Highly conserved proteinaceous residues protein residues. Medical search. Frequent questions

While we could place a number of these peptides within proteins that had already been identified, there were many cysteine-rich peptides that traced to fragments of avian nucleic acid sequences that have yet to find their proper place in the chicken genome. (udel.edu)
Nearly 39% of the ESTs were predicted to encode proteins of fungal origin and among these, 162 ESTs were predicted to contain N-terminal signal peptides (SPs) in their deduced open reading frames (ORFs). (biomedcentral.com)

Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates based on a conserved mechanism involving activation of an active site-bound water molecule by a Zn 2+ ion. (evelinvahter.com)
Although the catalytic domain of MMPs is structurally highly similar, there are many differences with respect to substrate specificity, cellular and tissue localization, membrane binding and regulation that make this a very versatile family of enzymes with a multitude of physiological functions, many of which are still not fully understood. (evelinvahter.com)
The C P residue is conserved in all Prx enzymes. (molcells.org)
2-Cys Prx enzymes are homodimeric and contain two conserved (C P and C R ) cysteine residues per subunit. (molcells.org)

Indeed, within the pyrenoids of eukaryotic algae, the functional homologues of carboxysomes, Rubisco adopts a liquid-like state by interacting with the intrinsically disordered protein EPYC1 14 . (nature.com)
Intrinsically disordered regions in Pex13 and Pex5 resemble those found in nuclear pore complex proteins. (tcdb.org)

1993 ). Catalysis of protein substrates is (most probably) carried out via a general base mechanism involving activation of a zinc-bound water molecule by the carboxylate group of the conserved glutamate residue in the catalytic pocket followed by attack of water on the polarized carbonyl group in the substrate's scissile bond (Browner et al. (evelinvahter.com)

As such as proteins, lipids, glycans, nucleic acids, and isoporous ultrafiltration membrane they can apparently combination of that. (2medicalcare.com)
Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)

Several viruses require lysosomal cathepsins to cleave structural proteins and thus depend on functional GlcNAc-1-phosphotransferase. (stanford.edu)

In contrast to apoferritin bacterial secretion systems are typical examples of multi protein complexes exhibiting high flexibility owing to their functions relating to the transportation of small molecules, proteins, and DNA into the extracellular space or target cells. (bvsalud.org)
Their unique hourglass-shaped architecture is highly conserved among different bacterial membrane proteins and other biological channels. (ibecbarcelona.eu)

2011) addresses two of these aspects, the translocation of soluble proteins into the peroxisomal matrix and the biogenesis of the peroxisomal membrane. (tcdb.org)

Eleven candidate effector genes were identified based on features common to characterized fungal effectors, i.e. they encode small, soluble (lack of transmembrane domain), cysteine-rich proteins with a putative SP. (biomedcentral.com)

A large pore is formed by transmembrane proteins. (tcdb.org)

As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis. (springer.com)
In the budding yeast Saccharomyces cerevisiae , the minimal transport machinery includes the membrane proteins Pex13 and Pex14 and the cargo-protein-binding transport receptor, Pex5. (tcdb.org)
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. (lookformedical.com)

In addition, the comparison with stony coral skeletomes highlighted the low proportion of similar proteins between the biomineral OMs of hexacorallian and octocorallian corals, suggesting an independent acquisition of calcification in anthozoans. (biomedcentral.com)
The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)

Experimentally, we are involved, in collaboration with the Glockshuber group (ETHZ), in structural studies of a proteinaceous organelle, the type 1 pilus from uropathogenic Escherichia coli (UPEC), and in particular of its main subunit FimA. (psi.ch)
The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)

Hsp40/DNAJ proteins interact differently with Hsp70 chaperones [ 13 ] . (encyclopedia.pub)

Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)

Biopolymers, such as proteins, DNA, and polysaccharides, which are available in almost unlimited quantity in nature, as well as many synthetic polymers, which are industrially produced on a large scale, belong to this fascinating class of polymers. (mdpi.com)
Using cryo-histochemistry as well as infrared and sum frequency generation spectroscopy on the mucus of two arboreal ( H. cinerea and Osteopilus septentrionalis ) and of two terrestrial, non-climbing frog species ( Pyxicephalus adspersus and Ceratophrys cranwelli ), we find neutral and acidic polysaccharides, and indications for proteinaceous and lipid-like mucus components. (biomedcentral.com)

P-type ATPases are α-helical bundle primary transporters named based upon their ability to catalyze auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue within the pump and their energy source, adenosine triphosphate (ATP). (wikipedia.org)

Hsp70, Hsp90, and their co-chaperones are crucial members of the proteostasis network that are able to recognize misfolded proteins, aberrant condensates and protein aggregates, triaging proteins for refolding or degradation. (encyclopedia.pub)
Indeed, Hsp70, Hsp90 and their co-chaperones are increasingly recognized as therapeutic targets for the development of treatments against prevalent protein misfolding diseases. (encyclopedia.pub)
Human Hsp70 presents a variety of highly identical isoforms that coexist in cellular compartments, yet show functional specificity [ 3 ] . (encyclopedia.pub)
Hop (Hsp-organizing protein) promotes the transfer of the substrate from the Hsp70 machinery to Hsp90. (encyclopedia.pub)
Interestingly, these variable regions determine the differential effects of Hsp70 isoforms on the aggregation or degradation of the Alzheimer's-disease-related protein tau [ 16 ] . (encyclopedia.pub)

HC RSs are characterized by the presence of a sphere-shaped proteinaceous organelle (also known as dense body) adjacent to the presynaptic membrane. (jneurosci.org)

P-type ATPases fall under the P-type ATPase (P-ATPase) Superfamily (TC# 3.A.3) which, as of early 2016, includes 20 different protein families. (wikipedia.org)
2016). As the first step we used Ka/Ks ratios to detect if a protein-protein interface has a biological character (CRK method, Schärer et al. (psi.ch)

The latter represents a conformationally modified form of a normal cellular PrP C , which is a normal host protein found on the surface of many cells, in particular neurons. (medscape.com)
and the intrinsic pathway, which is activated by cellular stress and is regulated primarily at the level of mitochondria by the Bcl-2 family of proteins ( Fig. 1 ). (biologists.com)
A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (lookformedical.com)

The type 6 protein secretion system (T6SS) is prevalently utilized by Gram-negative bacteria to compete for resources and space. (preprints.org)

This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)

Sequence analyses of unigenes revealed four potential groups: hydrolases, cell envelope associated proteins (CEAPs), candidate effectors and other proteins. (biomedcentral.com)
Using potato virus X (PVX) based transient expression assays, we showed that one of the candidate effectors, i. e. contig 8 that encodes a cerato-platanin (CP) domain containing protein, unlike CP proteins from other fungal pathogens was unable to elicit a hypersensitive response (HR). (biomedcentral.com)
In recent years, however, evidence has emerged on numerous T6SS effectors that interact with related immunity proteins in a range of eukaryotic hosts. (preprints.org)

represent the only wall component and can be so closely One of the great challenges for nano(bio)technology is associated with the plasma membrane that a hydrophobic the creation of supramolecular materials in which the domain of the constituent subunits is actually integrated into constituent units are highly regular molecular nanostructures. (2medicalcare.com)
We are studying protein structures and crystal lattices by employing a variety of approaches, in particular concepts from the field of molecular evolution. (psi.ch)
The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
This interdisciplinary connection between protein chemists, molecular biologists and stereo-chemists is essential for the protein-design cycle (Fig. 1) consisting of design, cloning, expression andtesting new proteins starting from known ones. (helmholtz-hzi.de)

The latest advances in EM have enabled the determination of protein complex structures at 1.4-3 Å resolution for an extremely broad range of sizes (from ~100 kDa up to hundreds of MDa (Bartesaghi et al. (bvsalud.org)
X-ray crystallography is a method of choice to determine and analyze protein structures. (bvsalud.org)
In general, immunobiologists have developed an integrated method for vaccine development based on analyzing protein sequences and structures of target viruses [ 10 ]. (biomedcentral.com)
However, only few protein structures have been currently resolved for the Iridoviridae family, none of which are associated with the outer capsid proteins. (biomedcentral.com)
Surface (S)-layer proteins and S-layer fusion proteins incorporating functional sequences, self-assemble into monomolecular lattices on solid supports and on various lipid structures. (2medicalcare.com)
In most prokaryotic organisms S-layers surface layers (S-layers) composed of identical protein- have to be considered as non-conservative structures with the aceous subunits represent unique patterning elements and potential to fulfil a broad spectrum of functions [3, 4, 9]. (2medicalcare.com)
He was a prolific crystallographer, with 70 protein structures in the Protein Data Bank (PDB) over the past two decades. (psi.ch)
From there, he worked with Markus Grütter at the University of Zurich, elucidating the structures of numerous proteins. (psi.ch)
He continued to solve protein structures at the Swiss Light Source, and also put forward a program of large-scale bioinformatic analysis of structures. (psi.ch)
The triplets cooperatively invaded and unraveled even highly stable RNA secondary structures, and support non-canonical primer-free and bidirectional modes of RNA synthesis and replication. (elifesciences.org)
Yet, some RNA strands can also fold to form ribozymes, 3D structures that could have guided life's chemical processes the way proteins do now. (elifesciences.org)

Over two dozen proteins involved in protein import and membrane insertion, peroxins, encoded by PEX genes, have been characterized. (tcdb.org)
The expression of foreign genes using recombinant DNA technology in various host systems has permitted the production of human proteins of therapeutic interest in high amounts. (helmholtz-hzi.de)

In addition, we identified proteins that interact with the KRAB domain of PRDM9 in yeast two-hybrid assay screens, particularly CXXC1, a member of the COMPASS complex. (springer.com)

Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)

TDP-43 is a highly conserved, ubiquitously expressed, multifunctional nucleic acid-binding protein composed of two RNA recognition motifs (RRM), nuclear localization (NLS) and export signals (NES), and a carboxy-terminal glycine rich region. (nature.com)

The results of the present study demonstrate that pigs are highly protected against heterologous Vietnamese HP-PRRSV challenge by immunity against a Japanese local strain, EDRD1. (biomedcentral.com)

PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)

The intrinsic apoptotic pathway is initiated in response to a variety of stress signals ( Willis and Adams, 2005 ), and a complex interplay of Bcl-2 proteins relays this signal to the mitochondrial outer membrane (OM) to initiate Bak and Bax activation, oligomerisation and OM damage ( Fig. 1 ). (biologists.com)
However, in certain cell types, the extrinsic pathway also induces mitochondrial damage by cleaving the pro-apoptotic Bcl-2 family protein Bid to its activated truncated form (tBid), which leads to Bak and Bax activation. (biologists.com)

The infectious agent in the prion disease is composed mainly or entirely of an abnormal conformation of a host-encoded glycoprotein called the prion protein. (medscape.com)
Since S-layers rapidly growing scientific and engineering discipline that are composed of a single protein or glycoprotein species crosses the boundaries of numerous existing fields. (2medicalcare.com)
The present communication considers aspects of glycoprotein research relevant to the field of biotechnology and protein design. (helmholtz-hzi.de)

Most peroxisomal membrane proteins do not have PTS1 or PTS2, and insertion requires several peroxins distinct from those required for import of soluble matrix proteins. (tcdb.org)

The nucleotide sequence analysis of nonstructural protein 2 gene of EDRD1 and comparison with Vietnamese HP-PRRSV showed that the 39 amino acid deletion sites of EDRD1 was nearly in the same region as the 29 amino acid deletion sites of HP-PRRSV. (biomedcentral.com)
The type 2 HP-PRRSV isolated in China in 2006 shows a unique discontinuous 30 amino acid deletion in the nonstructural protein 2 (nsp2) gene in open reading frame (ORF) 1a [ 5 , 7 ]. (biomedcentral.com)
There are 10°* ways to arrange aminoacids in a medium sized protein chain of 250 amino acids. (helmholtz-hzi.de)

1987 ). This superfamily of proteases is defined by the presence of a Zn 2+ ion at the catalytic center, which is coordinated by three histidine residues in the zinc-binding consensus sequence HExxHxxGxxH that is present in all proteolytically active metzincins, and a characteristic, strictly conserved methionine-containing tight 1,4 beta turn forming a hydrophobic cleft for the catalytic zinc ion (Bode et al. (evelinvahter.com)
A mineral is a naturally occurring solid chemical substance formed through biogeochemical processes, having characteristic chemical composition, highly ordered atomic structure, and specific physical properties. (niir.org)

C-terminal PTS1 [(SAC)-(KRH)-(LM)] and N-terminal PTS2 [(RK)-(LIV)-X 5 -(HQ)-(LA)] targeting sequences are recognized by Pex5p and Pex7p, respectively, which may shuttle with the substrate protein to the peroxisomal lumen. (tcdb.org)

Research projects in protein-design require a close cooperation between groupsspecialising in protein-isolation and purification, in fermentation techniques, in genetic-engineering, in DNAsynthesis and protein-crystallography (protein-NMR techniques are being established). (helmholtz-hzi.de)

The virus structure contains three domains, including an outer proteinaceous capsid, an intermediate lipid membrane, and a central core. (biomedcentral.com)

Pex4p is a membrane protein that may facilitate cycling of Pex5p back to the cytosol. (tcdb.org)
Based on these S-layer proteins, supramolecular assemblies can be constructed which are envisaged for label-free detection systems, as affinity matrix, as anti-allergic immuno-therapeutics, as membrane protein-based screening devices, and as drug targeting and delivery systems. (2medicalcare.com)

2009 ). At a larger scale, DSB formation occurs in the context of a specific chromosome architecture that consists of chromatin loops anchored to a proteinaceous axis (Zickler and Kleckner 1999 ). (springer.com)
DSB sites are preferentially located within chromatin loops, while several proteins that are required for DSB formation (Rec114, Mei4, and Mer2) localize on the chromosome axis (Blat et al. (springer.com)
A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)

A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. (lookformedical.com)

However, the inability of microbes to perform mammalian-type of posttranslational modifications of proteins is a major shortcoming. (helmholtz-hzi.de)
Principle mammalian types of protein modifications are N- and O-glycosylation. (helmholtz-hzi.de)
Results are presented that have been obtained by our group during the last four years concerning the expression of the glycoproteins human Interleukin 2 (Il-2) and Interferon-8 (IFN-8) in different mammalian cell lines, the determination of their carbohydrate residues, the effect of site-directed mutagenesis on their carbohydrate attachment sites and the insertion of peptide domains which function as acceptors for carbohydrates. (helmholtz-hzi.de)

Some viruses possess an outer envelope, and the outer capsid is composed of major capsid protein (MCP), which appears to be highly conserved among the family and possesses surface binding sites interacting with the surfaces of host's cells [ 2 ]. (biomedcentral.com)
Contrary to reef building corals, the red coral organic matrix possesses a large number of collagen-like proteins. (biomedcentral.com)

Here, we describe a generic approach to obtain crystals, solve the structure of a given protein, and perform a preliminary analysis, highlighting novel and efficient possibilities offered by automatization and contribution of Alpha Fold 2 structure prediction. (bvsalud.org)
His expertise in protein interfaces was widely appreciated in the community, and Guido was appointed as an assessor for the Critical Assessment of protein Structure Prediction (CASP) this year. (psi.ch)

The peroxisomal protein import machinery, which shares similarities with chloroplasts, is unique in transporting folded and large (up to 10 nm in diameter) protein complexes into peroxisomes. (tcdb.org)

The PRDM9 zinc finger array is highly polymorphic both within and between species (Berg et al. (springer.com)
their enzymatic repertoire is highly variable among species, individual cell types and under different physiological conditions. (biorxiv.org)

He also made significant contributions to computational structural biology, particularly in the analysis of protein-protein interfaces. (psi.ch)
We are interested in protein structure both from a structure determination and from a structural bioinformatics perspective, which means obtaining high resolution "bioimages" of proteins and extracting as much information as possible from them. (psi.ch)
The inferred regulatory function of these OM proteins suggests that the difference between the two biominerals is due to the modeling of the matrix network, rather than the presence of specific structural components. (biomedcentral.com)

The membrane bound docking subcomplex includes several Pex proteins, Pex13p, 14p and 17p. (tcdb.org)
This includes the Evolutionary Protein-Protein Interface Classifier (EPPIC) for assessing the biological relevance of protein-protein interfaces. (psi.ch)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)

Comparison of the mechanisms that govern the production of calcium carbonate (CaCO 3 ) biominerals in hexacorallians (scleractinians) and octocorallians is thus expected to shed light on the conservation of the protein toolkit used by these organisms for making their biocalcification. (biomedcentral.com)

2011 ) have reviewed the processes by which matrix and membrane proteins are incorporated into the peroxysome. (tcdb.org)

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) share overlapping genetic causes and disease symptoms, and are linked neuropathologically by the RNA binding protein TDP-43 (TAR DNA binding protein-43 kDa). (nature.com)

As a start, we have expressed four consecutive abab modules in Escherichia coli and find that the resulting 8-disulfide protein is well behaved and highly structured. (udel.edu)

and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)
Proteins found in the nucleus of a cell. (lookformedical.com)

These amyloid plaques are immunoreactive with antibodies to the prion protein and do not immunoreact with antibodies to other amyloidogenic proteins, such as the amyloid-beta (which is deposited in Alzheimer disease). (medscape.com)

In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)

This information can be useful not only to understand protein structure (structure analysis) but also for structure determination and validation. (psi.ch)

In order to gain insight into the red coral biomineralization process and cnidarian biomineralization evolution, we studied the protein repertoire forming the organic matrix (OM) of its two biominerals. (biomedcentral.com)

2010). In a second phase we used two sequence entropy-based evolutionary indicators and a simple geometric criterion to obtain accurate and efficient classification of protein-protein interfaces (Duarte et al. (psi.ch)

All of the cysteine residues are found as disulfides in ESM. (udel.edu)
We identified a total of 102 OM proteins, 52 are found in the two red coral biominerals with scleritin being the most abundant protein in each fraction. (biomedcentral.com)

The current development of anti-cancer agents that target the Bcl-2 protein family is showing considerable promise, although how this targeting triggers Bak and Bax to perform their crucial function of mitochondrial outer membrane permeabilisation (MOMP) is not clear. (biologists.com)

A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)

The Na+/K+-ATPase was only the first member of a large and still-growing protein family (see Swiss-Prot Prosite motif PS00154). (wikipedia.org)
Similarly, it was challenging to dissect a boundary between this section and U1(iii), "explain the control of blood glucose", but the large number of highly specific SAQs that ask to explain the control of blood glucose also suggested that it should be treated separately. (derangedphysiology.com)

PRDM9 is a member of the PRDM family of transcription regulators, but unlike other family members, it contains a Krüppel-associated box (KRAB)-related domain that is predicted to be a potential protein interaction domain. (springer.com)
In S. cerevisiae , this interaction is at least in part provided by Spp1 that directly interacts with both methylated H3K4 near DSB sites and the axis-localized protein Mer2 (Acquaviva et al. (springer.com)
C. truncatum likely secretes an arsenal of proteins that are implicated in maintaining a compatible interaction with its host. (biomedcentral.com)
Some of these proteins may have a role in establishing compatible interaction with the host plant. (biomedcentral.com)
During the transition, C. truncatum probably secretes a range of proteins to establish a compatible interaction with its host, including some that may exclusively be involved in switching the pathogen to the necrotrophic phase. (biomedcentral.com)

The cytoplasmic section consists of three cytoplasmic domains, designated the P, N, and A domains, containing over half the mass of the protein. (wikipedia.org)
Agrin-like glycoproteins and proteins with sugar-binding domains are also predominant. (biomedcentral.com)

Anatomy10

Organisms11

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes81

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science10

Health Care4

Peptides2

Enzymes4

Intrinsically disordered2

Glutamate1

Nucleic acids2

Cleave1

Bacterial2

Biogenesis1

Cysteine-rich1

Transmembrane1

Saccharomyces3

Similar proteins2

Subunit4

DnaJ1

Receptor1

Polysaccharides2

Phosphorylation1

Hsp705

Organelle1

20162

Cellular3

Secretion1

Putative1

Effectors3

Molecular4

Structures11

Genes2

Interact1

Substrates1

Nuclear1

Immunity1

Domain-contain2

Pathway2

Glycoprotein3

Soluble1

Amino3

Characteristic2

Substrate1

Crystallography1

Lipid1

Membrane protein2

Chromatin4

Chaperone1

Mammalian3

Possesses2

Prediction2

Peroxisomes1

Species2

Structural3

Includes3

Mechanisms1

Processes1

Genetic1

Escherichia1

Nucleus2

Amyloid1

Family protein1

Determination1

Repertoire1

Classification1

Found2

Outer1

Affinity1

Large2

Interaction5

Domains2