• An M554V mutation in α-actinin-4 ( ACTN4 ) resulted in the expected shift in dendritic spine morphology by increasing the density of thin spines. (frontiersin.org)
  • Despite the accumulating evidence of increased -actinin-4 levels as a biomarker for cancer invasion and metastasis, the actual cellular functions of ACTN4 remain undetermined. (neuroart2006.com)
  • Mice lacking in -actinin-4 present serious glomerular disease because of irregular podocyte adhesion , . (neuroart2006.com)
  • Studies in ALP knockout mice have shown that ALP facilitates the cross-linking of actin filaments by alpha actinin-2, and absence of ALP induces abnormal right ventricular chamber formation, dysplasia and cardiomyopathy. (wikipedia.org)
  • Improved degrees of -actinin-4 improve the motility of colorectal tumor cells and down rules of -actinin-4 significantly decreases the migration of glioblastoma cells . (neuroart2006.com)
  • Upon the stimulation of cells with epidermal growth factor, tyrosyl-phosphorylation of -actinin-4 impairs its actin binding activity allowing for dissolution of cytoskeletal bundles, a process required for both rapid cell migration and appropriate cytokinesis . (neuroart2006.com)
  • A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells. (semanticscholar.org)
  • Highly enriched populations of cardiomyocytes and their replicating precursors can be obtained, suitable for use in a variety of applications, such as drug screening and therapy for cardiac disease. (google.com)
  • ALP functions to enhance the crosslinking of actin by alpha actinin-2 and also appears to be essential for right ventricular chamber formation and contractile function. (wikipedia.org)
  • Observations from both of these areas provide insights into the evolution and cellular functions of actinins. (springer.com)
  • More broadly though, this structure presents a picture of the intimate interactions between the subunits in the actinin dimer, providing a framework to better understand the molecular details of actin cross-linking and its regulation in all actinins and perhaps in spectrins too. (springer.com)
  • A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability. (genetex.com)
  • Increased FHL3 expression was detected in highly motile cells migrating into an artificial wound, compared with non-motile cells. (nih.gov)