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  • viral
  • Recent studies show that conserved influenza viral proteins (such as HA2, M2, NP and M1) can provide protective immune response against a range of influenza virus subtypes. (springer.com)
  • An antigen may be a recombinant or native protein, partial protein, synthetic or natural peptide, chemical, toxin, viral or bacterial component, standard or reagent for ELISA assays, as well as an environmental agent. (mybiosource.com)
  • However, the classical vaccination approaches that have been successful in the control of various viral diseases by priming the adaptive immunity to recognize the viral envelope proteins have failed in the case of HIV-1. (wikipedia.org)
  • tumor
  • Essentially, what we have done is present a tumor protein to patients in such a way that their immune systems recognize it and then destroy any cells bearing that protein, said Larry W. (cancernetwork.com)
  • Imject
  • Imject Maleimide-Activated Carrier Proteins are prepared using a rigorous, carefully optimized manufacturing procedure, and each lot is tested to confirm that a high level of activation was achieved. (thermofisher.com)
  • residues
  • The ricin precursor protein is 576 amino acid residues in length and contains a signal peptide (residues 1-35), the ricin A chain (36-302), a linker peptide (303-314), and the ricin B chain (315-576). (wikipedia.org)
  • endoplasmic reticulum
  • Type 2 RIPs consist of an A chain that is functionally equivalent to a type 1 RIP, covalently connected by a single disulfide bond to a B chain that is catalytically inactive, but serves to mediate transport of the A-B protein complex from the cell surface, via vesicle carriers, to the lumen of the endoplasmic reticulum (ER). (wikipedia.org)
  • propensity
  • Some disadvantages of MC include its limited propensity for protein adsorption and neuronal cellular adhesion making it a non-bioactive hydrogel. (wikipedia.org)
  • glycosylation
  • Both encode large glycosylated proteins consisting of around 3400 amino acids and a molecular weight of around 390,000 Daltons, excluding the glycosylation. (wikipedia.org)
  • Superior
  • The rapidly growing interest in therapeutic vaccines (i.e. active immunotherapies) for cancer and the documented efficacy of KLH as a superior carrier protein for cancer vaccines are creating a significant biopharmaceutical market for KLH formulations. (wikipedia.org)
  • cysteines
  • Within the lumen of the ER the propolypeptide is glycosylated and a protein disulfide isomerase catalyzes disulfide bond formation between cysteines 294 and 318. (wikipedia.org)
  • Golgi
  • After being processed in the ER, PCSK9 co-localizes with the protein sortilin on its way through the Golgi and trans-Golgi complex. (wikipedia.org)
  • The propolypeptide is further glycosylated within the Golgi apparatus and transported to protein storage bodies. (wikipedia.org)
  • form
  • The simultaneous expression of different M2e and HA2-2(76-130) in recombinant protein form induces a strong M2e-specific IgG response and CD4+/ CD8+ T-cell response. (springer.com)
  • The CCH protein is composed of two very large polypeptide subunits (404/351 kDa) that form an extremely stable heterodidecameric structure even in the absence of divalent cations. (thermofisher.com)
  • The protein oligomerises to form a barrel shaped didecameric complex which is composed of 20 monomers. (wikipedia.org)
  • Whereas type 1 RIPs are composed of a single protein chain that possesses catalytic activity, type 2 RIPs, also known as holotoxins, are composed of two different protein chains that form a heterodimeric complex. (wikipedia.org)
  • species
  • and B. andersonii (U.S.). Some of these species are carried by ticks not currently recognized as carriers of Lyme disease. (wikipedia.org)
  • structure
  • Computational immunology is a branch of bioinformatics and it is based on similar concepts and tools, such as sequence alignment and protein structure prediction tools. (wikipedia.org)
  • However
  • However, posaconazole has low and highly variable bioavailability due to saturable oral absorption, which is influenced by poor dissolution and intestinal pH, resulting in disproportionately increased exposure when administered in divided doses [Li et al. (google.com)
  • Copper
  • If the protein becomes denatured or if the copper ions are lost in the purification process, the opalescent blue color disappears and the solution becomes a dull grayish color. (wikipedia.org)
  • complex
  • It aims to study the complex protein-protein interactions and networks and allows a better understanding of immune responses and their role during normal, diseased and reconstitution states. (wikipedia.org)
  • found
  • While other plants contain the protein chains found in ricin, both protein chains must be present in order to produce toxic effects. (wikipedia.org)
  • Respiratory droplets(M12) Hand contact with nasal discharge and skin contact with impetigo lesions The pathogen can also be found in its carrier state (anus, vagina, skin, pharynx) Can also be spread from cattle to humans through raw milk and contaminated foods (salads, milk, eggs) In 1928, Rebecca Lancefield published a method for serotyping S. pyogenes based on its M protein, a virulence factor displayed on its surface. (wikipedia.org)
  • The M protein found on some serotypes is also able to prevent opsonization by binding to fibrinogen. (wikipedia.org)
  • produce
  • The propolypeptide is cleaved within protein bodies by an endopeptidase to produce the mature ricin protein that is composed of a 267 residue A chain and a 262 residue B chain that are covalently linked by a single disulfide bond. (wikipedia.org)
  • Different
  • Different proteins were added at 200mg/mL to ultrapure water and then incrementally diluted until they dissolved. (thermofisher.com)
  • The genome of different strains were sequenced (genome size is 1.8-1.9 Mbp) encoding about 1700-1900 proteins (1700 in strain NZ131, 1865 in strain MGAS5005). (wikipedia.org)
  • unique
  • M proteins are unique to each strain, and identification can be used clinically to confirm the strain causing an infection. (wikipedia.org)
  • cells
  • In addition, the capsule and several factors embedded in the cell wall, including M protein, lipoteichoic acid, and protein F (SfbI) facilitate attachment to various host cells. (wikipedia.org)
  • important
  • Our results show that highly conserved M2e and HA2-2(76-130) can be used as important targets for the development of universal flu vaccines. (springer.com)