Highly variable antigen immunogenic antigens carrier proteins. Medical search. Frequent questions

Although the efficacy of adoptive transfer of tumor infiltrating lymphocytes (TILs) was examined over several decades, genetically engineered T cells expressing chimeric antigen receptors (CARs) rapidly replaced the application of TILs due to their high specificity, non-MHC-restricted recognition of tumor antigen, superior potency, and improved in vivo persistency [ 9 , 13 , 14 ]. (biomedcentral.com)
Genetic engineering of T cells greatly increases the scope and potency of T-cell therapy: T-cell receptor (TCR) transfer allows targeting of intracellular cancer antigens, whereas chimeric antigen receptors (CARs) allow targeting of surface cancer or lineage-specific antigens. (ashpublications.org)

Protein-protein interactions among SARS-CoV-2 spike protein, human receptors and antibodies are key determinants of the potency of this virus and its ability to evade the human immune response. (bvsalud.org)
Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)

Current pneumococcal vaccines use the pneumococcal capsular polysaccharides as antigens to generate serotype-specific antibodies, which facilitate serotype-specific clearance of pneumococci through opsonophagocytosis ( 4 ). (cdc.gov)
Relative titers of antibodies to individual polypeptide antigens of herpes simplex virus type 1 in human sera. (microbiologyresearch.org)
The carbohydrate moieties on HIV-1 envelope glycoprotein (Env) act as shields to mask conserved neutralizing epitopes, while the hyperimmunogenic variable regions are immunodominant in inducing non-neutralizing antibodies, representing the major challenge for using Env as a vaccine candidate to induce broadly neutrali. (shengsci.com)
PRD-0038 S vaccination elicits greater titers of antibodies cross-reacting with vaccine-mismatched clade 2 and clade 1a sarbecoviruses compared with SARS-CoV-2 S due to broader antigenic targeting, motivating the inclusion of clade 3 antigens in next-generation vaccines for enhanced resilience to viral evolution. (uw.edu)
The invention provides antibodies that bind to a plurality of β-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. (justia.com)
Second, this MAP infection triggers a specific humoral response, as Sardinian T1D Olcegepant hydrochloride patients display high frequencies of antibodies (Abs) against mycobacterial proteins (heparin-binding hemagglutinin, glycosyl transferase) [17], whole MAP lysates (70% Ab+ T1D patients vs 7.6% Ab+ healthy controls) [16] and. (healthweblognews.info)
Syd Labs team has successfully developed a large number of high specificity and high affinity rabbit monoclonal antibodies against a wide range of difficult targets such as small molecules, antibody idiotype, and antigens non-immunogenic in murine, camel or Ilama. (sydlabs.com)
Syd Labs has successfully developed human and monkey monoclonal antibodies using antigen specific single B cell-based antibody generation technologies. (sydlabs.com)

These components are the Haemophilus influenzae type b capsular polysaccharide [polyribosylribitol phosphate (PRP)] that is covalently bound to an outer membrane protein complex (OMPC) of Neisseria meningitidis and hepatitis B surface antigen (HBsAg) from recombinant yeast cultures. (theodora.com)
The hepatitis viruses include a range of unrelated and often highly unusual human pathogens. (medmuv.com)
A nationwide vaccination programme in Italy against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers. (shengsci.com)
In order to prevent hepatitis B virus (HBV) infection of infants of hepatitis B surface antigen (HBsAg)-positive mothers, a nation-wide immunization programme was initiated in Italy in January 1984. (shengsci.com)
The RTS,S vaccine is a malaria subunit vaccine that is formulated from a fragment of the circumsporozoite protein (CSP) of Plasmodium falciparum 3D7 laboratory strain fused with the Hepatitis B surface antigen and the AS01 adjuvant [ 5 ]. (biomedcentral.com)

Nowadays, growing scientific interest to DT is associated with possibility of its use in medicine as a carrier protein in conjugate vaccines, a component of immunotoxin drugs, and in anticancer therapy. (org.ua)
This comprises of inactivated viruses, messenger RNA (mRNA), DNA vaccines, protein subunits, nonreplicating and replicating vector viral-like particles (VLP), and live attenuated vaccines. (springeropen.com)
The rapid emergence of the SARS-CoV-2 virus necessitated the development of vaccines targeting the spike protein in an unprecedented timeframe [ 20 ]. (springeropen.com)
Selection of particles and proteins for use as human cytomegalovirus subunit vaccines. (microbiologyresearch.org)

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

Through the bound monoclonal antibody protein vaccine peak shift in the size-exclusion chromatography profile, this method determines the percent closed (prefusion) conformation present in a sample. (bvsalud.org)
The anti-tumor agent will remain bound to the monoclonal antibody and inactive but will be released and activated by reduction once the immunocomplex binds to the cell surface antigen and internalized. (sydlabs.com)

Most of our recombinant proteins are fluorescent derivatives of various DT and proHB-EGF. (org.ua)
The antigen is harvested and purified from fermentation cultures of a recombinant strain of the yeast Saccharomyces cerevisiae containing the gene for the adw subtype of HBsAg. (theodora.com)

On the other hand, DT represents a very interesting molecular machine which allows using this protein in different bioengineering applications, such as ablation of certain cell types in transgenic mice, development of immunotoxins targeted for specific cell markers and also for delivery of certain proteins into the cytosol. (org.ua)

Prediction of protein antigenic determinants from amino acid sequences. (microbiologyresearch.org)

In addition to our existing immunoassays, we have developed a unique physicochemical approach using size-exclusion chromatography to assess binding between antibody and the structurally desired antigen protein. (bvsalud.org)
Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. (shengsci.com)
After detection and isolation of antigen specific memory B cells by flow cytometry-based single B cell sorting, the antibody variable regions (VH and VL) from single or clonal B cells are cloned and sequenced. (sydlabs.com)

This single-chain 535 amino acid long protein causes the symptoms of acute diphtheria infection. (org.ua)
Viral RNA polymerase, a nonstructural protein, has been termed "virus infection associated antigen" (VIAA) for diagnostic purposes but is more accurately termed "FMDV nonstructural protein 3D. (wikisource.org)
Although transmitted to man, MAP infection is asymptomatic in human carriers and is not therefore regarded as a zoonosis, nor subjected Olcegepant hydrochloride to eradication in contaminated animals. (healthweblognews.info)
First, MAP infection is highly prevalent in Sardinian T1D patients. (healthweblognews.info)

for complete blood count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and DNA isolation. (exposed-skin-care.net)

The HBsAg protein is released from the yeast cells by mechanical cell disruption and detergent extraction, and purified by a series of physical and chemical methods, which includes ion and hydrophobic chromatography, and diafiltration. (theodora.com)

Nucleotide sequence of a human cytomegalovirus DNA fragment encoding a 67-kilodalton phosphorylated viral protein. (microbiologyresearch.org)

Predicting protein properties from amino acid sequences is an important problem in biology and pharmacology. (bvsalud.org)

We introduce multiple interface string alignment (MISA), a visualization tool to display coherently various sequence and structure based statistics at protein-protein interfaces (SSE elements, buried surface area, ΔASA , B factor values, etc). (bvsalud.org)

Organisms colonize the nasopharynx and may remain only transiently or for several months in the absence of symptoms (asymptomatic carrier). (cdc.gov)

A closed prefusion conformation or an open (non-prefusion) conformational state of a protein vaccine candidate molecule can determine if it effectively elucidates a desired immunity. (bvsalud.org)

The PRP-OMPC conjugate is prepared by the chemical coupling of the highly purified PRP (polyribosylribitol phosphate) of Haemophilus influenzae type b (Haemophilus b, Ross strain) to an OMPC of the B11 strain of Neisseria meningitidis serogroup B. The coupling of the PRP to the OMPC is necessary for enhanced immunogenicity of the PRP. (theodora.com)

HLA- em DRB1 /em genotypes, high disease activity, high disability scores, and high levels of acute phase proteins [2]. (exposed-skin-care.net)

Here, we describe further development of an in vivo library selection platform based on self-assembling protein nanoparticles encapsulating their own mRNA genomes (synthetic nucleocapsids or synNCs). (uw.edu)

A 64,000 dalton matrix protein of human cytomegalovirus induces in vitro immune responses similar to those of whole viral antigen. (microbiologyresearch.org)

serum pools and individual sera from HCMV-infected patients recognized this particular protein intensively in immunoblot assays. (microbiologyresearch.org)
8-10 weeks once the polyclonal sera, PBMC, and antigen is available. (sydlabs.com)

We have created a highly compact marker/suicide gene for T cells combining target epitopes from both CD34 and CD20 antigens (RQR8). (ashpublications.org)

This peptide is neither immunogenic nor protective. (shengsci.com)
There are four structural viral proteins, of which VP1 has been shown to elicit protective immunity in cattle ( Bachrach 1977 ). (wikisource.org)

Identification of a 65000 dalton virion envelope protein of human cytomegalovirus. (microbiologyresearch.org)
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)

Due to the appearance of the highly virulent strain of E. coli of serotype O157:H7 in the US and Canada in the 1980's, and subsequently in other Latin American countries, there is an increase need for accurate testing for this and other pathogenic E. coli strains, substantially enhancing detection of virulent strains and, therefore, facilitating identification of sporadic E. coli infections and outbreaks. (eurekaselect.com)
A film detection method for tritium-labeled proteins and nucleic acids in polyacrylamide gels. (microbiologyresearch.org)

EBA-175 protein is used as ligand in Plasmodium falciparum binding to erythrocytes. (shengsci.com)
Extensive genetic diversity in the Plasmodium falciparum circumsporozoite protein (PfCSP) is a major contributing factor to the moderate efficacy of the RTS,S/AS01 vaccine. (biomedcentral.com)

The virus uses the spike protein to target epithelial cells by binding to the ACE2 receptor on the host cells. (springeropen.com)
However, the appearance of an Omicron variant with 32 mutations in its spike protein raises questions about the vaccine's efficacy. (springeropen.com)
The problem is made even worse by the Omicron variant, which has 32 mutations in its spike protein. (springeropen.com)
The SARS-CoV-2 spike protein is 97.4% similar to RaTG13. (springeropen.com)
We compare the effectiveness of these models in predicting the binding affinity and expression of SARS-CoV-2 spike protein sequences. (bvsalud.org)
We also explore how effective these predictive methods are when trained on laboratory-created data and are tasked with predicting the binding affinity of the in-the-wild SARS-CoV-2 spike protein sequences obtained from the GISAID datasets. (bvsalud.org)
Viruses belonging to the largest cluster acquired an amino acid substitution in the receptor binding domain of the Spike protein (position 486), evolved faster and spread longer and more widely. (bvsalud.org)

MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

RdRp is involved in viral genome replication and structural protein translation [ 6 ]. (springeropen.com)

Research endeavors over the past several decades have identified various types of cells as suitable living drugs and versatile drug carriers. (biomedcentral.com)
Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)

Protein counterparts of human and simian cytomegaloviruses. (microbiologyresearch.org)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)

FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

This leads to an almost complete arrest of protein synthesis in the cell and its death. (org.ua)
cell lines, these transcripts are translated into immunodetectable cytoplasmic and nuclear protein. (justia.com)
Evidence shows that conserved peptide 1815 from this protein having high red blood cell binding ability plays an important role in the invasion process. (shengsci.com)
Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)

High-mobility group box 1 (HMGB1), adenosine-triphosphate (ATP), uric acid, heparan-sulphate proteoglycans (HSPG) as a part of extracellular matrix (ECM), and heat-shock proteins are the most significant DAMPs [ 13 , 14 ]. (hindawi.com)

However, a significant risk exists that infections caused by highly virulent E. coli isolates, such as the enterohemorrhagic E. coli O157:H7, develop into serious and potentially lifethreatening complications, such as hemolytic uremic syndrome. (eurekaselect.com)
This report shows that recent clinical isolates of HCMV do not necessarily have pp65 as a prominent constituent, suggesting that the low immune reaction is due to variable expression of the pp65 in natural infections. (microbiologyresearch.org)

Injectable polymer-nanoparticle (PNP) hydrogels are leveraged as a depot technology for the sustained delivery of a nanoparticle antigen (RND-NP) displaying multiple copies of the SARS-CoV-2 receptor-binding domain (RBD) and potent adjuvants including CpG and 3M-052. (uw.edu)

We observe that TR is a better method when the sample size is small and test protein sequences are sufficiently similar to the training sequence. (bvsalud.org)

4-6 months once the antigen is available. (sydlabs.com)

The GLUT2 facilitated glucose transporter isoform is a membrane protein present in the pancreatic .beta. (justia.com)

We focused on disease activity and joint damage, evaluated on radiographs, as end result variables. (exposed-skin-care.net)

Anatomy17

Organisms13

Diseases3

Chemicals and Drugs145

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes45

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Chimeric antigen receptors2

Receptors2

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