentral.com)
A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. (biorxiv.org)
One prominent circuit-level hypothesis for brain disorders has been the idea of an imbalance in excitatory and inhibitory signaling. (biorxiv.org)
2021). However, the results reported here and those reported by others have not shown that endogenous RA is normally required for synaptic plasticity (or any other nongenomic effect) as there are no reports of genetic loss-of-function studies that remove endogenous RA in adult brain. (preprints.org)

Debanne D, Gähwiler BH, Thompson SM (1999) Heterogeneity of synaptic plasticity at unitary CA3-CA1 and CA3-CA3 connections in rat hippocampal slice cultures. (yale.edu)

and synaptic membranes. (health-articles.net)
In each of these mice we have inactivated the genes that encode for synaptic signalling molecules, such as agrin and laminins, or molecules that are needed to cluster ion channels in the postsynaptic membranes of muscles and/or neurones, such as rapsyn and gephyrin. (edu.au)

FHM1 mutations result in gain-of-function of recombinant human Ca V 2.1 channels and native neuronal Ca V 2.1 channels in FHM1 knock-in mice, causing the enhancement of action potential evoked Ca 2+ influx [ 12 , 13 , 14 , 15 ]. (biomedcentral.com)

Basal synaptic transmission was normal in the presence of CDK4 inhibitor. (biomedcentral.com)
Synaptic transmission and plasticity require the integrity of the anatomical substrate. (aopwiki.org)
An imbalance between excitatory/inhibitory (E/I) transmission is the putative hypothesis of ASD pathogenesis, supporting by the specific implications of inhibitory γ-aminobutyric acid (GABA)ergic system in autistic individuals and animal models of ASD. (biomedcentral.com)
Decreased synaptic GABA A R and gephyrin levels, and inhibitory transmission were found in the amygdala from two generations of the VPA-induced offspring with greater reductions in the F2 generation. (biomedcentral.com)
The computational model showed how these network effects may arise from a combination of changes in thalamocortical and intra-cortical synaptic transmission, with the former inducing a lower cortical activity and the latter inducing the higher frequencies ɣ oscillations. (biomedcentral.com)
Computational studies suggest that this shift is specifically due to enhanced cortical excitatory transmission. (biomedcentral.com)

Anatomy74

Organisms19

Diseases3

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Psychiatry and Psychology13

Phenomena and Processes37

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Health Care2

Neurons40

Synapses16

Forms of synaptic plasticity3

Slices7

Inputs6

Synapse7

Pyramidal cells1

Mechanisms7

Short-term synaptic2

Glutamatergic2

Action potentials1

Types of synaptic1

Long-term potenti3

Spines4

Neural8

Receptors8

Inhibitory synaptic1

AMPA2

Neuron1

Forebrain2

Changes in synaptic2

Cortical and hippocampal1

19981

Vivo1

Subunit1

Neuronal plasticity1

Post-synaptic1

Hippocampus1

Stimuli1

NMDA5

Inhibition1

Deficits5

Neurotransmitter1

Currents1

GABAergic1

EPSPs2

Receptor2

Extracellular1

Arbors1

Neuroscience2

Alterations2

Presynaptic1

Organization3

Kinetics1

Synaptogenesis1

Stimulation1

Activity-dependent1

Pathways1

Density2

Brain4

19991

Membranes2

Enhancement1

Transmission6