• This is a representative image of cultured dissociated hippocampal neurons transiently expressing psychLight1 and psychLight2. (eurekalert.org)
  • Here, we investigated the role of Sirt1 in the pathogenesis of brain injuries after modulating its activity in primary cultured hippocampal neurons. (frontiersin.org)
  • beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons. (alzforum.org)
  • Using a click-chemistry-based method to label the de novo proteome in live brain slices, we monitored translation in neurons and astrocytes of the basolateral amygdala (BLA) and dorsal hippocampal area CA3 (dCA3) in rats at different time-points after a single 2-hour exposure to immobilization stress. (ncbs.res.in)
  • Together our results demonstrate that stress causes an immediate upregulation of protein synthesis in both amygdalar and hippocampal neurons and astrocytes. (ncbs.res.in)
  • We recorded with silicon probes the activity of hippocampal neurons of the intermediate CA1 hippocampus, a subdomain of the hippocampus that has been hypothesized to be particularly important for the integration of sensory inputs. (medicalxpress.com)
  • In the present experiments, we used the highly selective AMPA receptor antagonist LY 303070 to pharmacologically isolate KA receptor-mediated excitatory postsynaptic currents (EPSCs) in rat hippocampal CA3 pyramidal neurons and tested their sensitivity to ethanol. (aspetjournals.org)
  • These results suggest that in addition to its well-described depressant effect on NMDA receptor-mediated synaptic transmission, ethanol has an even greater inhibitory effect on glutamatergic synaptic transmission mediated by KA receptors in rat hippocampal CA3 pyramidal neurons. (aspetjournals.org)
  • In particular, TMT targets hippocampal pyramidal neurons in CA3 and CA1. (cdc.gov)
  • The highest levels are in neurons of entorhinal cortex layer II, alongside hippocampal neurons at the CA1/subiculum border. (lu.se)
  • These are 3-repeat tau-immunopositive bodies predominantly located in granular neurons in the hippocampal dentate gyrus, hippocampal CA1 pyramidal neurons, and layer II of frontal and temporal cortices. (medscape.com)
  • Enlargement of the hippocampal sulcus has been associated with medial temporal lobe atrophy occurring in Alzheimer's disease. (wikipedia.org)
  • PNFA and FTD also displayed atrophy on the left side, restricted to the hippocampal head in FTD. (nih.gov)
  • Finally, AD displayed most atrophy in left hippocampal body with relative sparing of the hippocampal head. (nih.gov)
  • In the sepsis group, left-sided hippocampal atrophy was found compared to healthy controls. (bmj.com)
  • The present pooled analysis of three studies examined if hippocampal atrophy is more prominent than global brain atrophy in patients with T2DM relative to controls. (eur.nl)
  • Conclusion: Patients with T2DM had greater brain atrophy but not hippocampal atrophy, compared to controls. (eur.nl)
  • Additional loss of hippocampal stratum radiatum, hippocampal atrophy and ASTROGLIOSIS are common. (bvsalud.org)
  • Importantly, genetic disruption of TrkB-Shc signaling exacerbated hippocampal neuronal death induced by SE. (jneurosci.org)
  • Here we reveal that TrkB-mediated activation of Akt protects against hippocampal neuronal death in vivo following status epilepticus. (jneurosci.org)
  • In the present work, we challenge this simple notion by showing the stability of spontaneous neuronal activity in cultured hippocampal networks in situ . (scialert.net)
  • Significance: These results demonstrate that inhibition of microRNA 134 confers a seizure?protective effect without obvious interference with hippocampal neuronal properties or network function. (cureepilepsy.org)
  • Pérdida neuronal en las regiones del hipocampo CA1 y CA4 y, menos intensamente, CA2 y CA3. (bvsalud.org)
  • Neuronal loss in the hippocampal regions of CA1 and CA4 and less severely CA2 and CA3. (bvsalud.org)
  • The hippocampal sulcus, also known as the hippocampal fissure, is a sulcus that separates the dentate gyrus from the subiculum and the CA1 field in the hippocampus. (wikipedia.org)
  • The mechanisms by which the hippocampus regulates negative emotion are clearly complicated, but suggest that interventions aimed at restoring normal hippocampal function may help with disorders of negative affect, such as depression or post-traumatic stress disorder and depression. (nih.gov)
  • Importantly, both lifestyle (diet and exercise) and pharmacological interventions that are known to alleviate peripheral IR effectively restore hippocampal neuroplasticity in rodent models of T2DM and AD, and this effect may be due to restoration of insulin signalling in the hippocampus. (nature.com)
  • Hippocampal volume refers to the overall size of the hippocampus , a brain structure below the cerebral cortex. (ucdavis.edu)
  • The early decline in hippocampal neurogenesis raises questions about how the function of the dentate gyrus differs between humans and other species in which adult hippocampal neurogenesis is preserved. (nature.com)
  • Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via the mossy fibers. (frontiersin.org)
  • Adult hippocampal neurogenesis is a constitutive but highly regulated process that occurs in a neurogenic niche, the subgranular zone (SGZ) of the dentate gyrus (DG). (jneurosci.org)
  • We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated formation of synapses with mitochondrial support in the rat hippocampal CA1 and dentate gyrus. (au.dk)
  • Results Sepsis survivors showed cognitive deficits in verbal learning and memory and had a significant reduction of left hippocampal volume compared to healthy controls. (bmj.com)
  • After accounting for baseline cognitive function and experimental group, increased left hippocampal volume was independently associated with reduced verbal memory and learning performance as indexed by loss after interference (r=0.42, p=0.03). (bmj.com)
  • Altman, J. & Das, G. D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. (nature.com)
  • The present study has examined the cellular neurobiological consequences of subcutaneous injections of FGL, on hippocampal cell morphometry in young (4 month-old) rats. (open.ac.uk)
  • 1997. Congener-specific effects of maternal PCB exposure on functional plasticity in cortical and hippocampal slices of rats. (cdc.gov)
  • Immunostaining of Western-blots using HRP-conjugated anti-rat IgG confirmed the presence of antibodies, against purified proteins or hippocampal homogenates, in sera of rats exposed to TMT. (cdc.gov)
  • Hippocampal sclerosis in refractory temporal lobe epilepsy is associated with gluten sensitivity. (greenmedinfo.com)
  • Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery. (bvsalud.org)
  • To compare memory outcomes after surgery for unilateral hippocampal sclerosis (HS)-associated epilepsy in patients with unilateral and bilateral ictal electrographic involvement. (bvsalud.org)
  • Hippocampal sclerosis is associated with intractable TEMPORAL LOBE EPILEPSY. (bvsalud.org)
  • We monitored spiking activity of hippocampal CA3 neuron populations by using a functional Multineuron Calcium Imaging (fMCI) technique. (scialert.net)
  • CIL:40660, Rattus, hippocampal neuron. (cellimagelibrary.org)
  • We determined the effects of FGL on hippocampal volume, pyramidal neuron number/density (using unbiased quantitative stereology), and examined aspects of neurogenesis (using 2D morphometric analyses). (open.ac.uk)
  • In the CNS, could mediate hippocampal-neuron survival. (lu.se)
  • These results suggest that Tbr2+ IPCs play a major role in the regulation of adult hippocampal neurogenesis, and that a similar transcriptional program controls neurogenesis in adult SGZ as in embryonic cerebral cortex. (jneurosci.org)
  • Results: We report an association between adult hippocampal gene expression and prenatal ethanol exposure followed by postnatal separation stress that is related to behavioral changes. (bepress.com)
  • In the first, a method was developed for acutely isolating hippocampal pyramidal cells from the adult rat. (soton.ac.uk)
  • The question of adult hippocampal neurogenesis has generated numerous controversies regarding its simple presence or absence in humans versus rodents, whether it is best described as the tail of a distribution centered on early neural development, or is several distinct processes. (figshare.com)
  • Data from these experimental studies suggest that hippocampal IR is an important mechanistic mediator of the synaptic plasticity and cognitive deficits in T2DM and AD. (nature.com)
  • A number of electrophysiological techniques have been employed to study synaptic function in the rat hippocampal slice preparation. (soton.ac.uk)
  • Several pathological features of T2DM and AD may contribute to the development of hippocampal IR, including increases in oxidative stress and in the amount of pro-inflammatory cytokines and amyloid-β peptides, as well as hypothalamic-pituitary-adrenal axis dysfunction. (nature.com)
  • Animal models of IR help to bridge these gaps and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). (nature.com)
  • Our findings identify Ephexin5 as a key driver of hippocampal dysfunction and related behavioral deficits in AS mouse models. (biorxiv.org)
  • Questions remain with regard to how sleep enhances memory, what parameters of sleep after learning are optimal for memory consolidation, and what underlying hippocampal molecular players are targeted by sleep deprivation to impair memory consolidation and plasticity. (ed.gov)
  • I show that the TA pathway is subject to forms of short-term activity-dependent regulation, including paired-pulse and frequency- dependent plasticity, similar to other hippocampal pathways such as the Schaffer collateral (SC) input from CA3 to CA1. (caltech.edu)
  • Hippocampal cellular and molecular processes critical for memory consolidation are affected by the amount and quality of sleep attained. (ed.gov)
  • Voluntary exercise reduces both chemotherapy-induced neuropathic nociception and deficits in hippocampal cellular proliferation in a mouse model of paclitaxel-induced peripheral neuropathy. (iasp-pain.org)
  • Our studies support the hypothesis that voluntary exercise may be beneficial in suppressing both neuropathic pain and markers of hippocampal cellular function that are impacted by toxic challenge with chemotherapeutic agents. (iasp-pain.org)
  • Furthermore, proteomic analysis across human iPSC-based models and human post-mortem hippocampal tissue projected coherent longitudinal cellular changes indicative of early to end stage AD cellular pathogenesis. (lu.se)
  • Hippocampal pathology is central to Alzheimer's disease (AD) and other forms of dementia such as frontotemporal lobar degeneration (FTLD). (nih.gov)
  • Evidence for hippocampal IR has also been observed in rodent models of AD. (nature.com)
  • Because hippocampal BVs (including those of the DG where RGLs reside) are thought to have a fully-functional BBB, the question arises how are circulating substances accessible to the brain parenchyma without a loss of BBB function? (elifesciences.org)
  • A cell adhesion mimetic FGL, a 15 amino-acid peptide derived from the second fibronectin type-III module of NCAM, has been shown to act as a neuroprotective agent in experimental disease and ageing models, restoring hippocampal/cognitive function and markedly alleviating deleterious changes in the CNS. (open.ac.uk)
  • In those with bipolar disorder and glucose abnormalities, age was associated with lower hippocampal volume to a greater extent than in bipolar patients with normal glucose function. (bipolarnews.org)
  • the resulting damage triggers a cascade of changes that lead to impaired hippocampal function. (msdmanuals.com)
  • For many years, the hippocampal formation has been implicated in the regulation of negative emotion, yet the nature of this link has remained elusive. (nih.gov)
  • Remembering to eat: hippocampal regulation of meal onset. (scienceblogs.com)
  • Here, we extend and adapt a model of the cross-species transformation of early neurodevelopmental events which presently reaches up to the equivalent of the third human postnatal year for 18 mammalian species (www.translatingtime.net) to address questions relevant to hippocampal neurogenesis, which permit extending the database to adolescence or perhaps to the whole lifespan. (figshare.com)
  • Although this pathway has been implicated in various functions, such as memory encoding and retrieval, spatial navigation, generation of oscillatory activity, and control of hippocampal excitability, the details of its physiology are not well understood. (caltech.edu)
  • Ephexin5 is a putative UBE3A substrate that has restricted expression early in development, regulates synapse formation during hippocampal development, and is abnormally elevated in AS mice, modeled by maternally-derived Ube3a gene deletion. (biorxiv.org)
  • As a continuation of this line of research, and given the putative role of brain glial cells in mediating antidepressant responses the present study investigated early effects of vortioxetine on hippocampal microvasculature and Vascular Endothelial Growth Factor (VEGF) and astrocytes and microglia cells. (au.dk)
  • We evaluated whether voluntary running would suppress both neuropathic pain and deficits in hippocampal cell proliferation in a mouse model of CIPN induced by the taxane chemotherapeutic agent paclitaxel. (iasp-pain.org)
  • Researchers at Medical University of Vienna recently set out to examine the activity of different hippocampal interneurons as mice were completing an odor-driven spatial navigation task. (medicalxpress.com)
  • OBJECTIVE: We aimed to study the effect of chronic stress on the hippocampal proteome in male APPPS1 transgenic mice and wildtype (WT) littermates. (aau.dk)
  • A new University of California, Davis, study, however, shows that adolescents with large hippocampal volume were more, or less, susceptible to feelings of depression depending on how unsafe - or conversely - protected they felt in their home and community environments. (ucdavis.edu)
  • The study , "Hippocampal Volume as Amplifier of Effect of Social Context on Adolescent Depression," is co-authored by faculty from the UC Davis Center for Mind and Brain, and the departments of psychology and human ecology. (ucdavis.edu)
  • Total hippocampal volume was lower in patients with PTSD (p = .02), with a significant diagnosis by hippocampal-subregion interaction (p = .02). (psychiatrist.com)
  • Specifically, aerobic training (AT) improved spatial memory and hippocampal volume in healthy community-dwelling older adults. (bmj.com)
  • In this secondary analysis, we investigated: (1) the effect of RT and AT on hippocampal volume and (2) the association between change in hippocampal volume and change in memory. (bmj.com)
  • At baseline and trial completion, participants performed a 3T MRI scan to determine hippocampal volume. (bmj.com)
  • Conclusions Aerobic training significantly increased hippocampal volume in older women with probable MCI. (bmj.com)
  • More research is needed to ascertain the relevance of exercise-induced changes in hippocampal volume on memory performance in older adults with MCI. (bmj.com)
  • In SMART-Medea and UDES1, hippocampal volume was obtained by manual tracing on 1.5. (eur.nl)
  • In UDES2, hippocampal and total brain volume were determined by FreeSurfer and ICV by manual segmentation on 3. (eur.nl)
  • Results: Hippocampal field potential recordings determined that silencing of microRNA?134 by ant?134 injection was associated with a reduction in epileptiform activity following application of 9 mmol/L K+. (cureepilepsy.org)
  • Autopsy studies have shown that certain hippocampal subfields are more vulnerable than others to AD and FTLD pathology, in particular the subiculum and cornu ammonis 1 (CA1). (nih.gov)
  • tests were used to compare hippocampal efficiency metrics between patients and controls. (iasp-pain.org)
  • Linear regression was used to examine significant hippocampal efficiency metrics in relation to headache frequency in patients, controlling for age, sex, pubertal status, post-traumatic stress, anxiety, and depression symptoms. (iasp-pain.org)
  • In this thesis, I examine the contribution of the TA pathway to hippocampal processing. (caltech.edu)
  • Hippocampal tissue was used for proteomics analysis using label-free quantitative DIA based LC-MS/MS analysis. (aau.dk)
  • Increased hippocampal efficiency is associated with greater headache frequency in adolescents with chronic headache. (iasp-pain.org)
  • Adults with chronic headache have altered brain hippocampal efficiency networks. (iasp-pain.org)
  • We acquired quantitative data delimiting the envelope of hippocampal neurogenesis from cell cycle markers (i.e. (figshare.com)
  • Hippocampal and amygdalar cell-specific translation is similar soon after stress but diverge over time. (ncbs.res.in)
  • Early developmental events involving the olfactory and limbic system start and conclude possibly slightly early in primates than rodents, and we find a comparable early conclusion of primate hippocampal neurogenesis (as assessed by the relative number of Ki67 cells) suggesting a plateau to low levels at approximately 2 years of age in humans. (figshare.com)
  • When all species are so modeled, and represented in a common time frame, the envelopes of hippocampal neurogenesis are essentially superimposable. (figshare.com)
  • Results Compared with the BAT group, AT significantly improved left, right and total hippocampal volumes (p≤0.03). (bmj.com)
  • During human fetal development, the hippocampal sulcus first appears at approximately 10 weeks of gestational age. (wikipedia.org)
  • Graph-based topological analyses of brain networks, rendering hippocampal efficiency values were performed. (iasp-pain.org)