Highly conserved rna nuclear. Medical search. Frequent questions

The piwi domain is a protein domain found in piwi proteins and a large number of related nucleic acid-binding proteins, especially those that bind and cleave RNA. (wikipedia.org)
In the well-known cellular process of RNA interference, the argonaute protein in the RISC complex can bind both small interfering RNA (siRNA) generated from exogenous double-stranded RNA and microRNA (miRNA) generated from endogenous non-coding RNA, both produced by the ribonuclease Dicer, to form an RNA-RISC complex. (wikipedia.org)
This complex binds and cleaves complementary base pairing messenger RNA, destroying it and preventing its translation into protein. (wikipedia.org)
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) share overlapping genetic causes and disease symptoms, and are linked neuropathologically by the RNA binding protein TDP-43 (TAR DNA binding protein-43 kDa). (nature.com)
TDP-43 is a highly conserved, ubiquitously expressed, multifunctional nucleic acid-binding protein composed of two RNA recognition motifs (RRM), nuclear localization (NLS) and export signals (NES), and a carboxy-terminal glycine rich region. (nature.com)
KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. (spandidos-publications.com)
In neurons, local translation is supported by a variety of RNPs that can differ in their prevalence, mRNA cargoes, and RNA binding protein composition depending upon developmental stage, neuronal cell type, and subcellular location. (biorxiv.org)
FXGs contain one or more of the Fragile X related (FXR) family of RNA binding proteins: FMRP (Fragile X mental retardation protein), FXR2P, and FXR1P. (biorxiv.org)
FXG-regulated local protein synthesis may thus provide a conserved mechanism for regulating neuronal circuit function. (biorxiv.org)
This subfamily corresponds to the RRM of U11/U12-35K, also termed protein HM-1, or U1 snRNP-binding protein homolog, and is one of the components of the U11/U12 snRNP, which is a subunit of the minor (U12-dependent) spliceosome required for splicing U12-type nuclear pre-mRNA introns. (nih.gov)
Protein synthesis in cells infected by Autographa californica nuclear polyhedrosis virus (Ac-NPV): the effect of cytosine arabinoside. (microbiologyresearch.org)
Baculovirus replication: protein synthesis in Spodoptera frugiperda cells infected with Trichoplusia ni nuclear polyhedrosis virus. (microbiologyresearch.org)
Properties of the major nucleocapsid protein of Heliothis zea singly enveloped nuclear polyhedrosis virus. (microbiologyresearch.org)
Protein kinase activity associated with the extracellular and occluded forms of the baculovirus Autographa californica nuclear polyhedrosis virus. (microbiologyresearch.org)
At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)
CDC2 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF) , which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. (caslab.com)
We also identified three mutations in the leucine-rich C1-C1 interaction domain near the carboxyl terminus of the protein that both abolished C1 oligomerization and reduced RNA binding. (korea.ac.kr)
These results demonstrate that although the RBD is the primary determinant of C1 RNA binding, residues in the C1-C1 interaction domain also influence the RNA binding activity of the protein. (korea.ac.kr)
Here, we carried out the functional characterisation of the filamentous fungus-specific RNA-binding protein RBP35 required for full virulence and development in the rice blast fungus. (upv.es)
Immunoblots identified two RBP35 protein isoforms that show a steady-state nuclear localisation and bind RNA in vitro. (upv.es)
RBP35 coimmunoprecipitates in vivo with Cleavage Factor I (CFI) 25 kDa, a highly conserved protein involved in polyA site recognition and cleavage of pre-mRNAs. (upv.es)
Programmed Cell Death protein (Pdcd) 4 is a highly conserved nuclear/cytoplasmic shuttling and RNA binding protein that has been shown to suppress tumour progression by regulating transcription and translation and is therefore considered a promising target for anti-cancer therapies. (le.ac.uk)
The latter chapters contain NMR chemical shift perturbation experiments that identified the RNA Recognition Motifs (RRM) 2 and 3 of PABP1 as the main contact interface with the Pdcd4 protein. (le.ac.uk)
OsCDC48 was highly conserved with more than 90% identity in the protein levels among plant species. (jipb.net)
For this, the Sfmbt protein complex was affinity purified from the nuclear extract, followed by highly specific peptide sequencing (IP/LC-MS). As a result, a number of previously uncharacterized Sfmbt interactions were discovered. (sdbonline.org)
Evidence is provided that Hangover acts as a nuclear RNA binding protein and the phosphodiesterase 4d ortholog dunce as a target RNA. (sdbonline.org)
The hang gene encodes a large, approximately 210-kDa nuclear zinc finger protein that is expressed in most, if not all, neurons in the adult brain (Scholz, 2005). (sdbonline.org)
A Hang-related protein, ZNF699, is associated with alcoholism in humans (Riley, 2006), supporting the idea that a cellular stress mechanism underlying ethanol tolerance is evolutionarily conserved between humans and D. melanogaster. (sdbonline.org)
As snoMEN RNAs are encoded within introns it is relatively easy to design vectors that can communicate multiple snoMEN within different introns of a single transcript which also encodes LASS2 antibody a protein reporter. (biobender.com)
This approach using snoMEN vectors offers thus been used to Silodosin (Rapaflo) establish human being 'protein substitute' stable cell lines where manifestation of a targeted protein is definitely reduced by snoMEN RNAs and efficiently substituted from the manifestation of a recombinant protein encoded from the same transcript utilized to provide the snoMEN[6]. (biobender.com)
Strikingly, we found that liver-specific lincRNA gene promoters are more highly species conserved and have a significantly higher frequency of proximal binding by liver transcription factors than liver-specific protein-coding gene promoters. (omicsdi.org)
Comparative genomics has previously revealed widespread evolutionarily conserved microRNA targeting of protein-coding mRNAs, and here we applied a similar and mitochondrial tRNAs is modified, at position 5, through an unknown reaction pathway that utilizes the evolutionarily conserved MnmE and GidA proteins. (firebaseapp.com)
Dadurch konnten das „Chromodomain Helicase DNA binding protein 6" (CHD6) sowie Komponenten des „nuclear receptor corepressor complex" (N-CoR) als neue Interaktionspartner identifiziert werden. (uni-tuebingen.de)
Thus the „Chromodomain Helicase DNA binding protein 6" (CHD6) as well as components of the "nuclear receptor corepressor complex" (N-CoR could be identified as novel interaction partners. (uni-tuebingen.de)
Their RNA components fold into a similar secondary structure and they share several protein subunits. (embl-heidelberg.de)
The human Pop4 cDNA encodes a highly basic protein of 220 amino acids. (embl-heidelberg.de)
Polyclonal rabbit antibodies raised against recombinant hPop4 recognised a 30 kDa protein in total HeLa cell extracts and specifically co-immunoprecipitated the RNA components of the RNase MRP and RNase P complexes. (embl-heidelberg.de)
Despite differences in the residue and protein selectivities of prokaryotic and eukaryotic ROXs, comparison of the crystal structures of E. coli YcfD and Rhodothermus marinus YcfD with those of human MINA53 and NO66 reveals highly conserved folds and novel dimerization modes defining a new structural subfamily of 2OG-dependent oxygenases. (ox.ac.uk)

Piwi proteins are highly conserved RNA-binding proteins and are present in both plants and animals. (wikipedia.org)
Piwi proteins belong to the Argonaute/Piwi family and have been classified as nuclear proteins. (wikipedia.org)
The small RNA partners of Ago proteins are microRNAs (miRNAs). (wikipedia.org)
Ago proteins utilize miRNAs to silence genes post-transcriptionally or use small-interfering RNAs (siRNAs) in both transcription and post-transcription silencing mechanisms. (wikipedia.org)
Human Piwi proteins all contain two RNA binding domains, PAZ and Piwi. (wikipedia.org)
The four PIWI-like proteins have a spacious binding site within the PAZ domain which allows them to bind the bulky 2'-OCH3 at the 3' end of piwi-interacting RNA. (wikipedia.org)
The effects of piwi proteins in human and mouse germlines seems to stem from their involvement in translation control as Piwi and the small noncoding RNA, piwi-interacting RNA (piRNA), have been known to co-fractionate polysomes. (wikipedia.org)
The function of the domain is double stranded-RNA-guided hydrolysis of single stranded-RNA that has been determined in the argonaute family of related proteins. (wikipedia.org)
Argonautes, the most well-studied family of nucleic-acid binding proteins, are RNase H-like enzymes that carry out the catalytic functions of the RNA-induced silencing complex (RISC). (wikipedia.org)
Spatial segregation of proteins to neuronal axons arises in part from local translation of select mRNAs that are first transported into axons in ribonucleoprotein particles (RNPs), complexes containing mRNAs and RNA binding proteins. (biorxiv.org)
Fragile X granules (FXGs) are axonal RNPs containing the Fragile X related family of RNA binding proteins along with ribosomes and specific mRNAs. (biorxiv.org)
Restricting local translation to the appropriate cellular compartment at the correct developmental timepoint requires correct positioning of ribonucleoprotein particles (RNPs), complexes that contain mRNAs and the RNA binding proteins that control their translation. (biorxiv.org)
Autographa californica nuclear polyhedrosis virus phosphoproteins and synthesis of intracellular proteins after virus infection. (microbiologyresearch.org)
The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. (embl.de)
The heterogeneous nuclear ribonucleoprotein (hnRNP) C proteins, among the most abundant pre-mRNA-binding proteins in the eukaryotic nucleus, have a single RNP motif RNA-binding domain. (korea.ac.kr)
EN] RNA-binding proteins play a central role in post-transcriptional mechanisms that control gene expression. (upv.es)
The multi-functionality of HP1 reflects its ability to interact with diverse nuclear proteins, ranging from histones and transcriptional co-repressors to cohesion and DNA replication factors. (elsevierpure.com)
Package C/D snoRNAs are named after a common RNA motif with this subfamily that serves as a binding site for a group of box C/D proteins including NOP56 NOP58 15.5 and the conserved proteins fibrillarin which provides the particular 2'-O-methylase activity highly. (biobender.com)
In prior studies it had been proven that snoMEN vectors can reduce proteins appearance amounts by knocking-down the appearance of nuclear pre-mRNAs enabling the concentrating on of complementary sequences within intron and/or non-coding 5' and 3' flanking sequences within mRNA precursors (pre-mRNAs)[6]. (biobender.com)
For this purpose, we used the orthology assignments based on sequence similarity and … RNA editing in bacteria recodes multiple proteins and regulates an evolutionarily conserved toxin-antitoxin system. (firebaseapp.com)
Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA and ribosomal proteins have been shown to be important in translation relating to cellular growth, TH17-cell differentiation and translational accuracy. (ox.ac.uk)

The HP1 family is evolutionarily highly conserved and there are multiple members within the same species. (elsevierpure.com)
We used the nuclear dimorphic ciliate protozoan, Tetrahymena thermophila , to investigate the dynamics of H3 variant function in evolutionarily divergent eukaryotes. (biomedcentral.com)
Gene, evolutionarily conserved: A gene that has remained essentially unchanged throughout evolution. (firebaseapp.com)
The pathways are named Many translated example sentences containing "evolutionarily conserved" - Swedish-English dictionary and search engine for Swedish translations. (firebaseapp.com)
Issue Date dc.title, Evolutionarily Conserved Drug Targets. (firebaseapp.com)
This activity can be spontaneous, such as the retinal waves that course across the The GAIN domain is evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell‐adhesion GPCRs and 8 Mar 2017 Evidence for an Evolutionarily Conserved Memory Coding Scheme in the Mammalian Hippocampus. (firebaseapp.com)
Alexander Thome, Diano F. Marrone, 3 Jan 2018 These results suggest that genomic imprinting was evolutionarily conserved between closely related Triticum and Aegilops species and in the An evolutionarily conserved pathway controls proteasome homeostasis. (firebaseapp.com)
diagram boosting the proteasome (part) Cell survival 1 Sep 1989 The evolutionary conservation of the ability to degrade both insulin and TGF- alpha suggests that this property is important for the physiological Studies in Drosophila have identified an evolutionarily conserved signaling pathway that regulates organismal size and that includes the Drosophila insulin Like the EES, the Modern Synthesis also represents a particular way to understand evolution. (firebaseapp.com)
2020-05-18 · We identified evolutionarily conserved patterns of gene expression during retinal progenitor maturation and specification of all seven major retinal cell types. (firebaseapp.com)
Autophagy is an evolutionarily conserved pathway responsible for degradation of cytoplasmic material via Conservation of a gene indicates that it is unique and essential: There is not an extra copy of that gene with which evolution can tinker, and changes in the gene are likely to be lethal. (firebaseapp.com)
CONTINUE SCROLLING OR CLICK HERE FOR RELATED SLIDESHOW Gene, evolutionarily conserved: A gene that has remained essentially unchanged throughout evolution. (firebaseapp.com)

Here we show that the Set1 complex (Set1C) directly binds RNA in vitro through the regions that comprise the double RNA recognition motifs (dRRM) and N-SET domain within Set1 and its subunit Spp1. (prinsesmaximacentrum.nl)

The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. (embl.de)
We found both previously predicted, highly conserved residues as well as additional residues in the RBD to be essential for C1 RNA binding. (korea.ac.kr)

Limited evidence indicates that bunyaviruses cause mild disease such as arthritis but that they do not present a serious threat to human health ( 3 ), thereby suggesting that species of bunyaviruses in Australia may be less virulent than those found elsewhere, despite their close relatedness to highly pathogenic species. (cdc.gov)
Understanding the importance of local translation for a particular circuit requires not only identifying axonal RNPs and their mRNA cargoes, but also whether these RNPs are broadly conserved or restricted to only a few species. (biorxiv.org)
FXGs were previously identified in mouse, rat, and human brains in a conserved subset of neuronal circuits but with species-dependent developmental profiles. (biorxiv.org)
Here we asked whether FXGs are a broadly conserved feature of the mammalian brain and sought to better understand the species-dependent developmental expression pattern. (biorxiv.org)
We found FXGs in a conserved subset of neurons and circuits in the brains of every examined species that together include mammalian taxa separated by up to 160 million years of divergent evolution. (biorxiv.org)
The most interesting RNPs therefore are those whose expression is conserved across different species, since they are compelling candidates for supporting fundamental neurobiological functions. (biorxiv.org)
NBs are dynamic nuclear domains that contain an expanding list of enriched components with conserved functions across many species. (rupress.org)
Microbial LPS and viral dsRNA are potent inducers of nuclear factor (NF)-κB transcription factors, which have been implicated in regulation of host defense mechanisms in diverse species ranging from insects to mammals ( 3 ). (rupress.org)
Plastid parts offer the benefit of highly conserved regulatory sequences that can be used across species. (igem.org)
Here, we analyzed 45 mouse liver RNA sequencing (RNA-Seq) data sets collected under diverse conditions to systematically characterize 4,961 liver lincRNAs, 59% of them novel, with regard to gene structures, species conservation, chromatin accessibility, transcription factor binding, and epigenetic states. (omicsdi.org)
We examined each of these small RNA classes with respect to the newly assembled tammar wallaby genome for gene and repeat features, salient features that define their canonical sequences, and the constitution of both highly conserved and species-specific members. (biomedcentral.com)
The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)

TDP-43 regulates RNA metabolism, trafficking, and localization of thousands of target genes. (nature.com)
noncoding RNAs transcribed from heterochromatic DNA repeats regulates the assembly and function of heterochromatin ranging from fission yeast to animals. (elsevierpure.com)

This class includes RNAs derived from SET1, Ty1 retrotransposons, specific transcription factors genes and snRNAs (small nuclear RNAs). (prinsesmaximacentrum.nl)
Similarly, RNA-seq and ChIRP-seq data suggest that KO of Malat1 hampers immune evasion and downregulates metastasis associated genes including Serpins and Wnts. (bmj.com)
Binding sites for the nuclear factor (NF)-κB transcription factor have been identified within control regions of many genes involved in inflammatory and immune responses. (rupress.org)
Although inherently unstable, growth factor signaling leads to increased MYC levels and its association with MAX forming a transcriptional heterodimer complex that binds to conserved E-box elements (consensus CACGTG) in the promoters of target genes leading to gene activation [ 1 ]. (oncotarget.com)
ChIP-seq experiments in growing Tetrahymena show H3.3 enrichment over the promoters, gene bodies, and transcription termination sites of highly transcribed genes. (biomedcentral.com)
H3.3 knockout followed by RNA-seq reveals large-scale transcriptional alterations in functionally important genes. (biomedcentral.com)
The sex-biased lincRNA genes are enriched for nearby and correspondingly sex-biased accessible chromatin regions, as well as sex-biased binding sites for growth hormone-regulated transcriptional activators (STAT5, hepatocyte nuclear factor 6 [HNF6], FOXA1, and FOXA2) and transcriptional repressors (CUX2 and BCL6). (omicsdi.org)
Genes in active, inactive, and poised chromatin states exhibited differential responsiveness to ligand-activated nuclear receptors and distinct enrichments for functional gene categories. (omicsdi.org)
ii) Trimethylation of histone H3 at K27 (H3K27me3) is a major sex-biased repressive mark at highly female-biased but not at highly male-biased genes. (omicsdi.org)
Using a combination of miRNA hairpin predictions and co-mapping with miRBase entries, we identified a highly conserved cluster of miRNA genes on the X chromosome in the tammar and a total of 94 other predicted miRNA producing genes. (biomedcentral.com)
Mapping all miRNAs to the tammar genome and comparing target genes among tammar, mouse and human, we identified 163 conserved target genes. (biomedcentral.com)

In addition, we uncovered that Set1 binds to different classes of RNAs to levels that largely exceed the levels of binding to the general population of transcripts, suggesting the Set1 persists on these RNAs after transcription. (prinsesmaximacentrum.nl)

In keeping with endogenous snoRNAs snoMEN RNAs are effectively transcribed from RNA polymerase II promoters instead of in the RNA polymerase III promoters utilized for shRNA plasmids[7]. (biobender.com)
Highly repeated sequences, 100-300 bases long, which contain RNA polymerase III promoters. (lookformedical.com)

An autoimmune response to nuclear and cytoplasmic autoantigens is detected in about 60-80% of patients with polymyositis and dermatomyositis. (medscape.com)
This study provides insight into how nuclear Hangover/RNA signaling is linked to the cytoplasmic regulation of cAMP levels and results in neuronal adaptation and behavioral changes (Ruppert, 2017). (sdbonline.org)

Mutationsanalysen der 31E2C Domäne und RNA Interferenz-Experimente belegten, dass die E8^E2C/CHD6 Interaktion zur transkriptionellen Repression des E6/E7 Promoters beiträgt. (uni-tuebingen.de)
Highly repeated sequences, 6K-8K base pairs in length, which contain RNA polymerase II promoters. (lookformedical.com)

Endogenous snoRNAs are abundant nuclear RNAs that are efficiently prepared from principal transcripts highly. (biobender.com)

It contains a conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), followed by an adjacent glycine-rich region, and Arg-Asp and Arg-Glu dipeptide repeats rich domain, making U11/U12-35K a possible functional analog of U1-70K. (nih.gov)
RBP35 contains an N-terminal RNA recognition motif (RRM) and six Arg-Gly-Gly tripeptide repeats. (upv.es)
It is derived from the 7SL RNA component of the SIGNAL RECOGNITION PARTICLE and contains an RNA polymerase III promoter. (lookformedical.com)
The primate Alu (ALU ELEMENTS) and the rodent B1 SINEs are derived from 7SL RNA, the RNA component of the signal recognition particle. (lookformedical.com)

M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. (beds.ac.uk)
Our results provide an evolutionary perspective on H3.3's conserved role in maintaining the transcriptional landscape of cells and on the emergence of specialized chromatin assembly pathways. (biomedcentral.com)
Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone. (omicsdi.org)
Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)

The RNA-binding domain (RBD) is comprised of ∼80-100 amino acids, and its structure has been determined. (korea.ac.kr)
However, relatively little is known about the role of specific amino acids of the RBD in the binding to RNA. (korea.ac.kr)
We have devised a phage display-based screening method for the rapid identification of amino acids in hnRNP C1 that are essential for its binding to RNA. (korea.ac.kr)
Genetic studies have exhibited multiple HLA- em DRB1 /em alleles encoding a conserved sequence at amino acid positions 70C74 are associated with susceptibility and severity of RA. (exposed-skin-care.net)

snoRNAs are a family of conserved nuclear RNAs concentrated in nucleoli where they either function in the changes of ribosomal RNA (rRNA) or participate in the control of rRNA during ribosome subunit synthesis[2-5]. (biobender.com)

MALAT1 also known as NEAT2 (nuclear-enriched abundant transcript 2) is definitely a highly conserved nuclear lncRNA and a predictive marker for metastasis development in lung malignancy [23]. (opioid-receptors.com)
Malat1 is one of the most abundant and highly conserved nuclear lncRNAs and have shown the associated with metastasis and serving as a predictive marker for various tumor progression. (bmj.com)

The RNA expression and clinical data of The Cancer Genome Atlas (TCGA) and corresponding normal samples data of the Genotype-tissue expression (GTEx) database were obtained from the UCSC Xena database ( https://xenabrowser.net/datapages/ ). (biomedcentral.com)
These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)
As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)
Elements that are transcribed into RNA, reverse-transcribed into DNA and then inserted into a new site in the genome. (lookformedical.com)
Shortening of the 5'-terminus of the daughter strand, caused by the removal of the terminal RNA-primer and the subsequent incomplete replication of linear DNA molecules, is observed during the genome replication occurring upon cell fission. (actanaturae.ru)

Background Recent proof indicates that lengthy noncoding RNAs (lncRNAs) play a critical role in the regulation of cellular processes such as differentiation proliferation and metastasis. (opioid-receptors.com)
1-4 Long non-coding RNAs (lncRNAs) are involved in various biological processes and diseases. (bmj.com)

Rpp29 ( EC 3.1.26.5 ) catalyses the endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. (embl-heidelberg.de)
The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). (lookformedical.com)

To investigate the functional relevance of RNA binding, we performed UV RNA crosslinking (CRAC) for Set1 and RNA polymerase II in parallel with ChIP-seq experiments. (prinsesmaximacentrum.nl)
With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. (beds.ac.uk)
Functional proteomics and immunofluorescence analyses of H3.1 and H3.3 revealed a highly conserved role for Nrp1 and Asf1 histone chaperones in nuclear influx of histones. (biomedcentral.com)
They are spliced together to become a MESSENGER RNA or other functional RNA. (lookformedical.com)

Adenosine (A) to inosine (I) RNA editing is widespread in eukaryotes. (firebaseapp.com)

Innate immune responses are dependent on the presence of receptors that are capable of recognizing highly conserved features present on microorganisms ( 1 , 2 ). (rupress.org)
Thus, LPS present in cell walls of gram-negative bacteria is recognized by cell surface receptors present on many different types of cells, and viral products such as double-stranded (ds)RNA molecules can activate intracellular kinases ( 1 , 2 ). (rupress.org)

Within the tightly packed nuclear interior, which lacks defining membranes, various structurally distinct compartments and nuclear bodies (NBs) exist. (rupress.org)
The RNase MRP particle is structurally highly related to the RNase P particle, which is involved in pre-tRNA processing. (embl-heidelberg.de)
Ribosomal oxygenases are structurally conserved from prokaryotes to humans. (ox.ac.uk)

In addition, RNA interference resulted in the premature senescence and death phenotype. (jipb.net)

This successfully increases the selection of sequences in focus on RNAs that may be explored to attain gene-specific inhibitory results. (biobender.com)
Sequences of DNA or RNA that occur in multiple copies. (lookformedical.com)
Phylogeny based on concatenated sequences of 125 conserved ORFs showed that this isolate clustered most closely with the Mkuzi 1979 isolate. (cdc.gov)

Not only is m7G involved in the normal physiological metabolism of RNA, but recent research also shows that m7G and related regulators appear to be considerably dysregulated in tumors [ 12 ]. (beds.ac.uk)

In vitro, both peptides were highly active against intracellular Leishmania major in mouse macrophages without exerting toxicity in host cells. (unav.edu)

The Set1 family of histone H3 lysine 4 (H3K4) methyltransferases is highly conserved from yeast to human. (prinsesmaximacentrum.nl)
Epigenetics refers to heritable changes in gene expression without changing the nucleotide sequence of the gene, including DNA methylation, histone modifications, and RNA modifications. (beds.ac.uk)

Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)

GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)

Together with the EF-2-like GTPase RIA1 (EfI1), it triggers the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. (embl.de)

NLS, nuclear localization signal. (medscape.com)

These FXG properties are conserved in both mice and rats, suggesting these granules may support conserved cellular functions. (biorxiv.org)

and the C-terminal PIWI domain acts as an RNase H endonuclease that can cleave RNA. (wikipedia.org)
Using next generation sequencing, we have characterized the major classes of small RNAs, micro (mi) RNAs, piwi interacting (pi) RNAs, and the centromere repeat associated short interacting (crasi) RNAs in the tammar. (biomedcentral.com)

The widespread conservation of FXGs suggests that axonal translation is an ancient, conserved mechanism for regulating the proteome of mammalian axons. (biorxiv.org)

Using a recombinant endonuclease-deficient Cas9-based gene promoter pulldown approach coupled with mass spectrometry, we found that MCUb is upregulated in the T2D heart due to loss of glucose homeostasis regulator nuclear receptor corepressor 2 repression, and chromatin immunoprecipitation assays identified peroxisome proliferator-activated receptor α as a mediator of MCUb gene expression in T2D cardiomyocytes. (diabetesjournals.org)

Until recently regulation of translation inhibition was exclusively thought to be eIF4A mediated, and was shown to involve the interaction of the tandem MA3 domains of Pdcd4 with the RNA helicase, eIF4A. (le.ac.uk)
The detection of RNA modifications is fundamental to the study of m7G modifications in the regulation of gene expression. (beds.ac.uk)

Following a complex process of miRNA transcription, processing, and nuclear export, miRNAs are further processed by the RNaseIII enzyme, Dicer, and its cofactor TRBP. (biomedcentral.com)

This class of snoRNAs consist of an internal sequence (M package) that can be altered to make it complementary to RNA focuses on. (biobender.com)
This conserved sequence is commonly known as the shared epitope (SE). (exposed-skin-care.net)

5, 6] The DBD is the most highly conserved domain throughout the steroid receptor family. (medscape.com)
The long forms contain the upstream conserved region 1 and 2 (UCR1 and UCR2, respectively) domains, whereas the short forms lack the UCR1 domain and have either a partial or complete UCR2 domain. (sdbonline.org)
Telomerase consists of two major components: reverse transcriptase (TERT) and telomerase RNA (TER), which contains the template domain for the telomere repeat synthesis [ 9 ]. (actanaturae.ru)

To identify a nuclear marker pathognomonic of astrocytic phenotype, we assessed differential RNA expression by FACS-purified adult astrocytes and, on that basis, evaluated the expression of the transcription factor SOX9 in both mouse and human brain. (jneurosci.org)

Analogous experiments suggest the RNA Binding Region (RBD) and middle MA3 domains of Pdcd4 contain the main PABP1 binding sites. (le.ac.uk)

Genomic analysis of highly virulent isolate of African swine fever virus. (cdc.gov)

We show that FBP21 is present in highly purified spliceosomal complex A, is associated with U2 snRNPs, and colocalizes with splicing factors in nuclear speckle domains. (embl.de)
In general, PDE4s can be divided into two classes based on the presence or absence of the two highly conserved N-terminal domains. (sdbonline.org)

Each class of small RNAs is synthesized by a distinct mechanism and each has discrete biological functions. (biomedcentral.com)

to other RNAs may initiate epige- cleus pathways. (who.int)

Anatomy16

Organisms27

Diseases1

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes76

Information Science4

Health Care1

Protein40

Proteins21

Evolutionarily11

Motifs1

Residues2

Species12

Regulates2

Genes11

Binds1

Polymerase III promoters2

Cytoplasmic2

Promoters2

Endogenous1

Recognition4

Transcriptional4

Amino4

Subunit1

Abundant2

Genome6

LncRNAs2

Cleavage3

Functional4

Eukaryotes1

Receptors2

Structurally3

Interference1

Sequences3

Metabolism1

Vitro1

Histone2

Eukaryotic1

Analyses1

RRNA1

Localization1

Cellular1

Piwi2

Mammalian1

Receptor corepressor1

Regulation2

MiRNA1

Sequence2

Domain3

Phenotype1

Experiments1

Genomic1

Domains2

Mechanism1

Pathways1