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  • antitumor immunotherapy
  • This article summarizes recent evidence in the literature on the peculiar features that render memory NK cells an attractive tool for antitumor immunotherapy, including their long-term survival and in vivo persistence, the resistance to tumor-dependent immunosuppressive microenvironment, the amplified functional responses to IgG-opsonized tumor cells, and in vitro expansion capability. (hindawi.com)
  • The results gathered from more than 20 years of experimentation and almost 350 clinical trials demonstrated that DC-based antitumor immunotherapy is safe and with relevant clinical outcomes [ 3 ]. (intechopen.com)
  • hematopoietic stem cell trans
  • Conditions that require clinical tolerance to improve outcomes - autoimmune disease, solid organ transplantation, and hematopoietic stem cell transplantation - may benefit from Treg immunotherapy. (frontiersin.org)
  • He describes the evolution of his research, which has contributed significantly to advancing the field of gene transfer using retroviral vectors in the development of both autologous (AUTO) and allogeneic (ALLO) hematopoietic stem cell transplantation (HSCT) approaches to cancer immunotherapy, and the strategy of using chimeric antigen receptors (CARs) to modify T cells stimulating their activation, proliferation, and anti-tumor activity. (liebertpub.com)
  • autologous
  • The aim of this review is to highlight therapeutic strategies utilizing autologous and allogenic NK cells, combinations of NK cells with monoclonal antibodies to induce antibody-dependent cellular cytotoxicity, or immune checkpoint inhibitors. (frontiersin.org)
  • Adoptive transfer of autologous or allogeneic NK cells might be superior to the currently widely used donor lymphocyte infusion, which predominantly contain T lymphocytes, due to the fact that NK cells provide the first line of defense and generally mediate less graft-versus-host disease (GvHD) than T cells ( 10 , 11 ). (frontiersin.org)
  • However, NKT cell based-immunotherapy has been limited by the use of autologous antigen presenting cells and the quantity and quality of these stimulator cells can vary substantially. (jove.com)
  • checkpoint
  • Several of these new immunotherapies, particularly the immune checkpoint inhibitors, including ipilimumab in metastatic melanoma [ 4 ] and nivolumab in non-small cell lung cancer [ 5 ], have demonstrated impressive survival benefits in large phase III trials, leading to the FDA approval of these agents and solidifying immunotherapy as a new modality for the treatment of cancer. (hindawi.com)
  • effector
  • Highlighting this meeting were 2 outstanding keynote presentations regarding cutting- edge strategies that are demonstrating the impact of both innate and T-cell mediated immune effector mechanisms. (springer.com)
  • commercialization
  • Optimization of the current product development processes must benefit from prior experience especially with immunotherapies that underwent a successful cycle reaching commercialization. (biomedcentral.com)
  • Central to this effort, we were pleased to have amended the terms of our collaboration with Intrexon to facilitate the commercialization of our immunotherapy assets. (cnbc.com)
  • cytotoxic
  • In the present study, to clarify the feasibility of CML66-targeted cancer immunotherapy, we attempted to identify cytotoxic T lymphocyte (CTL) epitopes derived from CML66. (jove.com)
  • cell
  • In the world of NK cell structured immunotherapies this article "NKG2D Nutlin 3b and DNAM-1 Ligands: Molecular Goals for NK Cell-Mediated Immunotherapeutic Involvement in Multiple Myeloma" by C. Fionda et al. (welbourneprimary.com)
  • provides produce satisfactory leads to further potentiate NK cell structured immunotherapies. (welbourneprimary.com)
  • Examples include types of cell therapy like allogeneic cell therapy, embryonic stem cell therapy, or immunotherapy . (jpt.com)
  • progressively
  • During the last decades, posttransplant donor-derived adoptive cellular immunotherapeutic strategies have been progressively developed for the treatment of graft-versus-host disease (GvHD), infectious complications, and tumor relapses. (frontiersin.org)
  • Precision
  • Part of the meeting will also focus on new, developing technologies that are likely to expand our capacity to monitor the effects of cancer immunotherapy with a precision, refinement and at a level that has not been possible in the past. (bioportfolio.com)
  • Molecular
  • Dr. Lim is professor and chair of the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco. (hhmi.org)
  • therapy
  • However, the use TCRs with enhanced affinity for adoptive therapy carries with it the risk that they might recognize normal tissue, either as on-target or off-target reactivity. (aacrjournals.org)
  • How the inflammatory environment in the host affects immunotherapy and how commensal microbiota affects the response to therapy and to immunotherapy are not clear. (springer.com)
  • include
  • ASCO will recognize this year's awardees-which include a prominent researcher in the field of immunotherapy and an oncologist whose work has highlighted cancer risk factors particular to African populations-at its Annual Meeting in June. (ascopost.com)