Highly conserved transcription. Medical search. Frequent questions

In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. (wikipedia.org)
Nonstructural protein 1 (NS1) is a DNA-binding protein involved in gene transcription. (medscape.com)
NP1 is also nonstructural and is a highly conserved protein of unknown function. (medscape.com)
Activation of the Yap transcription co-activator was monitored using a high content, image based assay that measured the intracellular localization of native YAP protein. (selectbiosciences.com)
We have determined the solution structure of NusB, a transcription antitermination protein from Escherichia coli. (rcsb.org)
Residues that are highly conserved among homologs stabilize the protein core. (rcsb.org)
The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
The bZIP protein sequence contains 2 conserved bZIP domains with a total length of ~ 60-80 amino acids. (biomedcentral.com)
Current models of circadian clocks rely heavily on feedback loops based around transcription and translation - the "reading" of DNA and subsequent protein production. (thenakedscientists.com)
The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). (embl-heidelberg.de)
Molecular cloning of cDNA indicated that the AML1-MTG8-binding protein (MTGR1) is highly related to MTG8 and similar to Drosophila Nervy. (embl-heidelberg.de)
RUNX3 protein is a transcription factor, containing a highly conserved DNA binding domain which binds to a DNA core motif of 5′ pyGpyGGT 3′ designated as a "runt domain, RD" which shares a sequence similarity with D. melanogaster RUNX. (hindawi.com)
PURA encodes Pur-α, a highly conserved multifunctional protein that has an important role in normal postnatal brain development in animal models. (bmj.com)
KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. (spandidos-publications.com)
Previous studies have indicated that KIN17 is involved in global genome repair, DNA replication, transcription and regulation of the cell cycle as part of a multi-protein complex. (spandidos-publications.com)
In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
I wanted to determine if the TWIST protein or its conserved motifs interact with other regulatory proteins to help to regulate the TWIST transcriptional activity. (uni-marburg.de)
We hypothesized that CCAAT/enhancer-binding protein α (C/EBPα), one of the most studied lineage-specific transcription factors in hematopoiesis, might influence the expression of NKG2D-Ls. (bvsalud.org)

TALE homeobox proteins are highly conserved transcription regulators. (wikipedia.org)
Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
Krüppel-like factors (KLFs) are highly conserved zinc-finger proteins that regulate cellular transcription machinery [ 1 , 2 ]. (medsci.org)
PRX proteins are very highly conserved, and found in a huge range of species, including mammals, plants and algae. (thenakedscientists.com)
these proteins are also important in regulating gene transcription. (biomedcentral.com)
This activity is strongly conserved and probably represents a primordial function of these proteins. (biomedcentral.com)
Evolutionary alignment of Twist proteins from different species, indicate TWIST contain 4 additional conserved regions such as NSEEE, NLS1, NLS2, and WR-domain besides the bHLH motif. (uni-marburg.de)
TWIST belongs to class B bHLH proteins which are known to form stable heterodimers with members of class A bHLH transcription factors including gene products of E12 and E47, respectively. (uni-marburg.de)
Furthermore, two more highly conserved TWIST motifs NSEEE and WR were analyzed individually to find out their interacting proteins and their role in regulating the TWIST1 transcriptional activity. (uni-marburg.de)
Background: Plant bZIP proteins characteristically harbor a highly conserved bZIP domain with two structural features: a DNA-binding basic region and a leucine (Leu) zipper dimerization region. (datadryad.org)
Metallo-proteins regulate negative ESX-3 transcription in high conditions of iron and zinc. (bvsalud.org)

Conservation of order and transcription orientation of two proximal genes between fishes and mammals strongly indicates gene orthology. (nih.gov)
The results showed that nine ZmCAMTA genes showed highly diversified gene structures and tissue-specific expression patterns. (frontiersin.org)
The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. (nih.gov)
Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)
they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)
In a general gene expression pattern screen for panarthropod Fox genes including the red flour beetle Tribolium castaneum, the pill millipede Glomeris marginata, the common house spider Parasteatoda tepidariorum, and the velvet worm Euperipatoides kanangrensis, we identified a Fox gene with a highly conserved expression pattern along the ventral ectoderm of arthropod and onychophoran limbs. (lu.se)
The Research Group led by Michael Potente at the Max Planck Institute for Heart and Lung Research has now discovered a molecular switch that is involved in blood vessel growth and coordinates the division and metabolism of endothelial cells: the transcription factor FOXO1, which controls how genes are read in the cell nucleus. (medicalxpress.com)
Cell reprogramming has been generally promoted using "master regulators," meaning those genes coding for transcription factors that act during embryogenesis as cell lineage-specific determinants. (alzforum.org)
Chloroplast ROS signals induced RAP2.4b and RAP2.4d expression, but these two transcription factor genes are (in contrast to RAP2.4a) insensitive to low 2CP availability, and their expression decreased in APx knockout lines. (fu-berlin.de)
In every organism where the distribution of condensin has been determined, it was shown that it accumulates in the vicinity of highly-expressed genes. (ens-lyon.fr)
Using genetics and genome editing strategies in fission yeast, we have accumulated compelling evidence that the mechanisms of transcription termination at the 3' end of genes play a role in determining the local occupancy of condensin, whatever the RNA polymerase involved. (ens-lyon.fr)
Conclusions: In summary, this genome-wide identification, characterization and expression analysis of legume bZIP genes provides valuable information for understanding the molecular functions and evolution of the legume bZIP transcription factor family, and highlights potential legume bZIP genes involved in regulating tissue development and abiotic stress responses. (datadryad.org)
Transduce señales de calcio al núcleo, en donde puede interactuar con el FACTOR DE TRANSCRIPCIÓN AP-1 o NF-KAPPA B, e iniciar la TRANSCRIPCIÓN GENÉTICA de GENES que intervienen en la DIFERENCIACIÓN CELULAR y en el desarrollo celulares. (bvsalud.org)
They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. (bvsalud.org)

The Arabidopsis ERFIb / RAP2.4 transcription factor family consists of eight members with highly conserved DNA binding domains. (fu-berlin.de)

Four kinds of intron patterns (a-d) within the basic and hinge regions were defined and additional conserved motifs were identified, both presenting high group specificity and supporting the group classification. (datadryad.org)

The second is a relatively poorly conserved leucine zipper region characterised by leucine in the last position of every seven amino acids, and hydrophobic residues at positions 3 and 4. (biomedcentral.com)
We predicted the DNA-binding patterns and the dimerization properties, based on the characteristic features in the basic and hinge regions and the Leu zipper, respectively, which indicated that some highly conserved amino acid residues existed across each major group. (datadryad.org)

The transcription factor RBPJ is an integral part of the Notch signaling cascade. (mdpi.com)
New evidence in mice suggests that cells expressing the transcription factor FOXC2 may form a reservoir of quiescent stem cells that contributes to sperm formation. (elifesciences.org)
Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)
Pax6 is a transcription factor present during embryonic development. (biolegend.com)
As a transcription factor, Pax6 acts at the molecular level in the signaling and formation of the central nervous system 11 . (biolegend.com)
The homeobox transcription factor HOXC13 upregulates human papillomavirus E1 gene expression and contributes to viral genome maintenance. (nih.gov)
The basic leucine zipper (bZIP) transcription factor (TF) is one of the largest families of transcription factors (TFs). (biomedcentral.com)
The AML1-CBFbeta transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most frequent target of chromosomal rearrangements in human leukemia. (embl-heidelberg.de)
Runt-related transcription factor 3 ( RUNX3 ) is feasible tumour suppressor gene since its inactivation was shown to be related to carcinogenesis. (hindawi.com)
To identify a nuclear marker pathognomonic of astrocytic phenotype, we assessed differential RNA expression by FACS-purified adult astrocytes and, on that basis, evaluated the expression of the transcription factor SOX9 in both mouse and human brain. (jneurosci.org)
The ppGpp binds to the transcription factor DksA and RNA polymerase to orchestrate extensive transcriptional changes that repress proliferation and promote stress survival (8, 9). (duke.edu)
The redox-sensitive transcription factor RAP2.4a mediates chloroplast-to-nucleus redox signaling and controls induction of the three most prominent chloroplast peroxidases, namely 2-Cys peroxiredoxin A (2CPA) and thylakoid- and stromal ascorbate peroxidase (tAPx and sAPx). (fu-berlin.de)
These transcription factors bound, like RAP2.4c and RAP2.4g, the tAPx promoter, but hardly the 2CPA promoter.The RAP2.4 transcription factors form an environmentally and developmentally regulated transcription factor network, in which the various members affect the expression intensity of the others. (fu-berlin.de)
Within the transcription factor family, RAP2.4a has a unique function as a general transcriptional activator of chloroplast peroxidase activity. (fu-berlin.de)
The endosperm-specific transcription factor ZHOUPI has previously been shown to play a key role in this process, by regulating both endosperm breakdown and the formation of the embryonic cuticle. (biologists.com)
This gene encodes for a bHLH transcription factor, which inhibits osteogenic differentiation by transc. (uni-marburg.de)
In contrast, fd3F encodes a novel forkhead family transcription factor that is exclusively expressed in differentiating chordotonal neurons. (tcd.ie)
Translocation of EWSR1 (Ewing sarcoma breakpoint region 1) with an ETS (E26 transformation-specific) transcription factor gene occurs in more than 95% of Ewing sarcomas. (medscape.com)
The Role of MB0, MBI and MBII in Interaction and Dynamics of the Master Regulatory Transcription Factor c-Myc. (lu.se)

Now, John O'Neill & Akhilesh Reddy at Addenbrookes Hospital in Cambridge have shown that non-transcriptional mechanisms are capable of maintaining a clock in human red blood cells, which have no nucleus and are therefore incapable of transcription. (thenakedscientists.com)
Firstly, atonal directly regulates Rfx, a well-known highly conserved ciliogenesis transcriptional regulator. (tcd.ie)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)

The Hippo pathway regulates two highly conserved, transcription co-activators YAP and TAZ. (selectbiosciences.com)
such as components of the nuclear pore, by which YAP cytoplasmic/nuclear shuttling occurs, or how proteasomal degradation regulates intracellular YAP concentrations, which then alter YAP localization and transcription. (selectbiosciences.com)
Histone acetylation regulates most DNA transactions and is dynamically controlled by highly conserved enzymes. (nature.com)
RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (biolegend.com)
RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)

Doyon, Y. & Cote, J. The highly conserved and multifunctional NuA4 HAT complex. (nature.com)

The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
View our full list of available antibodies for transcription factors . (biolegend.com)
Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
Forkhead box (Fox) transcription factors evolved early in animal evolution and represent important components of conserved gene regulatory networks (GRNs) during animal development. (lu.se)
In other words, only those transcription factors known to promote a specific cell fate have been used for inducing cell reprogramming. (alzforum.org)
Compared to the factors we use (Brn2, Ascl1, Myt1l, and NeuroD1) to induce human neurons, the inducing factors Yoo and his colleagues report are remarkably similar, since three transcription factors are essentially the same (the helix-loop-helix domain of NeuroD1 and NeuroD2 is highly conserved). (alzforum.org)
Using the entire coding sequence of TWIST1 gene, an interesting candidate was found belonging to the class A bHLH transcription factors that includes the SEF2 gene product. (uni-marburg.de)
In neurogenesis, neural cell fate specification is generally triggered by proneural transcription factors. (tcd.ie)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. (bvsalud.org)
Located within the intrinsically disordered N-terminus part of c-Myc are the highly conserved so-called Myc boxes (MB0-IV), which are crucial for Myc function and interaction with other transcription factors. (lu.se)
We will present first molecular data showing how these boxes interact with critical transcription factors as well as with each other in a highly specific but also highly dynamic manner, and how these interactions can be interrupted. (lu.se)

Many, but not all, of these effectors contain a conserved 18 amino-acid binding motif that has been termed CRIB (Cdc42-Rac interactive binding), PBD (p21-binding domain) or GBD (GTPase-binding domain) [ 4 ]. (biomedcentral.com)

The functions of NSEEE, NLS1, NLS2, and conserved WR motifs are poorly understood at present. (uni-marburg.de)

The fish and mammalian sequences are also well conserved, particularly for zebrafish, to beyond the end of the hydrophobic sequence (identity 41-53%, 78 amino acids, zebrafish length). (nih.gov)
Comparison of amino acid sequences among MTGR1, MTG8, and Nervy revealed four evolutionarily conserved regions (NHR1 to NHR4). (embl-heidelberg.de)
In the late 20th century and the early 21st century, this junk DNA has been shown to not only contain important regulatory elements for transcription, but also sequences that encode various non-coding RNAs that have functions in many cellular mechanisms. (blogspot.com)
Sequences of the Myc oncogene have been highly conserved throughout evolution, from Drosophila to vertebrates. (sigmaaldrich.com)

The Aptima HIV-1 Quant Dx uses Hologic's proprietary real-time -transcription- mediated- amplification technology, a dual target approach against highly conserved regions in the HIV-1 genome, and redundancy of oligonucleotides in order to protect against potential future mutations in the HIV-1 genome. (aacc.org)
For example, growing evidence strongly suggests that transcription can interfere locally with genome duplication by DNA polymerases or with the SMC-driven 3D organization of chromosomes (Fig. 1). (ens-lyon.fr)
The features of transcription that are directly responsible for these genome-destabilizing threats are still under investigation and are the primary focus of our research. (ens-lyon.fr)
A by-product of transcription that is of a particular interest to explain the genome-destabilizing properties of transcription are R-loops. (ens-lyon.fr)

As expected, the genomic termini, possessing initiation signals for viral transcription and replication, were highly conserved. (usda.gov)
2) What are the requirements for DNA replication and transcription at the beginning of mammalian development? (nih.gov)

Recently we reported on an siRNA screen, in a liver biliary cell line, to identify regulators of the Yap-Hippo pathway that allow activation of the YAP transcription co-activator at high cell density. (selectbiosciences.com)

Second, we have identified the mammalian stringent response pathway which is highly similar to bacterial stringent response, but with some very interesting twists and novel mechanisms. (duke.edu)

Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. (biomedcentral.com)

The basic signaling properties of two major subgroups of Rho GTPases - the Cdc42 and Rac subfamilies - are highly conserved amongst all eukaryotes, but the means by which they act are not well understood. (biomedcentral.com)

each contains a highly conserved transcription control sequence, the paired box. (nih.gov)

The only essential histone acetyltransferase (HAT) in yeast, Esa1, is part of the 1-MDa NuA4 complex, which plays pivotal roles in both transcription and DNA-damage repair. (nature.com)
NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. (nature.com)

The locus of this system is highly conserved across mycobacterial species. (bvsalud.org)

Such results highlight how targeting conserved cellular functions can lead to validated activity in phenotypic assays. (selectbiosciences.com)

Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)

The results showed that lncRNA SNHG3 and TWIST were highly expressed in GC cell lines, while miR-326 was expressed to a low degree. (hindawi.com)

Consistently, among 13 drugs targeting chromatin modifiers, EHMT2 inhibitors were highly effective in reducing ERMS cell viability. (elifesciences.org)

The observed effect relied in part upon the presence of conserved helical repeats and upon the highly charged C-terminal domain (pI = 11.3). (wikigenes.org)

To test this hypothesis, we first examined the endogenous expression of wild-type C/EBPα (C/EBPα-p42) in human AML cell lines and demonstrated that its expression level was highly relevant to the sensitivity of AML cells to NK cell cytotoxicity. (bvsalud.org)

The calmodulin-binding transcription activators (CAMTA) play critical roles in plant growth and responses to environmental stimuli. (frontiersin.org)

Transcription is repressed in quiescent or terminally differentiated cells. (sigmaaldrich.com)

The importance of FOXO1 in the endothelium is reflected in the fact that the molecule has been highly conserved throughout evolution. (medicalxpress.com)
In addition, KIN17 is a highly conserved gene across evolution. (spandidos-publications.com)

We found that RUNX3 was highly methylated and downregulated in GBM. (hindawi.com)
In addition, we found that ferroptosis is highly regulated by cell density. (duke.edu)

However, the effect of VÎ³9VÎ´2 T cells on chemotherapy-resistant acute myeloid leukemia (AML) blasts, especially highly refractory leukemia stem cells (LSCs) is still unknown. (bvsalud.org)

Therefore, MESH1 knockdown leads to both stress survival and proliferation arrest, two cardinal features highly reminiscent of the bacterial stringent response. (duke.edu)

Through this mechanism, the virus infects the alveolar, esophageal epithelial, ileum, colon and other cells on which ACE2 is highly expressed, causing damage to target organs. (spandidos-publications.com)

Unlike water pipes, blood vessels do not form a rigid, static network of conduits but a complex and highly dynamic system - one that responds rapidly to changing requirements resulting, for example, from long-term increases in oxygen and nutrient requirements within tissues. (medicalxpress.com)
In particular, we investigate: how the efficiency of RNA polymerase elongation can influence the distribution of the SMC complex condensin during mitotic chromosome condensation and, how the transcription by-product R-loop can interfere with chromosome integrity. (ens-lyon.fr)
The highly-conserved SMC complex condensin drives the abrupt and complete reorganization of chromosomes that occurs in early mitosis. (ens-lyon.fr)

Anatomy15

Organisms9

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes84

Disciplines and Occupations1

Information Science3

Protein19

Proteins11

Genes16

Members with highly conserved1

Additional conserved1

Residues2

Factor19

Transcriptional3

Regulates5

Multifunctional1

Factors13

Motif1

Motifs1

Sequences4

Genome4

Replication2

Regulators1

Mammalian1

Mediate1

Eukaryotes1

Sequence1

Histone2

Species1

Cellular1

Gene Expression1

TWIST1

Chromatin1

Domain1

Human1

Roles1

Quiescent1

Evolution2

Found2

Stem cells1

Proliferation1

Target1

Complex3