In this study we investigated the potential that epigallocatechin-3-gallate (EGCg), an abundant catechin in green tea, would reduce signaling for apoptosis and promote skeletal muscle recovery in the fast plantaris muscle and the slow soleus muscle after hindlimb suspension (HLS) in senescent animals. (ironmagazine.com)
In the present study, we tested the ability of two NF-κB inhibitors to inhibit disuse-induced skeletal muscle NF-κB activation. (biomedcentral.com)
ROS and nNOS in the Regulation of Disuse-Induced Skeletal Muscle Atrophy. (tamu.edu)
Immobilization1
Models include horizontal or head-down bed rest, dry immersion bed rest, limb immobilization, and unilateral lower-limb suspension. (wikipedia.org)
Mice3
Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery of bone mass when mice were injected after bone loss due to a suspension period of 4 weeks (curative protocol). (uniba.it)
In vivo, a recent study found that mice lacking specific NF-κB family members (p105/50 or bcl3) are resistant to unloading-induced atrophy and NF-κB activation [ 6 ], supporting a role for NF-κB as a robust in vivo catabolic stimulus during disuse atrophy. (biomedcentral.com)
Muscle8
Epigallocatechin-3-gallate improves plantaris muscle recovery after disuse in aged rats. (ironmagazine.com)
Aging exacerbates muscle loss and slows the recovery of muscle mass and function after disuse. (ironmagazine.com)
But according to a review published in Frontiers in Physiology, modern lab techniques now allow us to see that nuclei gained during training persist even when muscle cells shrink due to disuse or start to break down. (robert-gorter.info)
This led to the assumption that a given nucleus controls a defined volume of cytoplasm - so that when a muscle shrinks or 'atrophies' due to disuse or disease, the number of myonuclei decreases. (robert-gorter.info)
Using a recently published rat model that combines both burn and disuse components, we compare the effects of insulin treatment vs. vehicle on glucose tolerance, hypermetabolic response, muscle loss, and circadian-metabolic protein expression after burns. (elsevierpure.com)
Our data reveal for the first time that Irisin retrieves disuse-induced bone loss and muscle atrophy. (uniba.it)
Since atrophy in space flight and disuse atrophy share similar pathophysiologic mechanisms [ 5 ], countermeasures to microgravity-induced muscle wasting may also be effective for the prevention of disuse atrophy and muscle weakness in long term bedridden patients. (biomedcentral.com)
Thus, there is considerable interest in the development of countermeasures that oppose the complications of muscle disuse. (biomedcentral.com)
Animals1
One group of animals received HLS for 14 days and a second group of rats received 14 days of HLS, then the HLS was removed and they recovered from this forced disuse for 2 weeks. (ironmagazine.com)
Function1
These data represent potentially important observations with clinical implications for the population of elderly persons who suffer from acute disuse and then go through some period of rehabilitation in an attempt to recover function", the researchers wrote. (ironmagazine.com)
Hind Limb Suspension2
6. Reloading Promotes Recovery of Disuse Muscle Loss by Inhibiting TGFβ Pathway Activation in Rats After Hind Limb Suspension. (nih.gov)
Perturbations in the eEF2k/eEF2 pathway during various stages of disuse muscle atrophy have been investigated utilizing a rat hind limb suspension (HS) model. (ox.ac.uk)