• After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)
  • Here, using the model species Drosophila melanogaster , we used a combination of Genome Wide Association mapping (GWAS) and transcriptomic profiling to characterize whether genes associated with thermal tolerance are primarily involved in dynamic stress responses or preparatory processes that influence physiological condition at the time of thermal stress. (frontiersin.org)
  • The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. (embl.de)
  • In this review, I discuss current knowledge and outstanding questions on the neuromodulators that influence aggressive behavior of the fruit fly Drosophila melanogaster. (deepdyve.com)
  • They were first discovered in 2001 in Drosophila melanogaster as small RNAs [8]. (jcimcr.org)
  • Heterochromatin protein 1 (HP1) was first described in Drosophila melanogaster as a heterochromatin associated protein with dose-dependent effect on gene silencing. (elsevierpure.com)
  • The work presented in this PhD thesis focuses on the study of awd (abnormal wing discs) gene function during the development of Drosophila melanogaster. (unibo.it)
  • OGA and OGT are synthesized from two conserved genes and are expressed throughout the human body with high levels in the brain and pancreas. (wikipedia.org)
  • Since Drosophila midgut has recently emerged as an ideal model for the study of the molecular mechanisms underlying somatic stem cell maintenance, it provides an useful system to evaluate the effects caused by loss of function of genes involved in this process. (unina.it)
  • To test the basis for defects in patterning, genes required for segment formation in the Drosophila embryo were examined. (sdbonline.org)
  • Results: Here, by phylogeny analysis, we found the three rab11 genes are highly conserved especially for their GTPase domains. (researchsquare.com)
  • We found that all the three genes were highly enriched in the central nervous system, but in different areas of the brain. (researchsquare.com)
  • In the present project, we showed that zebrafish rab11 genes are conserved in vertebrate evolution by in silicon analysis. (researchsquare.com)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
  • Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • The Drosophila extra sex combs (esc) protein, a member of the Polycomb group (PcG), is a transcriptional repressor of homeotic genes. (umn.edu)
  • This rearrangement leads to the fusion of BCR and ABL1 genes giving rise to a chimeric protein with constitutive kinase activity. (bioimagingnorthamerica.org)
  • Taken together, these data identify Nanos as primordial genes with highly conserved functions for both, the migration of the germinal cells and their maintenance in adults. (nature.com)
  • This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. (antibodypedia.com)
  • Scientific and social factors have resulted in a focus on well-studied proteins, leading to a concern that poorly understood genes are unjustifiably neglected. (biorxiv.org)
  • We applied RNAi in Drosophila to 260 unknown genes that are conserved between flies and humans. (biorxiv.org)
  • The advent of genome sequencing revealed in humans and other species thousands of genes encoding proteins that had not been identified by previous biochemical or genetic studies. (biorxiv.org)
  • The mystery and the potential biological significance of these unknown genes is enhanced by many of them being well conserved, and many of them being completely unrelated to known proteins and thus lacking clues to their function. (biorxiv.org)
  • Se caracterizan por poseer un dominio de unión al ADN emparejado altamente conservado que se identificó por vez primera en genes de segmentación de DROSOPHILA. (bvsalud.org)
  • They are characterized by a highly conserved paired DNA-binding domain that was first identified in DROSOPHILA segmentation genes. (bvsalud.org)
  • The mammalian orthologs of Derailed and SRC64B also form complexes, suggesting that Src roles in RYK signaling are conserved. (biologists.com)
  • In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)
  • Second, we have identified the mammalian stringent response pathway which is highly similar to bacterial stringent response, but with some very interesting twists and novel mechanisms. (duke.edu)
  • These participate in transcriptional/translational feedback loops and many homologous clock-components in the fruit fly Drosophila are also expressed in mammalian clock tissues with circadian rhythms. (bioone.org)
  • The highly conserved PNT (or Pointed) domain is found within a subset of the Ets transcription factors, including mammalian Ets-1, Ets-2, Erg, Fli-1, GABPalpha, and Tel, as well as Drosophila Pnt-P2 and Yan. (embl-heidelberg.de)
  • However, a recent study identified Drosophila and human MESH1 (Metazoan SpoT Homolog 1) as the homologs of the ppGpp hydrolase domain of the bacterial SpoT (10). (duke.edu)
  • We show that the butterfly homolog provides esc function in Drosophila, indicating that the sequence similarities reflect functional conservation. (umn.edu)
  • It is a member of a family of proteins that is highly conserved during evolution sharing high homology with its Drosophila homolog dCYFIP. (khas.edu.tr)
  • Ignesti, Marilena (2017) Uncovering the Relationship between Endocytosis and Awd, the Drosophila Homolog of Nme Metastasis Suppressor Proteins , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
  • The haploinsuffcient dVHL (von-Hippel Lindau) gene is the Drosophila homolog of the human VHL tumour suppressor gene. (unibo.it)
  • While DNMT3, the maintenance DNA methyltransferase DNMT1, HELLS, and CDCA7 are all highly conserved in vertebrates and green plants, they are frequently co-lost in other evolutionary clades. (elifesciences.org)
  • piRNAs form a complex with the PIWI protein and can be found in both vertebrates and invertebrates. (molcells.org)
  • N signalling is a highly conserved cell-cell communication pathway that mediates critical cell fate decision events occurring both in insects and vertebrates. (unibo.it)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • I thus used the GAL4/UAS system to silence in vivo Nop60b/mfl, the Drosophila ortholog of DKC1, and investigate in detail the effects triggered by gene silencing on the formation of larval Adult Midgut Precursor (AMPs) cells. (unina.it)
  • these proteins are also important in regulating gene transcription. (biomedcentral.com)
  • In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
  • Mutation in the Drosophila retained/dead ringer ( retn ) gene leads to female behavioral defects and alters a limited set of neurons in the CNS. (sdbonline.org)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • PIWI-interacting RNAs (piRNAs) are another subgroup of small non-coding RNAs emerging as key players in different biological activities, including regulating gene and protein expression, epigenetic silencing of transposable elements, and controlling the spermatogenesis by interacting with PIWI proteins. (jcimcr.org)
  • A member of the argonaut protein family encoded by the Drosophila piwi gene is involved in DNA methylation, transposon silencing, germline development, and fertility [12-14]. (jcimcr.org)
  • Genetic studies have shown that esc protein is required in early embryos at about the time that other PcG proteins become engaged in homeotic gene repression. (umn.edu)
  • A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)
  • ELAV/Hu proteins are gene-specific regulators of alternative splicing of mRNAs, but can also affect other aspects of the maturation of an mRNA and its cytoplasmic expression into a protein. (findaphd.com)
  • The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. (antibodypedia.com)
  • The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. (antibodypedia.com)
  • These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. (antibodypedia.com)
  • Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID) autism schizophrenia and epilepsy. (khas.edu.tr)
  • CYFIP1 interacts with the Fragile X mental retardation protein (FMRP encoded by the FMR1 gene) whose absence causes Fragile X syndrome and with the translation initiation factor eIF4E. (khas.edu.tr)
  • The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
  • One example is the conserved Drosophila tumor-suppressor protein Lethal giant larvae (Lgl). (biologists.com)
  • In a pairwise alignment, humans share 55% homology with Drosophila and 43% with C. elegans. (wikipedia.org)
  • Drosophila and C. elegans share 43% homology. (wikipedia.org)
  • However, OGA does not share significant homology with other proteins. (wikipedia.org)
  • However, short stretches of about 200 amino acids in OGA have homology with some proteins such as hyaluronidase, a putative acetyltransferase, eukaryotic translation elongation factor-1γ, and the 11-1 polypeptide. (wikipedia.org)
  • Homology modeling using the crystal structure of another WD repeat protein, the G-protein β- subunit, predicts that esc protein adopts a β-propeller structure. (umn.edu)
  • Among mammals, the OGA sequence is even more highly conserved. (wikipedia.org)
  • Members of the RYK/Derailed family have recently been shown to regulate axon guidance in both Drosophila and mammals by acting as Wnt receptors. (biologists.com)
  • Many of the regulatory processes and RNA-binding proteins are highly conserved between Drosophila and mammals. (leeds.ac.uk)
  • In Drosophila and mammals, Lgl contributes to the maintenance of cell polarity and plays a role in asymmetric cell division. (biologists.com)
  • [10] Homologous proteins have been identified in other organisms such as Drosophila (fruit flies), C. elegans (roundworms), [11] and all mammals . (handwiki.org)
  • The Nanos proteins family regroups highly conserved RNA-binding proteins in higher eukaryotes implicated in germ cell development and maintenance. (nature.com)
  • CTCF is one of the main architecture proteins in higher eukaryotes, and in combination with other architecture proteins and regulators, also shapes the three-dimensional organization of a genome. (biomedcentral.com)
  • Zebrafish rab11a was clustered in the Rab11a group, and rab11ba and rab11bb in the Rab11b group (Fig.1B) in the phylogenic tree constructed according to amino acid sequences of all the Rab11 proteins above. (researchsquare.com)
  • DNA methylation, particularly 5-methylcytosine (5mC) at CpG sequences, is widely conserved in eukaryotes. (elifesciences.org)
  • All identified mutations occurred at highly conserved sequences, not only in the FGFR family of molecules, but also throughout evolution and clustered in the immunoglobulin-like loop-III domain, highlighting the functional importance of this domain. (aacrjournals.org)
  • In this form, a single sugar (β-N-acetylglucosamine) is added to serine and threonine residues of nuclear or cytoplasmic proteins. (wikipedia.org)
  • Most, although not all, of the mutations causing skeletal abnormalities involve conserved residues that are predicted to play an important structural role in the correct folding of FGFRs, and substitutions with other residues result in constitutive activation of FGFRs with ligand-independent dimerization (11) . (aacrjournals.org)
  • These substitutions either create premature termination codons, which lead to truncated proteins, or substitute highly conserved residues in the bHLH region. (biomedcentral.com)
  • Both MESH1 proteins exhibit ppGpp hydrolase activity, and the deletion of Mesh1 in Drosophila led to a transcriptional response reminiscent of the bacterial stringent response (10). (duke.edu)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
  • The multi-functionality of HP1 reflects its ability to interact with diverse nuclear proteins, ranging from histones and transcriptional co-repressors to cohesion and DNA replication factors. (elsevierpure.com)
  • The basic signaling properties of two major subgroups of Rho GTPases - the Cdc42 and Rac subfamilies - are highly conserved amongst all eukaryotes, but the means by which they act are not well understood. (biomedcentral.com)
  • 5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. (elifesciences.org)
  • Collectively, this study provides the first evidence that transient levels of the evolutionarily conserved factor RACK1 are critical for adult SC activation and proper skeletal muscle regeneration, favoring the efficient progression of SC from a committed to a fully differentiated state. (sdbonline.org)
  • To test our hypotheses, we measured the critical thermal minimum (CT min ) and critical thermal maximum (CT max ) of 100 lines of the Drosophila Genetic Reference Panel (DGRP) and used GWAS to identify loci that explain variation in thermal limits. (frontiersin.org)
  • Here we provide genetic evidence in Drosophila that Notum requires glypicans to suppress Wnt signalling, but does not cleave their glycophosphatidylinositol anchor. (rcsb.org)
  • Genetic components of neuromodulatory systems are highly conserved across animals, suggesting that molecular and cellular mechanisms controlling Drosophila aggression can shed light on neural principles governing action choice during social interactions. (deepdyve.com)
  • Drosophila is an idea model for this work because it is amenable to genetic characterisations, suitable for biochemical purifications of material from organisms and tissue culture cells and the quality of genomic data available is excellent. (leeds.ac.uk)
  • We aim to dissect how ELAV activity is regulated by phosphorylation in Drosophila genetic and cell culture cell models for neurodegeneration. (findaphd.com)
  • This project will incorporate a wide range of molecular and cell biology techniques, which will be applied by using the genetic model organism Drosophila and various cell culture models. (findaphd.com)
  • Using a genetic screen for modifiers of Drosophila Myc ( dMyc )-induced growth, we identified and characterized a ubiquitin-specific protease (USP), Puffyeye (Puf), as a novel regulator of dMyc levels and function in vivo . (silverchair.com)
  • This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
  • ELAV mediated 3'-end processing of ewg transcripts is evolutionary conserved despite sequence degeneration of the ELAV binding site. (findaphd.com)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
  • Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)
  • In humans, ELAV/Hu proteins have been associated with schizophrenia, Alzheimer's and Parkinson's disease. (findaphd.com)
  • The TWIST1 protein is highly conserved from Drosophila to humans, where it plays a key role during embryonic morphogenesis, mesoderm patterning and development. (biomedcentral.com)
  • The extracellular E2 domain, a dimeric coiled coil and one of the most highly conserved regions of the protein from Drosophila to humans. (handwiki.org)
  • Protein O-GlcNAcase (EC 3.2.1.169, OGA, glycoside hydrolase O-GlcNAcase, O-GlcNAcase, BtGH84, O-GlcNAc hydrolase) is an enzyme with systematic name (protein)-3-O-(N-acetyl-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase. (wikipedia.org)
  • Protein O-GlcNAcases belong to glycoside hydrolase family 84 of the carbohydrate active enzyme classification. (wikipedia.org)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • Proteins interact with sequence elements within mRNAs to ensure accurate mRNA processing. (leeds.ac.uk)
  • The identity of proteins bound to mRNAs changes as they participate in different events. (leeds.ac.uk)
  • Other RNA-binding proteins affect the translation of mRNAs as well eg. (leeds.ac.uk)
  • The changing composition of these complexes is likely to be highly regulated and affect to what extent mRNAs are translated into proteins. (leeds.ac.uk)
  • While highly conserved among bacteria, the stringent response had not been reported in metazoans. (duke.edu)
  • The first of these is Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. (rupress.org)
  • In addition to the PAR proteins, other proteins are required for polarity in many metazoans. (biologists.com)
  • In metazoans, cell polarity is mediated in part by a conserved set of regulatory proteins, known collectively as the PAR (partitioning-defective) proteins. (biologists.com)
  • The analysis of Cdc42 and Rac function in evolutionarily distant organisms is useful as a tool to uncover the basic activities of these proteins. (biomedcentral.com)
  • The striking evolutive conservation of snoRNP functions, coupled with a highly divergent mechanism of telomere lenghthening, makes Drosophila a suitable system in which to assess the mechanisms by which pseudouridine synthases regulate stemness maintenance. (unina.it)
  • Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development. (researchsquare.com)
  • Among various Rab proteins, Rab11 is known to localize to recycling endosome and regulate vesicular recycling and primary ciliogenesis, playing a key role in Kupffer vesicle development in zebrafish [5-7]. (researchsquare.com)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. (molcells.org)
  • RNA-binding proteins interact with RNAs as soon as they are transcribed in the nucleus. (leeds.ac.uk)
  • Site-directed mutagenesis of specific loops, predicted to extend from the propeller surface, identifies conserved parts of esc protein required for function in vivo. (umn.edu)
  • Homologs exist in other species as O-GlcNAcase is conserved in higher eukaryotic species. (wikipedia.org)
  • To further investigate the domain organization of esc protein, we have isolated and characterized esc homologs from divergent insect species. (umn.edu)
  • The HP1 family is evolutionarily highly conserved and there are multiple members within the same species. (elsevierpure.com)
  • [12] The amyloid beta region of the protein, located in the membrane-spanning domain, is not well conserved across species and has no obvious connection with APP's native-state biological functions. (handwiki.org)
  • In the early embryo, a myosin II-dependent contraction of the cortical meshwork asymmetrically distributes the highly conserved PDZ proteins PAR-3 and PAR-6, as well as an atypical protein kinase C (PKC-3), to the anterior. (biologists.com)
  • My group addresses questions on the regulation of mRNA translation, non-coding RNA function and the role of specific RNA-protein complexes. (leeds.ac.uk)
  • Disruptions to RNA-protein interactions and translational regulation play significant roles in a variety of cancers and other disorders (e.g. spinal muscular atrophy). (leeds.ac.uk)
  • Intriguingly, human Hu proteins can substitute for ELAV in a Drosophila model for alternative splicing regulation. (findaphd.com)
  • Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
  • I suggest a consensus effect of each neuromodulatory molecule on Drosophila aggression, as well as effects of receptor proteins where relevant data are available. (deepdyve.com)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing NDK domain in the selected taxonomic class. (embl.de)
  • The protein encoded by DKC1, called dyskerin, is a pseudouridine synthase belonging to a highly evolutively conserved family. (unina.it)
  • NM23 belongs to a large family of structurally and functionally conserved proteins consisting of 4-6 identically folded subunits of approximately 16-20 kDa. (embl.de)
  • Kwon, SH & Workman, JL 2008, ' The heterochromatin protein 1 (HP1) family: Put away a bias toward HP1 ', Molecules and cells , vol. 26, no. 3, pp. 217-227. (elsevierpure.com)
  • Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. (findaphd.com)
  • Description: ARHGDIA regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (internationalshouldergroup.org)
  • In addition to its effects on dMyc, Puf regulates both Ago and its cell cycle substrate Cyclin E. Therefore, Puf influences cell growth by controlling the stability of key regulatory proteins. (silverchair.com)
  • A subset of these proteins is conserved across eukaryotic kingdoms. (embl.de)
  • Whilst the majority of our genome is transcribed, only a small fraction is protein-coding. (leeds.ac.uk)
  • Our results revealed different functions of dCTCF during the cell cycle and suggested that dCTCF might contribute to the establishment of the three-dimensional architecture of the Drosophila genome by maintaining local chromatin compartments throughout the whole cell cycle. (biomedcentral.com)
  • The human genome encodes ∼20,000 proteins, many still uncharacterised. (biorxiv.org)
  • Since the release of the first draft of the human genome sequence in 2000, the function of many of these new proteins has been identified. (biorxiv.org)
  • Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. (biomedcentral.com)
  • We suggest that these regions might mediate physical interaction with esc partner proteins. (umn.edu)
  • It is possible that CTCF, through using different combinations of zinc fingers, interacting with different protein partners, and the last but not the least, employing various post-translational modifications, could mediate extensive intra- and inter-chromatin interactions [ 7 , 8 ]. (biomedcentral.com)
  • Although Rab11a subcellular localization has been demonstrated by transgenic zebrafish [10], and molecular function of Rab11 proteins in primary cilia membrane assembly in Kupffer Vesicle has been studied [6], the developmental expression profile of Rab11 proteins in zebrafish remains elusive. (researchsquare.com)
  • Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons. (molcells.org)
  • Nanos are RNA-binding proteins playing crucial roles in germ cell development and maintenance. (nature.com)
  • The CCCTC-binding factor (CTCF) is a highly conserved insulator protein that plays various roles in many cellular processes. (biomedcentral.com)
  • Western blotting and immunofluorescence microscopy have been used to assay the roles of BCAS2 within the DSBs of PCa cells and apoptosis in Drosophila, respectively. (phylocommons.org)
  • By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)
  • the WD motif is responsible for a protein-protein interaction. (embl.de)
  • Many, but not all, of these effectors contain a conserved 18 amino-acid binding motif that has been termed CRIB (Cdc42-Rac interactive binding), PBD (p21-binding domain) or GBD (GTPase-binding domain) [ 4 ]. (biomedcentral.com)
  • The esc protein consists primarily of multiple copies of the WD repeat, a motif that has been implicated in protein-protein interaction. (umn.edu)
  • It has also been shown [ ( PUBMED:2175255 ) ] that the Drosophila awd (abnormal wing discs) protein, is a microtubule-associated NDK. (embl.de)
  • Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)
  • Therefore, PIWI proteins play a crucial role in fertility and germline development across both vertebrate and invertebrate animals. (molcells.org)
  • They provide NTPs for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerisation. (embl.de)
  • Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase. (rcsb.org)
  • Over 160 TWIST mutations have been described in SCS patients, a majority of which are present in the bHLH domains, mediating protein dimerization, and involving a single base pair substitution (54% of mutations). (biomedcentral.com)
  • Mutations in critical regions of amyloid precursor protein, including the region that generates amyloid beta (Aβ), cause familial susceptibility to Alzheimer's disease. (handwiki.org)
  • NDK are proteins of 17 Kd that act via a ping-pong mechanism in which a histidine residue is phosphorylated, by transfer of the terminal phosphate group from ATP. (embl.de)
  • The PIWI protein and piRNA form a complex, called piRNA-induced silencing complex (piRISC). (molcells.org)
  • The PIWI protein was initially described in Drosophila , and its name, P-element-induced wimpy testis (PIWI), was assigned as a result of the destructive effect on testis development observed in PIWI knockout ( Lin and Spradling, 1997 ). (molcells.org)
  • A) Domains of the PIWI protein. (molcells.org)
  • while the PIWI protein functions as the effector ( Tolia and Joshua-Tor, 2007 ). (molcells.org)
  • These oligomeric proteins exhibit nucleoside diphosphate kinase (NDPK) activity that catalyzes nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. (embl.de)
  • The PAR proteins include the PDZ domain-containing PAR-3 and PAR-6, the atypical protein kinase PKC-3, the serine/threonine kinase PAR-1 and, in nematodes, the putative ubiquitin E3 ligase PAR-2. (biologists.com)
  • When the tau protein in the brain is hyperphosphorylated, neurofibrillary tangles form, which are a pathological hallmark for neurodegenerative diseases such as Alzheimer's disease. (wikipedia.org)
  • In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)
  • retn is implicated as a major repressor of male courtship behavior in the absence of the fruitless ( fru ) male protein. (sdbonline.org)
  • We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
  • Since ELAV/Hu proteins bind short U-rich motifs embedded in a highly degenerate sequence context, it is thought that multimerization of ELAV/Hu proteins is key to generate target specificity and that this step is highly regulated by cellular signaling. (findaphd.com)
  • They also identify, at the active site of human and Drosophila Notum, a large hydrophobic pocket that accommodates palmitoleate. (rcsb.org)
  • From initial studies on human Hu proteins, we anticipate that altering phosphorylation will impact dramatically on ELAV function and will generate neurological phenotypes. (findaphd.com)
  • The expression of BCAS2 and different proteins in human PCa was decided by immunohistochemistry. (phylocommons.org)
  • BCAS2 helped restore radiation-induced DSBs effectively in each human PCa cells and Drosophila. (phylocommons.org)
  • RNA data sourced from Human Protein Atlas . (antibodypedia.com)
  • Nme1 is found in human body fluids and its protein level correlates with prognosis in cancer patients. (unibo.it)
  • Myc proteins control multiple cellular processes, including cell growth, proliferation, metabolism and apoptosis, and deregulation of Myc plays an important role in oncogenesis ( Dang, 2012 ). (silverchair.com)