• Taken together, our data suggest that C9ORF72 is required for synaptic plasticity and adult neurogenesis in the hippocampus and Klotho deregulations may be part of C9ORF72-mediated toxicity. (biomedcentral.com)
  • Here we examined the expression of eight genes, each implicated in neural plasticity and in the pathophysiology of mood disorder, in the hippocampus of these same adolescent marmosets, relative to their normally reared sibling controls. (ox.ac.uk)
  • In the hippocampus, theta rhythms (4-12 Hz) could contribute to several key physiological mechanisms including long-range synchrony, plasticity, and at the behavioral scale, support memory encoding and retrieval. (nih.gov)
  • In particular, we explore how theta rhythms could coordinate the integration of upstream signals in the hippocampus to form future decisions, the relevance of such integration to downstream regions, as well as setting the stage for behavioral timescale synaptic plasticity. (nih.gov)
  • Sharp-wave ripples orchestrate the induction of synaptic plasticity during reactivation of place cell firing patterns in the hippocampus by Sadowski, JHLP, Jones, MW & Mellor, JR (2016) in Cell Reports (in press). (bristol.ac.uk)
  • Stress is known to cause contrasting patterns of morphological and physiological plasticity in the hippocampus and amygdala. (ncbs.res.in)
  • Hypothyroidism changes synaptic transmission and plasticity in area CA1 of the hippocampus, which, in turn, may be the mechanism that leads to impairment in learning and memory. (medscape.com)
  • Furthermore, adult hippocampal neurogenesis was reduced in C9orf72 knockout mice. (biomedcentral.com)
  • These results suggest that Tbr2+ IPCs play a major role in the regulation of adult hippocampal neurogenesis, and that a similar transcriptional program controls neurogenesis in adult SGZ as in embryonic cerebral cortex. (jneurosci.org)
  • Adult hippocampal neurogenesis is a constitutive but highly regulated process that occurs in a neurogenic niche, the subgranular zone (SGZ) of the dentate gyrus (DG). (jneurosci.org)
  • In addition, the rats supplemented with BB and SB diets showed increased hippocampal neurogenesis and expression of insulin-like growth factor 1, although the improvements in working memory performance could not solely be explained by these increases. (cambridge.org)
  • Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity, learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing therapies to combat cognitive deficit in schizophrenia. (benthamscience.com)
  • Thyroid deficiency can impair hippocampal neurogenesis, differentiation, and maturation in developmental and adult rat brains, suggesting a similar mechanism in humans. (medscape.com)
  • We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines. (nih.gov)
  • Quantitative ultrastructural analysis of hippocampal excitatory synapses. (scienceopen.com)
  • Synaptic plasticity at hippocampal mossy fibre synapses. (scienceopen.com)
  • Here we describe recent work from several laboratories on the various forms of synaptic plasticity at hippocampal mossy fibre synapses. (scienceopen.com)
  • We also revealed that there are raft-positive and -negative synapses in the same neuron, proposing the hypothesis that glycosylation of AMPA―R decides the synaptic localization, resulting in the regulation of synaptic strength in synaptic plasticity. (nii.ac.jp)
  • Here, we examined in male rats whether acute exposure (7-9 days) to HFD during juvenility [from postnatal day (PND) 21 to PND 28-30] or adulthood (from PND 60 to PND 67-69) is sufficient to affect hippocampal functions and whether it is also dependent on GRs activation. (nature.com)
  • The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)
  • 1997. Congener-specific effects of maternal PCB exposure on functional plasticity in cortical and hippocampal slices of rats. (cdc.gov)
  • Using a click-chemistry-based method to label the de novo proteome in live brain slices, we monitored translation in neurons and astrocytes of the basolateral amygdala (BLA) and dorsal hippocampal area CA3 (dCA3) in rats at different time-points after a single 2-hour exposure to immobilization stress. (ncbs.res.in)
  • Aberrant forms of synaptic plasticity also accompany a variety of neurological and psychiatric diseases, and unraveling the biological basis of synaptic plasticity has been a major goal in neurobiology research. (aston.ac.uk)
  • The biochemical and structural mechanisms underlying different forms of synaptic plasticity are complex, involving multiple signaling cascades, reconfigurations of structural proteins and the trafficking of synaptic proteins. (aston.ac.uk)
  • Decoupling of sleep-dependent cortical and hippocampal interactions in a neurodevelopmental model of schizophrenia. (bristol.ac.uk)
  • Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1. (albany.edu)
  • Together our results demonstrate that stress causes an immediate upregulation of protein synthesis in both amygdalar and hippocampal neurons and astrocytes. (ncbs.res.in)
  • Memory consolidation impairment induced by Interleukin-1ß is associated with changes in hippocampal structural plasticity. (bvsalud.org)
  • The aim of this study was to establish whether the effect of IL-1 ß on contextual fear memory is associated with changes in hippocampal structural plasticity. (bvsalud.org)
  • Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder. (ox.ac.uk)
  • We have previously shown that repeated electroconvulsive stimulation, a safe and effective antidepressant treatment, has profound effects on hippocampal synaptic connectivity and plasticity in the rat. (dundee.ac.uk)
  • A critical question that remains elusive is exactly how changes early in life can have such persistent effects on hippocampal function. (fapesp.br)
  • Analysis of spine plasticity in CA1 hippocampal pyramidal neurons employing live cell nanoscopic imaging. (uni-muenchen.de)
  • In this project we will test the role of early growth response 1 (Egr1), which regulates synaptic function, synaptic plasticity and epigenetic modification of receptors for stress-hormones, and preliminary data from the University of Amsterdam (UvA) group indicates the Egr1 expression is affected by ELS. (fapesp.br)
  • Immunocytochemistry and confocal imaging of primary hippocampal neurons from newborn C57BL6 mice further show that feedback phosphorylation of KSR1 significantly reduces its localization to dendritic spines. (warwick.ac.uk)
  • The aim of this project is to better understand the effects of tDCS/aDCS applied on the cerebellum on hippocampal electrical activity, synaptic plasticity and memory in mice. (ac.be)
  • 2) apply the protocol of tDCS/aDCS tested in the first part to evaluate the potential rescue of impairments of synaptic plasticity and memory developed by these mice as they age. (ac.be)
  • It is now well-established that the hippocampal CA2 region plays an important role in social recognition memory in adult mice. (researchgate.net)
  • We also report differences in hippocampal synaptic plasticity between resilient and susceptible mice. (usda.gov)
  • Journal Article] Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice. (nii.ac.jp)
  • Estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes. (albany.edu)
  • This was required to find the exact right conditions for growing mouse hippocampal neurons in cell cultures in such a way that they allow bi-directional measurements of synaptic functions in isolated paired neurons. (technologynetworks.com)
  • These results suggest that acute exposure to HFD during juvenility is sufficient to impair hippocampal functions in a GR-dependent manner. (nature.com)
  • Early deprivation did not affect hippocampal volume. (ox.ac.uk)
  • Bidirectional modulation of their activity occurs during spatial navigation and time-dependent task in rodents influencing synaptic plasticity in both structures. (ac.be)
  • Conclusions: Given that fluoxetine and rECS share antidepressant properties, but differ in their effects on learning and memory, we propose that the common effects on dentate connectivity and synaptic plasticity described here are more likely to relate to affective rather than cognitive function. (dundee.ac.uk)
  • Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via the mossy fibers. (frontiersin.org)
  • Plasticity of the dentate gyrus during injury ( Perederiy and Westbrook, 2013 ). (frontiersin.org)
  • Structural plasticity in the dentate gyrus- revisiting a classic injury model. (frontiersin.org)
  • Consequently, electrophysiological recordings in hippocampal neurons expressing wild-type or feedback-deficient KSR1 demonstrate that KSR1 feedback phosphorylation restricts the potentiation of excitatory postsynaptic currents. (warwick.ac.uk)
  • To do so, we will use an animal model of early life stress (ELS), in which there is an abnormal and fragmented maternal care, and evaluate synaptic plasticity by electrophysiological assessment. (fapesp.br)
  • Hippocampal synaptic plasticity, spatial memory and anxiety. (ox.ac.uk)
  • Acute systemic injection of the selective 5-HT2C antagonist, RS-102,221 (2mg/kg, i.p., 2min prior the onset of stress), prevented tau hyperphosphorylation and also corrected the defects in hippocampal LTP and spatial memory. (torvergata.it)
  • These findings suggest that passive exposure to a combination of physical and sensory stressors causes a reversible hippocampal dysfunction, which might compromise mechanisms of synaptic plasticity and spatial memory for a few days. (torvergata.it)
  • In particular, AMPA-type glutamate receptor (AMPA-R) plays central roles in not only main excitatory neurotransmission, but also expression of synaptic plasticity. (nii.ac.jp)
  • These results are novel to show that MetS triggers a cascade of molecular events, which disrupt hippocampal functional plasticity, and specific aspects of learning and memory function. (unab.cl)
  • Because hippocampal BVs (including those of the DG where RGLs reside) are thought to have a fully-functional BBB, the question arises how are circulating substances accessible to the brain parenchyma without a loss of BBB function? (elifesciences.org)
  • Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity. (harvard.edu)
  • Our results show that local hippocampal administration of IL-1 ß just after memory encoding induced impairment in contextual memory and a reduction in the total density of CA1 hippocampal dendritic spines , particularly the mature ones. (bvsalud.org)
  • We first review cellular, anatomical, and physiological mechanisms underlying the generation and maintenance of hippocampal rhythms and how they contribute to memory function. (nih.gov)
  • We present an account of hippocampal function that explains its role in both memory and anxiety. (ox.ac.uk)
  • Consistent with an overall hippocampal dysfunction, there was a subsequent decrease in hippocampal dependent learning and memory performance, i.e., spatial learning and episodic memory. (unab.cl)
  • This suggests that hippocampal activation during rest may have a function not only in memory consolidation and retrieval, but also in planning: it contributes to the organization of the network for improving the encoding of future events. (wikipedia.org)
  • 3) analyze the delayed (long-term) effect of this stimulation on synaptic plasticity in acute slices and on memory with behavioral tests. (ac.be)
  • Although loss of theta rhythmicity impairs memory, these sequences of spatiotemporal representations persist in conditions of altered hippocampal oscillations. (nih.gov)
  • The focus of this review is to disentangle the relative contribution of hippocampal oscillations from single-neuron activity in learning and memory. (nih.gov)
  • We propose candidate hypotheses for how septohippocampal oscillations could support memory function while not contributing directly to hippocampal sequences. (nih.gov)
  • Finally, we leverage stimulation-based treatment in Alzheimer's disease conditions as an opportunity to assess the sufficiency of hippocampal oscillations for memory function. (nih.gov)
  • Equally, the negative results suggest that other features of mood disorder, such as decreased hippocampal volume and BDNF expression, are related to different aspects of the pathophysiological process. (ox.ac.uk)
  • We have previously shown that long-term exposure (8-12 weeks) to high-fat diet (HFD) during adolescence (from weaning to adulthood), but not at adulthood, was associated with altered amygdala and hippocampal functions. (nature.com)
  • The results suggest that neuro-inflammation induced by IL-1 ß interferes with experience-dependent structural plasticity in DH whereas α- MSH has a beneficial modulatory role in preventing this effect. (bvsalud.org)
  • Interestingly, this effect depends on the developmental period studied as acute exposure to HFD at adulthood did not impair, but rather enhanced, hippocampal functions. (nature.com)
  • Early deprivation led to decreases in hippocampal growth-associated protein-43 (GAP-43) mRNA, serotonin 1A receptor (5-HT(1A)R) mRNA and binding ([3H]WAY100635), and to increased vesicular GABA transporter mRNA. (ox.ac.uk)
  • In humans, rapid hippocampal development continues over the first two postnatal years, reflected in gross anatomical changes 18 . (nature.com)
  • These findings identify new metrics of stress-induced plasticity at the level of cell-type specific proteomic landscape that may provide important insights into the molecular basis of the divergent temporal effects of stress across brain regions and biological scales. (ncbs.res.in)
  • AMPA receptor trafficking and synaptic plasticity. (scienceopen.com)
  • While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies. (scienceopen.com)
  • The research team involved the University of Bristol's Centre for Synaptic Plasticity within the School of Physiology, Pharmacology & Neuroscience and was supported by the MRC, Wellcome Trust, EPSRC and Eli Lilly & Co. (bristol.ac.uk)
  • Differences in whole-brain metabolism are associated with the expression of genes related to neurovascular unit integrity and synaptic plasticity in temporal lobe epilepsy. (cdc.gov)
  • We discuss the particular challenges associated with proteomic interrogation of synaptic plasticity processes and outline ways in which we believe proteomics may advance the field over the next few years. (aston.ac.uk)
  • We pay particular attention to technical advances being made in small sample proteomics and the advent of proteomic imaging in studying brain plasticity. (aston.ac.uk)
  • In mood disorder, early stressors including parental separation are vulnerability factors, and hippocampal involvement is prominent. (ox.ac.uk)
  • We conclude that early deprivation in a nonhuman primate, in the absence of subsequent stressors, has a long-term effect on the hippocampal expression of genes implicated in synaptic function and plasticity. (ox.ac.uk)
  • In particular, altered hippocampal function has been related to reduced contextualization, and consequently, generalized fear responses. (fapesp.br)
  • After that, we will modulate the Egr1 expression in ELS animals using molecular tools, aiming to revert the possible ELS impacts on synaptic function and plasticity. (fapesp.br)
  • Here we uncovered a previously unrecognized communication route allowing exclusive direct access of blood-borne substances to hippocampal NSCs. (elifesciences.org)
  • Synaptic plasticity is the dynamic regulation of the strength of synaptic communication between nerve cells. (aston.ac.uk)
  • As such, proteomics should be a valuable tool in dissecting the molecular events underlying normal and disease-related forms of plasticity. (aston.ac.uk)
  • Such a mechanism greatly increases the computational power of this form of plasticity. (nature.com)
  • In this BEPE-Project, we intend to assess the immediate ELS impacts on synaptic plasticity and its relation with Egr1 gene expression. (fapesp.br)