• One of the key developments within the field of DCC is the use of proteins (or other biological macromolecules, such as nucleic acids) to influence the evolution and generation of components within a DCL. (wikipedia.org)
  • The differential abundance proteins from KBD and OA were validated using western blot analysis. (nature.com)
  • GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
  • And finally, many proteins from higher organisms require complex disulfide bonds for stability and proper folding. (neb.com)
  • We identified a total of 1,878 mimicked regions in 1,439 human proteins, and clustering analysis indicated diverse target proteins across pathogen species. (bvsalud.org)
  • NS1 contributes to pathogenicity through interactions with numerous host proteins, and many of the resulting complexes have been shown to be crucial for virulence. (bvsalud.org)
  • Sulfur is an important nutrient source found in a number of biological macromolecules, including proteins and lipids. (escholarship.org)
  • Biostatistics areas of interest include development of advanced statistical techniques and methodologies for design of biological experiments, collection and analysis of the data from those experiments and interpretation of, and inference from, the results. (nih.gov)
  • Salvatore Magazù, Federica Migliardo , " Dynamics of Biological Macromolecules by Neutron Scattering ", Bentham Science Publishers (2011). (benthamscience.com)
  • There is great interest to engineer in vitro models that allow the study of complex biological processes of the microvasculature with high spatiotemporal resolution. (biomedcentral.com)
  • The biophysical principle of MMC is based on macromolecules occupying space, thus increasing the effective concentration of other components and thereby accelerating various biological processes, such as extracellular matrix deposition. (biomedcentral.com)
  • International Journal of Biological Macromolecules , 14(3):166- 169. (ums.edu.my)
  • The scope of studies ranges from those focused-on sequencing, mass spectrometry, bioimaging and other high-through-put techniques in data to medicine, pharmacology, and populational studies. (nih.gov)
  • We combined High-Resolution Mass Spectrometry and transcriptome analysis to study the OM composition of the axial skeleton and the sclerites. (biomedcentral.com)
  • Among them AAT Bioquest's Buccutite™ crosslinking technology offer the most efficient method to conjugate antibodies with macromolecules such as enzyme tags. (stratech.co.uk)
  • As a result of their ability to bind target antigens selectively and with high affinity, antibodies are useful tools for protein purification, cell sorting, diagnostics, and therapeutics. (justia.com)
  • To build and strengthen institutional capacities in OMICS data analysis applied to host-pathogen interaction (HPI), the PHINDaccess project organized two hackathons in 2020 and 2021. (bvsalud.org)
  • Screen Quest™ assay kits, a set of HTS-ready tools for high throughput screening of biochemical and cellular targets such as protein kinases, proteases, HDAC, cell apoptosis and cytoxicity, GPCR, ion channels, ADME/metabolism and transporters. (stratech.co.uk)
  • Sulfur starvation also caused changes in the expression of genes involved in carbohydrate metabolism, such as those encoding glycosyl hydrolases. (escholarship.org)
  • Gene ontology (GO) and pathway enrichment analysis demonstrated that the DEGs were mainly implicated in energy metabolism, metabolism of terpenoids and polyketides, and carbohydrate metabolism related pathways. (biomedcentral.com)
  • Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity. (unav.edu)
  • The interaction network of all identified differentially expressed genes and metabolites was constructed to outline the regulatory genes and dominant pathways in response to acid stress. (springeropen.com)
  • KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
  • Genome sequence and spore germination-associated transcriptome analysis will contribute to the understanding of the molecular mechanism of pathogenicity and spore germination of C. cassiicola . (biomedcentral.com)
  • The tall fescue assembled transcriptome provided substantial molecular resources for further genomics analysis of turfgrass in response to heavy metal stress. (biomedcentral.com)
  • The results of real-time reverse transcription quantitative PCR (RT‒qPCR) further confirmed the results of the transcriptomic analyses. (springeropen.com)
  • The expression patterns of 16 randomly selected genes were in consistent with that from the Solexa analysis using quantitative reverse-transcription PCR. (biomedcentral.com)
  • The COVID-19 pandemic caused by SARS-CoV-2 has emphasized the need for portable and reproducible genomics analysis pipelines to study the genetic susceptibility of the human host and investigate human-SARS-CoV-2 protein interactions. (bvsalud.org)
  • In summary, we describe the first bioprinted, micro-vascularized neuroblastoma - tumor-environment model directly printed into fluidic chips and a novel medium-throughput biofabrication platform suitable for studying tumor angiogenesis and metastasis in precision medicine approaches in future. (regenhu.com)
  • High-throughput injection molding of transparent fused silica glass. (uni-freiburg.de)
  • This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
  • As a biochemist you study the way living organisms - from viruses and bacteria to mammals, plants and other higher organisms - function at the molecular level. (kent.ac.uk)
  • These atomistic details of the interaction of a cellulase within a crowded biomass environment, including both substrate interactions and lignin inhibition, explain why lignin is such an effective barrier to efficient enzymatic hydrolysis of post-pretreated biomass. (biomedcentral.com)
  • Using this method, expansion of each successfully created hybridoma then produces a monoclonal antibody in sufficiently high concentrations to measure its affinity and selectivity to a target antigen. (justia.com)
  • It is also suspected that the cellulose-binding module (CBM) of cellulases participates in lignin binding, as enzymes containing a CBM have a higher affinity for lignin than those without one [ 20 , 22 ]. (biomedcentral.com)
  • Proteomic results were analyzed with gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interactions (PPI). (nature.com)
  • If a membrane protein expresses at a high level, almost certainly some of this protein will be found in the insoluble fraction. (neb.com)
  • The interaction of biotin and Avidin or Streptavidin has been exploited for use in many protein and nucleic acid detection and purification methods. (genomicglossaries.com)
  • By understanding the minute details of protein structure, we can develop antivirals that target the most conserved, crucial regions to yield the highest chances of long-lasting success. (bvsalud.org)
  • There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. (justia.com)
  • and determining a binding interaction between the protein produced by the cell and the biomolecule. (justia.com)
  • Our findings provide insights into the broad range of host-pathogen interactions mediated by molecular mimicry and highlight potential targets for further investigation. (bvsalud.org)
  • Because the biotin label is stable and small, it rarely interferes with the function of labeled molecules enabling the Avidin-biotin interaction to be used for the development of robust and highly sensitive assays. (genomicglossaries.com)
  • Cell Meter™ cellular functional assay kits, a complete set of tools for functional analysis of cellular events. (stratech.co.uk)
  • First, we reported the draft genome sequences of the cucumber-sampled C. cassiicola isolate HGCC with high virulence. (biomedcentral.com)
  • Development of new or improved instruments, methods, and related software to elucidate 3D structures of macromolecules and macromolecular complexes. (nih.gov)
  • Our high quality reagents are available for every workflow, including popular DNA assembly methods such as NEBuilder ® HiFi DNA Assembly and NEBridge ® Golden Gate Assembly . (neb.com)
  • A general education chemistry course that uses the empirical inquiry methods of science applied to the interaction of molecules--in foods, in the environment, and in medicines--with humans. (uic.edu)
  • Such methods and apparatus are particularly useful in a wide variety of processes involving chemical and/or physical interactions in connection with a sample of interest located in the thin region. (patentsencyclopedia.com)
  • Methods of Soil Analysis: Part 1 Physical and Mineralogical properties. (ums.edu.my)
  • Although both varieties showed a similar profile, raw red cardoon had 1.7-fold higher (poly)phenol content than raw white cardoon. (unav.edu)
  • C. cassiicola showed pathogenic and genetic variation among isolates sampled in different host plants, proving that the intraspecific strains of C. cassiicola showed high host specialization [ 2 , 7 ]. (biomedcentral.com)
  • This fern is highly abundant at high-humidity/low-light microenvironments within the canopy, although rapid changes in humidity and light intensity are frequent. (frontiersin.org)
  • Identify the physical and chemical properties of the macromolecules and detecting their presence qualitatively in unknown samples. (uaeu.ac.ae)
  • This degree opens introduces you to potentially exciting career opportunities where you can make an impact in a variety of fields, including pharmaceutics, pharmaceutical analysis, chemical analysis, chemical manufacturing, and healthcare. (hud.ac.uk)
  • The transforming mechanism was further explored from physical and chemical aspects based on the analyses of surface morphology and surface chemistry. (flow3d.co.kr)
  • Further investigation of their regulative roles and interaction may provide new insights into the pathological mechanisms and therapeutic targets for KBD. (nature.com)
  • The assembly and analysis of microbial species on earth remains a largely unexplored area of life. (escholarship.org)
  • The precious Mediterranean red coral, Corallium rubrum , is an octocorallian species, which produces two distinct high-magnesium calcite biominerals, the axial skeleton and the sclerites. (biomedcentral.com)
  • The simulation results and the images captured by high-speed camera were highly consistent, which indicated that the computational fluid dynamics (CFD) is an effective method to predict the droplet motion on super- hydrophobic surfaces. (flow3d.co.kr)
  • In contrast, all risk factors of metabolic syndrome displayed a high association with group2 and group3. (eurekaselect.com)
  • One strategy to increase cure rates is the identification of patient-specific drug responses in tissue models that mimic the interaction between patient cancer cells and tumor environment. (regenhu.com)
  • This comprehensive analysis contributes to our understanding of the complex mechanisms employed by pathogens to subvert host defenses and we provide a resource to assist researchers in the development of novel therapeutic strategies. (bvsalud.org)
  • Conformations in polysaccarides and complex carbohydrates. (ums.edu.my)
  • Further analysis revealed that the candidate mimicry regions were enriched in solvent-accessible regions, highlighting their potential functional relevance. (bvsalud.org)
  • Although this approach was arguably utilised in the work of Fischer and Werner as early as the 19th century, their respective studies of carbohydrate and coordination chemistry were restricted to rudimentary speculation, requiring the rationale of modern thermodynamics. (wikipedia.org)
  • The single-molecule real-time (SMRTTM) sequencing platform developed by Pacific Biosciences (PacBio) offers several benefits including Single Molecule real-time analysis, longer read length at fast speed, low sequencing redundancy and bias. (escholarship.org)
  • Transcriptomic analysis was conducted using the Illumina sequencing platform followed by validation with real-time qPCR, while metabolomic analysis was completed using positive and negative ion modes. (springeropen.com)
  • The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
  • A major problem that plants have faced since they colonized earth's surface is the exposure to a high atmospheric demand of water. (frontiersin.org)
  • I subsequently took up a postdoctoral position in the Laboratory of Biophysics and Surface Analysis (LBSA), School of Pharmacy, University of Nottingham under the direction of Martyn Davies, Saul Tendler and David Jackson. (nottingham.ac.uk)
  • Investigate advanced topics such as drug design, drug analysis and analytical chemistry. (hud.ac.uk)
  • Studied pharmacy and undertook a PhD thesis on the physicochemistry of drug-macromolecule interactions and later attended to Chelsea College, University of London, as a postdoctoral research under the supervision of the late Arnold (Joe) H. Beckett. (theanalyticalscientist.com)
  • In many cases, getting high quantity of genomic DNA remains as a major challenge. (escholarship.org)
  • Previous efforts to resolve this challenge have included high-throughput workflows wherein many possible magnetic orderings are enumerated and calculated. (mrs.org)
  • Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
  • This analysis may be accomplished with software programs such as Mfold, UNAfold and other similar programs. (neb.com)
  • The highest quality of order, however, was found for the P3HT film cooled slowly from the melt. (uni-freiburg.de)