• Numerow LMMorita ETClark OHHiggins CB Persistent/recurrent hyperparathyroidism: a comparison of sestamibi scintigraphy, MRI, and ultrasonography. (jamanetwork.com)
  • Light VLMcHenry CRJarjoura DSodee DBMiron SD Prospective comparison of dual-phase technetium-99m-sestamibi scintigraphy and high resolution ultrasonography in the evaluation of abnormal parathyroid glands. (jamanetwork.com)
  • Our objective was to investigate the feasibility of subtraction for SPECT images of 99m Tc-MIBI double-phase parathyroid scintigraphy. (snmjournals.org)
  • All patients underwent 99m Tc-MIBI scintigraphy in addition to cervical ultrasonography, and they then underwent parathyroidectomy within 2 wk. (snmjournals.org)
  • Noninvasive parathyroid imaging studies include technetium (Tc)-99m sestamibi scintigraphy, ultrasound, computed tomography (CT) scanning, magnetic resonance imaging (MRI), and positron emission tomography (PET) scanning. (medscape.com)
  • Non-invasive imaging modalities for preoperative localization of hyper-functioning parathyroid glands include Tc-99m sestamibi scintigraphy ( sestamibi or MIBI ), single photon emission computed tomography ( SPECT ), positron emission tomography ( PET ). (wikidoc.org)
  • Technetium-99m -methoxyisobutylisonitrile ( 99mTc-sestamibi or MIBI) scintigraphy is the most popular investigation for preoperative localization of hyper-functioning parathyroid glands . (wikidoc.org)
  • The sensitivity of sestamibi scintigraphy can be increased by using it concomitantly with neck ultrasound and/or SPECT . (wikidoc.org)
  • Dual tracer Tc-99m sestamibi scintigraphy - A nuclear medicine parathyroid scan demonstrates a parathyroid adenoma adjacent to the left inferior pole of the thyroid gland. (wikidoc.org)
  • Single photon emission computed tomography may be used along with Tc-99m sestamibi scintigraphy for preoperative evaluation of hyper-functioning parathyroid gland. (wikidoc.org)
  • Various methodologies for 99m Tc-sestamibi parathyroid scintigraphy are in clinical use. (snmjournals.org)
  • Localization with dual-phase acquisition was more accurate than with single-phase 99m Tc-sestamibi scintigraphy for planar imaging, SPECT, and SPECT/CT. (snmjournals.org)
  • Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m ( 99m Tc)-labelled radiotracers. (cadth.ca)
  • SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography , but uses isotopes with longer half-lives and resolution is lower. (lookformedical.com)
  • This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography , where data is obtained and computed from individual sequential exposures. (lookformedical.com)
  • Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology. (lookformedical.com)
  • Among these imaging techniques, nuclear imaging (including single photon emission computed tomography and positron emission tomography) remains the premier clinical method owing to their high specificity and sensitivity. (oncotarget.com)
  • Both ultrasonography and 99m Tc-sestamibi (MIBI) SPECT images were obtained from all patients. (snmjournals.org)
  • Tc-99m sestamibi is considered the most sensitive and specific imaging modality, particularly when used with single-photon emission CT (SPECT). (medscape.com)
  • Sestamibi-SPECT is also called pinhone-SPECT (P-SPECT). (wikidoc.org)
  • Value of technetium 99m sestamibi iodine 123 imaging in reoperative parathyroid surgery. (jamanetwork.com)
  • Wei JPBurke GJMansberger AR Jr Prospective evaluation of the efficacy of technetium 99m-sestamibi and iodine 123 radionuclide imaging of abnormal parathyroid glands. (jamanetwork.com)
  • Subtraction technique uses dual contrast Tc-99m sestamibi along with iodine-123 or 99m-technicium pertechnetate, which are taken by thyroid tissue only. (wikidoc.org)
  • Iodine-123/99m-technicium pertechnetate images of thyroid are later digitally subtracted from Tc-99m sestamibi images leading to visualization of parathyroid tissue only. (wikidoc.org)
  • The above study was performed with Technetium-Sestamibi (1st column) and Iodine-123 (2nd column) simultaneous imaging and the subtraction technique (3rd column). (wikidoc.org)
  • 12.1 Mechanism of Action Technetium Tc 99m Sestamibi is cationic Tc 99m complex which has been found to accumulate in viable myocardial tissue in manner analogous to that of thallous chloride Tl-201. (drugcentral.org)
  • Table Biological and Effective ClearanceRESTSTRESSHeart LiverHeart LiverTimeBiologicalEffectiveBiologicalEffectiveBiologicalEffectiveBiologicalEffective5 min.1.21.219.619.41.51.55.95.830 min.1.11.012.211.51.41.34.54.21 hour1.00.95.65.01.41.22.42.12 hours1.00.82.21.71.21.00.90.74 hours0.80.50.70.41.00.60.30.2A study in dog myocardial ischemia model reported that Technetium Tc 99m Sestamibi undergoes myocardial distribution (redistribution), although more slowly and less completely than thallous chloride Tl-201. (drugcentral.org)
  • In patients with documented myocardial infarction, imaging revealed the infarct up to four hours post dose.MetabolismThe agent is excreted without any evidence of metabolism.EliminationThe major pathway for clearance of Tc 99m Sestamibi is the hepatobiliary system. (drugcentral.org)
  • CLINICAL TRIALS:MYOCARDIAL IMAGING: In trial of rest and stress Technetium Tc 99m Sestamibi imaging, the relationship of normal or abnormal perfusion scans and long term cardiac events was evaluated in 521 patients (511 men, 10 women) with stable chest pain. (drugcentral.org)
  • All subjects underwent Technetium-99 m sestamibi single-photon emission computed tomographic imaging for the estimation of myocardial ischemia, expressed as Summed Stress Score (SSS). (springer.com)
  • 7 Viable myocardial cells take up the radionuclide tracer (either thallium isotope [ 201 TI] or isotope 99m Tc-labelled radiotracer) in proportion to blood flow. (cadth.ca)
  • Wei JPBurke GJ Analysis of savings in operative time for primary hyperparathyroidism using localization with technetium 99m sestamibi scan. (jamanetwork.com)
  • Casas ATBurke GJMansberger AR JrWei JP Impact of technetium-99m-sestamibi localization on operative time and success of operations for primary hyperparathyroidism. (jamanetwork.com)
  • Borley NRCollins RECO'Doherty MCoakley A Technetium-99m sestamibi parathyroid localization is accurate enough for scan-directed unilateral neck exploration. (jamanetwork.com)
  • McHenry CRLee KSaadey JNeumann DREsselstyn CB Jr Parathyroid localization with technetium-99m-sestamibi: a prospective evaluation. (jamanetwork.com)
  • Multiphase CT has become the standard of care for diagnostically confounding cases or, at some institutions, for first-line preoperative localization given the high accuracy. (medscape.com)
  • Although studies of subcellular fractionation and electron micrographic analysis of heart cell aggregates suggest that Tc 99m Sestamibi cellular retention occurs specifically within the mitochondria as result of electrostatic interactions, the clinical relevance of these findings has not been determined.The mechanism of Tc 99m Sestamibi localization in various types of breast tissue (e.g., benign, inflammatory, malignant, fibrous) has not been established. (drugcentral.org)
  • V-vials are used to transport and store unit doses of radiopharmaceuticals containing high-energy beta-emitters, such as 186 Re. (snmjournals.org)
  • Therefore, the corresponding radiopharmaceuticals have been a major focus, and some of them like 99m Tc-Annexin V, 18 F-ML-10, 18 F-CP18, and 18 F-ICMT-11 are currently under clinical investigations in Phase I/II or Phase II/III clinical trials on a wide scope of diseases. (oncotarget.com)
  • METHODS: Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. (cnr.it)
  • Table illustrates the biological clearance as well as effective clearance (which includes biological clearance and radionuclide decay) of Tc 99m Sestamibi from the heart and liver. (drugcentral.org)
  • All patients had baseline rest and exercise Technetium Tc 99m Sestamibi scan and were followed for 13.2 +- 4.9 months (range: to 24 months). (drugcentral.org)
  • A sestamibi or tetrofosmin nuclear scan thus can identify cancer patients in whom certain drugs are unlikely to be effective. (axisimagingnews.com)
  • Tc-99m sestamibi scan - Parathyroid adenomas typically retain activity on late scans after wash-out in the thyroid has occurred. (wikidoc.org)
  • 99m Tc-Sestamibi (MIBI) has also been approved as an effective diagnostic imaging agent. (snmjournals.org)
  • Ultrasonography is the first diagnostic modality for the assessment of parathyroid glands because of its convenience and relatively high degree of sensitivity ( 1 - 4 ). (snmjournals.org)
  • Key studies have confirmed that MBI has a high sensitivity for the detection of small breast lesions. (nih.gov)
  • Technetium-99m (99mTc) is a metastable nuclear isomer of technetium-99 (itself an isotope of technetium), symbolized as 99mTc, that is used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope in the world. (wikipedia.org)
  • In 1938, Emilio Segrè and Glenn T. Seaborg isolated for the first time the metastable isotope technetium-99m, after bombarding natural molybdenum with 8 MeV deuterons in the 37-inch (940 mm) cyclotron of Ernest Orlando Lawrence's Radiation laboratory. (wikipedia.org)
  • The basis of "single-isotope, double-phase technique" is that sestamibi washes out of the thyroid more rapidly than from abnormal parathyroid tissue. (wikidoc.org)
  • Sestamibi is a lipophilic cationic on physioligical pH. (wikidoc.org)
  • 99mTc remained a scientific curiosity until the 1950s when Powell Richards realized the potential of technetium-99m as a medical radiotracer and promoted its use among the medical community. (wikipedia.org)
  • Technetium-99m is used as a radioactive tracer and can be detected in the body by medical equipment (gamma cameras). (wikipedia.org)
  • It was not until 1960 that Richards became the first to suggest the idea of using technetium as a medical tracer. (wikipedia.org)
  • Molecular breast imaging (MBI) is a new nuclear medicine technique that utilizes small semiconductor-based gamma-cameras in a mammographic configuration to provide high-resolution functional images of the breast. (nih.gov)
  • Most of the sestamibi is retained in mitochondria of thyroid and abnormal parathyroid tissue and is a function of mitochondrial activity. (wikidoc.org)
  • As all parathyroid lesions does not retain sestamibi nor all thyroid tissue washes out quickly, subtraction imaging may be beneficial. (wikidoc.org)
  • One approach uses thyroid imaging with 99m Tc-pertechnetate or 123 I-sodium iodide concomitantly and computer subtraction techniques. (snmjournals.org)
  • At high-contrast boundaries (jump discontinuity in mathematical terms), the Fourier transform corresponds to an infinite number of frequencies. (radiopaedia.org)
  • We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. (cnr.it)
  • CONCLUSION: Sestamibi imaging may detect impaired coronary vascular function in response to dipyridamole in patients with untreated mild essential hypertension and normal coronary arteries. (cnr.it)
  • 4 Because of the high prevalence of symptomatic and asymptomatic coronary artery disease (CAD) in this patient population, the clinical assessment aims to identify patients at increased risk of cardiac complications and apply strategies to reduce this risk. (cadth.ca)
  • Lee VSWilkinson RH JrLeight GS JrCoogan ACColeman RE Hyperparathyroidism in high-risk surgical patients: evaluation with double-phase technetium-99m sestamibi imaging. (jamanetwork.com)
  • Therefore, early identification of patients with DM at high risk for asymptomatic MI consists of a significant challenge. (springer.com)
  • Patients undergoing major high-risk vascular non-cardiac surgery (including aortic and peripheral vascular surgery). (cadth.ca)
  • Technetium-99m was discovered as a product of cyclotron bombardment of molybdenum. (wikipedia.org)
  • The American Association of Endocrine Surgeons (AAES) also recommend US, along with another imaging modality with high resolution for surgical planning. (medscape.com)
  • Current studies with MBI have used Tc-99m sestamibi, which is an approved agent for breast imaging. (nih.gov)
  • The basic technical requirements for a biological imaging method are high spatial and temporal resolution and the ability to detect nanomolar to picomolar concentrations of target molecules. (axisimagingnews.com)
  • The Biological Imaging Center at the Beckman Institute, California Institute of Technology, Pasadena, Calif, specializes in developmental biology and has a three-dimensional atlas of mouse anatomy based on magnetic resonance microscopy, as well as high-field MR images of murine models of human diseases. (axisimagingnews.com)
  • The use of 99m Tc-sestamibi for parathyroid imaging was first reported in 1989 ( 9 ). (snmjournals.org)
  • Although magnetic resonance imaging shows promise as a screening tool in some high-risk women, it is not currently recommended for general screening because of high false-positive rates and cost. (aafp.org)
  • The American Cancer Society recommends annual magnetic resonance imaging as an adjunct to screening mammography in high-risk women 30 years and older. (aafp.org)
  • Magnetic resonance imaging is recommended as an adjunct to screening mammography in women 30 years and older who are at high risk for breast cancer. (aafp.org)
  • This property allows for high-resolution imaging, enabling clinicians to visualise and diagnose various conditions accurately, especially in oncology, where precise tumour localisation is critical. (openmedscience.com)
  • MBI provides high-resolution functional images of the breast and its potential applications range from evaluation of the extent of disease to a role as an adjunct screening technique in certain high-risk populations. (nih.gov)
  • Multiple planar images are obtained, typically one shortly after injection of 99mTc-sestamibi and another after two hours to identify the areas of retained sestamibi showing hyper-functioning parathyroid tissue. (wikidoc.org)
  • however, the document search for this report was focused on major, high-risk vascular surgery. (cadth.ca)
  • The process begins by bombarding a stable nickel target with high-energy protons. (openmedscience.com)
  • the 6.6-h activity acquired the designation 'technetium-99m. (wikipedia.org)
  • So, the uptake of sestamibi into parathyroid adenoma cells depends on the activity of the P-gp [19] . (wikidoc.org)
  • Shen WSabanci UMorita ETSiperstein AEDuh QYClark OH Sestamibi scanning is inadequate for directing unilateral neck exploration for first-time parathyroidectomy. (jamanetwork.com)
  • With the help of PET, it is possible to determine the nature of a solitary lung nodule, to stage non-small-cell lung cancer and lymphoma, and to evaluate recurrence of colorectal cancer or lymphoma.2 Technetium Tc 99m sestamibi and technetium Tc 99m tetrofosmin are substrates for the membrane P-glycoprotein transporter that is responsible for multidrug resistance in cancer cells. (axisimagingnews.com)
  • Detailed description and high technical standards of experiments, statistics, and other analyses are required. (oap-journals.com)