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  • Gene
  • Ribosomal protein L9 was first implicated in decoding fidelity when a mutant version of L9 was found to increase the translation of a T4 phage gene. (ucf.edu)
  • RNAs
  • Intron-derived long noncoding RNAs with snoRNA ends ( sno-lncRNAs ) are highly expressed from the imprinted Prader-Willi syndrome (PWS) region on human chromosome 15. (biomedcentral.com)
  • molecular
  • We construct a molecular model of ribosomal evolution starting from primordial biological systems near the dawn of life, culminating with relatively recent changes specific to metazoans. (pnas.org)
  • recognize
  • The results support a model for ribosomal decoding in which A1492 and A1493 recognize the helical structure of cognate codon-anticodon complexes in the A site. (sciencemag.org)
  • Conservation
  • A common tacit assumption is that conserved regulatory mechanisms underlie module conservation, because coregulation imposes tight constraints on the evolution of a module's promoters. (pnas.org)
  • ancestral
  • Observation of insertion fingerprints in the ribosomal common core allows identification of probable ancestral expansion segments. (pnas.org)
  • analysis
  • Crystallographic analysis of archaeal ribosomal protein L11. (nih.gov)
  • Here, the crystallization and X-ray analysis of the ribosomal protein L11 from Methanococcus jannaschii are reported. (nih.gov)
  • Two modules with the lowest reciprocal orthology P values were defined as orthologous and were used in subsequent analysis of conserved transcriptional modules. (pnas.org)
  • Although primary sequence analysis revealed that snoRNAs themselves are conserved from human to mouse, sno-lncRNAs are not. (biomedcentral.com)
  • various
  • PromoKine's PCR Mycoplasma Test Kit I utilizes highly-sensitive PCR technology for fast, convenient and reliable in situ detection of contaminating mycoplasmas in various biological materials including cell cultures and virus stocks. (promokine.info)
  • role
  • We discuss the evidence supporting the biochemical assignment of these emerging enzymes as ribosomal protein hydroxylases, and provide an overview of their role in immunology, bone development, and cancer. (springer.com)
  • mechanism
  • We suggest that this formation of an intermediate redundant regulatory program allows conserved transcriptional modules to gradually switch from one regulatory mechanism to another while maintaining their functionality. (pnas.org)
  • specific
  • PCR has been shown to be a highly sensitive, specific and rapid method for the detection of mycoplasmas contamination in cell cultures. (promokine.info)
  • functions
  • The vascular endothelium is a highly specialized tissue with diverse functions that are regulated by many hormones, cytokines, and growth factors. (ahajournals.org)